Antifungal Compounds Discovery Book

Antifungal Compounds Discovery

  • Author : Marina Sokovic
  • Publisher : Elsevier
  • Release Date : 2020-09-18
  • Genre: Science
  • Pages : 290
  • ISBN 10 : 9780128158258

Antifungal Compounds Discovery Excerpt :

Fungi are both the cause of many major health problems and an incredible source of compounds for developing new medicinal treatments, and with the increasing emergence of multidrug resistance, the need for new antimicrobial agents is greater than ever. Antifungal Compounds Discovery provides researchers with a detailed study of both natural and synthetic compounds that can be effective against a variety of fungal species, supporting and encouraging the design of innovative, potent new drug candidates for the treatment of fungal infections. Beginning with an introduction to both the history and latest developments in this field, the book goes on to provide helpful background information on key fungal species before outlining current antifungal therapies and reasons further development is needed. Detailed chapters then follow reviewing a broad range of natural and synthetic antifungal agents, and discussing the synergistic effect of working with both simultaneously. Finally, the book concludes by considering potential future developments in this important field. Supported with detailed schemes and key information on the biological activity of all selected compounds, Antifungal Compounds Discovery is a comprehensive guide helping researchers understand the relationship between specific chemical structures and their antifungal potency, and a key tool for all those involved in the identification and development of antimicrobial compounds. Provides an overview of the most specific mycotic infections and fungal species as background for compound development Presents the chemical formulas of all natural and synthetic compounds reviewed Combines detailed information about origin, isolation and possible therapeutic uses of all indexed compounds, including biological activity, mechanism of action and SAR information

Antifungal Compounds  Discovery  development  and uses Book

Antifungal Compounds Discovery development and uses

  • Author : Malcolm R. Siegel
  • Publisher : Unknown
  • Release Date : 1977-01-01
  • Genre: Fungicides
  • Pages : 1274
  • ISBN 10 : 0824765575

Antifungal Compounds Discovery development and uses Excerpt :

V. 1- Discovery, developments, and uses; v. 2 - Interactions in biological and ecological systems.

Antifungal Drug Discovery  New Theories and New Therapies Book

Antifungal Drug Discovery New Theories and New Therapies

  • Author : Chaminda Jayampath Seneviratne
  • Publisher : Frontiers Media SA
  • Release Date : 2016-09-13
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : 9782889199501

Antifungal Drug Discovery New Theories and New Therapies Excerpt :

Fungal infections such as candidoses can range from superficial mucous membrane infection to life-threatening systemic mycoses. Candida infections are a significant clinical problem globally due to rapid rise in compromised host populations including HIV/AIDS, organ transplant recipients and patients on chemotherapy. In addition, sharp increase in aging populations which are susceptible to fungal infections is expected in next few decades. Antifungal drugs are relatively difficult to develop compared to the antibacterial drugs owing to the eukaryotic nature of the cells. Therefore, only a handful of antifungal agents are currently available to treat the myriad of fungal infections. Moreover, rising antifungal resistance and host-related adverse reactions have limited the antifungal arsenal against fungal pathogens. In this research topic, we tried to update the theoretical aspects pertaining to the antifungal drug discovery i.e. proposed novel mechanisms, new drug targets and pathways. In addition, invited authors explored the new antifungal drugs derived from natural and synthetic sources which are currently under development. Contributors were encouraged to bring new insight into the antifungal drug discovery. We hope the reader may arrive at a general consensus on the possible strategies to combat ever increasing ubiquitous fungal infection in this new century.

Fungi Book


  • Author : Sunil K. Deshmukh
  • Publisher : CRC Press
  • Release Date : 2018-12-20
  • Genre: Science
  • Pages : 496
  • ISBN 10 : 9781315360003

Fungi Excerpt :

The book deals with the application of fungi and the strategic management of some plant pathogens. It covers fungal bioactive metabolites, with emphasis on those secondary metabolites that are produced by various endophytes, their pharmaceutical and agricultural uses, regulation of the metabolites, mycotoxins, nutritional value of mushrooms, prospecting of thermophilic and wood-rotting fungi, and fungi as myconano factories. Strategies for the management of some plant pathogenic fungi of rice and soybean have also been dealt with. Updated information for all these aspects has been presented and discussed in different chapters.

Anticandidal Agents Book

Anticandidal Agents

  • Author : Awanish Kumar
  • Publisher : Academic Press
  • Release Date : 2016-09-12
  • Genre: Medical
  • Pages : 94
  • ISBN 10 : 9780128113127

Anticandidal Agents Excerpt :

Anticandidal Agents provides the latest information on candida drug resistance and its remedial implications. In this compilation, users will find a comprehensive view on overcoming resistance in anticandidal drugs, along with information on novel molecules. Candida albicans is an opportunistic pathogenic fungus responsible for life threating invasive and nosocomial infections across the globe. Candidiasis is a major cause of morbidity among immunocompromised patients. Infections caused by non-albicans candida like C. glabrata, C. parapsilosis, and C. tropicalis have also imposed a serious threat in the last few decades. Current treatment of candidiasis relies primarily on antifungal agents broadly categorized as azoles, polyenes, echinocandins, allylamines, and pyrimidines. Lately, antifungal resistance has emerged to be an obstruction of current treatment regime. A number of reasons are described in detail. Understanding the mechanisms of resistance is crucial for developing strategies for overcoming the hindrance in current therapeutics. Presents a complete understanding of candida resistance to help in the development of therapeutic expansion and novel drugs Provides thorough information on candida drug resistance and its remedial implications Covers crucial mechanisms of resistance that will help develop strategies for overcoming the hindrance in current therapeutics

Combating Fungal Infections Book

Combating Fungal Infections

  • Author : Iqbal Ahmad
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-08-03
  • Genre: Medical
  • Pages : 539
  • ISBN 10 : 9783642121739

Combating Fungal Infections Excerpt :

Fungi are eukaryotic microorganisms that are closely related to humans at cellular level. Human fungal pathogens belong to various classes of fungi, mainly zygo- cetes, ascomycetes, basidiomycetes, and deuteromycetes. In recent years, fungal infections have dramatically increased as a result of improved diagnosis, high frequency of catheterization, instrumentation, etc. However, the main cause remains the increasing number of immunosuppressed patients, mostly because of HIV infection and indiscriminate usage of antineoplastic and immunosuppressive agents, broad-spectrum antibiotics and prosthetic devices, and grafts in clinical settings. Presently available means of combating fungal infections are still weak and clumsy compared to control of bacterial infection. The present scenario of antifungal therapy is still based on two classes of antifungal drugs (polyenes and azoles). These drugs are effective in many cases, but display toxicity and limited spectrum of ef?cacy. The recent trend towards emergence of drug-resistant isolates in the clinic is an additional problem. In recent years, a few new antifungal drugs have entered the clinics, but they are expected to undergo same fate as the older antifungal drugs. The application of fungal genomics offers an unparalleled opportunity to develop novel antifungal drugs. However, it is too early to expect any novel drugs, as the antifungal drug discovery program is in the stage of infancy. Interestingly, several novel antifungal drug targets have been identi?ed and validated.

Antifungal Therapy Book

Antifungal Therapy

  • Author : Mahmoud A. Ghannoum, PhD, EMBA
  • Publisher : CRC Press
  • Release Date : 2016-04-19
  • Genre: Medical
  • Pages : 488
  • ISBN 10 : 9780849387869

Antifungal Therapy Excerpt :

A concise one-stop-practical reference for the various physicians dealing with fungal infections, Antifungal Therapy appeals to infectious disease physicians, transplant surgeons, dermatologists, and intensivists, as well as basic scientists and pharmaceutical company researchers interested in the state of antifungal therapy. This book provides a comprehensive, up-to-date overview of the pertinent issues pertaining to antifungal treatment. Divided into four interrelated sections for a cohesive discussion covers: history of antifungals from the discovery of the polyenes to the echinocandins antifungal susceptibility methods patient management animal models in drug development therapeutic strategies pharmacokinetic and pharmacogenomics trends in resistance

Antifungal Agents Book

Antifungal Agents

  • Author : G. K. Dixon
  • Publisher : Bios Scientific Pub Limited
  • Release Date : 1995
  • Genre: Antifungal agents
  • Pages : 292
  • ISBN 10 : UCSC:32106012733215

Antifungal Agents Excerpt :

Explores how new molecular technologies are interfacing with chemistry and biology in the search for new fungicide targets.

Pathogenic Yeasts Book

Pathogenic Yeasts

  • Author : Ruth Ashbee
  • Publisher : Springer Science & Business Media
  • Release Date : 2009-10-27
  • Genre: Science
  • Pages : 365
  • ISBN 10 : 3642031501

Pathogenic Yeasts Excerpt :

Mycological studies of yeasts are entering a new phase, with the sequencing of multiple fungal genomes informing our understanding of their ability to cause disease and interact with the host. At the same time, the ongoing use of traditional methods in many clinical mycology laboratories continues to provide information for the diagnosis and treatment of patients. This volume reviews various aspects of pathogenic yeasts and what is known about their molecular and cellular biology and virulence, in addition to looking at clinical and laboratory findings. As each chapter is written by a leading expert in the field, this book summarizes in one volume much of the latest research on several pathogenic yeasts, including Candida, Cryptococcus, Malassezia and yeasts of emerging importance. The importance of laboratory diagnosis, antifungal susceptibility testing, antifungal resistance and yeast diseases in animals are reviewed.

Anti fungal Drug Discovery Book

Anti fungal Drug Discovery

  • Author : Bradley Mark Tebbets
  • Publisher : Unknown
  • Release Date : 2012
  • Genre: Uncategoriezed
  • Pages : 208
  • ISBN 10 : OCLC:822841247

Anti fungal Drug Discovery Excerpt :

Antimicrobial Drug Discovery Book

Antimicrobial Drug Discovery

  • Author : George Tegos
  • Publisher : CABI
  • Release Date : 2012
  • Genre: Medical
  • Pages : 357
  • ISBN 10 : 9781845939434

Antimicrobial Drug Discovery Excerpt :

Resistance is on the rise among a variety of human pathogenic microorganisms associated with common and potentially life-threatening infections, including penicillin-resistant Streptococcus pneumonia and Methicillin-resistant Staphylococcus aureus (MRSA). There is increasing demand to approach the threat of multidrug resistance incorporating novel multidisciplinary methodologies and technological platforms. This book documents the latest research, covering current and promising activities in four key areas: computational chemistry and chemoinformatics, High Throughput Screening (HTS), non-vertebrate model hosts and light and nano-based technologies. It is essential reading for researchers and students in microbiology, biotechnology, pharmacology, chemistry and biology as well as medical professionals.

Antibacterial and Antifungal Drug Discovery  Benzimidazole Derivatives Book

Antibacterial and Antifungal Drug Discovery Benzimidazole Derivatives

  • Author : Muhammad Imran
  • Publisher : LAP Lambert Academic Publishing
  • Release Date : 2015-06-29
  • Genre: Uncategoriezed
  • Pages : 84
  • ISBN 10 : 3659750581

Antibacterial and Antifungal Drug Discovery Benzimidazole Derivatives Excerpt :

Drug discovery is a vast area of research due to increase in bacterial and fungal resistance against available drugs. This book will give the basic concepts of Schiff-Mannich Base derivatives of Benzimidazole, Metal complexes and their application in the field of drug discovery. It will also provide the basic mechanistic study as well as the knowledge about characterization techniques which will be helpful for young students and researchers to have a deep insight about Antibacterial and Antifungal agents.

Antimicrobial Compounds Book

Antimicrobial Compounds

  • Author : Tom├ís G. Villa
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-10-19
  • Genre: Science
  • Pages : 316
  • ISBN 10 : 9783642404443

Antimicrobial Compounds Excerpt :

Since penicillin and salvarsan were discovered, a number of new drugs to combat infectious diseases have been developed, but at the same time, the number of multi-resistant microorganism strains is increasing. Thus, the design of new and effective antibacterial, antiviral and antifungal agents will be a major challenge in the next years. This book reviews the current state-of-the-art in antimicrobial research and discusses new strategies for the design and discovery of novel therapies. Topics covered include the use of genetic engineering, genome mining, manipulation of gene clusters, X-ray and neutron scattering as well as the antimicrobial effects of essential oils, antimicrobial agents of plant origin, beta-lactam antibiotics, antimicrobial peptides, and cell-wall-affecting antifungal antibiotics.