Animal Models in Eye Research Book

Animal Models in Eye Research


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2011-04-28
  • Genre: Science
  • Pages : 232
  • ISBN 10 : 0080921035

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Animal Models in Eye Research Excerpt :

The eye is a complex sensory organ, which enables visual perception of the world. Thus the eye has several tissues that do different tasks. One of the most basic aspects of eye function is the sensitivity of cells to light and its transduction though the optic nerve to the brain. Different organisms use different ways to achieve these tasks. In this sense, eye function becomes a very important evolutionary aspect as well. This book presents the different animal models that are commonly used for eye research and their uniqueness in evaluating different aspects of eye development, evolution, physiology and disease. * Presents information on the major animal models used in eye research including invertebrates and vertebrates * Provides researchers with information needed to choose between model organisms * Includes an introductory chapter on the different types of eyes, stressing possible common molecular machinery

Animal Models of Ophthalmic Diseases Book

Animal Models of Ophthalmic Diseases


  • Author : Chi-Chao Chan
  • Publisher : Springer
  • Release Date : 2015-12-01
  • Genre: Medical
  • Pages : 152
  • ISBN 10 : 9783319194349

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Animal Models of Ophthalmic Diseases Excerpt :

This book describes experimental animal models that mimic common human ocular diseases: herpetic keratitis, cataract, glaucoma, age-related macular degeneration, diabetic retinopathy, uveitis, retinitis pigmentosa, Graves’ disease, and intraocular tumors. In conjunction, these models reflect the diversity and utility of tools used to study human disease. World expert clinicians discuss each model based on their clinical experience and the text is supported by numerous photos and diagrams. In describing the most pertinent animal models of ophthalmic diseases, this book will be of interest to ophthalmologists, vision researchers, fellows, residents and medical students.

Sourcebook of Models for Biomedical Research Book

Sourcebook of Models for Biomedical Research


  • Author : P. Michael Conn
  • Publisher : Springer Science & Business Media
  • Release Date : 2008-03-07
  • Genre: Medical
  • Pages : 778
  • ISBN 10 : 9781597452854

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Sourcebook of Models for Biomedical Research Excerpt :

The collection of systems represented in this volume is a unique effort to reflect the diversity and utility of models used in biomedicine. That utility is based on the consideration that observations made in particular organisms will provide insight into the workings of other, more complex systems. This volume is therefore a comprehensive and extensive collection of these important medical parallels.

Experimental Animal Models of Human Diseases Book

Experimental Animal Models of Human Diseases


  • Author : Bartholomew Ibeh
  • Publisher : BoD – Books on Demand
  • Release Date : 2018-05-23
  • Genre: Science
  • Pages : 410
  • ISBN 10 : 9781789231649

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Experimental Animal Models of Human Diseases Excerpt :

The world has recorded losses in terms of human life as well as extensive time spent in experimentation with development of new drugs, elucidation of disease mechanism(s), and therapeutic agent discovery. Ethical and legal issues cojoin in slowing down scientific discoveries in medicine and biology. The past two (2) decades, therefore, have seen tremendous attempts that largely are successful in developing animal models with the characteristics of mimicking, approximating, or expressing transplanted human organs/tissues. These models or rather approaches seem to be fast, cost-effective, and easy to maintain compared to primates. This book is a collection of expert essays on animal models of human diseases of global interest. A visible objective of the book is to provide real-time experimental approach to scientists, clinicians, ethicists, medicolegal/medical jurisprudence workers, immunologists, postgraduate students, and vaccinologists and informative and multidisciplinary approach for the identification of new therapeutic targets and biomarkers using animal models as well as investigating the pathogenesis and therapeutic strategies of human diseases. An increased understanding of the genetic, molecular, and cellular mechanisms responsible for the development of human diseases has laid out the foundation for the development of rational therapies mainly with animal models.

Use of Laboratory Animals in Biomedical and Behavioral Research Book

Use of Laboratory Animals in Biomedical and Behavioral Research


  • Author : National Research Council
  • Publisher : National Academies Press
  • Release Date : 1988-02-01
  • Genre: Science
  • Pages : 113
  • ISBN 10 : 9780309038393

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Use of Laboratory Animals in Biomedical and Behavioral Research Excerpt :

Scientific experiments using animals have contributed significantly to the improvement of human health. Animal experiments were crucial to the conquest of polio, for example, and they will undoubtedly be one of the keystones in AIDS research. However, some persons believe that the cost to the animals is often high. Authored by a committee of experts from various fields, this book discusses the benefits that have resulted from animal research, the scope of animal research today, the concerns of advocates of animal welfare, and the prospects for finding alternatives to animal use. The authors conclude with specific recommendations for more consistent government action.

Advancing Disease Modeling in Animal Based Research in Support of Precision Medicine Book

Advancing Disease Modeling in Animal Based Research in Support of Precision Medicine


  • Author : National Academies of Sciences, Engineering, and Medicine
  • Publisher : National Academies Press
  • Release Date : 2018-05-29
  • Genre: Science
  • Pages : 138
  • ISBN 10 : 9780309471190

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Advancing Disease Modeling in Animal Based Research in Support of Precision Medicine Excerpt :

Precision medicine is focused on the individual and will require the rapid and accurate identification and prioritization of causative factors of disease. To move forward and accelerate the delivery of the anticipated benefits of precision medicine, developing predictable, reproducible, and reliable animal models will be essential. In order to explore the topic of animal-based research and its relevance to precision medicine, the National Academies of Sciences, Engineering, and Medicine convened a 2-day workshop on October 5 and 6, 2017. The workshop was designed to focus on the development, implementation, and interpretation of model organisms to advance and accelerate the field of precision medicine. Participants examined the extent to which next-generation animal models, designed using patient data and phenotyping platforms targeted to reveal and inform disease mechanisms, will be essential to the successful implementation of precision medicine. This publication summarizes the presentations and discussions from the workshop.

Improving the Utility and Translation of Animal Models for Nervous System Disorders Book

Improving the Utility and Translation of Animal Models for Nervous System Disorders


  • Author : Institute of Medicine
  • Publisher : National Academies Press
  • Release Date : 2013-04-25
  • Genre: Medical
  • Pages : 111
  • ISBN 10 : 9780309266338

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Improving the Utility and Translation of Animal Models for Nervous System Disorders Excerpt :

Nervous system diseases and disorders are highly prevalent and substantially contribute to the overall disease burden. Despite significant information provided by the use of animal models in the understanding of the biology of nervous system disorders and the development of therapeutics; limitations have also been identified. Treatment options that are high in efficacy and low in side effects are still lacking for many diseases and, in some cases are nonexistent. A particular problem in drug development is the high rate of attrition in Phase II and III clinical trials. Why do many therapeutics show promise in preclinical animal models but then fail to elicit predicted effects when tested in humans? On March 28 and 29, 2012, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders convened the workshop "Improving Translation of Animal Models for Nervous System Disorders" to discuss potential opportunities for maximizing the translation of new therapies from animal models to clinical practice. The primary focus of the workshop was to examine mechanisms for increasing the efficiency of translational neuroscience research through discussions about how and when to use animal models most effectively and then best approaches for the interpretation of the data collected. Specifically, the workshop objectives were to: discuss key issues that contribute to poor translation of animal models in nervous system disorders, examine case studies that highlight successes and failures in the development and application of animal models, consider strategies to increase the scientific rigor of preclinical efficacy testing, explore the benefits and challenges to developing standardized animal and behavioral models. Improving the Utility and Translation of Animal Models for Nervous System Disorders: Workshop Summary also identifies methods to facilitate development of corresponding animal and clinical endpoints, indentifies methods that would maximize bidirectional tra

Animal Eyes Book

Animal Eyes


  • Author : Michael F. Land
  • Publisher : OUP Oxford
  • Release Date : 2012-03-01
  • Genre: Science
  • Pages : 288
  • ISBN 10 : 9780191625367

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Animal Eyes Excerpt :

Animal Eyes provides a comparative account of all known types of eye in the animal kingdom, outlining their structure and function with an emphasis on the nature of the optical systems and the physical principles involved in image formation. A universal theme throughout the book is the evolution and taxonomic distribution of each type of eye, and the roles of different eye types in the behaviour and ecology of the animals that possess them. In comparing the specific capabilities of eyes, it considers the factors that lead to good resolution of detail and the ability to function under a wide range of light conditions. This new edition is fully updated throughout, incorporating more than a decade of new discoveries and research.

Regenerative Medicine and Stem Cell Therapy for the Eye Book

Regenerative Medicine and Stem Cell Therapy for the Eye


  • Author : Brian G. Ballios
  • Publisher : Springer
  • Release Date : 2019-02-18
  • Genre: Science
  • Pages : 212
  • ISBN 10 : 9783319980805

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Regenerative Medicine and Stem Cell Therapy for the Eye Excerpt :

This book provides an overview of the types, sources, and applications of stem cells in regenerating various ocular tissues, with a perspective on both potential applications of stem cells and possible challenges. The scope of the chapters include both preclinical and clinical applications, including stem cell-derived therapies based on endogenous tissue repair; stem cell transplantation and cell replacement therapy; gene therapy; and in vitro disease modelling. Additionally, the volume presents applications in both anterior and posterior ocular disease, with a particular focus on diseases of the ocular surface, cornea, limbus, and retina, including inherited retinal dystrophies as well as acquired diseases, such as age-related macular degeneration. Regenerative Medicine and Stem Cell Therapy for the Eye is an ideal book for advanced researchers in stem cell and ocular biology as well as clinical ophthalmologists, and will be of interest to readers with backgrounds in developmental biology and bioengineering. This book also Skillfully reviews cutting-edge advances in stem cell biology as applied to regenerative medicine and ocular disease Provides expert viewpoints on key hurdles and challenges to successful implementation of stem cell-derived therapies in the clinical domain Offers a multi-disciplinary, broad understanding of cell-based therapies for ocular diseases by incorporating perspectives from biomedical scientists, physicians, and engineers Examines the connection between cell therapy and gene editing, in particular relation to ocular disease

Retinal Degenerative Diseases Book

Retinal Degenerative Diseases


  • Author : Robert E. Anderson
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-03-19
  • Genre: Medical
  • Pages : 715
  • ISBN 10 : 9781441913982

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Retinal Degenerative Diseases Excerpt :

This is the proceedings of the XIIIth International Symposium on Retinal Degenerations, which will be held in Emeishan, Sichuan, China on September 18 - 23, 2008. The themes will include "Molecular and genetic mechanisms in photoreceptor degeneration", "Age-related macular degeneration", "New diagnostic techniques for retinal degenerations". "Neuroprotection in the prevention of retinal degeneration", "Gene therapy and the correction of gene defects", as well as other emerging topics that may develop over the next few months.

Animal Models in Medicine and Biology Book

Animal Models in Medicine and Biology


  • Author : Eva Tvrdá
  • Publisher : BoD – Books on Demand
  • Release Date : 2020-04-08
  • Genre: Science
  • Pages : 248
  • ISBN 10 : 9781838800116

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Animal Models in Medicine and Biology Excerpt :

Thanks to animal models, our knowledge of biology and medicine has increased enormously over the past decades, leading to significant breakthroughs that have had a direct impact on the prevention, management and treatment of a wide array of diseases.This book presents a comprehensive reference that reflects the latest scientific research being done in a variety of medical and biological fields utilizing animal models. Chapters on Drosophila, rat, pig, rabbit, and other animal models reflect frontier research in neurology, psychiatry, cardiology, musculoskeletal disorders, reproduction, chronic diseases, epidemiology, and pain and inflammation management. Animal Models in Medicine and Biology offers scientists, clinicians, researchers and students invaluable insights into a wide range of issues at the forefront of medical and biological progress.

Scientific Frontiers in Developmental Toxicology and Risk Assessment Book

Scientific Frontiers in Developmental Toxicology and Risk Assessment


  • Author : National Research Council
  • Publisher : National Academies Press
  • Release Date : 2000-12-21
  • Genre: Nature
  • Pages : 348
  • ISBN 10 : 9780309070867

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Scientific Frontiers in Developmental Toxicology and Risk Assessment Excerpt :

Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.

The Biology of the Laboratory Rabbit Book

The Biology of the Laboratory Rabbit


  • Author : Patrick J. Manning
  • Publisher : Academic Press
  • Release Date : 2014-04-25
  • Genre: Science
  • Pages : 483
  • ISBN 10 : 9781483288826

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The Biology of the Laboratory Rabbit Excerpt :

After nearly 20 years, the publication of this Second Edition of The Biology of the Laboratory Rabbit attests to its popularity within the scientific community as well as to the need to update an expanding database on the rabbit as a major species in laboratory investigation. The principal aim of this text is to provide a comprehensive and authoritative source of scientifically based information on a major laboratory animal species. The text continues to emphasize the normal biology as well as diseases of the European (domestic) rabbit, Orytolagus cuniculus, especially the New Zealand White breed, with occasional reference to other rabbit species (Sylvilagus sp.) and hares (Lepus sp.). New topics have been added to this second edition in response to changing trends in biomedical research and product testing as well as to suggestions from readers. New chapters included on: Anesthesia and analgesia Models in infectious disease research Models in ophthalmology and vision research Polyclonal antibody production Toxicity and safety testing Drug doses and clinical reference data

Animal Models of Human Disease Book

Animal Models of Human Disease


  • Author : Kyung-Tai Min
  • Publisher : Academic Press
  • Release Date : 2011-03-17
  • Genre: Medical
  • Pages : 552
  • ISBN 10 : 9780123848789

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Animal Models of Human Disease Excerpt :

Animal experiments have contributed much to our understanding of mechanisms of disease and are important for determining new therapies. This volume reviews the latest research and developments in this field. * Discusses new discoveries, approaches, and ideas * Contributions from leading scholars and industry experts * Reference guide for researchers involved in molecular biology and related fields

Myopia Book
Score: 4
From 1 Ratings

Myopia


  • Author : Roger W. Beuerman
  • Publisher : World Scientific
  • Release Date : 2010
  • Genre: Medical
  • Pages : 420
  • ISBN 10 : 9789812832986

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Myopia Excerpt :

Section 1. Epidemiology and risk factors. ch. 1.1. Epidemiology of myopia and myopic shift in refraction / Barbara E.K. Klein. ch. 1.2. Environmental risk factors for myopia in children / Wilson C.J. Low, Tien-Yin Wong and Seang-Mei Saw. ch. 1.3. Gene-environment interactions in the aetiology of myopia / Ian G. Morgan and Kathryn A. Rose. ch. 1.4. The economics of myopia / Marcus C.C. Lim and Kevin D. Frick -- Section 2. Clinical studies and pathologic myopia. ch. 2.1. Quality of life and myopia / Ecosse L. Lamoureux and Hwee-Bee Wong. ch. 2.2. Ocular morbidity of pathological myopia / V. Swetha E. Jeganathan, Seang-Mei Saw and Tien-Yin Wong. ch. 2.3. Myopia and glaucoma / Shamira A. Perera and Tin Aung. ch. 2.4. The myopic retina / Shu-Yen Lee. ch. 2.5. Retinal function / Chi D. Luu and Audrey W.L. Chia -- Section 3. Genetics of myopia. ch. 3.1. New approaches in the genetics of myopia / Liang K. Goh, Ravikanth Metlapally and Terri Young. ch. 3.2. Twins studies and myopia / Maria Schäche and Paul N. Baird. ch. 3.3. TIGR, TGFB1, cMET, HGF, collagen genes, and myopia / Chiea-Chuen Khor. ch. 3.4. Statistical analysis of genome-wide association studies for myopia / Yi-Ju Li and Qiao Fan -- Section 4. Animal models and the biological basis of myopia. ch. 4.1. The relevance of studies in chicks for understanding myopia in humans / Josh Wallman and Debora L. Nickla. ch. 4.2. The mechanisms regulating scleral change in myopia / Neville A. McBrien. ch. 4.3. The mouse model of myopia / Frank Schaeffel. ch. 4.4. Gene analysis in experimental animal models of myopia / Roger W. Beuerman, Liang K. Goh and Veluchamy A. Barathi -- Section 5. Interventions for myopia. ch. 5.1. Atropine and other pharmacological approaches to prevent myopia / Louis M.G. Tong, Veluchamy A. Barathi and Roger W. Beuerman. ch. 5.2. Physical factors in myopia and potential therapies / Wallace S. Foulds and Chi D. Luu