Biochemistry of Collagens  Laminins and Elastin Book

Biochemistry of Collagens Laminins and Elastin


  • Author : Morten Karsdal
  • Publisher : Academic Press
  • Release Date : 2019-05-15
  • Genre: Science
  • Pages : 416
  • ISBN 10 : 0128170689

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Biochemistry of Collagens Laminins and Elastin Excerpt :

There are 28 different collagens, with 46 unique chains, which allows for a collagen for each time and place. Some collagens are specialized for basement membrane, whereas others are the central structural component of the interstitial matrix. There are eight collagens among the 20 most abundant proteins in the body, which makes these molecules essential building blocks of tissues. In addition, lessons learned from monogenomic mutations in these proteins result in grave pathologies, exemplifying their importance in development. These molecules, and their post-translationally modified products serve as biomarkers of diseases in a range of pathologies associated with the extracellular matrix. Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers, Second Edition provides researchers and students current data on key structural proteins (collagens, laminins, and elastin), reviews on how these molecules affect pathologies, and information on how selected modifications of proteins can result in altered signaling properties of the original extracellular matrix component. Further, it discusses the novel concept that an increasing number of components of the ECM harbor cryptic signaling functions that may be viewed as endocrine function, and it highlights how this knowledge can be exploited to modulate fibrotic disease. Provides an updated comprehensive introduction to collagen and structural proteins Gives insight into emerging analytical technologies that can detect biomarkers of extracellular matrix degradation Includes eight new chapters, including one on how collagen biomarkers are used in clinical research to support drug development and in precision medicine Contains insights into the biochemical interactions and changes to structural composition of proteins in disease states Proves the importance of proteins for collagen assembly, function, and durability

Biochemistry of Collagens  Laminins and Elastin Book
Score: 5
From 1 Ratings

Biochemistry of Collagens Laminins and Elastin


  • Author : Morten Karsdal
  • Publisher : Academic Press
  • Release Date : 2016-07-29
  • Genre: Science
  • Pages : 272
  • ISBN 10 : 9780128098998

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Biochemistry of Collagens Laminins and Elastin Excerpt :

Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers provides a comprehensive introduction to collagen and structural proteins. Type I collagen is one of the most abundant molecules in the body, playing essential roles in different tissues, particularly bone and skin. A key aspect of type I collagen is its post-translational modifications which are essential for correct synthesis and structural integrity of collagens, for tissue-specific functionality, as well as for application as biomarkers of different pathologies. This volume summarizes current data on key structural proteins (collagens, laminins and elastin), reviews how these molecules affect pathologies, and describes selected modifications of proteins that result in altered signaling properties of the original extracellular matrix component. Further, it discusses the novel concept that an increasing number of components of the ECM harbor cryptic signaling functions that may be viewed as endocrine functions. Additionally, it highlights how this knowledge can be exploited to modulate fibrotic disease. Provides a comprehensive introduction to collagen and structural proteins Provides insight into emerging analytical technologies that can detect biomarkers of extracellular matrix degradation Includes a chapter dedicated to the biomarkers of structural proteins Contains insights into the biochemical interactions and changes to structural composition of proteins in disease states

Biochemistry of Collagens  Laminins and Elastin Book

Biochemistry of Collagens Laminins and Elastin


  • Author : Morten Karsdal
  • Publisher : Academic Press
  • Release Date : 2019-05-28
  • Genre: Science
  • Pages : 434
  • ISBN 10 : 9780128170694

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Biochemistry of Collagens Laminins and Elastin Excerpt :

There are 28 different collagens, with 46 unique chains, which allows for a collagen for each time and place. Some collagens are specialized for basement membrane, whereas others are the central structural component of the interstitial matrix. There are eight collagens among the 20 most abundant proteins in the body, which makes these molecules essential building blocks of tissues. In addition, lessons learned from monogenomic mutations in these proteins result in grave pathologies, exemplifying their importance in development. These molecules, and their post-translationally modified products serve as biomarkers of diseases in a range of pathologies associated with the extracellular matrix. Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers, Second Edition provides researchers and students current data on key structural proteins (collagens, laminins, and elastin), reviews on how these molecules affect pathologies, and information on how selected modifications of proteins can result in altered signaling properties of the original extracellular matrix component. Further, it discusses the novel concept that an increasing number of components of the extracellular matrix harbor cryptic signaling functions that may be viewed as endocrine function, and it highlights how this knowledge can be exploited to modulate fibrotic disease. Provides an updated comprehensive introduction to collagen and structural proteins Gives insight into emerging analytical technologies that can detect biomarkers of extracellular matrix degradation Includes seven new chapters, including one on how collagen biomarkers are used in clinical research to support drug development and in precision medicine Contains insights into the biochemical interactions and changes to structural composition of proteins in disease states Proves the importance of proteins for collagen assembly, function, and durability

Progress in Heritable Soft Connective Tissue Diseases Book

Progress in Heritable Soft Connective Tissue Diseases


  • Author : Jaroslava Halper
  • Publisher : Springer Science & Business Media
  • Release Date : 2014-01-18
  • Genre: Medical
  • Pages : 245
  • ISBN 10 : 9789400778931

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Progress in Heritable Soft Connective Tissue Diseases Excerpt :

This volume is a reference handbook focusing on diseases like Marfan syndrome, Ehlers-Danlos syndrome, Loeys-Dietz syndrome and other heritable soft connective tissue diseases. The book presents detailed information for both basic scientists and for clinicians seeing patients. It is also a stepping stone for new investigations and studies that goes beyond the facts about the composition and biochemistry of the connective tissue and extracellular matrix, as the authors connect individual components to specific aspects of various soft tissue disorders and to the actual or potential treatment of them. Progress in Heritable Soft Connective Tissue Diseases features very prominent physicians and scientists as contributors who bring their most recent discoveries to the benefit of readers. Their expertise will help clinicians with proper diagnosis of sometimes elusive and uncommon heritable diseases of soft connective tissues. This book also offers an update on the pathophysiology of these diseases, including an emphasis on unifying aspects such as connections between embryonic development of the different types of connective tissues and systems, and the role of TGF-beta in development and physiology of soft tissues. This new set of data explains, at least in part, why many of these disorders are interconnected, though the primary pathophysiological events, such as gene mutations, may be different for each disorder.

The Extracellular Matrix Factsbook Book

The Extracellular Matrix Factsbook


  • Author : Shirley Ayad
  • Publisher : Elsevier
  • Release Date : 1998-03-27
  • Genre: Science
  • Pages : 301
  • ISBN 10 : 9780080531519

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The Extracellular Matrix Factsbook Excerpt :

The Second Edition of The Extracellular Matrix FactsBook has been completely revised, updated and expanded by over 50 percent. It contains over 85 entries on the diverse group of macromolecules that assemble toform the extracellular matrix. Entries provide information on molecular structure, isolation, primary structure, structural and functional sites, gene structure, database accession numbers, and key references. Key Features * Compiled by members of one of the foremost centers of matrix biochemistry in the world * Contains over 30 new entries, with all previous entries being revised and updated * Includes new entries on proteinases involved in the deposition of the extracellular matrix * Presents 3D ribbon diagrams in cases where the protein structure is now known

Methods in Extracellular Matrix Biology Book

Methods in Extracellular Matrix Biology


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2018-01-05
  • Genre: Science
  • Pages : 468
  • ISBN 10 : 9780128122983

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Methods in Extracellular Matrix Biology Excerpt :

Methods in Extra Cellular Matrix, Volume 142, a new volume in the Methods in Cell Biology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Unique to this updated volume are sections devoted to Elastin, Quantification of collagen and elastin, Fibrillins, Lysyl oxidase, Fibulins, Matrilins, Hyaluronic Acid, Small leucine-rich proteoglycans, Syndecans, Fibronectin, SPARC, Thrombospondins, Tenascins, Collagen IV, Multi-photon analysis of ECM, Cell-derived extracellular matrices, Laminins, Fibrillar Collagens, Imaging ECM in developing embryos, Analysis of Matrix Degradation, Ultrastructural analysis of ECM, Versican and Large proteoglycans, and an ECM crosslink analysis. This series covers a wide array of topics about the extracellular matrix, including an understanding of crucial proteins and glycoproteins components of ECM. Contains contributions from experts in the field from across the world Covers a wide array of topics on the extracellular matrix, including an understanding crucial proteins and the glycoproteins components of ECM Includes analysis based topics, such as quantification of collagen and elastin, mulit-photon analysis of ECM and ECM crosslink analysis

The Extracellular Matrix  an Overview Book

The Extracellular Matrix an Overview


  • Author : Robert Mecham
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-02-16
  • Genre: Science
  • Pages : 426
  • ISBN 10 : 9783642165559

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The Extracellular Matrix an Overview Excerpt :

Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept that ECM components together with their cell surface receptors can be viewed as intricate nano-devices that allow cells to physically organize their 3-D-environment. Further, the role of the ECM in human disease and pathogenesis is discussed as well as the use of model organisms in elucidating ECM function.

Extracellular Matrix Degradation Book

Extracellular Matrix Degradation


  • Author : William C. Parks
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-04-07
  • Genre: Science
  • Pages : 255
  • ISBN 10 : 9783642168611

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Extracellular Matrix Degradation Excerpt :

Regulated turnover of extracellular matrix (ECM) is an important component of tissue homeostasis. In recent years, the enzymes that participate in, and control ECM turnover have been the focus of research that touches on development, tissue remodeling, inflammation and disease. This volume in the Biology of Extracellular Matrix series provides a review of the known classes of proteases that degrade ECM both outside and inside the cell. The specific EMC proteases that are discussed include cathepsins, bacterial collagenases, matrix metalloproteinases, meprins, serine proteases, and elastases. The volume also discusses the domains responsible for specific biochemical characteristics of the proteases and the physical interactions that occur when the protease interacts with substrate. The topics covered in this volume provide an important context for understanding the role that matrix-degrading proteases play in normal tissue remodeling and in diseases such as cancer and lung disease.

Composition and Function of the Extracellular Matrix in the Human Body Book

Composition and Function of the Extracellular Matrix in the Human Body


  • Author : Francesco Travascio
  • Publisher : BoD – Books on Demand
  • Release Date : 2016-06-15
  • Genre: Science
  • Pages : 376
  • ISBN 10 : 9789535124153

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Composition and Function of the Extracellular Matrix in the Human Body Excerpt :

The extracellular matrix (ECM) is an ensemble of non-cellular components present within all tissues and organs of the human body. The ECM provides structural support for scaffolding cellular constituents and biochemical and biomechanical support for those events leading to tissue morphogenesis, differentiation and homeostasis. Essential components of all ECMs are water, proteins and polysaccharides. However, their composition, architecture and bioactivity greatly vary from tissue to tissue in relation to the specific role the ECM is required to assume. This book overviews the role of the ECM in different tissues and organs of the human body.

Carbohydrate Chemistry  Chemical and Biological Approaches Volume 44 Book

Carbohydrate Chemistry Chemical and Biological Approaches Volume 44


  • Author : Amelia Pilar Rauter
  • Publisher : Royal Society of Chemistry
  • Release Date : 2020-10-06
  • Genre: Science
  • Pages : 307
  • ISBN 10 : 9781788013680

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Carbohydrate Chemistry Chemical and Biological Approaches Volume 44 Excerpt :

Carbohydrate Chemistry is an invaluable volume demonstrating the interdisciplinary nature of modern carbohydrate research and containing analysed, evaluated and distilled information on the latest research in the area.

Evolution of Extracellular Matrix Book

Evolution of Extracellular Matrix


  • Author : Fred W. Keeley
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-03-15
  • Genre: Science
  • Pages : 290
  • ISBN 10 : 9783642360022

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Evolution of Extracellular Matrix Excerpt :

The evolution of single cells into multicellular organisms was mediated, in large part, by the extracellular matrix. The proteins and glycoconjugates that make up the extracellular matrix provide structural support to cellular complexes, facilitate cell adhesion and migration, and impart mechanical properties that are important for tissue function. Each class of ECM macromolecule has evolved to incorporate distinctive properties that are defined by conserved modules that are mixed together to achieve appropriate function. This volume provides a comprehensive analysis of how the major ECM components evolved over time in order to fill their specific roles found in modern organisms. The major focus is on the structural matrix proteins, matricellular proteins, and more complex ECM structures such as basement membranes. Adhesive proteins and their receptors are also discussed.

Molecular Biology of the Cell Book
Score: 4.5
From 5 Ratings

Molecular Biology of the Cell


  • Author : Bruce Alberts
  • Publisher : Unknown
  • Release Date : 2004
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : 0815332181

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Molecular Biology of the Cell Excerpt :

The Human Gut Liver Axis in Health and Disease Book

The Human Gut Liver Axis in Health and Disease


  • Author : Aleksander Krag
  • Publisher : Springer
  • Release Date : 2018-11-09
  • Genre: Medical
  • Pages : 294
  • ISBN 10 : 9783319988900

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The Human Gut Liver Axis in Health and Disease Excerpt :

The book brings together the current knowledge and future perspectives of the complex physiology and pathophysiology of gut-liver interactions in health and disease. It provides readers with a unique overview and access to knowledge that cannot be obtained elsewhere. The structure is logical and covers all aspect including the normal physiology, changes in various liver diseases, technology, sample collection and various interventions. Thus suitable for general reading, lookup for specific questions or as a reference book within the area. The book allows the reader to access all the knowledge that has been generated within the last 10 years in this field.

Biochemistry and Cell Biology of Ageing  Part II Clinical Science Book

Biochemistry and Cell Biology of Ageing Part II Clinical Science


  • Author : J. Robin Harris
  • Publisher : Springer
  • Release Date : 2019-03-19
  • Genre: Medical
  • Pages : 499
  • ISBN 10 : 9789811336812

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Biochemistry and Cell Biology of Ageing Part II Clinical Science Excerpt :

This volume of the subcellular Biochemistry series will attempt to bridge the gap between the subcellular events that are related to aging as they were described in the first volume of this set of two books and the reality of aging as this is seen in clinical practice. All chapters will start from the biochemistry or cell biology, where the data is available and work up towards the understanding that we have of aging in the various areas that are related to the subject. Key focus points for this volume are nutrition, external factors and genetics on aging. There will also be chapters that will focus on various organs or tissues in which aging has been well studied, like the eyes, the muscles, the immune system and the bones. The aim of the book project and the book project that is published in concert with this volume is to bring the subcellular and clinical areas into closer contact.