Autophagy  Biology and Diseases Book

Autophagy Biology and Diseases


  • Author : Zheng-Hong Qin
  • Publisher : Springer Nature
  • Release Date : 2019-11-27
  • Genre: Science
  • Pages : 727
  • ISBN 10 : 9789811506024

GET BOOK
Autophagy Biology and Diseases Excerpt :

This book series consists of 3 volumes covering the basic science (Volume 1), clinical science (Volume 2) and the technology and methodology (Volume 3) of autophagy. Volume 1 focuses on the biology of autophagy, including the signaling pathways, regulating processes and biological functions. Autophagy is a fundamental physiological process in eukaryotic cells. It not only regulates normal cellular homeostasis, and organ development and function, but also plays an important role in the pathogenesis of a wide range of human diseases. Thanks to the rapid development of molecular biology and omic technologies, research on autophagy has boomed in recent decades, and more and more cellular and animal models and state-of the-art technologies are being used to shed light on the complexity of signaling networks involved in the autophagic process. Further, its involvement in biological functions and the pathogenesis of various diseases has attracted increased attention around the globe. Presenting cutting-edge knowledge, this book series is a useful reference resource for researchers and clinicians who are working on or interested in autophagy.

Autophagy  Biology and Diseases Book

Autophagy Biology and Diseases


  • Author : Zhiping Xie
  • Publisher : Springer Nature
  • Release Date : 2021-07-14
  • Genre: Medical
  • Pages : 453
  • ISBN 10 : 9789811628306

GET BOOK
Autophagy Biology and Diseases Excerpt :

This book series consists of 3 volumes covering the basic science (Volume 1), clinical science (Volume 2) and the technology and methodology (Volume 3) of autophagy. Volume 3 focuses on the technical aspects of autophagy research. It is comprised of two parts. The first part discusses the basic process of autophagy, including its overall classification and individual stages in the life cycle of autophagosomes. The second part discusses the tools, strategies, and model systems in current autophagy research, including cell and animal models, detection and manipulation methods, as well as screening, genomic, proteomic and bioinformatic approaches. The book is written and edited by a team of active scientists. It is intended as a practical reference resource for interested researchers to get started on autophagy studies.

Autophagy in Health and Disease Book

Autophagy in Health and Disease


  • Author : Roberta A. Gottlieb
  • Publisher : Academic Press
  • Release Date : 2012-10-16
  • Genre: Medical
  • Pages : 227
  • ISBN 10 : 9780123851017

GET BOOK
Autophagy in Health and Disease Excerpt :

Autophagy in Health and Disease offers an overview of the latest research in autophagy with a translational emphasis. This publication takes scientific research in autophagy a step further and offers integrated content with advancements in autophagy from cell biology and biochemical research to clinical treatments. A necessary reference for the bookshelf of medical and scientific researchers and students, Autophagy in Health and Disease presents high quality, reputable information on autophagy, allowing the reader quick access to the most applicable information. Discusses current understanding of the roles of autophagy in health and disease Covers the background of autophagy, the development of tools and therapeutics to measure and modulate autophagy, and autophagy in tissues and disease processes Features an accompanying website with figures and tables

Autophagy in Health and Disease Book

Autophagy in Health and Disease


  • Author : Beverly Rothermel
  • Publisher : Elsevier
  • Release Date : 2021-09-22
  • Genre: Science
  • Pages : 454
  • ISBN 10 : 9780128220047

GET BOOK
Autophagy in Health and Disease Excerpt :

Autophagy in Health and Disease, Second Edition provides a comprehensive overview of the process of autophagy and its impact on human physiology and pathophysiology. It expands on the scope of the first edition by covering a wider range of cell types, developmental processes, and organ systems. The second edition is an international effort by investigators from 15 different countries whose many contributions are comprised in 28 chapters organized into six sections. The first section (Chapters 1-7) covers foundational concepts, including history, trajectory of the research field, mechanisms of autophagy, and autophagy regulation. The second section (Chapters 8-11) details developmental aspects, including stem cells, embryogenesis, hematopoiesis, and paligenosis. The subsequent sections are devoted to the role of autophagy in specific organ systems involved in metabolic control and diabetes (Chapters 12-15), the cardiovascular system (Chapters 16-18), and the nervous system (Chapters 19-20). The final section (Chapters 21-28) addresses autophagy in other organ systems vital to human health and longevity. Also included are chapters on microautophagy, chaperone-mediated autophagy, and the potential for autophagy as a therapeutic target. Autophagy in Health and Disease is invaluable to anyone new to the field as well as established investigators looking for a broader understanding of autophagy from outside their specific field of study. Provides a comprehensive overview of the process of autophagy and its impact on human physiology and pathology Offers extended coverage of the mechanisms that mediate autophagy Covers the role of autophagy in stem cells and induced pluripotent stem cells, as well as the regenerative process of paligenosis Highlights important questions that remain to be addressed

Autophagy in Health and Disease Book

Autophagy in Health and Disease


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2020-06-30
  • Genre: Science
  • Pages : 444
  • ISBN 10 : 9780128220221

GET BOOK
Autophagy in Health and Disease Excerpt :

Autophagy in Health and Disease, Volume 175, presents the latest insights from renowned experts in the field who discuss the key role of autophagic responses in the preservation of cellular and organismal homeostasis and how defects in the molecular apparatus for autophagy drive or accompany disease. Specific chapters in this new release include Crosstalk between autophagy and cell death signaling: mechanisms and therapeutic relevance, C. elegans to model autophagy-related human disorders, Autophagy in Kidney Disease: advances and therapeutic potential, Autophagy in Chronic Lung Disease, Autophagy in motoneuronal disorders, Strategies employed by viruses to manipulate autophagy, and much more. Provides an outstanding panel of recognized experts in the field who discuss the latest in autophagy Includes critical discussions of autophagy in the context of each major human disorder Models autophagy-related human pathologies in lower eukaryotes

Autophagy  Biology and Diseases Book

Autophagy Biology and Diseases


  • Author : Weidong Le
  • Publisher : Springer Nature
  • Release Date : 2020-07-15
  • Genre: Medical
  • Pages : 736
  • ISBN 10 : 9789811542725

GET BOOK
Autophagy Biology and Diseases Excerpt :

This book consists of 3 volumes: Basic Science (Volume 1), Clinical Science (Volume 2) and Technology and Methodology (Volume 3). Volume 2 focuses on the clinical aspects of autophagy research, discussing the role of autophagy in neuropsychiatric disorders, the cardiovascular, immune, digestive and endocrine systems, as well as tumors, infection, the kidney, and the respiratory and hematological systems. It also addresses autophagy-related drug development. Written and edited by a team of 90 experts, and presenting the state of the art in autophagy research, this book is a valuable reference resource for researchers and clinicians alike. It can also be used as supplementary material for graduate students majoring in biology and medicine

Lysosomes Book

Lysosomes


  • Author : Frederick R. Maxfield
  • Publisher : John Wiley & Sons
  • Release Date : 2016-06-22
  • Genre: Medical
  • Pages : 544
  • ISBN 10 : 9781118978313

GET BOOK
Lysosomes Excerpt :

Discussing recent findings, up-to-date research, and novel strategies, the book integrates perspectives from pharmacology, toxicology, and biochemistry to illustrate the potential of lysosomes in drug discovery and development. • Explores basic principles and properties of lysosomes that allow them to act as regulators of cell metabolism, therapeutic targets, and sites for activation of drug conjugates • Discusses the role of lysosomes in metabolism, drug targeting, apoptosis, cancer, aging, inflammation, autophagy, metabolism, toxicity, and membrane repair • Introduces new pathways in therapeutic development and new mechanisms in drug development

Autophagy in Health and Disease Book

Autophagy in Health and Disease


  • Author : Kursad Turksen
  • Publisher : Springer
  • Release Date : 2018-10-06
  • Genre: Science
  • Pages : 177
  • ISBN 10 : 9783319981468

GET BOOK
Autophagy in Health and Disease Excerpt :

This timely volume explores the impact of autophagy in various human diseases, emphasizing the cell biological aspects and focusing on therapeutic approaches to these diseases. The chapters cover autophagy and its potential applications on diseases ranging from obesity, osteoarthritis, pulmonary fibrosis, and inflammation, through ALS, Parkinson's, retinal degeneration, breast cancer, alcoholic liver disease and more. The final chapters round out the book with a discussion of autophagy in drug discovery and 'bench to bedside'. Chapters are contributed by leading authorities and describe the general concepts of autophagy in health and disease, marrying cell biology and pharmacology and covering: studies derived from preclinical experiments, manufacturing considerations,and regulatory requirements pertaining to drug discovery and manufacturing and production. This volume will be useful for basic scientists as well as already practicing clinicians and advanced graduate students.

Cell Death Book

Cell Death


  • Author : Tobias Ntuli
  • Publisher : BoD – Books on Demand
  • Release Date : 2015-12-16
  • Genre: Science
  • Pages : 446
  • ISBN 10 : 9789535122364

GET BOOK
Cell Death Excerpt :

This book is a collection of selected and relevant research, concerning the developments within the Cell Death field of study. Each contribution comes as a separate chapter complete in itself but directly related to the books topics and objectives. The target audience comprises scholars and specialists in the field.

Autophagy Regulation of Innate Immunity Book

Autophagy Regulation of Innate Immunity


  • Author : Jun Cui
  • Publisher : Springer Nature
  • Release Date : 2019-11-14
  • Genre: Medical
  • Pages : 203
  • ISBN 10 : 9789811506062

GET BOOK
Autophagy Regulation of Innate Immunity Excerpt :

This book discusses novel concepts and discoveries concerning the regulation of innate immunity by autophagy and autophagy-related proteins. In the past decade, there have been major advances in our understanding of the molecular mechanisms of autophagy and its physiological functions. This book highlights emerging studies on the underlying mechanisms of autophagy regulation of innate immunity, including inflammation, antiviral immunity and anti-bacterial responses and the signaling pathways that prompt or inhibit the initiation and progression of related diseases. It also offers new ideas and strategies for future drugs based on manipulating autophagy, especially selective autophagy mediated by cargo receptors. Providing a comprehensive overview of the autophagy regulation of innate immunity, it is a valuable resource for graduate students and researchers in the fields of immunology, cell biology and translational medicine.

Biochemistry of Apoptosis and Autophagy Book

Biochemistry of Apoptosis and Autophagy


  • Author : Lorrie A. Kirshenbaum
  • Publisher : Springer Nature
  • Release Date : 2022-05-19
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : 9783030787998

GET BOOK
Biochemistry of Apoptosis and Autophagy Excerpt :

Proteolytic Signaling in Health and Disease Book

Proteolytic Signaling in Health and Disease


  • Author : Andre Zelanis
  • Publisher : Academic Press
  • Release Date : 2021-10-13
  • Genre: Science
  • Pages : 308
  • ISBN 10 : 9780323856973

GET BOOK
Proteolytic Signaling in Health and Disease Excerpt :

In recent years, powered by evolving technologies and experimental design, studies have better illuminated the regulating role of proteolytic enzymes across human development and pathologies. Proteolytic Signaling in Health and Disease provides an in-depth discussion of fundamental physiological and developmental processes regulated by proteases, from protein turnover and autophagy to antigen processing and presentation and major histocompatibility complex (MHC) molecules. Moving on from basic biology, international chapter authors examine a range of pathological conditions associated with proteolysis, including inflammation, wound healing, and cancer. Later chapters discuss the newly discovered network of connected events among proteases (and their inhibitors), the so-called ‘protease web’, and how best to study it. This book also empowers new research with up-to-date analytical methods and step-by-step protocols for studying proteolytic signaling events. Examines biological events triggered by proteolytic enzyme activity across human development and pathologies Discusses the role of proteolytic signaling in inflammation, wound healing, and cancer, among other disease types Features methods and protocols supporting further study of proteolytic signaling events Includes chapter contributions from international leaders in the field

Autophagy of the Nervous System Book

Autophagy of the Nervous System


  • Author : Zhenyu Yue
  • Publisher : World Scientific
  • Release Date : 2012
  • Genre: Medical
  • Pages : 426
  • ISBN 10 : 9789814350440

GET BOOK
Autophagy of the Nervous System Excerpt :

What is autophagy? Why would neurons or other brain cells digest parts of themselves through autophagy? How can autophagy save the lives of cells under some conditions, but act as a culprit or accomplice to cell death in others? How does dysfunction of autophagy contribute to neurological diseases and can it be repaired or restored? This book addresses these questions and provide an expert view of the emerging concepts in autophagy research, focusing on autophagic processes and regulation in neurons. Current experimental evidence for both evolutionarily conserved and specialized regulatory mechanisms for autophagy in the mammalian nervous system will be presented. Advances in our understanding of the complex interplay of autophagy induction and downregulation will be discussed in relation to the critical balance needed to modulate neuroprotection versus neurodegeneration in the context of neurological diseases including Alzheimer's, Parkinson's, Huntington's, ischemic-hypoxic and lysosomal diseases.