Animal Models For The Study Of Human Disease

Animal Models for the Study of Human Disease

• Author : P. Michael Conn
• Publisher : Academic Press
• Release Date : 2013-05-29
• Genre: Science
• Pages : 1108
• ISBN 10 : 9780124159129

Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders, cancer, hypertension, genetic diseases, and diseases of abuse. Organized by disease orientation for ease of searchability Provides information on locating resources, animal alternatives and animal ethics Covers a broad range of animal models used in research for human disease

Animal Models for the Study of Human Disease

• Author : P. Michael Conn
• Publisher : Academic Press
• Release Date : 2013
• Genre: Medical
• Pages : 1089
• ISBN 10 : 0124158943

Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders, cancer, hypertension, genetic diseases, and diseases of abuse. Organized by disease orientation for ease of searchability Provides information on locating resources, animal alternatives and animal ethics Covers a broad range of animal models used in research for human disease

Animal Models of Human Disease

• Author : Kyung-Tai Min
• Publisher : Academic Press
• Release Date : 2011-03-17
• Genre: Medical
• Pages : 552
• ISBN 10 : 9780123848789

Animal experiments have contributed much to our understanding of mechanisms of disease and are important for determining new therapies. This volume reviews the latest research and developments in this field. * Discusses new discoveries, approaches, and ideas * Contributions from leading scholars and industry experts * Reference guide for researchers involved in molecular biology and related fields

Experimental Animal Models of Human Diseases

• Author : Bartholomew Ibeh
• Publisher : BoD – Books on Demand
• Release Date : 2018-05-23
• Genre: Science
• Pages : 410
• ISBN 10 : 9781789231649

The world has recorded losses in terms of human life as well as extensive time spent in experimentation with development of new drugs, elucidation of disease mechanism(s), and therapeutic agent discovery. Ethical and legal issues cojoin in slowing down scientific discoveries in medicine and biology. The past two (2) decades, therefore, have seen tremendous attempts that largely are successful in developing animal models with the characteristics of mimicking, approximating, or expressing transplanted human organs/tissues. These models or rather approaches seem to be fast, cost-effective, and easy to maintain compared to primates. This book is a collection of expert essays on animal models of human diseases of global interest. A visible objective of the book is to provide real-time experimental approach to scientists, clinicians, ethicists, medicolegal/medical jurisprudence workers, immunologists, postgraduate students, and vaccinologists and informative and multidisciplinary approach for the identification of new therapeutic targets and biomarkers using animal models as well as investigating the pathogenesis and therapeutic strategies of human diseases. An increased understanding of the genetic, molecular, and cellular mechanisms responsible for the development of human diseases has laid out the foundation for the development of rational therapies mainly with animal models.

Use of Laboratory Animals in Biomedical and Behavioral Research

• Author : National Research Council
• Publisher : National Academies Press
• Release Date : 1988-02-01
• Genre: Science
• Pages : 113
• ISBN 10 : 9780309038393

Scientific experiments using animals have contributed significantly to the improvement of human health. Animal experiments were crucial to the conquest of polio, for example, and they will undoubtedly be one of the keystones in AIDS research. However, some persons believe that the cost to the animals is often high. Authored by a committee of experts from various fields, this book discusses the benefits that have resulted from animal research, the scope of animal research today, the concerns of advocates of animal welfare, and the prospects for finding alternatives to animal use. The authors conclude with specific recommendations for more consistent government action.

Autoimmune Disease Models

• Author : Irun R. Cohen
• Publisher : Academic Press
• Release Date : 2014-06-28
• Genre: Medical
• Pages : 329
• ISBN 10 : 9780080917368

Because autoimmune disorders can wreak havoc in both humans and animals, these disorders are now the objects of intense and focused research. This book details specific animal models for a variety of autoimmune disorders. The contributors are recognized authorities who deal with the panoply of experimentally induced autoimmune disorders, including encephalomyelitis, allergic neuritis, uveoretinitis, myocarditis, and hepatitis. Also included are discussions of spontaneously appearing diseases such as autoimmune thyroiditis and systemic lupus erythematosus. Many other disorders are also covered in this comprehensive guide. Certain to be an aid in the planning of individual experiments and broader research programs, this book will be a valuable addition to the library of all practicing immunologists interested in immune system function and dysfunction.

Advancing Disease Modeling in Animal Based Research in Support of Precision Medicine

• Author : National Academies of Sciences, Engineering, and Medicine
• Publisher : National Academies Press
• Release Date : 2018-06-29
• Genre: Science
• Pages : 139
• ISBN 10 : 9780309471169

Precision medicine is focused on the individual and will require the rapid and accurate identification and prioritization of causative factors of disease. To move forward and accelerate the delivery of the anticipated benefits of precision medicine, developing predictable, reproducible, and reliable animal models will be essential. In order to explore the topic of animal-based research and its relevance to precision medicine, the National Academies of Sciences, Engineering, and Medicine convened a 2-day workshop on October 5 and 6, 2017. The workshop was designed to focus on the development, implementation, and interpretation of model organisms to advance and accelerate the field of precision medicine. Participants examined the extent to which next-generation animal models, designed using patient data and phenotyping platforms targeted to reveal and inform disease mechanisms, will be essential to the successful implementation of precision medicine. This publication summarizes the presentations and discussions from the workshop.

Cellular and Animal Models in Human Genomics Research

• Author : Anonim
• Publisher : Academic Press
• Release Date : 2019-07-30
• Genre: Medical
• Pages : 226
• ISBN 10 : 9780128165744

Cellular and Animal Models in Human Genomics Research provides an indispensable resource for applying comparative genomics in the annotation of disease-gene associated variants that are identified by human genomic sequencing. The book presents a thorough overview of effective protocols for the use of cellular and animal modeling methods to turn lists of plausible genes into causative biomarkers. With chapters written by international experts, the book first addresses the fundamental aspects of using cellular and animal models in genetic and genomic studies, including in-depth examples of specific models and their utility, i.e., yeast, worms, flies, fish, mice and large animals. Protocols for properly conducting model studies, genomic technology, modeling candidate genes vs. genetic variants, integrative modeling, utilizing induced pluripotent stem cells, and employing CRISPR-Cas9 are also discussed in-depth. Provides a thorough, accessible resource that helps researchers and students employ cellular and animal models in their own genetic and genomic studies Offers guidance on how to effectively interpret the results and significance of genetic and genomic model studies for human health Features chapters from international experts in the use of specific cellular and animal models, including yeast, worms, flies, fish, mice, and large animals, among other organisms

The Alchemy of Disease

• Author : John Whysner
• Publisher : Columbia University Press
• Release Date : 2020-06-02
• Genre: Science
• Pages : 328
• ISBN 10 : 9780231549509

Since the dawn of the industrial age, we have unleashed a bewildering number of potentially harmful chemicals. But out of this vast array, how do we identify the actual threats? What does it take to prove that a certain chemical causes cancer? How do we translate academic knowledge of the toxic effects of particular substances into understanding real-world health consequences? The science that answers these questions is toxicology. In The Alchemy of Disease, John Whysner offers an accessible and compelling history of toxicology and its key findings. He details the experiments and discoveries that revealed the causal connections between chemical exposures and diseases. Balancing clear accounts of groundbreaking science with human drama and public-policy relevance, Whysner describes key moments in the development of toxicology and their thorny social and political implications. The book features discussions of toxicological problems past and present, including DDT, cigarettes and other carcinogens, lead poisoning, fossil fuels, chemical warfare, pharmaceuticals—including opioids—and the efficacy of animal testing. Offering valuable insight into the science and politics of crucial public-health concerns, The Alchemy of Disease shows that toxicology’s task—pinpointing the chemical cause of an illness—is as compelling as any detective story.

Animals for Medical Research

• Author : Brij M. Mitruka
• Publisher : Unknown
• Release Date : 1982
• Genre: Diseases
• Pages : 616
• ISBN 10 : PSU:000017806800

This text provides valuable information in selecting and using suitable animal species for research so that the experimental data can be meaningful and relevant to human disease. It will be useful to those involved in experimental biology and medical research.

Human and Animal Models for Translational Research on Neurodegeneration Challenges and Opportunities From South America

• Author : Agustín Ibáñez
• Publisher : Frontiers Media SA
• Release Date : 2018-06-21
• Genre: Uncategoriezed
• Pages : 217
• ISBN 10 : 9782889454945

Neurodegenerative diseases are the most frequent cause of dementia, representing a burden for public health systems (especially in middle and middle-high income countries). Although most research on this issue is concentrated in first-world centers, growing efforts in South America are affording important breakthroughs. This emerging agenda poses new challenges for the region but also new opportunities for the field. This book aims to integrate the community of experts across the globe and the region, and to establish new challenges and developments for future investigation. We present research focused on neurodegenerative research in South America. We introduce studies assessing the interplay among genetic, neural, and behavioral dimensions of these diseases, as well as articles on vulnerability factors, comparisons of findings from various countries, and works promoting multicenter and collaborative networking. More generally, our book covers a broad scope of human-research approaches (behavioral assessment, neuroimaging, electromagnetic techniques, brain connectivity, peripheral measures), animal methodologies (genetics, epigenetics, proteomics, metabolomics, other molecular biology tools), species (all human and non-human animals, sporadic, and genetic versions), and article types (original research, review, and opinion papers). Through this wide-ranging proposal, we hope to introduce a fresh approach to the challenges and opportunities of research on neurodegeneration in South America.

Overcoming Challenges to Develop Countermeasures Against Aerosolized Bioterrorism Agents

• Author : National Research Council
• Publisher : National Academies Press
• Release Date : 2006-08-07
• Genre: Political Science
• Pages : 87
• ISBN 10 : 0309180902

The National Institute of Allergy and Infectious Diseases (NIAID) gives the highest priority to developing countermeasures against bioterrorism agents that are highly infective when dispersed in aerosol form. Developing drugs to prevent or treat illnesses caused by bioterrorism agents requires testing their effectiveness in animals since human clinical trials would be unethical. At the request of NIAID, the National Academies conducted a study to examine how such testing could be improved. Overcoming Challenges to Develop Countermeasures Against Aerosolized Bioterrorism Agents provides recommendations to researchers on selecting the kinds of animal models, aerosol generators, and bioterrorism agent doses that would produce conditions that most closely mimic the disease process in humans. It also urges researchers to fully document experimental parameters in the literature so that studies can be reproduced and compared. The book recommends that all unclassified data on bioterrorism agent studies--including unclassified, unpublished data from U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID)--be published in the open literature. The book also calls on the U.S. Food and Drug Administration to improve the process by which bioterrorism countermeasures are approved based on the results of animal studies.

Sourcebook of Models for Biomedical Research

• Author : P. Michael Conn
• Publisher : Springer Science & Business Media
• Release Date : 2008
• Genre: Medical
• Pages : 756
• ISBN 10 : 9781588299338

The collection of systems represented in this volume is a unique effort to reflect the diversity and utility of models used in biomedicine. That utility is based on the consideration that observations made in particular organisms will provide insight into the workings of other, more complex systems. This volume is therefore a comprehensive and extensive collection of these important medical parallels.

Mouse Cell Culture

• Author : Ivan Bertoncello
• Publisher : Unknown
• Release Date : 2019
• Genre: Uncategoriezed
• Pages : 315
• ISBN 10 : 1493990861

Animal Models for the Study of Human Disease

• Author : Judith Axler Turner
• Publisher : Elsevier Inc. Chapters
• Release Date : 2013-05-29
• Genre: Medical
• Pages : 1108
• ISBN 10 : 9780128071922

Identifying and selecting the most appropriate animal model is a challenge, but the U.S. Federal Government’s National Institutes of Health, has supported several efforts to make the job of finding disease models easier. These efforts began with support for databases about specific species, and have graduated to support for discipline-specific studies and cross-species resources. This article tracks LAMHDI, the initiative to Link Animal Models to Human DIsease (www.lamhdi.org), which brings together data about five species: flies, mice, rats, yeast, and zebrafish, and allows scientists to search across these data, principally by disease and gene. This chapter explains how LAMHDI was conceived, and where LAMHDI hopes to go in moving into phenotypical as well as genotypical data through networks and visualization.