Biomaterials and Devices for the Circulatory System Book

Biomaterials and Devices for the Circulatory System


  • Author : Terence Gourlay
  • Publisher : Elsevier
  • Release Date : 2010-10-28
  • Genre: Medical
  • Pages : 400
  • ISBN 10 : 9780857090553

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Biomaterials and Devices for the Circulatory System Excerpt :

Cardiovascular disease is one of the leading causes of death in the world today. Thanks to major advances in circulatory biomaterials and medical devices over the past few decades, many complications of this prevalent disease can be managed with great success for prolonged periods. Biomaterials and devices for the circulatory system reviews the latest developments in this important field and how they can be used to improve the success and safety in this industry. Part one discusses physiological responses to biomaterials with chapters on tissue response, blood interface and biocompatibility. Part two then reviews clinical applications including developments in valve technology, percutaneous valve replacement, bypass technologies and cardiovascular stents. Part three covers future developments in the field with topics such as nanomedicine, cardiac restoration therapy, biosensor technology in the treatment of cardiovascular disease and vascular tissue engineering. With its distinguished editors and international team of contributors Biomaterials and devices for the circulatory system is a vital reference for those concerned with bioengineering, medical devices and clinicians within this critical field. Reviews the latest developments in this important field and how they can be used to improve success and safety in the industry Both current clinical advances as well as future innovation are assessed taking a progressive view of the role of biomaterials in medical applications An examination of the physiological responses to biomaterials features tissue responses to implanted materials and strategies to improve the biocompatibility of medical devices

Bioengineering and Biomaterials in Ventricular Assist Devices Book

Bioengineering and Biomaterials in Ventricular Assist Devices


  • Author : Eduardo Guy PerpĂ©tuo Bock
  • Publisher : CRC Press
  • Release Date : 2021-10-07
  • Genre: Technology & Engineering
  • Pages : 362
  • ISBN 10 : 9781000462852

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Bioengineering and Biomaterials in Ventricular Assist Devices Excerpt :

Often associated with artificial hearts, ventricular assist devices (VADs) are blood pumps that can provide circulatory assistance to the left ventricle, the right ventricle, or both. Bioengineering and Biomaterials in Ventricular Assist Devices reviews constructive details of VADs and the biomaterials used in their development and support. FEATURES Establishes an area of intersection between engineering and medicine Shows process development from mechanical design to automation and control Discusses biofunctional materials, tribology in ceramic biomaterials, biosensors, and surface engineering and blood This text is aimed at advanced students, researchers, and practicing engineers conducting work on VADs and will be of interest to a broad interdisciplinary group, including bioengineers, materials engineers, chemical engineers, mechanical engineers, and electrical engineers.

Characterization of Biomaterials Book

Characterization of Biomaterials


  • Author : Ming H. Wu
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-03-12
  • Genre: Science
  • Pages : 450
  • ISBN 10 : 9780128071052

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Characterization of Biomaterials Excerpt :

The cardiovascular system consists of the heart and the vasculature. The physiology of the system is to circulate blood through the vasculature ensuring delivery of oxygen and vital nutrients to cells and organs in the body. Consequences of diseases disrupting normal cardiovascular function can be severe or fatal. Recent advancements in cardiovascular medicine have contributed significantly to improving life span and quality for patients by restoring normal cardiovascular function through the use of implantable devices. Examples of these cardiovascular implantable devices include endovascular stents, embolic protection devices and filters, closure devices, heart valve prostheses, cardiac rhythm management devices, such as pacemakers and defibrillators, and left ventricular assist devices. The main objective of this chapter is to provide an overview of device test methods commonly used in the development process from concept to commercialization of implantable cardiovascular devices. It is recognized that general device testing methodology and understanding for developing these cardiovascular devices can be extended to other devices as well as new product concepts under development. Developments of new medical devices are closely regulated by regulatory agencies. U.S. and international regulatory requirements for medical devices and drugs provide specific guidance for bench-top in vitro testing, in vivo animal study, clinical research, manufacturing, sterilization, and post-market surveillance for various device categories. Implantable cardiovascular devices generally fall within the Class II and Class III categories. Commercialization of these products in the United States requires FDA's Premarket Notifications (510Ks), Premarket Approvals (PMAs), or Exemptions. The design control element in the new product development procedure requires detailed documentation of design inputs and outputs as well as rational design verification through testing to ensure device funct

Minimized Cardiopulmonary Bypass Techniques and Technologies Book

Minimized Cardiopulmonary Bypass Techniques and Technologies


  • Author : Terence Gourlay
  • Publisher : Elsevier
  • Release Date : 2012-04-19
  • Genre: Medical
  • Pages : 272
  • ISBN 10 : 9780857096029

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Minimized Cardiopulmonary Bypass Techniques and Technologies Excerpt :

Traditional cardiopulmonary bypass (CPB) techniques have suffered from a number of disadvantages including haemodilution, inflammation and post-operative bleeding. Minimised cardiopulmonary bypass techniques use developments in perfusion technology to significantly reduce foreign surface-blood interactions to make bypass simpler and safer. This important book reviews key developments and issues relating to this promising technology. Part one covers the broad range of CPB pathophysiology, including anticoagulant protocols, the impact of CPB circuit surfaces, optimal haemodilution levels, and the important issue of CPB-induced systemic inflammatory response syndrome. Part two focuses on the issues of the new equipment developed for mini-CPB, optimal myocardial protection protocols and CPB perfusate options. Part three discusses clinical issues, including patient selection, coronary and valve surgery protocols and, among others, paediatric patients. With its distinguished editors and international team of expert contributors, Minimized cardiopulmonary bypass techniques and technologies is a valuable reference for cardiac surgery teams and those researching this important technology. Covers a broad range of cardiopulmonary bypass (CPB) pathophysiology, including anticoagulant protocols, the impact of CPB circuit surfaces and optimal haemodilution levels Focuses on new equipment specially developed for minimized-CPB and myocardial protection protocols Discusses clinical issues, including patient selection

Applications of Polyurethanes in Medical Devices Book

Applications of Polyurethanes in Medical Devices


  • Author : Ajay Padsalgikar
  • Publisher : William Andrew
  • Release Date : 2022-06-01
  • Genre: Technology & Engineering
  • Pages : 282
  • ISBN 10 : 9780128231685

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Applications of Polyurethanes in Medical Devices Excerpt :

Applications of Polyurethanes in Medical Devices provides detailed coverage of polyurethane (PU) chemistry, processing and preparation for performant medical devices. Polyurethanes have found many uses in medical applications, due to their biocompatibility, biostability, physical properties, surface polarity, and the ability to suit the field of application. This book enables the reader to understand polyurethane and how this valuable material can be used in medical devices. Sections cover the chemistry, structure, and properties of polyurethane, with in-depth sections examining raw materials, reaction chemistry, synthesis techniques, reaction kinetics, material microstructure, and structure-property relationships. Subsequent chapters demonstrate how polyurethane can be utilized in medical device applications, examining biological properties, rheology and processing before methodical coverage explains how polyurethane may be used for each category of medical device. Finally, future directions, and safety and environmental aspects, are covered. Bridges the gap between polyurethane chemistry, processing and preparation for cutting-edge medical device applications Includes in-depth coverage of polyurethane, covering raw materials, chemistry, synthesis techniques, reaction kinetics, properties and microstructural analysis Takes a valuable and practical approach, addressing manufacturing issues and using testing and modeling to solve problems encountered in processing

Inhaler Devices Book

Inhaler Devices


  • Author : Polina Prokopovich
  • Publisher : Elsevier
  • Release Date : 2013-04-23
  • Genre: Technology & Engineering
  • Pages : 192
  • ISBN 10 : 9780857098696

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Inhaler Devices Excerpt :

Given their direct impact on the health and quality of life for millions, inhalers represent a major turning point in the history of modern medicine. Inhaler devices: Fundamentals, design and drug delivery provides readers with an introduction to the fundamentals of inhaler technology, with a comprehensive discussion of the history of inhalers as well as a discussion on current research and development. Part one discusses the fundamentals and development of inhaler devices as well as drug formulations for inhalers. The treatment of asthma is also discussed. Part two reviews recent developments in drug formulation and nanotechnology for inhaler devices, emerging inhaler technology and possible future trends. Inhaler devices: Fundamentals, design and drug delivery is an essential design guide for good industrial practice, and will be an invaluable resource for those researching and treating conditions such as asthma; and those developing and manufacturing inhalation devices. Introduces the fundamentals of inhaler technology Discusses the history of inhalers as well as current research and development as well as possible future trends Considers the development of inhaler devices, drug formulations and discusses the treatment of asthma

Medical Devices Book

Medical Devices


  • Author : Seeram Ramakrishna
  • Publisher : Woodhead Publishing
  • Release Date : 2015-08-18
  • Genre: Medical
  • Pages : 256
  • ISBN 10 : 9780081002919

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Medical Devices Excerpt :

Medical Devices and Regulations: Standards and Practices will shed light on the importance of regulations and standards among all stakeholders, bioengineering designers, biomaterial scientists and researchers to enable development of future medical devices. Based on the authors’ practical experience, this book provides a concise, practical guide on key issues and processes in developing new medical devices to meet international regulatory requirements and standards. Provides readers with a global perspective on medical device regulations Concise and comprehensive information on how to design medical devices to ensure they meet regulations and standards Includes a useful case study demonstrating the design and approval process

Biocompatibility and Performance of Medical Devices Book

Biocompatibility and Performance of Medical Devices


  • Author : Jean-Pierre Boutrand
  • Publisher : Elsevier
  • Release Date : 2012-10-26
  • Genre: Medical
  • Pages : 544
  • ISBN 10 : 9780857096456

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Biocompatibility and Performance of Medical Devices Excerpt :

Implant and device manufacturers are increasingly facing the challenge of proving that their products are safe and biocompatible, and that they will perform as expected. Biocompatibility and performance of medical devices provides an essential guide to the performance analysis of these vital devices. Part one introduces the key concepts and challenges faced in relation to biocompatibility in medical devices, with consideration of biological safety evaluation planning and biomechanical and biochemical compatibility in innovative biomaterials. Part two goes on to discuss the evaluation and characterisation of biocompatibility in medical devices. Topics covered include material and chemical characterisation, allowable limits for toxic leachables, in vivo and in vitro testing and blood compatibility assessment. Testing and interpreting medical device performance is the focus of part three, with chapters describing preclinical performance studies for bone, dental and soft tissue implants, and mechanical testing of soft and hard tissue implants. Part four provides information on the regulation of medical devices in the European Union, Japan and China, and the book concludes with part five, a review of histopathology principles for biocompatibility and performance studies. With its distinguished editor and international team of expert contributors, Biocompatibility and performance of medical devices is a vital tool for all those involved in the research, design, production and application of medical devices, including research directors, production companies and medical regulatory agencies, as well as industry professionals and academics. Examines the key concepts and challenges faced in relation to biocompatibility in medical devices Discusses evaluation and characterisation issues, including material and chemical characterization, allowable limits for toxic leachables, in vivo and in vitro testing, and blood compatibility assessment Delivers a comprehensive overview of t

Joining and Assembly of Medical Materials and Devices Book

Joining and Assembly of Medical Materials and Devices


  • Author : Y N Zhou
  • Publisher : Elsevier
  • Release Date : 2013-05-31
  • Genre: Technology & Engineering
  • Pages : 574
  • ISBN 10 : 9780857096425

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Joining and Assembly of Medical Materials and Devices Excerpt :

As medical devices become more intricate, with an increasing number of components made from a wide range of materials, it is important that they meet stringent requirements to ensure that they are safe to be implanted and will not be rejected by the human body. Joining and assembly of medical materials and devices provides a comprehensive overview of joining techniques for a range of medical materials and applications. Part one provides an introduction to medical devices and joining methods with further specific chapters on microwelding methods in medical components and the effects of sterilization on medical materials and welded devices. Part two focuses on medical metals and includes chapters on the joining of shape memory alloys, platinum (Pt) alloys and stainless steel wires for implantable medical devices and evaluating the corrosion performance of metal medical device welds. Part three moves on to highlight the joining and assembly of medical plastics and discusses techniques including ultrasonic welding, transmission laser welding and radio frequency (RF)/dielectric welding. Finally, part four discusses the joining and assembly of biomaterial and tissue implants including metal-ceramic joining techniques for orthopaedic applications and tissue adhesives and sealants for surgical applications. Joining and assembly of medical materials and devices is a technical guide for engineers and researchers within the medical industry, professionals requiring an understanding of joining and assembly techniques in a medical setting, and academics interested in this field. Introduces joining methods in medical applications including microwelding and considers the effects of sterilization on the resulting joints and devices Considers the joining, assembly and corrosion performance of medical metals including shape memory alloys, platinum alloys and stainless steel wires Considers the joining and assembly of medical plastics including multiple welding methods, bonding strate

Plastics in Medical Devices for Cardiovascular Applications Book

Plastics in Medical Devices for Cardiovascular Applications


  • Author : Ajay Padsalgikar
  • Publisher : William Andrew
  • Release Date : 2017-02-01
  • Genre: Technology & Engineering
  • Pages : 196
  • ISBN 10 : 9780323371223

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Plastics in Medical Devices for Cardiovascular Applications Excerpt :

Plastics in Medical Devices for Cardiovascular Applications enables designers of new cardiovascular medical devices to make decisions about the kind of plastics that can go into the manufacture of their device by explaining the property requirements of various applications in this area, including artificial valves, lead insulation, balloons, vascular grafts, and more. Enables designers to improve device performance and remain compliant with regulations by selecting the best material for each application Presents a range of applications, including artificial valves, stents, and vascular grafts Explains which materials can be used for each application, and why each is appropriate, thus assisting in the design of better tools and processes

Modelling Degradation of Bioresorbable Polymeric Medical Devices Book

Modelling Degradation of Bioresorbable Polymeric Medical Devices


  • Author : J Pan
  • Publisher : Elsevier
  • Release Date : 2014-10-24
  • Genre: Technology & Engineering
  • Pages : 260
  • ISBN 10 : 9781782420255

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Modelling Degradation of Bioresorbable Polymeric Medical Devices Excerpt :

The use of bioresorbable polymers in stents, fixation devices and tissue engineering is revolutionising medicine. Both industry and academic researchers are interested in using computer modelling to replace some experiments which are costly and time consuming. This book provides readers with a comprehensive review of modelling polymers and polymeric medical devices as an alternative to practical experiments. Chapters in part one provide readers with an overview of the fundamentals of biodegradation. Part two looks at a wide range of degradation theories for bioresorbable polymers and devices. The final set of chapters look at advances in modelling biodegradation of bioresorbable polymers. This book is an essential guide to those concerned with replacing tests and experiments with modelling. Provides a comprehensive mathematical framework for computer modelling of polymers and polymeric medical devices that can significantly reduce the number of experiments needed. Reviews the fundamental methods of modelling degradation, and applies these to particular materials including amorphous bioresorbable polyesters, semicrystalline biodegradable polyesters, and composite materials made of biodegradable polyesters and triclcium phosphates

Biomaterials in Translational Medicine Book

Biomaterials in Translational Medicine


  • Author : Lei Yang
  • Publisher : Academic Press
  • Release Date : 2018-11-30
  • Genre: Technology & Engineering
  • Pages : 358
  • ISBN 10 : 9780128134788

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Biomaterials in Translational Medicine Excerpt :

Biomaterials in Translational Medicine delivers timely and detailed information on the latest advances in biomaterials and their role and impact in translational medicine. Key topics addressed include the properties and functions of these materials and how they might be applied for clinical diagnosis and treatment. Particular emphasis is placed on basic fundamentals, biomaterial formulations, design principles, fabrication techniques and transitioning bench-to-bed clinical applications. The book is an essential reference resource for researchers, clinicians, materials scientists, engineers and anyone involved in the future development of innovative biomaterials that drive advancement in translational medicine. Systematically introduces the fundamental principles, rationales and methodologies of creating or improving biomaterials in the context of translational medicine Includes the translational or commercialization status of these new biomaterials Provides the reader with enough background knowledge for a fundamental grip of the difficulties and technicalities of using biomaterial translational medicine Directs the reader on how to find other up-to-date sources (i.e. peer reviewed journals) in the field of translational medicine and biomaterials

Implantable Sensor Systems for Medical Applications Book

Implantable Sensor Systems for Medical Applications


  • Author : Andreas Inmann
  • Publisher : Elsevier
  • Release Date : 2013-01-02
  • Genre: Science
  • Pages : 544
  • ISBN 10 : 9780857096289

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Implantable Sensor Systems for Medical Applications Excerpt :

Implantable sensor systems offer great potential for enhanced medical care and improved quality of life, consequently leading to major investment in this exciting field. Implantable sensor systems for medical applications provides a wide-ranging overview of the core technologies, key challenges and main issues related to the development and use of these devices in a diverse range of medical applications. Part one reviews the fundamentals of implantable systems, including materials and material-tissue interfaces, packaging and coatings, microassembly, electrode array design and fabrication, and the use of biofuel cells as sustainable power sources. Part two goes on to consider the challenges associated with implantable systems. Biocompatibility, sterilization considerations and the development of active implantable medical devices in a regulated environment are discussed, along with issues regarding data protection and patient privacy in medical sensor networks. Applications of implantable systems are then discussed in part three, beginning with Microelectromechanical systems (MEMS) for in-vivo applications before further exploration of tripolar interfaces for neural recording, sensors for motor neuroprostheses, implantable wireless body area networks and retina implants. With its distinguished editors and international team of expert contributors, Implantable sensor systems for medical applications is a comprehensive guide for all those involved in the design, development and application of these life-changing technologies. Provides a wide-ranging overview of the core technologies, key challenges and main issues related to the development and use of implantable sensor systems in a range of medical applications Reviews the fundamentals of implantable systems, including materials and material-tissue interfaces, packaging and coatings, and microassembly Considers the challenges associated with implantable systems, including biocompatibility and sterilization

Joint Replacement Technology Book
Score: 5
From 1 Ratings

Joint Replacement Technology


  • Author : P.A. Revell
  • Publisher : Elsevier
  • Release Date : 2014-06-13
  • Genre: Technology & Engineering
  • Pages : 724
  • ISBN 10 : 9780857098474

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Joint Replacement Technology Excerpt :

This second edition of Joint Replacement Technology provides a thoroughly updated review of recent developments in joint replacement technology. Joint replacement is a standard treatment for joint degradation and has improved the quality of life of millions of patients. Collaboration between clinicians and researchers is critical to its continued success and to meet the rising expectations of patients and surgeons. Part one introduces the advances in joint replacement technology, tribological considerations and experiments, and immune and regenerative responses to joint replacements. Part two covers the materials and techniques used in joint replacement. The advantages and disadvantages of different metals are explained here, as well as the use of ceramics. This section also addresses challenges in joint bearing surfaces, design, and cementless fixation techniques. Biological and mechanical issues are considered in part three, including healing responses to implants and biological causes of prosthetic joint failure, and a new chapter on imaging of joint prostheses. Each chapter in part four describes the clinical challenges of replacing specific joints, with specific focus on hip, knee, intervertebral disc joint, shoulder arthroplasty, elbow arthroplasty, and pyrocarbon small joint arthroplasty. Thanks to its widespread collaboration and international contributors, Joint Replacement Technology is useful for materials scientists and engineers in both academia and biomedical industry. Chemists, clinicians, and other researchers in this area will also find it invaluable. This second edition provides an updated comprehensive review of recent developments in joint replacement technology Provides coverage for the most pertinent materials science and engineering issues in depth Reviews the specific joints, biological and mechanical issues and fixation techniques

Developments in Tissue Engineered and Regenerative Medicine Products Book

Developments in Tissue Engineered and Regenerative Medicine Products


  • Author : Joydeep Basu
  • Publisher : Elsevier
  • Release Date : 2012-04-19
  • Genre: Technology & Engineering
  • Pages : 226
  • ISBN 10 : 9781908818119

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Developments in Tissue Engineered and Regenerative Medicine Products Excerpt :

Developments in tissue engineered and regenerative medicine products summarizes recent developments in tissue engineering and regenerative medicine with an emphasis on commercialization and product development. Features of current cell therapy and tissue engineered products which have facilitated successful commercialization are emphasized and roadblocks to successful product development are also highlighted. Preclinical and clinical testing of tissue engineered and regenerative medicine products, regulatory, quality control, manufacturing issues, as well as generating and securing intellectual property and freedom to operate considerations are presented. This book represents a complete 'how-to' manual for the development of tissue engineered and regenerative medicine products from conceptualization to clinical trial to manufacturing. Addresses practical considerations for the field of tissue engineering and regenerative medicine from the perspective of the biotechnology industry Written as a manual for tissue engineering and regenerative medicine product development applicable to the US and EU Illustrates pathway integration of science and business required for successful product development