Animal Models in Cancer Drug Discovery Book

Animal Models in Cancer Drug Discovery


  • Author : Asfar Azmi
  • Publisher : Academic Press
  • Release Date : 2019-04-16
  • Genre: Business & Economics
  • Pages : 470
  • ISBN 10 : 9780128147054

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Animal Models in Cancer Drug Discovery Excerpt :

Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on how these newer models could de-risk modern drug discovery. Areas covered include up to date information on latest organoid derived models and newer genetic models. Additionally, the book discusses humanized animal tumor models for cancer immunotherapy and how they leverage personalized therapies. The chapter on larger animal, canine models and their use in and their use in pre-investigational new drug (pre-IND) development makes the volume unique. Unlike before, the incorporation of several simplified protocols, breeding methodologies, handling and assessment procedures to study drug intervention makes this book a must read. Animal Models in Cancer Drug Discovery is a valuable resource for basic and translational cancer researchers, drug discovery researchers, contract research organizations, and knowledge seekers at all levels in the biomedical field. Encompasses discussions on innovative animal models, xenograft, genetic models, primary models, organoid systems, humanized and other models in modern biology paradigms that are enhancing research in the field of drug discover Covers the use of these models in personalized medicine, immunotherapy, toxicology, pre-IND assessments and related drug development arenas Presents protocols, procedures, and a comprehensive glossary to help new readers understand technical terms and specialized nomenclature

Tumor Models in Cancer Research Book

Tumor Models in Cancer Research


  • Author : Beverly A. Teicher
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-12-01
  • Genre: Medical
  • Pages : 693
  • ISBN 10 : 9781607619680

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Tumor Models in Cancer Research Excerpt :

The past 6 years since the first edition of this book have seen great progress in the development of genetically engineered mouse (GEM) models of cancer. These models are finding an important role in furthering our understanding of the biology of malignant disease. A comfortable position for GEM models in the routine conduct of screening for potential new therapeutics is coming more slowly but is coming. Increasing numbers of genetically engineered mice are available, some with conditional activation of oncogenes, some with multiple genetic changes providing mouse models that are moving closer to the human disease.

Translational Animal Models in Drug Discovery and Development Book

Translational Animal Models in Drug Discovery and Development


  • Author : Xinkang Wang
  • Publisher : Bentham Science Publishers
  • Release Date : 2012-10-03
  • Genre: Science
  • Pages : 287
  • ISBN 10 : 9781608054695

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Translational Animal Models in Drug Discovery and Development Excerpt :

Animal models of diseases play a pivotal role in drug discovery and development, not only for proof of the concept studies of efficacy, PK/PD relationship but also for drug safety assessment. Since considerable differences in variables exist between animal models and human models (such as genetics, physiology, anatomy, gene expression, heterogeneity of disease conditions, etc.), not all the preclinical models are able to represent the pathophysiological conditions in human diseases. Therefore, partly due to the lack of congruency between animal and human disease models, several proposed therapeutic agents in the past decades have been demonstrated to be effective in preclinical models but failed in clinical studies. This e-book focuses on animal models of diseases from a translational perspective and highlights the key advantages and limitations of each model described to facilitate drug discovery and development. A unique feature of the volume is that it contains a selection of details disease models in various therapeutic niches with significant unmet medical needs, including inflammation, neurological diseases, cardiovascular and metabolic diseases, and oncology. This e-book is, therefore, of considerable value to researchers and clinicians involved in drug discovery and development as well as pathology.

Animal Models in Cancer Drug Discovery Book

Animal Models in Cancer Drug Discovery


  • Author : Asfar Azmi
  • Publisher : Academic Press
  • Release Date : 2019-05-15
  • Genre: Business & Economics
  • Pages : 600
  • ISBN 10 : 0128147040

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Animal Models in Cancer Drug Discovery Excerpt :

Animal Models in Cancer Drug Discovery covers recent developments in tumor model systems for translational cancer research. Virtually all types of existing and emerging tumor models in use by the research community are discussed. Areas covered include the latest organoid derived models and newer genetic models. Additionally, the book discusses humanized animal tumor models for cancer immunotherapy and how they leverage personalized therapies. Chapters on larger animal models, canine models and their use in pre-IND development make this a unique volume. In addition, sections on breeding methodologies and handling and assessment procedures make this book a must read. This book will be a valuable resource for basic and translational cancer researchers, drug discovery researchers, contract research organizations and knowledge seekers at all levels of the biomedical field. Encompasses discussions on innovative animal models, xenograft, genetic models, primary models, organoid system, humanized and other models in modern biology paradigms Covers the use of these models in personalized medicine, immunotherapy, toxicology, Pre-IN assessments and related drug development arenas Presents protocols, procedures and a comprehensive glossary to help newer readers understand technical terms and specialized nomenclature

Mouse Models for Drug Discovery Book

Mouse Models for Drug Discovery


  • Author : Gabriele Proetzel
  • Publisher : Humana
  • Release Date : 2016-08-23
  • Genre: Medical
  • Pages : 421
  • ISBN 10 : 1493961217

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Mouse Models for Drug Discovery Excerpt :

As the drug discovery process shifts more and more toward specifically targeting pathways and molecules, model systems continue to increase in importance, and the mouse, with its versatility, ease of use, and remarkable similarity to the human genome, has clearly risen to the forefront of animal model studies. In Mouse Models for Drug Discovery: Methods and Protocols, experts in the field present some background for those less familiar with mice as experimental model platforms as well as a collection of techniques involving general methods as well as specific disease topics such as type 1 and 2 diabetes, cardiovascular disease, arthritis, skin disorders, cancer, the use of behavioral models for depression and anxiety, neurodegenerative diseases, neuromuscular diseases, and infectious diseases. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easy-to-use, Mouse Models for Drug Discovery: Methods and Protocols will stimulate those not familiar with the power of the mouse and its potential for the drug discovery process, and it will encourage the development of new models and new ways to utilize existing models in order to further the use of this dynamic animal in this vital field.

Unravelling Cancer Signaling Pathways  A Multidisciplinary Approach Book

Unravelling Cancer Signaling Pathways A Multidisciplinary Approach


  • Author : Kakoli Bose
  • Publisher : Springer Nature
  • Release Date : 2019-11-25
  • Genre: Medical
  • Pages : 583
  • ISBN 10 : 9789813298163

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Unravelling Cancer Signaling Pathways A Multidisciplinary Approach Excerpt :

Unravelling the intricate cell signalling networks and their significance in cancer poses major intellectual challenge. Keeping this in mind, the book aims at understanding the mechanism of action of different proteins and their complexes in the cancer signalling pathways. Hence, the proposed book that comprises 20 chapters provides a comprehensive introduction on cell signalling, its alterations in cancer, molecules that have been popular targets as well as the ones that are emerging as targets. In addition, it discusses different forms of therapy that are coming up for its treatment. Other than that, a major portion of the book is focused on studying different disciplines at the interface of biology and other areas of science that are being used to understand cancer biology in depth.

Advancing Disease Modeling in Animal Based Research in Support of Precision Medicine Book

Advancing Disease Modeling in Animal Based Research in Support of Precision Medicine


  • Author : National Academies of Sciences, Engineering, and Medicine
  • Publisher : National Academies Press
  • Release Date : 2018-05-29
  • Genre: Science
  • Pages : 138
  • ISBN 10 : 9780309471190

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Advancing Disease Modeling in Animal Based Research in Support of Precision Medicine Excerpt :

Precision medicine is focused on the individual and will require the rapid and accurate identification and prioritization of causative factors of disease. To move forward and accelerate the delivery of the anticipated benefits of precision medicine, developing predictable, reproducible, and reliable animal models will be essential. In order to explore the topic of animal-based research and its relevance to precision medicine, the National Academies of Sciences, Engineering, and Medicine convened a 2-day workshop on October 5 and 6, 2017. The workshop was designed to focus on the development, implementation, and interpretation of model organisms to advance and accelerate the field of precision medicine. Participants examined the extent to which next-generation animal models, designed using patient data and phenotyping platforms targeted to reveal and inform disease mechanisms, will be essential to the successful implementation of precision medicine. This publication summarizes the presentations and discussions from the workshop.

The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research Book

The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research


  • Author : National Academies of Sciences, Engineering, and Medicine
  • Publisher : National Academies Press
  • Release Date : 2015-12-09
  • Genre: Medical
  • Pages : 82
  • ISBN 10 : 9780309379939

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The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research Excerpt :

Traditional preclinical mouse models of cancer have been very useful for studying the biology of cancer, however they often lack key characteristics of human cancers. As a result, many novel drug candidates fail in human clinical trials despite evidence of drug efficacy in those preclinical models. Thus, researchers are seeking new approaches to augment preclinical knowledge before undertaking clinical trials for human patients. Recently, there has been renewed interest in comparative oncology - the study of naturally developing cancers in animals as models for human disease - as one way to improve cancer drug development and reduce attrition of investigational agents. Tumors that spontaneously develop in pet dogs and other companion animals as a result of normal aging share many characteristics with human cancers, such as histological appearance, tumor genetics, biological behavior, molecular targets, and therapeutic response. In June 2015 the Institute of Medicine hosted a workshop to examine the rationale and potential for integrating clinical trials for pet patients with naturally occurring cancers into translational cancer research and development. Participants discussed the research needs, strategies, and resources to support greater integration of clinical trials for pets with cancer into translational research pathways, and challenges and potential solutions for facilitating that integration. This report summarizes the presentations and discussions from the workshop.

Alternatives to Animal Testing Book

Alternatives to Animal Testing


  • Author : Hajime Kojima
  • Publisher : Springer
  • Release Date : 2018-12-27
  • Genre: Medical
  • Pages : 130
  • ISBN 10 : 9789811324475

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Alternatives to Animal Testing Excerpt :

This open access book presents recent advances in the pure sciences that are of significance in the quest for alternatives to the use of animals in research and describes a variety of practical applications of the three key guiding principles for the more ethical use of animals in experiments – replacement, reduction, and refinement, collectively known as the 3Rs. Important examples from across the world of implementation of the 3Rs in the testing of cosmetics, chemicals, pesticides, and biologics, including vaccines, are described, with additional information on relevant regulations. The coverage also encompasses emerging approaches to alternative tests and the 3Rs. The book is based on the most informative contributions delivered at the Asian Congress 2016 on Alternatives and Animal Use in the Life Sciences. It will be of value for those working in R&D, for graduate students, and for educators in various fields, including the pharmaceutical and cosmetic sciences, pharmacology, toxicology, and animal welfare. The free, open access distribution of Alternatives to Animal Testing is enabled by the Creative Commons Attribution license in International version 4: CC BY 4.0.

Humanized Mice Book

Humanized Mice


  • Author : Tatsuji Nomura
  • Publisher : Springer Science & Business Media
  • Release Date : 2008-03-11
  • Genre: Medical
  • Pages : 199
  • ISBN 10 : 9783540756477

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Humanized Mice Excerpt :

The term humanized mouse in this text refers to a mouse in which human tissues and cells have been transplanted and show the same biological function as they do in the human body. That is, the physiological properties and functions of tra- planted human tissues and cells can be analyzed in the mouse instead of using a living human body. It should therefore be possible to study the pathophysiology and treatment of human diseases in mice with good reproducibility. Thus, the hum- ized mouse can be used as a potent tool in both basic and clinical research in the future. The development of appropriate immunodeficient mice has been indispensable in the creation of the humanized mouse, which has been achieved through many years of efforts by several laboratories. The first stage on the road to the humanized mouse was the report on nude mice by Isaacson and Cattanach in 1962. Thereafter, nude mice were studied in detail by Falanagan and, in 1968, Pantelouris found that these mice have no thymus gland, which suggested that the mice lack transplan- tion immunity against xenografts such as human hematopoietic stem cells. At the Nude Mouse Workshops (organized by Regard, Povlsen, Nomura and colleagues) that were held nine times between 1972 and 1997, the possibility of creating a humanized mouse using nude mice was extensively examined. The results, however, showed that certain human cancers can be engrafted in nude mice, but unfortunately engraftment of normal human tissue was almost impossible.

In vivo Models for Drug Discovery Book

In vivo Models for Drug Discovery


  • Author : José Miguel Vela
  • Publisher : John Wiley & Sons
  • Release Date : 2014-08-11
  • Genre: Medical
  • Pages : 600
  • ISBN 10 : 9783527333288

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In vivo Models for Drug Discovery Excerpt :

This one-stop reference is the first to present the complete picture -- covering all relevant organisms, from single cells to mammals, as well as all major disease areas, including neurological disorders, cancer and infectious diseases. Addressing the needs of the pharmaceutical industry, this unique handbook adopts a broad perspective on the use of animals in the early part of the drug development process, including regulatory rules and limitations, as well as numerous examples from real-life drug development projects. After a general introduction to the topic, the expert contributors from research-driven pharmaceutical companies discuss the basic considerations of using animal models, including ethical issues. The main part of the book systematically surveys the most important disease areas for current drug development, from cardiovascular to endocrine disorders, and from infectious to neurological diseases. For each area, the availability of animal models for target validation, hit finding and lead profiling is reviewed, backed by numerous examples of both successes and failures among the use of animal models. The whole is rounded off with a discussion of perspectives and challenges. Key knowledge for drug researchers in industry as well as academia.

Phenotypic Drug Discovery Book

Phenotypic Drug Discovery


  • Author : Angelique Augustin
  • Publisher : Royal Society of Chemistry
  • Release Date : 2020-12-10
  • Genre: Medical
  • Pages : 273
  • ISBN 10 : 9781788018760

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Phenotypic Drug Discovery Excerpt :

Phenotypic drug discovery has been highlighted in the past decade as an important strategy in the discovery of novel medical entities. This book aims to equip researchers with a thought-provoking guide to the application and development of contemporary phenotypic drug discovery for clinical success.

Mouse Models of Cancer Book

Mouse Models of Cancer


  • Author : Cory Abate-Shen
  • Publisher : Unknown
  • Release Date : 2013-11-30
  • Genre: Medical
  • Pages : 521
  • ISBN 10 : 1621820033

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Mouse Models of Cancer Excerpt :

Too often both composition teachers and their students experience knowledge and authority as lying outside their rhetorical interactions with others. Drawing on feminist, cultural, and poststructuralist theory, as well as work in the rhetorical tradition and composition studies, Hill offers less debilitating methods of thinking that teachers can model for their students. Richly illustrated with examples of classroom interactions and student work, the book also shows teachers how to enrich their own intellectual and political lives within the academy.

Drug Repurposing in Cancer Therapy Book

Drug Repurposing in Cancer Therapy


  • Author : Kenneth K.W. To
  • Publisher : Academic Press
  • Release Date : 2020-07-29
  • Genre: Science
  • Pages : 458
  • ISBN 10 : 9780128199039

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Drug Repurposing in Cancer Therapy Excerpt :

Drug Repurposing in Cancer Therapy: Approaches and Applications provides comprehensive and updated information from experts in basic science research and clinical practice on how existing drugs can be repurposed for cancer treatment. The book summarizes successful stories that may assist researchers in the field to better design their studies for new repurposing projects. Sections discuss specific topics such as in silico prediction and high throughput screening of repurposed drugs, drug repurposing for overcoming chemoresistance and eradicating cancer stem cells, and clinical investigation on combination of repurposed drug and anticancer therapy. Cancer researchers, oncologists, pharmacologists and several members of biomedical field who are interested in learning more about the use of existing drugs for different purposes in cancer therapy will find this to be a valuable resource. Presents a systematic and up-to-date collection of the research underpinning the various drug repurposing approaches for a quick, but in-depth understanding on current trends in drug repurposing research Brings better understanding of the drug repurposing process in a holistic way, combining both basic and clinical sciences Encompasses a collection of successful stories of drug repurposing for cancer therapy in different cancer types

Mouse Models of Human Cancer Book

Mouse Models of Human Cancer


  • Author : Eric C. Holland
  • Publisher : John Wiley & Sons
  • Release Date : 2004-08-27
  • Genre: Science
  • Pages : 504
  • ISBN 10 : 9780471444602

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Mouse Models of Human Cancer Excerpt :

Mice have become the species of choice for modeling the complex interactions between tumor cells and the host environment. Mouse genetics are easily manipulated, and a growing array of technology exists for this purpose. Mouse models allow investigators to better understand causal relationships between specific genetic alterations and tumors, utilize new imaging techniques, and test novel therapies. Recent developments along these lines show great promise for the development of new anti-cancer treatments. Mouse Models of Human Cancer provides researchers and students with a complete resource on the subject, systematically presenting the principles, methodologies, applications, and challenges associated with this exciting field. Offering a survey of the latest research and a description of future areas of interest, this text: Presents real experimental data Describes organ site-specific mouse models Clearly identifies suitable models for further drug testing Critically analyzes current methodologies and their limitations Features numerous recognizable expert contributors Lists key Web sites, reagents, and companies From mouse handling and genetic engineering to preclinical trials, Mouse Models of Human Cancer is a comprehensive guide to using these models and relating them to human disease. Its uniform presentation describes organ-specific models in clinical, imaging, and molecular terms, and lays out the relevant genetics, experimental approaches, histological comparisons with human disease, and conclusions. Combining stellar chapter authors, rich illustrations, and clear, up-to-date coverage, Mouse Models of Human Cancer is an invaluable resource for advanced students and cutting-edge researchers.