Antimalarial Agents Book

Antimalarial Agents


  • Author : Graham L. Patrick
  • Publisher : Elsevier
  • Release Date : 2020-05-30
  • Genre: Science
  • Pages : 622
  • ISBN 10 : 9780081012413

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Antimalarial Agents Excerpt :

Antimalarial Agents: Design and Mechanism of Action seeks to support medicinal chemists in their work towards antimalarial solution, providing practical guidance on current developments and highlighting promising leads for the future. Malaria is a deadly disease which threatens half of the world’s population. Advances over the last decade have seen vast improvements in the effectiveness of both preventative measures and treatments, but the rapid adaptability of the disease means that the ongoing search for improved and novel antimalarial drugs is essential. Beginning with a focus on biological aspects of malaria, this book highlights the lifecycle of the parasite responsible for malaria, the problem of resistance, genetic mapping of the parasite’s genome, established drug targets, and potential drug targets for the future. The book also includes detailed study of the medicinal chemistry of antimalarial agents and a focus on the design of antimalarial drugs. Drawing on the knowledge of its expert authors and coupling historic research with current findings to provide a full picture of both past and current milestones, Antimalarial Agents: Design and Mechanism of Action is a comprehensive yet accessible guide for all those involved in the design, development and administration of antimalarial drugs, including academic researchers, medicinal chemists, malaria researchers and pharmaceutical scientists. Consolidates both past and current developments in the discovery and design of antimalarial drugs Presents content in a style that is both thorough and engaging, providing a supportive and guiding reference to students and researchers from interdisciplinary backgrounds Highlights drug targets currently considered to be the most promising for future therapies, and the classes of compounds that are currently being studied and perfected

Hepatotoxicity Book
Score: 5
From 1 Ratings

Hepatotoxicity


  • Author : Hyman J. Zimmerman
  • Publisher : Lippincott Williams & Wilkins
  • Release Date : 1999
  • Genre: Medical
  • Pages : 789
  • ISBN 10 : 0781719526

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Hepatotoxicity Excerpt :

Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.

Malaria Control During Mass Population Movements and Natural Disasters Book

Malaria Control During Mass Population Movements and Natural Disasters


  • Author : Program on Forced Migration and Health at the Mailman School of Public Health of Columbia University
  • Publisher : National Academies Press
  • Release Date : 2003-01-16
  • Genre: Medical
  • Pages : 180
  • ISBN 10 : 9780309086158

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Malaria Control During Mass Population Movements and Natural Disasters Excerpt :

Admittedly, the world and the nature of forced migration have changed a great deal over the last two decades. The relevance of data accumulated during that time period can now be called into question. The roundtable and the Program on Forced Migration at the Mailman School of Public Health of Columbia University have commissioned a series of epidemiological reviews on priority public health problems for forced migrants that will update the state of knowledge. Malaria Control During Mass Population Movements and Natural Disasters -- the first in the series, provides a basic overview of the state of knowledge of epidemiology of malaria and public health interventions and practices for controlling the disease in situations involving forced migration and conflict.

Saving Lives  Buying Time Book

Saving Lives Buying Time


  • Author : Institute of Medicine
  • Publisher : National Academies Press
  • Release Date : 2004-10-09
  • Genre: Medical
  • Pages : 384
  • ISBN 10 : 9780309092180

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Saving Lives Buying Time Excerpt :

For more than 50 years, low-cost antimalarial drugs silently saved millions of lives and cured billions of debilitating infections. Today, however, these drugs no longer work against the deadliest form of malaria that exists throughout the world. Malaria deaths in sub-Saharan Africaâ€"currently just over one million per yearâ€"are rising because of increased resistance to the old, inexpensive drugs. Although effective new drugs called “artemisinins†are available, they are unaffordable for the majority of the affected population, even at a cost of one dollar per course. Saving Lives, Buying Time: Economics of Malaria Drugs in an Age of Resistance examines the history of malaria treatments, provides an overview of the current drug crisis, and offers recommendations on maximizing access to and effectiveness of antimalarial drugs. The book finds that most people in endemic countries will not have access to currently effective combination treatments, which should include an artemisinin, without financing from the global community. Without funding for effective treatment, malaria mortality could double over the next 10 to 20 years and transmission will intensify.

CDC Yellow Book 2018  Health Information for International Travel Book

CDC Yellow Book 2018 Health Information for International Travel


  • Author : Centers for Disease Control and Prevention CDC
  • Publisher : Oxford University Press
  • Release Date : 2017-04-17
  • Genre: Medical
  • Pages : 672
  • ISBN 10 : 9780190628635

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CDC Yellow Book 2018 Health Information for International Travel Excerpt :

THE ESSENTIAL WORK IN TRAVEL MEDICINE -- NOW COMPLETELY UPDATED FOR 2018 As unprecedented numbers of travelers cross international borders each day, the need for up-to-date, practical information about the health challenges posed by travel has never been greater. For both international travelers and the health professionals who care for them, the CDC Yellow Book 2018: Health Information for International Travel is the definitive guide to staying safe and healthy anywhere in the world. The fully revised and updated 2018 edition codifies the U.S. government's most current health guidelines and information for international travelers, including pretravel vaccine recommendations, destination-specific health advice, and easy-to-reference maps, tables, and charts. The 2018 Yellow Book also addresses the needs of specific types of travelers, with dedicated sections on: · Precautions for pregnant travelers, immunocompromised travelers, and travelers with disabilities · Special considerations for newly arrived adoptees, immigrants, and refugees · Practical tips for last-minute or resource-limited travelers · Advice for air crews, humanitarian workers, missionaries, and others who provide care and support overseas Authored by a team of the world's most esteemed travel medicine experts, the Yellow Book is an essential resource for travelers -- and the clinicians overseeing their care -- at home and abroad.

Assessment of Long Term Health Effects of Antimalarial Drugs When Used for Prophylaxis Book

Assessment of Long Term Health Effects of Antimalarial Drugs When Used for Prophylaxis


  • Author : National Academies of Sciences, Engineering, and Medicine
  • Publisher : National Academies Press
  • Release Date : 2020-03-24
  • Genre: Medical
  • Pages : 426
  • ISBN 10 : 9780309672139

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Assessment of Long Term Health Effects of Antimalarial Drugs When Used for Prophylaxis Excerpt :

Among the many who serve in the United States Armed Forces and who are deployed to distant locations around the world, myriad health threats are encountered. In addition to those associated with the disruption of their home life and potential for combat, they may face distinctive disease threats that are specific to the locations to which they are deployed. U.S. forces have been deployed many times over the years to areas in which malaria is endemic, including in parts of Afghanistan and Iraq. Department of Defense (DoD) policy requires that antimalarial drugs be issued and regimens adhered to for deployments to malaria-endemic areas. Policies directing which should be used as first and as second-line agents have evolved over time based on new data regarding adverse events or precautions for specific underlying health conditions, areas of deployment, and other operational factors At the request of the Veterans Administration, Assessment of Long-Term Health Effects of Antimalarial Drugs When Used for Prophylaxis assesses the scientific evidence regarding the potential for long-term health effects resulting from the use of antimalarial drugs that were approved by FDA or used by U.S. service members for malaria prophylaxis, with a focus on mefloquine, tafenoquine, and other antimalarial drugs that have been used by DoD in the past 25 years. This report offers conclusions based on available evidence regarding associations of persistent or latent adverse events.

Antimalarial Agents Book

Antimalarial Agents


  • Author : Poul Thompson
  • Publisher : Elsevier
  • Release Date : 2012-12-02
  • Genre: Health & Fitness
  • Pages : 408
  • ISBN 10 : 9780323151689

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Antimalarial Agents Excerpt :

Medicinal Chemistry, Volume 12: Antimalarial Agents: Chemistry and Pharmacology presents the essentials of both biology and chemistry pertinent to the chemotherapy of malaria. This book discusses the nature of the disease, the physiology and biochemistry of the plasmodia, and the mode of action of drugs. Organized into 19 chapters, this volume begins with an overview of the most intensive efforts to develop synthetic antimalarial drugs. This text then examines how drugs are evaluated as well as the specific chemotherapy in malaria. Other chapters consider the diversity of chemical structures exhibiting antimalarial activity with emphasis on structure–activity relationships and methods of synthesis. This book discusses as well the plasmodial effects by quinine in vivo. The final chapter deals with the miscellaneous structures known to have activity against some types of plasmodial infection in animals. This book is a valuable resource for chemists and biologists involved in the development of antimalarial drugs.

From Artemisia Annua L  to Artemisinins  Hindi Edition  Book

From Artemisia Annua L to Artemisinins Hindi Edition


  • Author : Youyou Tu
  • Publisher : Unknown
  • Release Date : 2021-10-31
  • Genre: Uncategoriezed
  • Pages : 456
  • ISBN 10 : 1487804458

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From Artemisia Annua L to Artemisinins Hindi Edition Excerpt :

From Artemisia annua L. to Artemisinins: The Discovery and Development of Artemisinins and Antimalarial Agents is the first book that systematically introduces the origin and development of artemisinine and artemisinine-based drugs. It includes four distinct sections, including Artemisia annua L., Artemisinin, Dihydroartemisinin, and other artemisinin derivatives. Tu Youyou, the chief inventor of artemisinin, together with other members from the research team, have written a book that will be a valuable reference work for both researchers involved in the medical industry and scholars who are interested in undertaking innovative research.

Antimalarial Chemotherapy Book

Antimalarial Chemotherapy


  • Author : Philip J. Rosenthal
  • Publisher : Springer Science & Business Media
  • Release Date : 2001-04-01
  • Genre: Medical
  • Pages : 396
  • ISBN 10 : 9781592591114

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Antimalarial Chemotherapy Excerpt :

Philip Rosenthal, MD, and a panel of leading malaria experts drawn from academia, the military, and international health organizations survey the latest scientific understanding of antimalarial chemotherapy, emphasizing the molecular mechanisms of resistance and the description of important new targets. Their survey covers the current status of malarial and antimalarial chemotherapy, the relevant biology and biochemistry of malaria parasites, the antimalarial drugs currently available, new chemical approaches to chemotherapy, and possible new targets for chemotherapy. Comprehensive and cutting-edge, Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery clearly delineates all the basic and clinical research now addressing one of the world's major unresolved disease problems, work that is now powerfully driving the rapid pace of antimalarial drug discovery today.

Malaria Book

Malaria


  • Author : Institute of Medicine
  • Publisher : National Academies Press
  • Release Date : 1991-02-01
  • Genre: Medical
  • Pages : 328
  • ISBN 10 : 0309045274

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Malaria Excerpt :

Malaria is making a dramatic comeback in the world. The disease is the foremost health challenge in Africa south of the Sahara, and people traveling to malarious areas are at increased risk of malaria-related sickness and death. This book examines the prospects for bringing malaria under control, with specific recommendations for U.S. policy, directions for research and program funding, and appropriate roles for federal and international agencies and the medical and public health communities. The volume reports on the current status of malaria research, prevention, and control efforts worldwide. The authors present study results and commentary on the: Nature, clinical manifestations, diagnosis, and epidemiology of malaria. Biology of the malaria parasite and its vector. Prospects for developing malaria vaccines and improved treatments. Economic, social, and behavioral factors in malaria control.

Antimalarial Natural Products Book

Antimalarial Natural Products


  • Author : A. Douglas Kinghorn
  • Publisher : Springer
  • Release Date : 2022-01-04
  • Genre: Science
  • Pages : 106
  • ISBN 10 : 3030898725

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Antimalarial Natural Products Excerpt :

This volume begins with a short history of malaria and follows with a summary of its biology. It then traces the fascinating history of the discovery of quinine for malaria treatment, and then describes quinine’s biosynthesis, its mechanism of action, and its clinical use, concluding with a discussion of synthetic antimalarial agents based on quinine’s structure. It also covers the discovery of artemisinin and its development as the source of the most effective current antimalarial drug, including summaries of its synthesis and biosynthesis, its mechanism of action, and its clinical use and resistance. A short discussion of other clinically used antimalarial natural products leads to a detailed treatment of additional natural products with significant antiplasmodial activity, classified by compound type. Although the search for new antimalarial natural products from Nature’s combinatorial library is challenging, it is very likely to yield new antimalarial drugs. This book thus ends by identifying ten natural products with development potential as clinical antimalarial agents.

Antimalarial Drugs Book

Antimalarial Drugs


  • Author : Qigui Li
  • Publisher : Nova Science Pub Incorporated
  • Release Date : 2013-01-01
  • Genre: Medical
  • Pages : 657
  • ISBN 10 : 1629480134

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Antimalarial Drugs Excerpt :

Anti-malarial drugs are medicines that prevent or treat malaria, a disease which takes a great toll on human health and well-being, particularly in tropical regions including Africa south of the Sahara, South and Southeast Asia, Oceania, and parts of the Americas. In recent years, strains of Plasmodium have become increasingly resistant to more anti-malarial drugs and researchers have stepped up efforts to revise anti-malarial drug policies and develop new anti-malarial strategies. Resistance has arisen to all classes of antimalarials (chloroquine, amodiaquine, mefloquine and sulfadoxine-pyrimethamine) except, as yet, definitively to the artemisinin derivatives. In order to prevent widespread resistance, the concept of anti-malarial combination therapy (CT) has been employed and a global resistance surveillance system (World Anti-malarial Resistance Networks) has been established. This book explores the use of these drugs in current health care.

Current Topics in Malaria Book

Current Topics in Malaria


  • Author : Alfonso J. Rodriguez-Morales
  • Publisher : Unknown
  • Release Date : 2016-11-30
  • Genre: Uncategoriezed
  • Pages : 506
  • ISBN 10 : 9789535127895

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Current Topics in Malaria Excerpt :

Neglected Diseases and Drug Discovery Book

Neglected Diseases and Drug Discovery


  • Author : Michael J Palmer
  • Publisher : Royal Society of Chemistry
  • Release Date : 2011-10-28
  • Genre: Science
  • Pages : 458
  • ISBN 10 : 9781849733496

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Neglected Diseases and Drug Discovery Excerpt :

There are about 8 million deaths each year from neglected tropical diseases (NTDs) in the underdeveloped world, whilst drug discovery focus and practice is only recently taking on greater urgency and embracing the latest technologies. This unique book is a state of the art review of drug discovery in respect of NTDs and highlights best practice to guide the ongoing drug discovery effort and also to raise debate and awareness in areas that remain highly neglected. All the major diseases such as malaria, trypanosomatids and TB are covered, with a review of each disease and established compounds, new mechanistic classes and new horizons. Each chapter highlights the key science that has led to breakthroughs, with detailed assessment of the key medicinal chemistry involved, and critical appraisal of new emerging approaches. Later chapters highlight under publicized disease areas where the medical needs are neglected and research is very limited, to raise awareness. The editors, acknowledged experts in the field, have a wealth of experience in successful drug discovery practice and tropical diseases.

Artemisinin Based and Other Antimalarials Book

Artemisinin Based and Other Antimalarials


  • Author : Guoqiao Li
  • Publisher : Academic Press
  • Release Date : 2017-11-28
  • Genre: Medical
  • Pages : 736
  • ISBN 10 : 9780128132111

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Artemisinin Based and Other Antimalarials Excerpt :

Artemisinin-Based and Other Antimalarials: Detailed Account of Studies by Chinese Scientists Who Discovered and Developed Them provides a historical and scientific background of the discovery and development of artemisinin, artemisinin derivatives, combination drugs and related chemicals. It is a historical document, a scientific treatise, and a fascinating description of innovative research on new drug development that is carried out under extremely difficult conditions. The book also includes detailed experiments, physical-chemical procedures, practical methodologies and clinical trials. It is a valuable reference for students and researchers in the fields of scientific history, medicine, pharmaceutical science, chemistry, pharmacology and toxicology. Presents details of all stages of drug development, including in vitro experiment, animal exploratory studies, animal tests for toxicity, safety and efficacy followed by stages I, II, III and IV, safety and efficacy in human volunteers and patients with malaria Provides many physical-chemical laboratory procedures, such as NMR, MS, HPLC and X-ray diffraction used in drug development Includes practical methodology of clinical trials from many research centers and countries to demonstrate the importance of this discovery