Anticandidal Agents Book

Anticandidal Agents


  • Author : Awanish Kumar
  • Publisher : Academic Press
  • Release Date : 2016-09-12
  • Genre: Medical
  • Pages : 94
  • ISBN 10 : 9780128113127

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Anticandidal Agents Excerpt :

Anticandidal Agents provides the latest information on candida drug resistance and its remedial implications. In this compilation, users will find a comprehensive view on overcoming resistance in anticandidal drugs, along with information on novel molecules. Candida albicans is an opportunistic pathogenic fungus responsible for life threating invasive and nosocomial infections across the globe. Candidiasis is a major cause of morbidity among immunocompromised patients. Infections caused by non-albicans candida like C. glabrata, C. parapsilosis, and C. tropicalis have also imposed a serious threat in the last few decades. Current treatment of candidiasis relies primarily on antifungal agents broadly categorized as azoles, polyenes, echinocandins, allylamines, and pyrimidines. Lately, antifungal resistance has emerged to be an obstruction of current treatment regime. A number of reasons are described in detail. Understanding the mechanisms of resistance is crucial for developing strategies for overcoming the hindrance in current therapeutics. Presents a complete understanding of candida resistance to help in the development of therapeutic expansion and novel drugs Provides thorough information on candida drug resistance and its remedial implications Covers crucial mechanisms of resistance that will help develop strategies for overcoming the hindrance in current therapeutics

Antifungal Compounds Discovery Book

Antifungal Compounds Discovery


  • Author : Marina Sokovic
  • Publisher : Elsevier
  • Release Date : 2020-09-18
  • Genre: Science
  • Pages : 290
  • ISBN 10 : 9780128158258

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Antifungal Compounds Discovery Excerpt :

Fungi are both the cause of many major health problems and an incredible source of compounds for developing new medicinal treatments, and with the increasing emergence of multidrug resistance, the need for new antimicrobial agents is greater than ever. Antifungal Compounds Discovery provides researchers with a detailed study of both natural and synthetic compounds that can be effective against a variety of fungal species, supporting and encouraging the design of innovative, potent new drug candidates for the treatment of fungal infections. Beginning with an introduction to both the history and latest developments in this field, the book goes on to provide helpful background information on key fungal species before outlining current antifungal therapies and reasons further development is needed. Detailed chapters then follow reviewing a broad range of natural and synthetic antifungal agents, and discussing the synergistic effect of working with both simultaneously. Finally, the book concludes by considering potential future developments in this important field. Supported with detailed schemes and key information on the biological activity of all selected compounds, Antifungal Compounds Discovery is a comprehensive guide helping researchers understand the relationship between specific chemical structures and their antifungal potency, and a key tool for all those involved in the identification and development of antimicrobial compounds. Provides an overview of the most specific mycotic infections and fungal species as background for compound development Presents the chemical formulas of all natural and synthetic compounds reviewed Combines detailed information about origin, isolation and possible therapeutic uses of all indexed compounds, including biological activity, mechanism of action and SAR information

Antifungal Agents Book

Antifungal Agents


  • Author : Erika J. Ernst
  • Publisher : Springer Science & Business Media
  • Release Date : 2008-02-02
  • Genre: Medical
  • Pages : 210
  • ISBN 10 : 9781592599431

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Antifungal Agents Excerpt :

A collection of state-of-the-art molecular methods for studying antifungal resistance, for discovering and evaluating both new and existing antifungal drugs, and for understanding the host response and immunotherapy of such agents. The protocols follow the successful Methods in Molecular MedicineTM series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Antifungal Agents: Methods and Protocols offers clinician-scientists, microbiologists and molecular biologists the productive tools they need today to understand and successfully develop new therapeutic agents for yeast, mold, and fungal infections.

Antifungal Therapy Book

Antifungal Therapy


  • Author : Mahmoud Ghannoum
  • Publisher : CRC Press
  • Release Date : 2016-04-19
  • Genre: Medical
  • Pages : 484
  • ISBN 10 : 9780849387869

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Antifungal Therapy Excerpt :

A concise one-stop-practical reference for the various physicians dealing with fungal infections, Antifungal Therapy appeals to infectious disease physicians, transplant surgeons, dermatologists, and intensivists, as well as basic scientists and pharmaceutical company researchers interested in the state of antifungal therapy. This book provides a c

Recent Trends in Antifungal Agents and Antifungal Therapy Book

Recent Trends in Antifungal Agents and Antifungal Therapy


  • Author : Amit Basak
  • Publisher : Springer
  • Release Date : 2016-09-21
  • Genre: Science
  • Pages : 250
  • ISBN 10 : 9788132227823

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Recent Trends in Antifungal Agents and Antifungal Therapy Excerpt :

Fungal infections have taken a new spectrum due to the increased incidence of multi-drug resistant fungal pathogens. Freedom of choice for drugs to treat fungal infections is also narrow because of lesser probability of discovering drugs that would bypass affecting human cells and target fungal cells producing fewer side effects in patients. An approach has gained prominence in research is to look for bioactive antifungal compounds from natural to synthetic sources. It is necessary to discover new classes of antifungals to control the recent emergence of multi-drug resistant fungal infections. This book proposed a details top to bottom outline of antifungal compounds derived naturally or synthetically. The details of their modifications or synthetic analogues have been described, helpful to understand the structure-activity relationship which leads to new compound development in antifungal chemotherapy. Each chapter begins with a comprehensive, top-bottom in-depth discussion of antifungal agents with updated bibliographic references. This compendium will serve as a companion not only for Scientists, Researchers, and Professors, Medical Practitioners but also a valuable reference text for the university students.

Hydroxy Pyridones as Antifungal Agents with Special Emphasis on Onychomycosis Book

Hydroxy Pyridones as Antifungal Agents with Special Emphasis on Onychomycosis


  • Author : Sam Shuster
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-11-11
  • Genre: Medical
  • Pages : 109
  • ISBN 10 : 9783642584015

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Hydroxy Pyridones as Antifungal Agents with Special Emphasis on Onychomycosis Excerpt :

This book summarizes the results of two symposia held on hydroxy-pyridones as antifungal agents organized on the occasion of the International Summit on Cutaneous Antifungal Therapy 1996 in Vancouver and the 19th World Congress of Dermatology 1997 in Sydney. Some of the papers deal with the basic mechanisms of action and how these translate into product features, e.g. activity spectrum. Other papers describe the unique properties of hydroxy-pyridones, such as high penetration into and through keratinic tissues or their activity as dual inhibitor on 5-lipoxygenase and cyclooxygenase which leads to a remarkable antiinflammatory effect. Last but not least various accounts are given which show how this unique product profile aids the treatment of various fungal diseases, especially onychomycosis.

Hydroxy Pyridones as Antifungal Agents with Special Emphasis on Onychomycosis Book

Hydroxy Pyridones as Antifungal Agents with Special Emphasis on Onychomycosis


  • Author : Sam Shuster
  • Publisher : Springer Science & Business Media
  • Release Date : 1999-03-08
  • Genre: Medical
  • Pages : 126
  • ISBN 10 : 3540654941

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Hydroxy Pyridones as Antifungal Agents with Special Emphasis on Onychomycosis Excerpt :

This book presents a series of papers on a special group of antifungal agents - the hydroxypyridones (e.g. Ciclopirox, Rilopirox, and Piroctone) given by international experts at conferences in Vancouver and Sydney. The action of this group of agents is unique. Hydroxypyridones are not only active against all relevant fungi, but they are active against dermato­ phytes, yeasts, moulds as well as gram positive and gram negative bacteria. They have an inhibitory effect on the lipoxygenase and cyclo-oxygenase path­ ways and, in vitro, exhibit fungicidal and even sporicidal activity. Ciclopirox is particularly able to penetrate keratin. These properties facilitate the treatment not only of tinea pedis caused by fungi but also of infections by gram negative bacteria. The special ability of Ciclopirox to penetrate keratin opens the door to an efficacious topical treat­ ment for onychomycosis, with a transungual drug delivery system specially adapted to infections of the nail organ. The absence of drug interactions and systemic side effects of this formulation is an appreciable advantage over the newer systemic therapies for onychomycosis. Papers are presented covering the mode of action, antimicrobial spectrum, pharmacological properties, penetration potential, clinical efficacy and the various indications for this group of drugs. They will enable the reader to as­ sess the advantage and disadvantage of this new therapeutic modality.

Anticandidal Therapeutics Book

Anticandidal Therapeutics


  • Author : Awanish Kumar
  • Publisher : Elsevier
  • Release Date : 2023-01-31
  • Genre: Science
  • Pages : 198
  • ISBN 10 : 9780443187452

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Anticandidal Therapeutics Excerpt :

Developments of antifungal agents have declined as compared to other antibiotics that have displayed a potent development with time. There is an urgent need for both prophylactic and therapeutic treatments worldwide to control the severity of infections caused by Candida. Anticandidal Therapeutics provides the readers with a compiled knowledge of the fungal human infection Candida and the development of anticandidal drugs. Anticandidal Therapeutics helps researchers form the basis for the discovery and development of novel anticandidal therapies. In 14 chapters this book provides collective information on anticandidal agents and their discovery and development with respect to major drug transporter families, different stages of anticandidal agent development, recent trends and progress in antifungal translational research, clinical studies status of anticandidal therapeutic agents, and drug repurposing for development of novel anticandidal agents. • Highlights the mechanistic actions of some therapeutic agents against Candida. • Focuses on anticandidal agents rather than general antifungal agents. • Discusses the stage of development of new antifungal drugs, the repositioning of drugs, and how this could help in treatment.

Antifungal Agents Book

Antifungal Agents


  • Author : Ernst M. Jucker
  • Publisher : Birkhäuser
  • Release Date : 2012-12-06
  • Genre: Medical
  • Pages : 248
  • ISBN 10 : 9783034879743

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Antifungal Agents Excerpt :

This second volume of PDR SPECIAL TOPICS contains five review articles, covering nearly the entire field of fungal diseases in humans as well as therapeutic approaches. The main emphasis of the book lies in antifungal therapy: the most relevant information on the present state of the art of antifungal chemotherapy for dermatomycoses, subcutaneous and invasive mycoses is summarized, and open questions and unsolved problems are presented. The book is ideal for both the practitioner as well as advanced student.

Ruthenium Complexes Book

Ruthenium Complexes


  • Author : Alvin A. Holder
  • Publisher : John Wiley & Sons
  • Release Date : 2018-02-27
  • Genre: Science
  • Pages : 344
  • ISBN 10 : 9783527339570

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Ruthenium Complexes Excerpt :

Edited by a team of highly respected researchers combining their expertise in chemistry, physics, and medicine, this book focuses on the use of rutheniumcontaining complexes in artificial photosynthesis and medicine. Following a brief introduction to the basic coordination chemistry of ruthenium complexes and their synthesis in section one, as well as their photophysical and photochemical properties, the authors discuss in detail the major concepts of artificial photosynthesis and mechanisms of hydrogen production and water oxidation with ruthenium in section two. The third section of the text covers biological properties and important medical applications of ruthenium complexes as therapeutic agents or in diagnostic imaging. Aimed at stimulating research in this active field, this is an invaluable information source for researchers in academia, health research institutes and governmental departments working in the field of organometallic chemistry, green and sustainable chemistry as well as medicine/drug discovery, while equally serving as a useful reference also for scientists in industry.

Antifungal Agents Book

Antifungal Agents


  • Author : Ernst M. Jucker
  • Publisher : Springer Science & Business Media
  • Release Date : 2003-02-24
  • Genre: Medical
  • Pages : 260
  • ISBN 10 : 3764369264

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Antifungal Agents Excerpt :

This second volume of PDR SPECIAL TOPICS contains five review articles, covering nearly the entire field of fungal diseases in humans as well as therapeutic approaches. The main emphasis of the book lies in antifungal therapy: the most relevant information on the present state of the art of antifungal chemotherapy for dermatomycoses, subcutaneous and invasive mycoses is summarized, and open questions and unsolved problems are presented. The book is ideal for both the practitioner as well as advanced student.

Oxford Textbook of Medical Mycology Book

Oxford Textbook of Medical Mycology


  • Author : Christopher C. Kibbler
  • Publisher : Oxford University Press
  • Release Date : 2017-12-14
  • Genre: Medical
  • Pages : 401
  • ISBN 10 : 9780198755388

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Oxford Textbook of Medical Mycology Excerpt :

The Oxford Textbook of Medical Mycology is a comprehensive reference text which brings together the science and medicine of human fungal disease. Written by a leading group of international authors to bring a global expertise, it is divided into sections that deal with the principles of mycology, the organisms, a systems based approach to management, fungal disease in specific patient groups, diagnosis, and treatment. The detailed clinical chapters take account of recent international guidelines on the management of fungal disease. With chapters covering recent developments in taxonomy, fungal genetics and other 'omics', epidemiology, pathogenesis, and immunology, this textbook is well suited to aid both scientists and clinicians. The extensive illustrations, tables, and in-depth coverage of topics, including discussion of the non-infective aspects of allergic and toxin mediated fungal disease, are designed to aid the understanding of mechanisms and pathology, and extend the usual approach to fungal disease. This textbook is essential reading for microbiologists, research scientists, infectious diseases clinicians, respiratory physicians, and those managing immunocompromised patients. Part of the Oxford Textbook in Infectious Disease and Microbiology series, it is also a useful companion text for students and trainees looking to supplement mycology courses and microbiology training.

The Fungal Cell Wall Book

The Fungal Cell Wall


  • Author : Jean-Paul Latgé
  • Publisher : Springer Nature
  • Release Date : 2020-08-12
  • Genre: Science
  • Pages : 369
  • ISBN 10 : 9783030499280

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The Fungal Cell Wall Excerpt :

This book illustrates, that the fungal cell wall is critical for the biology and ecology of all fungi and especially for human fungal pathogens. Readers will learn, that the composition of the fungal cell wall is a unique structure, which cannot be found in the human host. Consequently, the chapters outline, how the immune systems of both animals and humans have evolved to recognize conserved and unique elements of the fungal cell wall. As an application example, the authors also show, that the three-dimensional structures of the cell wall are excellent targets for the development of antifungal agents and chemotherapeutic strategies. With the combination of biological findings and medical outlooks, this volume is a fascinating read for scientists, clinicians and biomedical students.

Antifungal Therapy  Second Edition Book

Antifungal Therapy Second Edition


  • Author : Mahmoud A. Ghannoum
  • Publisher : CRC Press
  • Release Date : 2019-02-14
  • Genre: Medical
  • Pages : 524
  • ISBN 10 : 9780429687693

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Antifungal Therapy Second Edition Excerpt :

This new edition of Antifungal Therapy aims at providing concise, practical, need-to-know information for busy physicians dealing with fungal infections, such as infectious disease physicians, transplant surgeons, dermatologists, and intensivists, as well as basic scientists and pharmaceutical company researchers interested in the state of antifungal therapy. It provides a comprehensive, up-to-date overview of the pertinent issues pertaining to antifungal treatment including the basics of clinical mycology, management insights for various infections, evidence-based treatment recommendations, and helpful tables summarizing currently available pharmacokinetics data. Key Features • Features useful information on administration, dosage and pharmacology of antifungal drugs that can be difficult to use in clinical practice • Contains common Clinical Questions & Answers to highlight frequently encountered patient issues • Covers clinical mycology essentials in addition to antifungal treatment to create a well-rounded reference • Presents illustrations and clinical photos in full color to elucidate the concepts • Provides detailed evidence of treatment recommendations

Cutaneous Fungal Infections Book

Cutaneous Fungal Infections


  • Author : B. Elewski
  • Publisher : Wiley-Blackwell
  • Release Date : 1998-03-13
  • Genre: Medical
  • Pages : 400
  • ISBN 10 : 0865425272

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Cutaneous Fungal Infections Excerpt :

With greater occurance of fungal infections of the skin, especially in immuno compromised patients, the attention paid to this topic has increased in recent years. The second edition of Cutaneous Fungal Infections answers the need for more information on skin infections and the many new easy-to-use, effective drugs on the market today.