AGO Driven Non Coding RNAs Book

AGO Driven Non Coding RNAs


  • Author : Bibekanand Mallick
  • Publisher : Academic Press
  • Release Date : 2019-01-20
  • Genre: Science
  • Pages : 387
  • ISBN 10 : 9780128156704

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AGO Driven Non Coding RNAs Excerpt :

The ‘RNA world’ hypothesis that proposed RNA molecules as the first form of genetic material was put forwarded in the late 1980s but got impetus only recently when high-throughput sequencing technologies began unearthing new types of non-coding RNA (ncRNA) transcripts in higher eukaryotes. Till then, research on ncRNAs were primarily confined to transfer RNAs and, ribosomal RNAs, which act as the messengers of the protein synthesis and allow translation of genetic information encoded by DNA into proteins. In recent years, the integration of high-throughput genomic technologies with molecular biology and omics sciences have revolutionized the fields of ncRNA research by identifying the hidden treasures of several new types of ncRNAs encoded in the genomes of several organisms and decrypting their versatile roles in gene expression and epigenetics. Among these, two small endogenous ncRNAs, namely microRNAs (miRNAs) and piwi-interacting RNAs (piRNAs) that drive argonaute (AGO) family of proteins namely Ago and Piwi respectively and silence the expression of genes have geared up molecular and disease biology research in recent years. Both miRNAs and piRNAs are expressed in higher eukaryotes, including human and act as cellular rheostats by regulating the expression of significant fraction of genes encoded in the genomes. The aberrant expressions of these small ncRNAs within the cells cause various abnormalities and diseases including cancer. Manipulating their aberrant expression or function can serve as potential novel diagnostic/prognostic biomarkers and bring in new therapeutic strategies for multiple human diseases. This can be further translated from bench-side to clinic for improving human health. This book captures the essence of the pioneering work of some of the world’s leading researchers showcasing the scientific excitements surrounding the evolving regulatory roles of miRNAs and piRNAs highlighting their potential towards the diagnosis and therapeutics

Clinical Applications of Noncoding RNAs in Cancer Book

Clinical Applications of Noncoding RNAs in Cancer


  • Author : Subash Gupta
  • Publisher : Academic Press
  • Release Date : 2022-01-28
  • Genre: Science
  • Pages : 478
  • ISBN 10 : 9780128245514

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Clinical Applications of Noncoding RNAs in Cancer Excerpt :

Clinical Applications of Noncoding RNAs in Cancer summarizes the existing strategies, advances, and future opportunities on the role of noncoding RNAs in cancer patients. Established clinicians and researchers from all around the world share their views and expertise and provide readers with invaluable knowledge on the subject. This book provides a comprehensive collection of information on the utility of noncoding RNAs in the diagnosis, prognosis, and therapy of cancer. It also discusses the evolutionary significance of noncoding RNAs and how the molecular tools such as RNA-seq, RNA-FISH, ic-SHAPE, and quantitative real-time PCR help in the detection and elucidation of the functions of noncoding RNAs. Additionally, the challenges associated with noncoding RNA approaches and future developments are discussed. It is a valuable resource for cancer researchers, oncologists, clinicians, and other biomedical field members who want to learn more about noninvasive ways to diagnose and efficiently treat diverse cancer types. Presents a beginning chapter summary to help readers understand the content thoroughly Encompasses detailed description of information from clinical studies on noncoding RNAs in cancer therapy Discusses one cancer type per chapter making the content easy to reference

 Essentials of Cancer Genomic  Computational Approaches and Precision Medicine Book

Essentials of Cancer Genomic Computational Approaches and Precision Medicine


  • Author : Nosheen Masood
  • Publisher : Springer Nature
  • Release Date : 2020-03-20
  • Genre: Medical
  • Pages : 499
  • ISBN 10 : 9789811510670

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Essentials of Cancer Genomic Computational Approaches and Precision Medicine Excerpt :

This book concisely describes the role of omics in precision medicine for cancer therapies. It outlines our current understanding of cancer genomics, shares insights into the process of oncogenesis, and discusses emerging technologies and clinical applications of cancer genomics in prognosis and precision-medicine treatment strategies. It then elaborates on recent advances concerning transcriptomics and translational genomics in cancer diagnosis, clinical applications, and personalized medicine in oncology. Importantly, it also explains the importance of high-performance analytics, predictive modeling, and system biology in cancer research. Lastly, the book discusses current and potential future applications of pharmacogenomics in clinical cancer therapy and cancer drug development.

Non coding RNAs and Cancer Book

Non coding RNAs and Cancer


  • Author : Muller Fabbri
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-10-28
  • Genre: Medical
  • Pages : 284
  • ISBN 10 : 9781461484448

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Non coding RNAs and Cancer Excerpt :

The discovery of microRNAs and its role as gene expression regulators in human carcinogenesis represents one of the most important scientific achievements of the last decade. More recently, other non-coding RNAs have been discovered and its implications in cancer are emerging as well, suggesting a broader than anticipated involvement of the non-coding genome in cancer. Moreover, completely new and unexpected functions for microRNAs are being revealed, leading to the identification of new anticancer molecular targets. This book represents a comprehensive guide on non-coding RNAs and cancer, spanning from its role as cancer biomarkers, to providing the most useful bioinformatic tools, to presenting some of the most relevant discoveries, which indicates how these fascinating molecules act as fine orchestrators of cancer biology.

Long Non Coding RNAs and Immunity Book

Long Non Coding RNAs and Immunity


  • Author : Adam Williams
  • Publisher : Frontiers Media SA
  • Release Date : 2021-06-29
  • Genre: Medical
  • Pages : 68
  • ISBN 10 : 9782889669172

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Long Non Coding RNAs and Immunity Excerpt :

We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). We hereby state publicly that the IUIS has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, unbiased by any specific policy or opinion of the IUIS.

Long Noncoding RNAs in Plants Book

Long Noncoding RNAs in Plants


  • Author : Santosh Kumar Upadhyay
  • Publisher : Academic Press
  • Release Date : 2020-11-13
  • Genre: Science
  • Pages : 390
  • ISBN 10 : 9780128214633

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Long Noncoding RNAs in Plants Excerpt :

The growth of human population has increased the demand for improved yield and quality of crops and horticultural plants. However, plant productivity continues to be threatened by stresses such as heat, cold, drought, heavy metals, UV radiations, bacterial and fungal pathogens, and insect pests. Long noncoding RNAs are associated with various developmental pathways, regulatory systems, abiotic and biotic stress responses and signaling, and can provide an alternative strategy for stress management in plants. Long Noncoding RNAs in Plants: Roles in development and stress provides the most recent advances in LncRNAs, including identification, characterization, and their potential applications and uses. Introductory chapters include the basic features and brief history of development of lncRNAs studies in plants. The book then provides the knowledge about the lncRNAs in various important agricultural and horticultural crops such as cereals, legumes, fruits, vegetables, and fiber crop cotton, and their roles and applications in abiotic and biotic stress management. Includes the latest advances and research in long noncoding RNAs in plants Provides alternative strategies for abiotic and biotic stress management in horticultural plants and agricultural crops Focuses on the application and uses of long noncoding RNAs

Transcriptional and Post transcriptional Regulation Book

Transcriptional and Post transcriptional Regulation


  • Author : Ghedira Kais
  • Publisher : BoD – Books on Demand
  • Release Date : 2018-10-10
  • Genre: Medical
  • Pages : 134
  • ISBN 10 : 9781789237917

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Transcriptional and Post transcriptional Regulation Excerpt :

This book focuses on the transcriptional and post-transcriptional gene regulations and presents a detailed portrait of many novel aspects related to highlighting the importance of key TFs in some vital biological processes, the role of certain TFs to control some infectious diseases, the role of non-coding RNAs in controlling mRNA expression, the involvement of these non-coding RNAs in diseases, and the interplay between TFs and microRNAs as key players for gene expression regulation giving a complete picture of how genes are regulated at the cellular level. The editor embarked upon this writing project entitled "Transcriptional and Post-transcriptional Regulation" to make pertinent contributions accessible to the scientific community. Hopefully, a large audience will enjoy reading and benefit from the chapters of this book.

Essentials of Noncoding RNA in Neuroscience Book

Essentials of Noncoding RNA in Neuroscience


  • Author : Davide De Pietri Tonelli
  • Publisher : Academic Press
  • Release Date : 2017-06-14
  • Genre: Science
  • Pages : 338
  • ISBN 10 : 9780128498996

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Essentials of Noncoding RNA in Neuroscience Excerpt :

Essentials of Noncoding RNA in Neuroscience: Ontogenetics, Plasticity of the Vertebrate Brain focuses on the role of miRNAs in neurogenesis, gliogenesis, neuronal network formation, and the cell biology of forebrain development. The important role miRNAs play in neuronal maturation, neocortex function, and in some neurodevelopmental disorders is discussed, as are the computational challenges and methods used in the identification of miRNA targets. This book is a valuable reference for neuroscientists who wish to better understand the role of miRNAs in complex processes. It is of strong interest to those working to develop enabling technologies to detect and monitor miRNA expression and function, and to evaluate its roles in neural progenitor proliferation/differentiation, neuronal plasticity, and learning and memory. Discusses the unique features of neural miRNAs Details functional investigation of miRNA actions and current experimental approaches Includes extensive coverage of miRNA biology, developmental and postnatal neurogenesis, and computational challenges for miRNA target identification Contains thorough discussion of the transcriptional control of miRNA expression in forebrain development and in specific neuronal subtypes, as well as miRNA function in neurogenesis, neuronal network maturation, plasticity, gliogenesis, and dysfunction Provides an overview of miRNA roles in neurodevelopmental disorders and their possible role in the evolution of the neocortex

Omics Technologies for Sustainable Agriculture and Global Food Security  Vol II  Book

Omics Technologies for Sustainable Agriculture and Global Food Security Vol II


  • Author : Anirudh Kumar
  • Publisher : Springer Nature
  • Release Date : 2021-08-05
  • Genre: Technology & Engineering
  • Pages : 351
  • ISBN 10 : 9789811629563

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Omics Technologies for Sustainable Agriculture and Global Food Security Vol II Excerpt :

This edited book brings out a comprehensive collection of information on the modern omics-based research. The main focus of this book is to educate researchers about utility of omics-based technologies in rapid crop improvement. In last two decades, omics technologies have been utilized significantly in the area of plant sciences and has shown promising results. Omics technology has potential to address the challenge of food security in the near future. The comprehensive use of omics technology occurred in last two decades and helped greatly in the understanding of complex biological problems, improve crop productivity and ensure sustainable use of ecosystem services. This book is of interest to researchers and students of life sciences, biotechnology, plant biotechnology, agriculture, forestry, and environmental sciences. It is also a useful knowledge resource for national and international agricultural scientists.

Regulation by non coding RNAs Volume 1 Book

Regulation by non coding RNAs Volume 1


  • Author : Nicholas Delihas
  • Publisher : MDPI
  • Release Date : 2018-10-09
  • Genre: Non-coding RNA.
  • Pages : 837
  • ISBN 10 : 9783038420057

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Regulation by non coding RNAs Volume 1 Excerpt :

Printed Edition of the Special Issue Published in IJMS

Gene Expression Profiling in Cancer Book

Gene Expression Profiling in Cancer


  • Author : Dimitrios Vlachakis
  • Publisher : BoD – Books on Demand
  • Release Date : 2019-06-19
  • Genre: Medical
  • Pages : 78
  • ISBN 10 : 9781838801755

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Gene Expression Profiling in Cancer Excerpt :

The contribution of modern-day genetics in designing efficient gene expression profiles for cancer is immense. The progress of technology and science in recent years provides the opportunity for discovery and application of new techniques for treating various diseases that affect humanity. Methods for finding and analyzing the profile of gene expression of infected cells give scientists the ability to develop more targeted and effective treatments, especially for diseases such as cancer. The development of gene expression profiling is one of the most important achievements in cancer genetics in our time. It is essentially the driving force behind personalized and precision medicine. This book highlights recent developments, applications, and breakthroughs in the field of gene expression profiling in cancer.

RNA Based Regulation in Human Health and Disease Book

RNA Based Regulation in Human Health and Disease


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2020-08-19
  • Genre: Medical
  • Pages : 444
  • ISBN 10 : 9780128171943

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RNA Based Regulation in Human Health and Disease Excerpt :

RNA-based Regulation in Human Health and Disease offers an in-depth exploration of RNA mediated genome regulation at different hierarchies. Beginning with multitude of canonical and non-canonical RNA populations, especially noncoding RNA in human physiology and evolution, further sections examine the various classes of RNAs (from small to large noncoding and extracellular RNAs), functional categories of RNA regulation (RNA-binding proteins, alternative splicing, RNA editing, antisense transcripts and RNA G-quadruplexes), dynamic aspects of RNA regulation modulating physiological homeostasis (aging), role of RNA beyond humans, tools and technologies for RNA research (wet lab and computational) and future prospects for RNA-based diagnostics and therapeutics. One of the core strengths of the book includes spectrum of disease-specific chapters from experts in the field highlighting RNA-based regulation in metabolic & neurodegenerative disorders, cancer, inflammatory disease, viral and bacterial infections. We hope the book helps researchers, students and clinicians appreciate the role of RNA-based regulation in genome regulation, aiding the development of useful biomarkers for prognosis, diagnosis, and novel RNA-based therapeutics. Comprehensive information of non-canonical RNA-based genome regulation modulating human health and disease Defines RNA classes with special emphasis on unexplored world of noncoding RNA at different hierarchies Disease specific role of RNA - causal, prognostic, diagnostic and therapeutic Features contributions from leading experts in the field

Non coding RNA and the Reproductive System Book

Non coding RNA and the Reproductive System


  • Author : Dagmar Wilhelm
  • Publisher : Springer
  • Release Date : 2015-12-11
  • Genre: Medical
  • Pages : 198
  • ISBN 10 : 9789401774178

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Non coding RNA and the Reproductive System Excerpt :

This book provides an overview of the role and function of regulatory RNAs that lack protein-coding potential in key reproductive tissues. This includes the role of small interfering RNAs (siRNAs), microRNAs (miRNAs), PIWI-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs) and long non-coding RNAs (lncRNAs). Through clear, detailed and comprehensive debate, international leading experts discuss the role these novel regulators in normal development of sexual dimorphisms, including the differentiation of ovaries and testes, the genital tract including prostate, epididymis and uterus, as well as mammary glands. In addition, particular attention is paid on their role in pathophysiological processes within the reproductive tract. The power of next generation sequencing has proved to be an invaluable tool to discover new non-coding RNAs. While the identification of non-coding RNA is relatively easy, analysing their function represents still a challenge today. In this book, authors present historical and conceptual background information, highlight the ways in which non-coding RNAs function is analysed and present their vision of the future research in their key research area.

Long Non coding RNAs in Human Disease Book

Long Non coding RNAs in Human Disease


  • Author : Kevin V. Morris
  • Publisher : Springer
  • Release Date : 2016-04-13
  • Genre: Medical
  • Pages : 262
  • ISBN 10 : 9783319239071

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Long Non coding RNAs in Human Disease Excerpt :

This volume focuses on the roles of long non-coding RNAs (lncRNAs) in contexts ranging from human cancers to cardiovascular disease and ageing. The role of lncRNAs in X-inactivation and those lncRNAs derived from pseudogenes, past retroelements integrated within the human genome, as well as the role these pseudogene-derived lncRNAs play in cancer development are discussed in detail. Further, the book examines the function of lncRNAs in diseases such as diabetes, in smooth muscle formation, and in the modulation of nuclear receptors, as well as in connection with perspectives on the development of personalized therapeutics. It offers an appealing and insightful resource for scientists and clinicians alike.