Adenosine Receptors in Neurodegenerative Diseases Book

Adenosine Receptors in Neurodegenerative Diseases

  • Author : David Blum
  • Publisher : Academic Press
  • Release Date : 2017-03-10
  • Genre: Science
  • Pages : 280
  • ISBN 10 : 9780128037454

Adenosine Receptors in Neurodegenerative Diseases Excerpt :

Adenosine Receptors in Neurodegenerative Diseases covers the role of adenosine receptors in brain function, also focusing on related methodologies and perspectives in therapeutics. The book provides an up-to-date overview by the best specialists in the field, helping readers consider the importance of adenosine and expand the global impact and visibility of adenosine research in the CNS field. Chapters include adenosine biology and signaling, gene regulation, control of motor function, and novel adenosine-based therapies in the CNS. It is an ideal resource for researchers, advanced graduate students, clinicians, and industry scientists working in the fields of clinical neuroscience and molecular and cellular neuroscience. Comprehensive reference that details adenosine receptors in neurodegenerative disorders, with details on brain function and possible therapeutics Gives insights on how these receptors modulate the neurodegenerative outcomes in different disorders Edited by two of the leading researchers in the field regarding adenosine role in the brain in aging and neurodegenerative conditions

Adenosine Receptors and Parkinson s Disease Book

Adenosine Receptors and Parkinson s Disease

  • Author : Hiroshi Kase
  • Publisher : Elsevier
  • Release Date : 1999-10-27
  • Genre: Medical
  • Pages : 275
  • ISBN 10 : 9780080525952

Adenosine Receptors and Parkinson s Disease Excerpt :

This book is the first definitive overview on adenosine receptor antagonists and their application to the treatment of Parkinson's Disease. The effect of these novel non-dopamine drugs on vitro and in vivo systems clearly shows their potential for the treatment of this debilitating disease. This book covers how the Parkinson's disease antagonist drug, A2A, has been researched, developed, and tested. It is an essential book for researchers interested in the basal ganglia, purine biology, and Parkinson's Disease. Discusses the discovery and development of a novel non-dopaminomimetic agent for Parkinson's disease Provides the first definitive overview of adenosine antagonists and their role in the treatment of Parkinson's disease Presents a new mechanism of action of adenosine A2A receptor antagonists in motor function Proposes a hypothesis of adenosine A2A receptor function in the striatum Comprehensive overview of adenosine, its receptor subtypes, their antagonists/agonists from biochemistry, molecular biology, medicinal chemistry, physiology, pharmacology, and neurochemistry viewpoints

Adenosine Receptors in Health and Disease Book
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Adenosine Receptors in Health and Disease

  • Author : Constance N. Wilson
  • Publisher : Springer Science & Business Media
  • Release Date : 2009-07-28
  • Genre: Medical
  • Pages : 652
  • ISBN 10 : 3540896155

Adenosine Receptors in Health and Disease Excerpt :

Since their discovery approximately 25 years ago, adenosine receptors have now emerged as important novel molecular targets in disease and drug discovery. These proteins play important roles in the entire spectrum of disease from inflammation to immune suppression. Because of their expression on a number of different cell types and in a number of different organ systems they play important roles in specific diseases, including asthma, rheumatoid arthritis, Parkinson’s disease, multiple sclerosis, Alzheimer’s disease, heart disease, stroke, cancer, sepsis, and obesity. As a result of intense investigations into understanding the molecular structures and pharmacology of these proteins, new molecules have been synthesized that have high specificity for these proteins and are now entering clinical trials. These molecules will define the next new classes of drugs for a number of diseases with unmet medical needs.

The Adenosine Receptors Book

The Adenosine Receptors

  • Author : Pier Andrea Borea
  • Publisher : Humana Press
  • Release Date : 2018-07-28
  • Genre: Medical
  • Pages : 593
  • ISBN 10 : 9783319908083

The Adenosine Receptors Excerpt :

This book traces the history of adenosine receptor research from molecular biology to medicinal chemistry to behavior, including their implications in disease and potential strategies as therapeutic targets. It provides the reader with a comprehensive overview of the adenosine receptors that includes information on all subtypes - A1, A2A, A2B and A3. Aspects addressed include the most up to date information on their functional distribution in the nervous and peripheral systems, behavioral roles in inflammation, cancer, pain and neurological diseases such as Huntington’s disease, Epilepsy, Parkinson’s disease and Alzheimer’s disease.

Methylxanthines Book


  • Author : Bertil B. Fredholm
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-09-22
  • Genre: Medical
  • Pages : 559
  • ISBN 10 : 3642134432

Methylxanthines Excerpt :

In the present volume of the Handbook of Experimental Pharmacology well known experts describe the actions of different xanthines with a focus on caffeine and theophylline. A special chapter is devoted to theobromine, an active component of chocolate, the actions of which are less well characterized. This book also presents the pharmacology of one xanthine derivative, propentofylline, as an example of a xanthine that has gone through extensive development for a novel therapeutic area.

Adenosine Receptors Book

Adenosine Receptors

  • Author : Gyorgy Hasko
  • Publisher : CRC Press
  • Release Date : 2006-07-20
  • Genre: Medical
  • Pages : 363
  • ISBN 10 : 9781420005776

Adenosine Receptors Excerpt :

After a century of research, several lines of evidence now indicate that the ability of adenosine to directly control inflammatory cells has a major impact on the functions of the inflammatory and immune systems. Consequently, many promising therapeutic approaches are beginning to emerge that focus on the modulation of adenosine, including the development of compounds that interfere with the breakdown of adenosine, as well as specific agonists and antagonists of various adenosine subtypes. Some of these compounds have already entered clinical trials. While information on the role of adenosine is growing rapidly, until now it has remained scattered in the literature. Edited by three pioneering researchers in the field, Adenosine Receptors: Therapeutic Aspects for Inflammatory and Immune Diseases presents the first single volume compilation of reviews on how adenosine, acting on its cellular receptors, regulates immune responses. The book is organized to provide the reader with a general overview of adenosine receptors, delving into molecular biology, cell biology, and pharmacology. Separate chapters focus on the role of adenosine receptors in regulating the function of the various cell types that are involved in immune responses. Further chapters delineate the role of purinergic signaling in the pathophysiology of a variety of disease states associated with an overzealous or insufficient immune response. These include autoimmune diseases, asthma, atherosclerosis, ischemia-reperfusion injury, and cancer. Much of the methodology and findings documented in this text may well lead to new therapeutic modalities for pathologies such as ischemia and reperfusion, heart disease, wound healing, tumors, pain, and a variety of central nervous system diseases including Parkinson’s, Alzheimer’s, and epilepsy, as well as mood and sleep disorders. This resource provides background and direction for those researchers entering the field of adenosine and inflammatory disease, and p

Adenosine Book


  • Author : Susan Masino
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-08-30
  • Genre: Medical
  • Pages : 680
  • ISBN 10 : 9781461439035

Adenosine Excerpt :

Homeostasis of key metabolites and metabolic health affects all bodily systems. Not surprisingly, altered metabolic function is associated with a wide spectrum of dysfunctions in the central nervous system – including developmental disorders, acute nervous system injury, and neurodegenerative disorders. Accordingly, metabolism-based therapies offer significant promise as new category of treatment options designed to limit, delay or reverse the disease process by reconstructing homeostatic functions. Increasingly it is appreciated that restoring metabolic health could promote normal nervous system activity, and improve behavior and cognition. Adenosine: A Key Link Between Metabolism and Central Nervous System Activity focusses on diverse aspects of adenosine, an evolutionarily conserved homeostatic bioenergetic regulator in the central nervous system. Because of its interrelationship with ATP (adenosine triphosphate), adenosine is integral to cell metabolism. At the same time, adenosine influences neuronal activity directly via receptors, and is involved in biochemical processes related to gene expression. Thus, adenosine is uniquely placed as a reciprocal and rapid link between changes in metabolism and changes in neuronal activity, and, on a longer time scale, to changes in gene expression and long term changes in cell function. Leaders in the field feature basic research on adenosine at the cellular level in the central nervous system, and relate these findings to its recognized potential in diverse acute and chronic disorders. This comprehensive overview of adenosine also highlights emerging adenosine-based treatments and associated opportunities for central nervous system disorders.

Imaging of the Human Brain in Health and Disease Book

Imaging of the Human Brain in Health and Disease

  • Author : Philip Seeman
  • Publisher : Elsevier
  • Release Date : 2013-11-15
  • Genre: Medical
  • Pages : 532
  • ISBN 10 : 9780124186842

Imaging of the Human Brain in Health and Disease Excerpt :

Brain imaging technology remains at the forefront of advances in both our understanding of the brain and our ability to diagnose and treat brain disease and disorders. Imaging of the Human Brain in Health and Disease examines the localization of neurotransmitter receptors in the nervous system of normal, healthy humans and compares that with humans who are suffering from various neurologic diseases. Opening chapters introduce the basic science of imaging neurotransmitters, including sigma, acetylcholine, opioid, and dopamine receptors. Imaging the healthy and diseased brain includes brain imaging of anger, pain, autism, the release of dopamine, the impact of cannabinoids, and Alzheimer's disease. This book is a valuable companion to a wide range of scholars, students, and researchers in neuroscience, clinical neurology, and psychiatry, and provides a detailed introduction to the application of advanced imaging to the treatment of brain disorders and disease. A focused introduction to imaging healthy and diseased brains Focuses on the primary neurotransmitter release Includes sigma, acetylcholine, opioid, and dopamine receptors Presents the imaging of healthy and diseased brains via anger, pain, autism, and Alzheimer's disease

Synthesis and Evaluation of 7 deazapurine Derivatives as Ligands of Adenosine A1 and A2A Receptors Book

Synthesis and Evaluation of 7 deazapurine Derivatives as Ligands of Adenosine A1 and A2A Receptors

  • Author : North-West University (South Africa). Potchefstroom Campus
  • Publisher : Unknown
  • Release Date : 2020
  • Genre: Electronic dissertations
  • Pages : 181
  • ISBN 10 : OCLC:1285906864

Synthesis and Evaluation of 7 deazapurine Derivatives as Ligands of Adenosine A1 and A2A Receptors Excerpt :

Pyrrolopyrimidines -- 7-deazapurine derivatives -- 7-azaindole derivatives -- Neurodegenerative disorders -- Alzheimer’s disease -- Parkinson’s disease -- A1 adenosine receptors -- A2A adenosine receptors -- Antagonists.pirrolopirimidiene -- 7-deazapurien-derivate -- 7-azaindole-derivate -- neurodegeneratiewe afwykings -- Alzheimer siekte -- Parkinson se siekte -- A1 adenosienreseptore -- A2A adenosienreseptore -- Antagoniste

Coffee Book


  • Author : Adriana Farah
  • Publisher : Royal Society of Chemistry
  • Release Date : 2019-01-31
  • Genre: Medical
  • Pages : 594
  • ISBN 10 : 9781788014977

Coffee Excerpt :

This book covers how health is influenced by the consumption of coffee. Aimed at postgraduates and researchers, it provides an impactful and accessible guide to the current research in the field and information for nutritionists and other health professionals.

Neuroprotection Book


  • Author : Raymond Chuen-Chung Chang
  • Publisher : BoD – Books on Demand
  • Release Date : 2019-08-28
  • Genre: Medical
  • Pages : 102
  • ISBN 10 : 9781789847369

Neuroprotection Excerpt :

Neuroprotection is a strategy to prevent or delay the progression of chronic neurodegenerative diseases, acute neurological disorders, or even mental disorders. The major aim of this book is to focus on different approaches to achieve neuroprotection. In this book, there are chapters discussing imidazoline ligands and opioid ligands in Alzheimer's disease, the beneficial effects of adenosine A2A receptor antagonist, adrenergic receptor agonists and antagonists modulating microglial responses, and different approaches to achieve neuroprotection against aging-associated macular degeneration. This book will give insights to scientists in the field to stimulate their research, medical professionals to review their clinical practices, and others who would like to learn more about different neuroprotective approaches.

Adenosine Receptors in the Nervous System Book

Adenosine Receptors in the Nervous System

  • Author : J. A. Ribeiro
  • Publisher : Taylor & Francis Group
  • Release Date : 1989
  • Genre: Adenosine
  • Pages : 225
  • ISBN 10 : UOM:39015017744395

Adenosine Receptors in the Nervous System Excerpt :

A satellite Symposium on Adenosine Receptors in the Nervous System was held in April 1989 in Portugal. This book contains the manuscripts of the papers presented by the participants, who were from Europe, America and Asia.

The Adenosinergic System Book

The Adenosinergic System

  • Author : Micaela Morelli
  • Publisher : Springer
  • Release Date : 2015-10-01
  • Genre: Medical
  • Pages : 337
  • ISBN 10 : 9783319202730

The Adenosinergic System Excerpt :

Adenosine A2A receptor antagonists have shown great promise in the treatment of Parkinson's Disease and alleviation of symptoms. This book addresses various aspects of this class of drugs from their chemical development to their clinical use. Among the many insightful chapters contained in this book, there are three unique reviews that have not previously been published in any format: (1) a history of istradefylline, the first A2A antagonist approved for treatment of Parkinson's Disease, (2) an overview of neuroimaging studies in human death and disease and (3) a study of urate as a possible biomarker and neuroprotectant.

Glial Cells in Health and Disease of the CNS Book

Glial Cells in Health and Disease of the CNS

  • Author : Rommy von Bernhardi
  • Publisher : Springer
  • Release Date : 2016-10-06
  • Genre: Medical
  • Pages : 348
  • ISBN 10 : 9783319407647

Glial Cells in Health and Disease of the CNS Excerpt :

A timely overview covering the three major types of glial cells in the central nervous system - astrocytes, microglia, and oligodendrocytes. New findings on glia biology are overturning a century of conventional thinking about how the brain operates and are expanding our knowledge about information processing in the brain. The book will present recent research findings on the role of glial cells in both healthy function and disease. It will comprehensively cover a broad spectrum of topics while remaining compact in size.