Anti Angiogenesis Strategies in Cancer Therapies Book

Anti Angiogenesis Strategies in Cancer Therapies


  • Author : Shaker Mousa
  • Publisher : Academic Press
  • Release Date : 2016-11-28
  • Genre: Medical
  • Pages : 210
  • ISBN 10 : 9780128026731

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Anti Angiogenesis Strategies in Cancer Therapies Excerpt :

Anti-angiogenesis Strategies in Cancer Therapeutics provides a detailed look at the current status and future directions in the discovery and development of novel anti-angiogenesis strategies in oncology. This book highlights the different mechanisms involved in the modulation of angiogenesis, including inflammation, thrombosis, and microRNA, and shows how nanotechnology can further enhance the potential of existing and new anti-angiogenesis approaches. Written for industry scientists, researchers, oncologists, hematologists, and professors and students in the field, this comprehensive book covers all aspects of anti-angiogenesis strategies and their differences. Covers important preclinical models and clinical trials in the discovery and development of novel anti-angiogenesis agents Reviews FDA-approved anti-angiogenesis agents Illustrates the value of nanotechnology in improving the utility of anti-angiogenesis agents Offers insight into the development of novel anti-angiogenesis agents and future direction in this area

Mechanisms of Angiogenesis Book

Mechanisms of Angiogenesis


  • Author : Matthias Clauss
  • Publisher : Springer Science & Business Media
  • Release Date : 2004-11-22
  • Genre: Medical
  • Pages : 342
  • ISBN 10 : 3764364599

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Mechanisms of Angiogenesis Excerpt :

Is it advisable to go back from bedside to the bench? During the last decade, few topics encountered such a broad interest in bio- gy and medicine as angiogenesis. The amazing ability of the body to restore blood flow by induction of blood vessel growth as part of an adaptive process has alarmed physicians dealing with diseases in which angiogenesis is either exaggerated (as in tumors) or too slow (as in ischemic diseases of heart and brain). Not surprisingly, pro- and antiangiogenic strategies have found their way into clinical trials. For instance, for the USA, the NIH website in early 2004 displayed 38 clinical studies involving either pro- or antiangiogenic th- apies. Given the expected overwhelming wealth of clinical data, the question may be asked whether further exploration of biological mechanisms is required or whether results from the bedside are instructive enough to proceed. This question depends also on the progress of pro- and antiangiogenic clinical trials. In the following, I give a short overview about some of the progress that has been made in this field. Since Judah Folkman proposed antiangiogenic tumor therapy thirty years ago, it has become increasingly evident that agents which interfere with blood vessel formation also block tumor progression. Accordingly, antiangiogenic therapy has gained much attention as a potential adjunct to conventional c- cer therapy.

Anti Angiogenesis Strategies in Cancer Therapeutics Book

Anti Angiogenesis Strategies in Cancer Therapeutics


  • Author : Shaker Mousa
  • Publisher : Academic Press
  • Release Date : 2016-12-16
  • Genre: Uncategoriezed
  • Pages : 304
  • ISBN 10 : 012802576X

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Anti Angiogenesis Strategies in Cancer Therapeutics Excerpt :

"Anti-angiogenesis Strategies in Cancer Therapeutics" provides a detailed look at the current status and future directions in the discovery and development of novel anti-angiogenesis strategies in oncology. This book highlights the different mechanisms involved in the modulation of angiogenesis, including inflammation, thrombosis, and microRNA, and shows how nanotechnology can further enhance the potential of existing and new anti-angiogenesis approaches. Written for industry scientists, researchers, oncologists, hematologists, and professors and students in the field, this comprehensive book covers all aspects of anti-angiogenesis strategies and their differences. Covers important preclinical models and clinical trials in the discovery and development of novel anti-angiogenesis agentsReviews FDA-approved anti-angiogenesis agentsIllustrates the value of nanotechnology in improving the utility of anti-angiogenesis agentsOffers insight into the development of novel anti-angiogenesis agents and future direction in this area

Physiologic and Pathologic Angiogenesis Book

Physiologic and Pathologic Angiogenesis


  • Author : Dan Simionescu
  • Publisher : BoD – Books on Demand
  • Release Date : 2017-04-05
  • Genre: Medical
  • Pages : 466
  • ISBN 10 : 9789535130239

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Physiologic and Pathologic Angiogenesis Excerpt :

The purpose of this book is to highlight novel advances in the field and to incentivize scientists from a variety of fields to pursue angiogenesis as a research avenue. Blood vessel formation and maturation to capillaries, arteries, or veins is a fascinating area which can appeal to multiple scientists, students, and professors alike. Angiogenesis is relevant to medicine, engineering, pharmacology, and pathology and to the many patients suffering from blood vessel diseases and cancer, among others. We are hoping that this book will become a source of inspiration and novel ideas for all.

Tumor Angiogenesis Book

Tumor Angiogenesis


  • Author : Dieter Marmé
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-12-05
  • Genre: Medical
  • Pages : 845
  • ISBN 10 : 9783540331773

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Tumor Angiogenesis Excerpt :

Tumor angiogenesis is one of the most prominent mechanisms driving tumor development and progression. This book is written by internationally renowned experts. Part 1 describes the basic mechanisms. Tumor-angiogenic signaling pathways are presented as new potential targets for anti-angiogenic therapy. Part 2 reviews the efforts made to validate new targets and to show efficacy in animals. Part 3 is devoted to the clinical development of the novel anti-angiogenic drugs and their use in clinical practice.

Inflammation and Angiogenesis Book

Inflammation and Angiogenesis


  • Author : Domenico Ribatti
  • Publisher : Springer
  • Release Date : 2017-11-08
  • Genre: Medical
  • Pages : 111
  • ISBN 10 : 9783319684482

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Inflammation and Angiogenesis Excerpt :

This book is focused on the analysis of the role played by immune cell components in the angiogenic process associated with inflammation and tumor growth. Both innate and adaptive immune cells are involved in the mechanisms of endothelial cell proliferation, migration and activation, through the production and release of a large spectrum of pro-angiogenic mediators. These may create the specific microenvironment that favors an increased rate of tissue vascularization. The link between chronic inflammation and tumorigenesis was first proposed by Rudolf Virchow in 1863 after the observation that infiltrating leukocytes are a hallmark of tumors and first established a causative connection between the lymph reticular infiltrate at sites of chronic inflammation and the development of cancer. Tumors were described as wounds that never heal and surgeons have long described the tendency of tumors to recur in healing resection margin and it has been reported that wound healing environment provides an opportunistic matrix for tumor growth. As angiogenesis is the result of a net balance between the activities exerted by positive and negative regulators, this book will also provide information on some anti-angiogenic properties of immune cells that may be utilized for a potential pharmacological use as anti-angiogenic agents in inflammation as well as in cancer. The work is written for researchers in the field and also for graduate students which approach this matter.

Angiogenesis Modulations in Health and Disease Book

Angiogenesis Modulations in Health and Disease


  • Author : Shaker A. Mousa
  • Publisher : Springer Science & Business Media
  • Release Date : 2014-07-08
  • Genre: Medical
  • Pages : 206
  • ISBN 10 : 9789400764675

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Angiogenesis Modulations in Health and Disease Excerpt :

This book is a major update of novel targets in angiogenesis modulation, including pro- and anti-angiogenesis. There is in-depth coverage of preclinical and clinical methods and models, investigational status, and clinical applications. The impact of nanotechnology in advancing the applications of pro-and anti-angiogenesis strategies is also highlighted, along with stem cell and biotechnologies in research and development of angiogenesis modulating targets.

Metronomic Chemotherapy Book

Metronomic Chemotherapy


  • Author : Guido Bocci
  • Publisher : Springer
  • Release Date : 2014-09-04
  • Genre: Medical
  • Pages : 295
  • ISBN 10 : 9783662436042

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Metronomic Chemotherapy Excerpt :

This book analyzes all aspects of metronomic chemotherapy, a new approach involving low-dose, long-term, and frequently administered therapy that has preclinical and clinical activity in various tumors. After an opening section on the pharmacological bases of metronomic chemotherapy, including its antiangiogenic effects and impact on immunity, preclinical studies on various classes of drug are discussed. Clinical applications of metronomic chemotherapy in a wide variety of tumors are then addressed in detail, with description of the results of all published studies. The clinical pharmacology of metronomic chemotherapy is also considered in depth, encompassing pharmacokinetics, pharmacogenetics, pharmacoeconomics, and adverse drug reactions. The book closes by describing the role of this therapy in the veterinarian clinic.

Nanoparticles in Angiogenesis and Cancer Book

Nanoparticles in Angiogenesis and Cancer


  • Author : Sudip Mukherjee
  • Publisher : Springer Nature
  • Release Date : 2022
  • Genre: Blood-vessels
  • Pages : 85
  • ISBN 10 : 9783031112843

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Nanoparticles in Angiogenesis and Cancer Excerpt :

This book highlights recent developments of organic and inorganic nanomedicine that play a major role in anti-angiogenic cancer therapy. In addition, the authors present examples of nanomedicine based anti-angiogenic agents and their applications in cancer therapy. Angiogenesis is a pathophysiological phenomenon that modulates cell proliferation and cell migration and plays important roles in cancer. Anti-angiogenic nanotherapies have gained immense attention in recent times as alternative cost-effective therapies that opened a new dimension in cancer theranostics. Further the challenges of the anti-angiogenic nanotherapies and possible future perspective are detailed.

Tumour Angiogenesis Book

Tumour Angiogenesis


  • Author : R. John Bicknell
  • Publisher : Oxford University Press, USA
  • Release Date : 1997
  • Genre: Medical
  • Pages : 416
  • ISBN 10 : UOM:39015041324271

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Tumour Angiogenesis Excerpt :

It is now widely recognised that the growth of solid tumours is angiogenesis dependent. The inhibition of tumour angiogenesis offers a novel anti-cancer therapeutic strategy. In this first book to be devoted solely to tumour angiogenesis each chapter is written by leading world experts and the twenty seven chapters taken together cover all aspects of the field.

Angiogenesis Inhibitors and Stimulators Book

Angiogenesis Inhibitors and Stimulators


  • Author : Shaker A. Mousa
  • Publisher : CRC Press
  • Release Date : 2000-10
  • Genre: Medical
  • Pages : 162
  • ISBN 10 : UOM:39015051595091

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Angiogenesis Inhibitors and Stimulators Excerpt :

The regulation of blood vessel growth underlies many normal biological processes such as reproduction, development, repair and wound healing. It also is a critical feature of pathological processes such as cancer, diabetic retinopathy, macular degeneration, inflammatory arthritis and ischemic heart disease. What causes blood vessels to grow? What inhibits their growth? This book comprehensively describes the angiogenic proteins that enhance and inhibit normal and abnormal angiogenesis. It describes the potential therapeutic applications of basic fibroblast growth factor, vascular endothelial growth factor, PECAM-1 and thrombospondin as well as other factors. The book brings together information about new blood vessel formation in many organ systems and comprises an outstanding resource on the state-of-the art in angiogenesis.

Angiogenesis Inhibition Book

Angiogenesis Inhibition


  • Author : Rüdiger Liersch
  • Publisher : Springer Science & Business Media
  • Release Date : 2009-12-24
  • Genre: Medical
  • Pages : 231
  • ISBN 10 : 3540782818

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Angiogenesis Inhibition Excerpt :

Angiogenesis is attracting increased scientific and clinical interest. The identification of novel mediators and targeting molecules has led to significant progress in our understanding of tumor angiogenesis and tumor vessel targeting. Important advances in cancer treatment have already emerged, and in the future, blood vessel targeting will play a significant role within individualized therapeutic strategies. This volume provides a general overview of the latest developments in angiogenesis inhibition in cancer. All aspects from the bench to the bedside are considered, with detailed attention both to basic research and to its translation into clinical practice. Individual chapters are devoted to the roles of angiopoietins, HIF-1a, chemokines, PDGF and VEGF, and vascular integrins. The latest results of clinical trials are presented, and various advanced targeting strategies are discussed. This book will be invaluable to all who wish to learn of the most recent advances in this exciting field.

Anti Angiogenesis Drug Discovery and Development Book

Anti Angiogenesis Drug Discovery and Development


  • Author : Atta-ur-Rahman
  • Publisher : Elsevier
  • Release Date : 2015-06-16
  • Genre: Science
  • Pages : 326
  • ISBN 10 : 9780128039649

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Anti Angiogenesis Drug Discovery and Development Excerpt :

The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of cardiovascular diseases, wound healing disorders, and more. Efforts to understand the molecular basis, both for inhibition and induction, have yielded fascinating results. Originally published by Bentham and now distributed by Elsevier, Anti-Angiogenesis Drug Discovery and Development, Volume 2 is an compilation of well-written reviews on various aspects of the anti-angiogenesis process. These reviews have been contributed by leading practitioners in drug discovery science and highlight the major developments in this exciting field in the last two decades. These reader-friendly chapters cover topics of great scientific importance, many of which are considered significant medical breakthroughs, making this book excellent reading both for the novice as well as for expert medicinal chemists and clinicians. Edited and written by leading experts in angiogenesis drug development Reviews recent advances in the field, such as coverage of anti-angiogenetic drugs in ovarian cancer Reports current strategies and future outlook for anti-angiogenic therapy and cardiovascular diseases

Anti angiogenesis Drug Discovery and Development Book

Anti angiogenesis Drug Discovery and Development


  • Author : Atta-ur- Rahman
  • Publisher : Bentham Science Publishers
  • Release Date : 2011
  • Genre: Medical
  • Pages : 197
  • ISBN 10 : 9781608051625

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Anti angiogenesis Drug Discovery and Development Excerpt :

"The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of cardiovascular diseases, wound healing disorders, etc. Efforts to"

Antiangiogenic Agents in Cancer Therapy Book
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Antiangiogenic Agents in Cancer Therapy


  • Author : Beverly A. Teicher
  • Publisher : Springer Science & Business Media
  • Release Date : 2008-01-08
  • Genre: Medical
  • Pages : 559
  • ISBN 10 : 9781597451840

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Antiangiogenic Agents in Cancer Therapy Excerpt :

This volume represents a compendium of scientific findings and approaches to the study of angiogenesis in cancer. The second edition of Antiangiogenic Agents in Cancer Therapy is intended to give a current perspective on the state-of-the-art of angiogenensis and therapy directed at this process. Antiangiogenesis is a dynamic and evolving field in oncology. New therapeutic targets continue to emerge followed by the rapid development of new therapeutic agents to be investigated in clinical trials. Optimizing the therapeutic potential of antiangiogenic agents in combination with the other therapies in the armamentarium to fight cancer will be an on-going challenge.