Anaerobiosis and Stemness Book

Anaerobiosis and Stemness


  • Author : Zoran Ivanovic
  • Publisher : Academic Press
  • Release Date : 2015-11-01
  • Genre: Uncategoriezed
  • Pages : 326
  • ISBN 10 : 0128005408

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Anaerobiosis and Stemness Excerpt :

Anaerobiosis and Stemness: An evolutionary paradigm provides a context for understanding the many complexities and evolutionary features of stem cells and the clinical implications of anaerobiosis stem cells. Combining theoretical and experimental knowledge, the authors provide a broad understanding of how the absence or low concentration of oxygen can play an influential role in the maintenance and self-renewal of stem cells and stem cell differentiation. This understanding has clinical implications for the fields of regenerative medicine, cancer biology and transplantation, as well as cell engineering and cell therapy. Anaerobiosis and Stemness is an important resource for stem cell and developmental biologists alike, as well as oncologists, cancer biologists, and researchers using stem cells for regeneration. Highlights the molecular and evolutionary features of stem cells which make them so important to all biological research Explores methods of isolation, characterization, activation, and maintenance of stem cells Includes models for clinical application in regenerative medicine, cancer therapy, and transplantation

Anaerobiosis and Stemness Book

Anaerobiosis and Stemness


  • Author : Zoran Ivanovic
  • Publisher : Academic Press
  • Release Date : 2015-11-28
  • Genre: Science
  • Pages : 326
  • ISBN 10 : 9780128006115

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Anaerobiosis and Stemness Excerpt :

Anaerobiosis and Stemness: An evolutionary paradigm provides a context for understanding the many complexities and evolutionary features of stem cells and the clinical implications of anaerobiosis stem cells. Combining theoretical and experimental knowledge, the authors provide a broad understanding of how the absence or low concentration of oxygen can play an influential role in the maintenance and self-renewal of stem cells and stem cell differentiation. This understanding has clinical implications for the fields of regenerative medicine, cancer biology and transplantation, as well as cell engineering and cell therapy. Anaerobiosis and Stemness is an important resource for stem cell and developmental biologists alike, as well as oncologists, cancer biologists, and researchers using stem cells for regeneration. Highlights the molecular and evolutionary features of stem cells which make them so important to all biological research Explores methods of isolation, characterization, activation, and maintenance of stem cells Includes models for clinical application in regenerative medicine, cancer therapy, and transplantation

Animal and Plant Stem Cells Book

Animal and Plant Stem Cells


  • Author : Mirjana Pavlović
  • Publisher : Springer
  • Release Date : 2017-02-08
  • Genre: Technology & Engineering
  • Pages : 234
  • ISBN 10 : 9783319477633

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Animal and Plant Stem Cells Excerpt :

This book provides a multifaceted look into the world of stem cells and explains the similarities and differences between plant and human stem cells. It explores the intersection between animals and plants and explains their cooperative role in bioengineering studies. The book treats both theoretical and practical aspects of stem cell research. It covers the advantages and limitations of many common applications related to stem cells: their sources, categories, engineering of these cells, reprogramming of their functions, and their role as novel cellular therapeutic approach. Written by experts in the field, the book focuses on aspects of stem cells ranging from expansion-propagation to metabolic reprogramming. It introduces the emergence of cancer stem cells and different modalities in targeted cancer stem cell therapies. It is a valuable source of fresh information for academics and researchers, examining molecular mechanisms of animal and plant stem cell regulation and their usage for therapeutic applications. Students at all levels of medical or engineering backgrounds will enjoy the case studies that illustrate and explain mechanisms, interactions, targeted effects, and multimodal therapeutic approaches. Academics, researchers, and professionals who want to expand their knowledge in this field will find this book an exceptional resource.

Mitochondria and Anaerobic Energy Metabolism in Eukaryotes Book

Mitochondria and Anaerobic Energy Metabolism in Eukaryotes


  • Author : William F. Martin
  • Publisher : Walter de Gruyter GmbH & Co KG
  • Release Date : 2020-12-07
  • Genre: Science
  • Pages : 269
  • ISBN 10 : 9783110612417

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Mitochondria and Anaerobic Energy Metabolism in Eukaryotes Excerpt :

Mitochondria are sometimes called the powerhouses of eukaryotic cells, because mitochondria are the site of ATP synthesis in the cell. ATP is the universal energy currency, it provides the power that runs all other life processes. Humans need oxygen to survive because of ATP synthesis in mitochondria. The sugars from our diet are converted to carbon dioxide in mitochondria in a process that requires oxygen. Just like a fire needs oxygen to burn, our mitochondria need oxygen to make ATP. From textbooks and popular literature one can easily get the impression that all mitochondria require oxygen. But that is not the case. There are many groups of organismsm known that make ATP in mitochondria without the help of oxygen. They have preserved biochemical relicts from the early evolution of eukaryotic cells, which took place during times in Earth history when there was hardly any oxygen avaiable, certainly not enough to breathe. How the anaerobic forms of mitochondria work, in which organisms they occur, and how the eukaryotic anaerobes that possess them fit into the larger picture of rising atmospheric oxygen during Earth history are the topic of this book.

Stem Cells and Biomaterials for Regenerative Medicine Book

Stem Cells and Biomaterials for Regenerative Medicine


  • Author : Marek J. Los
  • Publisher : Academic Press
  • Release Date : 2018-11-07
  • Genre: Science
  • Pages : 249
  • ISBN 10 : 9780128122785

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Stem Cells and Biomaterials for Regenerative Medicine Excerpt :

Stem Cells and Biomaterials for Regenerative Medicine addresses the urgent need for a compact source of information on both the cellular and biomaterial aspects of regenerative medicine. By developing a mutual understanding between three separately functioning areas of science—medicine, the latest technology, and clinical economics—the volume encourages interdisciplinary relationships that will lead to solutions for the significant challenges faced by today's regenerative medicine. Users will find sections on the homeostatic balance created by apoptosis and proliferating tissue stem cells, the naturally regenerative capacities of various tissue types, the potential regenerative benefits of iPS-generation, various differentiation protocols, and more. Written in easily accessbile language, this volume is appropriate for any professional or medical staff looking to expand their knowledge with regard to stem cells and regenerative medicine. Arms readers with key information on tissue engineering, artificial organs and biomaterials, while using broadly accessible language Provides broad introduction to, and examples of, various types of stem cells, core concepts of regenerative medicine, biomaterials, nanotechnology and nanomaterials, somatic cell transdyferentiation, and more Edited and authored by researchers with expertise in regenerative medicine, (cancer) stem cells, biomaterials, genetics and nanomaterials

Osteochondral Tissue Engineering Book

Osteochondral Tissue Engineering


  • Author : J. Miguel Oliveira
  • Publisher : Springer
  • Release Date : 2018-04-24
  • Genre: Science
  • Pages : 438
  • ISBN 10 : 9783319767116

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Osteochondral Tissue Engineering Excerpt :

This book reviews the most recent developments in the field of osteochondral tissue engineering (OCTE) and presents challenges and strategies being developed that face not only bone and cartilage regeneration, but also establish osteochondral interface formation in order to translate it into a clinical setting. Topics include nanotechnology approaches and biomaterials advances in osteochondral engineering, advanced processing methodology, as well as scaffolding and surface engineering strategies in OCTE. Hydrogel systems for osteochondral applications are also detailed thoroughly. Osteochondral Tissue Engineering: Nanotechnology, Scaffolding-Related Developments and Translation is an ideal book for biomedical engineering students and a wide range of established researchers and professionals working in the orthopedic field.

Microenvironment Derived Stem Cell Plasticity Book

Microenvironment Derived Stem Cell Plasticity


  • Author : Jelena Krstic
  • Publisher : Frontiers Media SA
  • Release Date : 2017-12-21
  • Genre: Electronic book
  • Pages : 116
  • ISBN 10 : 9782889453443

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Microenvironment Derived Stem Cell Plasticity Excerpt :

Plasticity is the hallmark of stem cells. At the same time, stem cells, like any other cell type, are influenced by their microenvironment and respond to it accordingly. A specific microenvironment is defined by a variety of factors, including biological and chemical factors, cell-cell interactions, but also metabolic and mechanical cues. Such dynamic and specialized microenvironment where the stem cells reside is considered a stem cell niche. Tissue injury as well as malignant tissue alterations lead to changes in the niche influencing the plasticity and biology of residing stem cells. Similarly, the niche changes upon tissue damage, which eventually induces differentiation of stem cells and ultimately regeneration of the tissue.

Regenerative Biology and Medicine Book

Regenerative Biology and Medicine


  • Author : David L. Stocum
  • Publisher : Academic Press
  • Release Date : 2012-06-07
  • Genre: Technology & Engineering
  • Pages : 474
  • ISBN 10 : 9780123848611

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Regenerative Biology and Medicine Excerpt :

Regenerative Biology and Medicine, Second Edition — Winner of a 2013 Highly Commended BMA Medical Book Award for Medicine — discusses the fundamentals of regenerative biology and medicine. It provides a comprehensive overview, which integrates old and new data into an ever-clearer global picture. The book is organized into three parts. Part I discusses the mechanisms and the basic biology of regeneration, while Part II deals with the strategies of regenerative medicine developed for restoring tissue, organ, and appendage structures. Part III reflects on the achievements of regenerative biology and medicine; future challenges; bioethical issues that need to be addressed; and the most promising developments in regenerative medicine. The book is designed for multiple audiences: undergraduate students, graduate students, medical students and postdoctoral fellows, and research investigators interested in an overall synthesis of this field. It will also appeal to investigators from fields not directly related to regenerative biology and medicine, such as chemistry, informatics, computer science, mathematics, physics, and engineering. Highly Commended 2013 BMA Medical Book Award for Medicine Includes coverage of skin, hair, teeth, cornea, and central neural tissues Provides description of regenetive medicine in digestive, respiratory, urogenital, musculoskeletal, and cardiovascular systems Includes amphibians as powerful research models with discussion of appendage regeneration in amphibians and mammals

Metabolic Plasticity of Cancer Book

Metabolic Plasticity of Cancer


  • Author : Tuuli Käämbre
  • Publisher : Frontiers Media SA
  • Release Date : 2020-12-24
  • Genre: Medical
  • Pages : 176
  • ISBN 10 : 9782889662760

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Metabolic Plasticity of Cancer Excerpt :

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Culture of Human Stem Cells Book

Culture of Human Stem Cells


  • Author : R. Ian Freshney
  • Publisher : John Wiley & Sons
  • Release Date : 2007-07-16
  • Genre: Science
  • Pages : 360
  • ISBN 10 : 0470167513

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Culture of Human Stem Cells Excerpt :

This book collects the most effective and cutting-edge methods and protocols for deriving and culturing human embryonic and adult stem cells—in one handy resource. This groundbreaking book follows the tradition of previous books in the Culture of Specialized Cells Series—each methods and protocols chapter is laid out exactly like the next, with stepwise protocols, preceded by specific requirements for that protocol, and a concise discussion of methods illustrated by data. The editors describe a limited number of representative techniques across a wide spectrum of stem cells from embryonic, newborn, and adult tissue, yielding an all-encompassing and versatile guide to the field of stem cell biology and culture. The book includes a comprehensive list of suppliers for all equipment used in the protocols presented, with websites available in an appendix. Additionally, there is a chapter on quality control, and other chapters covering legal and ethical issues, cryopreservation, and feeder layer culture. This text is a one-stop resource for all researchers, clinical scientists, teachers, and students involved in this crucial area of study.

The Pathology of the Human Placenta Book

The Pathology of the Human Placenta


  • Author : KURT BENIRSCHKE
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-06
  • Genre: Medical
  • Pages : 519
  • ISBN 10 : 9781461298090

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The Pathology of the Human Placenta Excerpt :

This presentation of the diseases of the placenta differs in many ways from the first such treatment in these volumes by the eminent Robert Meyer. It is a deliberate attempt to bring together the practical information which has been gathered about the pathology of this complex organ and to make it available to the practicing pathologist as well as clinician. Despite the ready availability of the placenta for study, the pathologist is often ill-prepared to interpret lesions which he may find. Moreover, it has been difficult for him to find reference material, published commonly in journals and books with which he is not familiar. Further more, the interpretation of lesions affecting the placenta seemed less challenging since the organ had served its function, was to be discarded and presumably little of significance could be expected from such a retrospective study. Recently, with new emphasis on maternal and fetal health and disease, it has become apparent that knowledge of pathologic changes in the placenta often provides a unique insight into antenatal events. Thus, there has been an abundance of publications in this field in recent years, several in book form. These and the most important older investigations on the morbid anatomy of the human pla centa are here reviewed. This book has been written with a special point of view, however, which reflects our own bias.

Catalytic Antibodies Book

Catalytic Antibodies


  • Author : Sudhir Paul
  • Publisher : Karger Medical and Scientific Publishers
  • Release Date : 2000-01-01
  • Genre: Medical
  • Pages : 172
  • ISBN 10 : 9783805570992

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Catalytic Antibodies Excerpt :

This volume addresses fundamental questions concerning the immunological genesis of the catalytic activity in antibodies, its relationship with classical antigen binding activity, and the biochemical mechanisms involved in catalysis. The contents reflect three main challenges in the field, i.e. to delineate the biological functions of catalytic antibodies in autoimmune disease; to isolate therapy-grade antibody catalysts with sufficient specificity and turnover to permit rapid removal of microbial and tumor antigens; and to develop immunogens that recruit immature catalyst-producing B cells into the clonal selection pathway and induce adaptive improvements of the catalytic function. Well-edited and up-to-date, this book reviews the current knowledge in the field and explores ways by which natural and engineered catalytic activities can be harnessed for medical applications. It should therefore be of special interest to immunologists, biochemists, biotechnologists, rheumatologists and pathologists.

Protocol Handbook for Cancer Biology Book

Protocol Handbook for Cancer Biology


  • Author : Gauri Misra
  • Publisher : Academic Press
  • Release Date : 2021-02-12
  • Genre: Science
  • Pages : 216
  • ISBN 10 : 9780323898171

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Protocol Handbook for Cancer Biology Excerpt :

Protocol Handbook for Cancer Biology brings together a comprehensive collection of the methods used for cancer assessment, diagnostics, and therapeutics. Various protocols are discussed along with alternative strategies, including the advantages and limitations of techniques that have been used in labs globally. These protocols are presented by cancer biology experts based on their real-world experience. The protocols in this book will be a valuable resource for cancer researchers and graduate students, who can utilize the techniques described to conduct research more efficiently and successfully. Presents comprehensive protocols used for cancer assessment, diagnostics, and therapeutics all in one place Encompasses alternative strategies considering the requirements of the end user and taking into consideration diverse research settings Discusses limitations and advantages of each method in experimental design and execution, thus saving time during the research process

Cellular Endocrinology in Health and Disease Book

Cellular Endocrinology in Health and Disease


  • Author : Alfredo Ulloa-Aguirre
  • Publisher : Academic Press
  • Release Date : 2021-02-02
  • Genre: Science
  • Pages : 486
  • ISBN 10 : 9780128198025

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Cellular Endocrinology in Health and Disease Excerpt :

Cellular Endocrinology in Health and Disease, Second Edition, describes the underlying basis of endocrine function, providing an important tool to understand the fundamentals of endocrine diseases. Delivering a comprehensive review of the basic science of endocrinology, from cell biology to human disease, this work explores and dissects the function of a number of cellular systems. The new edition provides an understanding of how endocrine glands function by integrating information resulting in biological effects on both local and systemic levels, also providing new information on the molecular physiopathogenesis of endocrine neoplasic cells. The new edition expands the most used chapters from the first edition and proposes a series of substitutions and additions to the table of contents. New chapters cover signaling, brown adipose tissue, hypothalamic cell models, cellular basis of insulin resistance, genetics and epigenetics of neuroendocrine tumors, and a series of chapters on endocrine-related cancer. Providing content that crosses disciplines, Cellular Endocrinology in Health and Disease, Second Edition, details how cellular endocrine function contributes to system physiology and mediates endocrine disorders. A methods section proves novel and useful approaches across research focus that will be attractive to medical students, residents, and specialists in the field of endocrinology, as well as to those interested in cellular regulation. Editors Alfredo Ulloa-Aguirre and Ya-Xiong Tao, experts in molecular and cellular aspects of endocrinology, deliver contributions carefully selected for relevance, impact, and clarity of expression from leading field experts Explores endocrine cells biology in normal and pathologic conditions Covers new aspects of endocrine cell function in distinct tissues Provides a view into the biological effect in local and systemic levels 15 new chapters covering the recent developments in the field