Alzheimer   s Disease Theranostics Book

Alzheimer s Disease Theranostics


  • Author : Magisetty Obulesu
  • Publisher : Academic Press
  • Release Date : 2019-01-20
  • Genre: Medical
  • Pages : 80
  • ISBN 10 : 9780128167397

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Alzheimer s Disease Theranostics Excerpt :

Alzheimer’s Disease Theranostics discusses the latest information on recent theranostic avenues for both the diagnosis and treatment of Alzheimer’s patients. It presents the pros and cons of the probable mechanistic role of nanoparticles in crossing the blood-brain barrier and improving disease symptoms. Finally, it highlights the merits of existing maneuvers and suggests perspectives to aid in future developments. Despite the difficulty of drug delivery to the brain, there are some nanoparticulate platforms demonstrating promise in treating neurodegenerative disorders such as Alzheimer’s disease. Manifold theranostic maneuvers include antioxidants, natural bioactive compounds, gene therapy, and nanotechnological approaches, all of which are discussed in this important work. Examines various theranostic applications for the diagnosis and treatment of Alzheimer’s disease Features a comprehensive overview of nanoparticle therapeutics in the area and use of antioxidants Assesses the common challenges and lessons learned from blood-brain barrier challenges, viral vector approaches and mitochondria-targeted therapeutics

Adverse Effects of Engineered Nanomaterials Book

Adverse Effects of Engineered Nanomaterials


  • Author : Bengt Fadeel
  • Publisher : Academic Press
  • Release Date : 2012
  • Genre: Medical
  • Pages : 347
  • ISBN 10 : 9780123869401

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Adverse Effects of Engineered Nanomaterials Excerpt :

An essential reference that discusses occupational exposure and the adverse health effects of engineered nanomaterials and highlights current and future biomedical applications of these nanomaterials in relation to nanosafety. Multi-authored book written by leading US and European experts on nanotoxicology and nanomedicine Discusses the health implications and a clinical translation of experimental data in this area Takes a schematic, non-exhaustive approach to summarize the most important research data in this field Includes a glossary, with a brief explanation of the term and with a reference to where the term or phrase has been used will be included within the book

The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging Book

The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging


  • Author : Andre S. Merbach
  • Publisher : John Wiley & Sons
  • Release Date : 2013-04-15
  • Genre: Science
  • Pages : 496
  • ISBN 10 : 9781119991762

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The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging Excerpt :

"The second edition of The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging is a comprehensive treaty covering all aspects of production, use, operating mechanism and theory of these diagnostic agents used to produce high contrast images in MRI..It has been completed to now include recent developments on "classical" Gd-based and iron-oxide probes and chapters dedicated to the most significant advances in molecular imaging probes. Chemical Exchange Saturation Transfer is discussed, which is a novel means of generating MRI contrast"--

Personalized Medicine  beyond PET Biomarkers  Book

Personalized Medicine beyond PET Biomarkers


  • Author : Sushil Sharma (Ph. D., D.M.R.I.T.)
  • Publisher : Nova Biomedical Books
  • Release Date : 2016
  • Genre: Medical
  • Pages : 475
  • ISBN 10 : 1634853334

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Personalized Medicine beyond PET Biomarkers Excerpt :

Nova Science Publishers, New York, U.S.A has now released Personalized Medicine (Beyond PET Biomarkers), which is an extension of the author''s recently published book Progress in PET Radiopharmaceuticals: Quality Control and Theranostics. In addition to recently-developed clinically-significant PET-RPs as biomarkers, this book describes various other emerging biotechnologies including: genomic medicine, nanotechnology, novel molecular biomarkers, and noninvasive imaging biotechnologies for early theranostics and personalized patient care, with minimum or no adverse effects. New therapeutic interventions including gene and cell therapies, pharmacogenomics, next generation sequencing, genome-wide association studies, proteomics, metabolomics, bioinformatics, systems biology complementing areas of pharmacokinetics and pharmacodynamics, human investigations and clinical trials, pharmacovigilance, pharmacoepidemiology, and population pharmacology are some of the most significant disciplines of predictive, precision, and personalized medicine (PM) as described in this book. More specifically, different sub-specialties of omics biotechnology including: genomic, proteomic, glycomic, lipidomic, metabolomics, metalomic, and microRNA biomarkers are described to accomplish early and personalized theranostics of chronic illnesses with currently limited therapeutic options and success. Recent advances in nanotechnology and novel biomarkers to accomplish personalized theranostics of chronic diseases including, but not limited to: cancer, fetal alcohol syndrome, Alzheimer''s disease, Parkinson''s disease, vascular dementia, amyotrophic lateral sclerosis, and multiple sclerosis. Usually, nanoparticles (NPs) are trapped in the reticuloendothelial system (RES) comprising the lungs, liver, and spleen. To prevent their entry into the RES system and enhance drug targeting, stealth property of polyethylene glycol (PEG) as a covalent linker is utilized. However, pegylation may reduce the

Nanotheranostics Book

Nanotheranostics


  • Author : Mahendra Rai
  • Publisher : Springer Nature
  • Release Date : 2019-11-22
  • Genre: Medical
  • Pages : 409
  • ISBN 10 : 9783030297688

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Nanotheranostics Excerpt :

This book is specifically designed to provide information about various nanocarriers currently developed under the emerging field of nanotheranostics for a sustained, controlled, and targeted co-delivery of diagnostic and therapeutic agents. Diverse theranostic applications of nanotechnology and their limitations are also addressed. It integrates nanobiotechnology with theranostic applications. The combined term nanotheranostics has diverse application particularly in chemotherapy and other infectious diseases.Among other topics addressed are antimicrobial resistance, targeting intra-cellular pathogens, viruses and bacteria, chemotherapy, cancer therapeutics, and inflammatory disorders. This interdisciplinary volume is essential for a diverse group of readers including nanotechnologists, microbiologists, biotechnologists, bioengineering and bioprocess industry.

Nanobiotechnology in Diagnosis  Drug Delivery and Treatment Book

Nanobiotechnology in Diagnosis Drug Delivery and Treatment


  • Author : Mahendra Rai
  • Publisher : John Wiley & Sons
  • Release Date : 2020-12-02
  • Genre: Science
  • Pages : 416
  • ISBN 10 : 9781119671770

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Nanobiotechnology in Diagnosis Drug Delivery and Treatment Excerpt :

Presents nanobiotechnology in drug delivery and disease management Featuring contributions from noted experts in the field, this book highlights recent advances in the nano-based drug delivery systems. It also covers the diagnosis and role of various nanomaterials in the management of infectious diseases and non-infectious disorders, such as cancers and other malignancies and their role in future medicine. Nanobiotechnology in Diagnosis, Drug Delivery and Treatment starts by introducing how nanotechnology has revolutionized drug delivery, diagnosis, and treatments of diseases. It then focuses on the role of various nanocomposites in diagnosis, drug delivery, and treatment of diseases like cancer, Alzheimer's disease, diabetes, and many others. Next, it discusses the application of a variety of nanomaterials in the diagnosis and management of gastrointestinal tract disorders. The book explains the concept of nanotheranostics in detail and its role in effective monitoring of drug response, targeted drug delivery, enhanced drug accumulation in the target tissues, sustained as well as triggered release of drugs, and reduction in adverse effects. Other chapters cover aptamer-incorporated nanoparticle systems; magnetic nanoparticles; theranostics and vaccines; toxicological concerns of nanomaterials used in nanomedicine; and more. Provides a concise overview of state-of-the-art nanomaterials and their application like drug delivery in infectious diseases and non-infectious disorders Highlights recent advances in the nano-based drug delivery systems and role of various nanomaterials Introduces nano-based sensors which detect various pathogens Covers the use of nanodevices in diagnostics and theranostics Nanobiotechnology in Diagnosis, Drug Delivery and Treatment is an ideal book for researchers and scientists working in various disciplines such as microbiology, biotechnology, nanotechnology, pharmaceutical biotechnology, pharmacology, pharmaceutics, and nanomedicine.

Synthesis and application of   configured  18 19F FDGs Book

Synthesis and application of configured 18 19F FDGs


  • Author : Mathias Elgland
  • Publisher : Linköping University Electronic Press
  • Release Date : 2018-02-21
  • Genre: Uncategoriezed
  • Pages : 100
  • ISBN 10 : 9789176853764

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Synthesis and application of configured 18 19F FDGs Excerpt :

Positron emission tomography (PET) is a non-invasive imaging method that renders three-dimensional images of tissue that selectively has taken up a radiolabelled organic compound, referred to as a radiotracer. This excellent technique provides clinicians with a tool to monitor disease progression and to evaluate how the patient respond to treatment. The by far most widely employed radiotracer in PET is called 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG), which is often referred to as the golden standard in PET. From a molecular perspective, [18F]FDG is an analogue of glucose where a hydroxyl group has been replaced with a radioactive fluorine atom (18F). It is well known that covalent attachment of carbohydrates (i.e., glycosylation) to biomolecules tend to improve their properties in the body, in terms of; improved pharmacokinetics, increased metabolic stability and faster clearance from blood and other non-specific tissue. It is therefore natural to pursuit the development of a [18F]fluoroglycosylation method where [18F]FDG is chemically conjugated to a ligand with high affinity for a given biological target (e.g., tumors or disease-associated protein aggregates). This thesis describes a novel [18F]fluoroglycosylation method that in a simple and general manner facilitate the conjugation of [18F]FDG to biological ligands using click chemistry. The utility of the developed [18F]fluoroglycosylation method is demonstrated by radiolabelling of curcumin, thus forming a tracer that may be employed for diagnosis of Alzheimer’s disease. Moreover, a set of oligothiophenes were fluoroglycosylated for potential diagnosis of Alzheimer’s disease but also for other much rarer protein misfolding diseases (e.g., Creutzfeldt-Jakob disease and systemic amyloidosis). In addition, the synthesis of a series of 19F-fluoroglycosylated porphyrins is described which exhibited promising properties not only to detect but also to treat melanoma cancer. Lastly, the synthesis of a set of 19F-

Charnolophagy in Health and Disease Book

Charnolophagy in Health and Disease


  • Author : Sushil Sharma
  • Publisher : CRC Press
  • Release Date : 2021-09-03
  • Genre: Technology & Engineering
  • Pages : 608
  • ISBN 10 : 9781000298451

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Charnolophagy in Health and Disease Excerpt :

This book introduces charnolophagy (CP) as energy-driven, lysosomal-dependent mitochondrial inclusion-specific pleomorphic Charnoly body (CB) autophagy (ATG) involving free radical-induced Ca2+ dyshomeostasis, ΔΨ collapse, and ATP depletion in congenital diseases, pressure ulcers, metabolic diseases, hepatic diseases, diabetes, obesity, inflammatory diseases, musculoskeletal diseases, sarcopenia, cachexia, respiratory diseases, gastrointestinal diseases, hyperlipidemia, skin and hair diseases, pulmonary diseases, cardiovascular diseases, renal diseases, sepsis-induced multi-organ failure, reproductive diseases, inflammatory diseases, ophthalmic diseases, neurodegenerative diseases, drug addiction, aging, microbial (including COVID-19) infections, and belligerent malignancies implicated in early morbidity and mortality and disease-specific spatiotemporal, targeted, safe, and effective evidence-based personalized theranostic charnolopharmacotherapeutics to cure them. Basic DRESS and GELS principles, nanoparticles to cure chronic multidrug-resistant (MDR) diseases, antioxidants as free radical scavengers, CB antagonists, CP regulators, and CS stabilizers to curb CB molecular pathogenesis (CBMP) are described for better quality of life and longevity. Specific guidelines for environmental protection and preservation of zoological and botanical species at the verge of extinction, Triple "I" Hypothesis for mitochondrial quality control, and transcriptional regulation of CSexR and CSendoR to cure chronic diseases are presented. Novel CP index is introduced to evaluate MDR malignancies and other chronic diseases. WHO, CDC, FDA, NIH, policy planners, cosmetologists, trichologists, players, athletes, dancers, wrestlers, equestrians, young women, aging population, toxicologists, environmental protectionists, pharmaceutical industry, biomedical scientists, researchers, medical students, physicians, nurses, paramedical professionals, and global audience will be interested in th

Novel Bifunctional Compounds as Theranostic Agents for Alzheimer s Disease Book

Novel Bifunctional Compounds as Theranostic Agents for Alzheimer s Disease


  • Author : Liang Sun (Chemist)
  • Publisher : Unknown
  • Release Date : 2019
  • Genre: Electronic dissertations
  • Pages : 137
  • ISBN 10 : OCLC:1110621017

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Novel Bifunctional Compounds as Theranostic Agents for Alzheimer s Disease Excerpt :

Alzheimer's Disease (AD) is the most prevalent neurodegenerative disease, currently affecting 5 million in the US and 25 million population worldwide. Unfortunately, there is no treatment for AD, and its accurate diagnosis requires a detailed post-mortem examination of the brain. The formation of extracellular amyloid plaques containing the amyloid [beta] (A[beta]) peptide is one of the pathological hallmarks in the brains of Alzheimer's patients. In addition, numerous studies show that the metal ions can interact with the A[beta] peptides and affect the aggregation process dramatically, especially for copper ions that can stabilize the A[beta] oligomers, leading to high neurotoxicity.In this regard, we developed a series of novel bifunctional molecules that have high binding affinity with various A[beta]42 species and strong metal-binding ligands to modulate the interaction of copper ions with A[beta]42 species to alleviate the Cu2+-induced A[beta]42 cytotoxicity. Different A[beta] binding fragments, bis-styryl stilbene and benzofuran derivatives, were synthesized successfully and modified by adding strong metal-binding ligand through the Mannich reaction. Several in vitro assays were performed to evaluate the ability to quench ROS and attenuate the cytotoxicity of Cu2+-induced A[beta] species. Moreover, immunostaining studies were also employed to see the binding specificity of the compounds. The fluorescence images show that most of the bifunctional compounds can bind to the amyloid plaques specifically. More interestingly, some of the compounds show high binding specificity of soluble A[beta] oligomers, confirming by the oligomer-specific antibody labeling.Furthermore, the novel bifunctional compounds were also evaluated as PET imaging agents for AD. Taking advantage of the high binding affinity with Cu2+, the developed bifunctional compounds were preloaded with 64Cu, and these 64Cu complexes were evaluated to be potential PET imaging agents for Alzheimer's Dise

The Alzheimer s Disease Challenge Book

The Alzheimer s Disease Challenge


  • Author : Athanasios Alexiou
  • Publisher : Frontiers Media SA
  • Release Date : 2019-12-04
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : 9782889631285

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The Alzheimer s Disease Challenge Excerpt :

Alzheimer’s disease is undoubtedly the major health challenge of our Century with significant social and economic consequences. This Frontiers eBook offers a contribution of 39 innovative papers on the multidimensional and crucial problem of Alzheimer’s disease management and treatment. Several perspectives, research updates, and trials describing methods on potential diagnosis and treatment are presented including biological mechanisms, biomarkers and risk factors for an early and efficient prognosis, diagnosis and prevention. Additionally, while the rapidly increasing Alzheimer’s disease population demands holistic solutions and clinical studies with new therapeutic target approaches, several of the contributive papers present promising drugs targeting Alzheimer’s disease treatment. We give our deepest acknowledgment to all the authors for their important and innovative contributions, to the reviewers for their valuable recommendations on improving the submitting studies and all the Frontiers Editorial team for continuous support.

Neurodegenerative Diseases Book

Neurodegenerative Diseases


  • Author : Nagehan Ersoy Tunalı
  • Publisher : BoD – Books on Demand
  • Release Date : 2021-01-20
  • Genre: Science
  • Pages : 178
  • ISBN 10 : 9781838801496

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Neurodegenerative Diseases Excerpt :

Neurodegenerative diseases represent a very large group of heterogeneous disorders affecting specific subtypes of neurons in the brain. This book contributes insight both to the awareness of the brain and its neurodegenerative states. The chapters present current knowledge regarding genetics, molecular mechanisms, and new therapeutic strategies against neurodegenerative disorders. The book is intended to serve as a source to aid clinicians and researchers in the field, and also life science readers to increase their understanding and awareness of the clinical correlations, genetic aspects, neuropathological findings, and current therapeutic interventions in neurodegenerative diseases. I believe that this book will enlighten the curiosity for neurodegeneration and also encourage researchers to work on potentially effective molecular therapies for still mysterious neurodegenerative disorders.

Handbook on Nanobiomaterials for Therapeutics and Diagnostic Applications Book

Handbook on Nanobiomaterials for Therapeutics and Diagnostic Applications


  • Author : Krishnan Anand
  • Publisher : Elsevier
  • Release Date : 2021-03-18
  • Genre: Technology & Engineering
  • Pages : 610
  • ISBN 10 : 9780128219140

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Handbook on Nanobiomaterials for Therapeutics and Diagnostic Applications Excerpt :

Handbook of Nano-biomaterials for Therapeutics and Diagnostic Applications covers in-depth topics on nano-biomaterials and nano drug delivery systems (biosensors and bioimaging) involving polymer nanocomposites, metal nanocomposites, and other carbon family fibers and proteins. The book covers the current application of tiny machines or nanodevices and their use as early detection systems for life threatening diseases, giving detailed literature on the development of nanodevices, their use as diagnostic tools, and their present trend in the industry and market. In addition, their synthesis, potential applications and future of smart nanodevices in diagnosis of diseases and their use as smart clinical devices is covered. Users will find sections on recent advances in interdisciplinary research on the processing, morphology, structure and properties of nanostructured materials and their applications in drug delivery for various diseases such as cancer, tuberculosis, Alzheimer disease, ophthalmic diseases, and more. Offers a comprehensive coverage of the therapeutics and smart nanodevices as diagnostic tools and their potential clinical applications in biosensing and bioimaging Includes a glimpse into the nano-biomaterials that are essential components in nanomedicines Describes nanodevices in the early diagnosis of the diseases Explains the nano-drug delivery system for the treatment of various diseases, including cancer, tuberculosis, Alzheimer disease, and ophthalmic diseases Encompasses all information, starting from the design of nano-biomaterials to their applications in theranostics

Nanotheranostics for Cancer Applications Book

Nanotheranostics for Cancer Applications


  • Author : Prakash Rai
  • Publisher : Springer
  • Release Date : 2018-11-12
  • Genre: Technology & Engineering
  • Pages : 480
  • ISBN 10 : 9783030017750

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Nanotheranostics for Cancer Applications Excerpt :

This book is the first to focus specifically on cancer nanotheranostics. Each of the chapters that make up this comprehensive volume is authored by a researcher, clinician, or regulatory agency member known for their expertise in this field. Theranostics, the technology to simultaneously diagnose and treat a disease, is a nascent field that is growing rapidly in this era of personalized medicine. As the need for cost-effective disease diagnosis grows, drug delivery systems that can act as multifunctional carriers for imaging contrast and therapy agents could provide unique breakthroughs in oncology. Nanotechnology has enabled the development of smart theranostic platforms that can concurrently diagnose disease, start primary treatment, monitor response and initiate secondary treatments if required. In oncology, chemotherapeutics have been routinely used. Some drugs have proven effective but all carry risks of adverse side effects. There is growing interest in using remotely triggered drug delivery systems to limit cytotoxicity in the diseased area. This book reviews the use of theranostic nanoparticles for cancer applications over the past decade. First, it briefly discusses the challenges and limitations of conventional cancer treatments, and presents an overview of the use of nanotechnology in treating cancer. These introductory chapters are followed by those exploring cancer diagnosis and a myriad of delivery methods for nanotherapeutics. The book also addresses multifunctional platforms, treatment monitoring, and regulatory considerations. As a whole, the book aims to briefly summarize the development and clinical potential of various nanotheranostics for cancer applications, and to delineate the challenges that must be overcome for successful clinical development and implementation of such cancer theranostics.