Biomaterials for Vasculogenesis and Angiogenesis Book

Biomaterials for Vasculogenesis and Angiogenesis

  • Author : Saeid Kargozar
  • Publisher : Woodhead Publishing
  • Release Date : 2022-06-01
  • Genre: Medical
  • Pages : 520
  • ISBN 10 : 9780128218686

Biomaterials for Vasculogenesis and Angiogenesis Excerpt :

Biomaterials for Angiogenesis and Vasculogenesis covers the application of materials designed to encourage new blood vessel formation. Angiogenesis and vasculogenesis play an important role in tissue engineering and regenerative medicine research by promoting vascular networks inside engineered tissues and thereby increasing tissue healing and regeneration. However, researchers are faced with the challenge of finding suitable materials for improving angiogenesis and vascular formation in assays. This book reviews a broad range of biomaterials for the promotion of blood vessel genesis, from polymers and bioactive glass, to nanomaterial scaffolds and 3D angiogenic constructs. In addition, the book covers a variety of applications for biomaterials in tissue repair and regeneration, including cardiovascular regeneration, liver tissue engineering and much more. It will serve as a detailed reference for researchers in academia and industry, working in the fields of biomedical science and engineering, materials science, regenerative medicine and translational medicine. Introduces readers to the molecular and cellular basis of angiogenesis and vasculogenesis Helps researchers find suitable biomaterials to promote angiogenesis in engineered tissues and assays Describes a range of biomaterials and their properties, including glass-ceramics, nano-carriers, polymers, and more

Vascularization Book


  • Author : Eric M. Brey
  • Publisher : CRC Press
  • Release Date : 2014-08-07
  • Genre: Medical
  • Pages : 402
  • ISBN 10 : 9781466580459

Vascularization Excerpt :

A Complex and Growing Field The study of vascularization in tissue engineering and regenerative medicine (TERM) and its applications is an emerging field that could revolutionize medical approaches for organ and tissue replacement, reconstruction, and regeneration. Designed specifically for researchers in TERM fields, Vascularization: Regenerative Medicine and Tissue Engineering provides a broad overview of vascularization in TERM applications. This text summarizes research in several areas, and includes contributions from leading experts in the field. It defines the difficulties associated with multicellular processes in vascularization and cell-source issues. It presents advanced biomaterial design strategies for control of vascular network formation and in silico models designed to provide insight not possible in experimental systems. It also examines imaging methods that are critical to understanding vascularization in engineered tissues, and addresses vascularization issues within the context of specific tissue applications. This text is divided into three parts; the first section focuses on the basics of vascularization. The second section provides general approaches for promoting vascularization. The final section presents tissue and organ-specific aspects of vascularization in regenerative medicine. Presents Areas of Substantial Clinical and Societal Impact The material contains research and science on the process of vessel assembly with an emphasis on methods for controlling the process for therapeutic applications. It describes the tissue and organ-specific aspects of vascularization in regenerative medicine, and refers to areas such as bone tissue engineering, vascularization of encapsulated cells, adipose tissue, bone and muscle engineering. It also provides a mechanistic understanding of the process and presentation of experimental and computational approaches that facilitate the study of vascular assembly, and includes enabling technologies such as nan

Vascularization for Tissue Engineering and Regenerative Medicine Book

Vascularization for Tissue Engineering and Regenerative Medicine

  • Author : Wolfgang Holnthoner
  • Publisher : Springer
  • Release Date : 2021-06-03
  • Genre: Technology & Engineering
  • Pages : 555
  • ISBN 10 : 3319545841

Vascularization for Tissue Engineering and Regenerative Medicine Excerpt :

This reference work presents the basic principles of angiogenesis induction, including the roles of signaling factors such as hypoxia-inducible factors, biophysical stimulation and angiogenic cells. The book also covers lymphogenesis induction. Both the established fundamentals in the field as well as new trends in the vascularization of engineered tissues are discussed. These include pre-vascularization strategies using preparation of channeled scaffolds and preparation of decellularized blood vessel trees, approaches to inducing formation of microvasculature and approaches to inducing the growth of vascular networks. The authors expand on these concepts with current studies of dual-level approaches to engineer vascularized tissue composites. The book concludes with a discussion of current clinical approaches and the use of vascular grafts in the context of providing clinical practice with new tissue engineering strategies.

Quantifying the Vasculogenic Potential of Induced Pluripotent Stem Cell derived Endothelial Progenitors in Angiogenic Hydrogels Book

Quantifying the Vasculogenic Potential of Induced Pluripotent Stem Cell derived Endothelial Progenitors in Angiogenic Hydrogels

  • Author : Cody O'Keefe Crosby
  • Publisher : Unknown
  • Release Date : 2020
  • Genre: Uncategoriezed
  • Pages : 0
  • ISBN 10 : OCLC:1346368899

Quantifying the Vasculogenic Potential of Induced Pluripotent Stem Cell derived Endothelial Progenitors in Angiogenic Hydrogels Excerpt :

The circulatory system, composed of an intricate hierarchical network of branching blood vessels, delivers dissolved nutrients and gases to more than 37 trillion cells in the human body. Pathologies that impair these blood vessels, i.e., cardiovascular disease, afflict nearly a million Americans and more than 17 million patients worldwide. To combat the incidence and subsequent progression of cardiovascular disease, researchers have sought to develop in vitro models of vasculature and transplant engineered, vascularized tissue. These efforts have encountered three primary obstacles that have hindered the translation of vascular tissue engineering to the clinic. First, current cell sources are inadequate: cells isolated from other adult patients rapidly undergo senescence and engender an immune response upon implantation. Second, there is a dearth of biomaterials that recapitulate the dynamic signaling environment of the extracellular matrix, which is critical to ensuring a physiological response in vivo. Third, current quantification methods are insufficient: comparing vascular network topologies across different studies remains a difficult endeavor, and many algorithms unnecessarily simplify a complex three-dimensional structure to a planar analysis. To specifically address these three challenges, we quantitatively evaluated the vasculogenic potential, i.e., ability to self-assemble into vessel-like networks, of induced pluripotent stem cell-derived endothelial progenitors (iPSC-EPs) in extracellular matrix-mimicking biomaterials. In this dissertation, we describe the derivation, isolation, and encapsulation of iPSC-EPs in collagen hydrogels. We varied the structural protein density, the concentration of angiogenic growth factor, and proteolytic activity to optimize the resulting microvascular network. We additionally developed a novel computational pipeline, constructed in ImageJ and MATLAB, to quantitatively evaluate vascular network topology while preserving the

Biosynthetic Polymers for Medical Applications Book

Biosynthetic Polymers for Medical Applications

  • Author : Laura Poole-Warren
  • Publisher : Elsevier
  • Release Date : 2015-11-23
  • Genre: Medical
  • Pages : 358
  • ISBN 10 : 9781782421139

Biosynthetic Polymers for Medical Applications Excerpt :

Biosynthetic Polymers for Medical Applications provides the latest information on biopolymers, the polymers that have been produced from living organisms and are biodegradable in nature. These advanced materials are becoming increasingly important for medical applications due to their favorable properties, such as degradability and biocompatibility. This important book provides readers with a thorough review of the fundamentals of biosynthetic polymers and their applications. Part One covers the fundamentals of biosynthetic polymers for medical applications, while Part Two explores biosynthetic polymer coatings and surface modification. Subsequent sections discuss biosynthetic polymers for tissue engineering applications and how to conduct polymers for medical applications. Comprehensively covers all major medical applications of biosynthetic polymers Provides an overview of non-degradable and biodegradable biosynthetic polymers and their medical uses Presents a specific focus on coatings and surface modifications, biosynthetic hydrogels, particulate systems for gene and drug delivery, and conjugated conducting polymers

Mechanical and Chemical Signaling in Angiogenesis Book

Mechanical and Chemical Signaling in Angiogenesis

  • Author : Cynthia A Reinhart-King
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-09-14
  • Genre: Technology & Engineering
  • Pages : 282
  • ISBN 10 : 9783642308567

Mechanical and Chemical Signaling in Angiogenesis Excerpt :

This volume describes and discusses recent advances in angiogenesis research. The chapters are organized to address all biological length scales of angiogenesis: molecular, cellular and tissue in both in vivo and in vitro settings. Specific emphasis is given to novel methodologies and biomaterials that have been developed and applied to angiogenesis research. Angiogenesis experts from diverse fields including engineering, cell and developmental biology, chemistry and physics will be invited to contribute chapters which focus on the mechanical and chemical signals which affect and promote angiogenesis.

Vasculogenesis and Angiogenesis Book

Vasculogenesis and Angiogenesis

  • Author : Dan Simionescu
  • Publisher : BoD – Books on Demand
  • Release Date : 2011-11-07
  • Genre: Medical
  • Pages : 242
  • ISBN 10 : 9789533078823

Vasculogenesis and Angiogenesis Excerpt :

Vasculogenesis is the process of new blood vessel formation during embryonic development of the cardiovascular system. This is followed by formation of a vascular tree and finally the cardiovascular system with the myriad of blood vessels that nourish all tissues and organs. Angiogenesis, on the other hand is the process by which new blood vessels take shape from existing blood vessels by "sprouting" of endothelial cells thus expanding the vascular tree. Both scenarios are based on activation, migration, proliferation and maturation of unique precursor cells. The study of blood vessel formation is an essential component of embryonic development, congenital malformations, degenerative diseases, inflammation and cancer and thus has widespread appeal to the biomedical field. Moreover, scientists are now harnessing this information for the purpose of building living blood vessel substitutes for replacement of diseased arteries and veins. This book highlights novel advances in the field of vasculogenesis and angiogenesis, including embryogenesis and development, regulation of progenitor cells, cancer and blood vessel regeneration. We consider this book a good initial source of information for graduate students, medical students and scientists interested in the intricacies of blood vessel formation, maturation, disease and replacement.

Concise Encyclopedia of Biomedical Polymers and Polymeric Biomaterials Book

Concise Encyclopedia of Biomedical Polymers and Polymeric Biomaterials

  • Author : Munmaya Mishra
  • Publisher : CRC Press
  • Release Date : 2017-08-16
  • Genre: Medical
  • Pages : 2856
  • ISBN 10 : 9781351651202

Concise Encyclopedia of Biomedical Polymers and Polymeric Biomaterials Excerpt :

The Concise Encyclopedia of Biomedical Polymers and Polymeric Biomaterials presents new and selected content from the 11-volume Biomedical Polymers and Polymeric Biomaterials Encyclopedia. The carefully culled content includes groundbreaking work from the earlier published work as well as exclusive online material added since its publication in print. A diverse and global team of renowned scientists provide cutting edge information concerning polymers and polymeric biomaterials. Acknowledging the evolving nature of the field, the encyclopedia also features newly added content in areas such as tissue engineering, tissue repair and reconstruction, and biomimetic materials.

Smart Biomaterial Devices Book

Smart Biomaterial Devices

  • Author : A.K. Bajpai
  • Publisher : CRC Press
  • Release Date : 2016-12-19
  • Genre: Medical
  • Pages : 393
  • ISBN 10 : 9781315354323

Smart Biomaterial Devices Excerpt :

Polymers have emerged as one of the most innovative classes of materials in modern materials science, leading to new applications in medicine and pharmacy. This book offers a convincing and understandable approach to polymer biomaterial devices being used in various areas related to biomedical and pharmaceutical fields. The polymer materials finding application as biomaterials are discussed and described in detail pertaining to the areas of artificial implants, orthopedics, ocular devices, dental implants, drug delivery systems, burns and wounds.

Physiologic and Pathologic Angiogenesis Book

Physiologic and Pathologic Angiogenesis

  • Author : Dan Simionescu
  • Publisher : BoD – Books on Demand
  • Release Date : 2017-04-05
  • Genre: Medical
  • Pages : 466
  • ISBN 10 : 9789535130239

Physiologic and Pathologic Angiogenesis Excerpt :

The purpose of this book is to highlight novel advances in the field and to incentivize scientists from a variety of fields to pursue angiogenesis as a research avenue. Blood vessel formation and maturation to capillaries, arteries, or veins is a fascinating area which can appeal to multiple scientists, students, and professors alike. Angiogenesis is relevant to medicine, engineering, pharmacology, and pathology and to the many patients suffering from blood vessel diseases and cancer, among others. We are hoping that this book will become a source of inspiration and novel ideas for all.

Advances in Bioengineering Research and Application  2013 Edition Book

Advances in Bioengineering Research and Application 2013 Edition

  • Author : Anonim
  • Publisher : ScholarlyEditions
  • Release Date : 2013-06-21
  • Genre: Technology & Engineering
  • Pages : 867
  • ISBN 10 : 9781481693998

Advances in Bioengineering Research and Application 2013 Edition Excerpt :

Advances in Bioengineering Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about ZZZAdditional Research in a concise format. The editors have built Advances in Bioengineering Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Bioengineering Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at

Biomaterials for Cell Delivery Book

Biomaterials for Cell Delivery

  • Author : Aaron S. Goldstein
  • Publisher : CRC Press
  • Release Date : 2018-11-16
  • Genre: Medical
  • Pages : 264
  • ISBN 10 : 9781351647793

Biomaterials for Cell Delivery Excerpt :

The purpose of this book is to summarize key strategies and recent accomplishments in the area of developing cell/biomaterial constructs for regenerative medicine. The first section is a review of the state-of-the-art of biomaterial carriers and is divided into synthetic and natural materials. A subset of the latter are decellularized organs which retain the structure and some of the biological activities of the target organ. The bulk of the book is devoted to unique problems associated with key tissue and organ targets.

Comprehensive Biomaterials Book
Score: 4
From 1 Ratings

Comprehensive Biomaterials

  • Author : Paul Ducheyne
  • Publisher : Elsevier
  • Release Date : 2015-08-28
  • Genre: Technology & Engineering
  • Pages : 3672
  • ISBN 10 : 9780080552941

Comprehensive Biomaterials Excerpt :

Comprehensive Biomaterials brings together the myriad facets of biomaterials into one, major series of six edited volumes that would cover the field of biomaterials in a major, extensive fashion: Volume 1: Metallic, Ceramic and Polymeric Biomaterials Volume 2: Biologically Inspired and Biomolecular Materials Volume 3: Methods of Analysis Volume 4: Biocompatibility, Surface Engineering, and Delivery Of Drugs, Genes and Other Molecules Volume 5: Tissue and Organ Engineering Volume 6: Biomaterials and Clinical Use Experts from around the world in hundreds of related biomaterials areas have contributed to this publication, resulting in a continuum of rich information appropriate for many audiences. The work addresses the current status of nearly all biomaterials in the field, their strengths and weaknesses, their future prospects, appropriate analytical methods and testing, device applications and performance, emerging candidate materials as competitors and disruptive technologies, and strategic insights for those entering and operational in diverse biomaterials applications, research and development, regulatory management, and commercial aspects. From the outset, the goal was to review materials in the context of medical devices and tissue properties, biocompatibility and surface analysis, tissue engineering and controlled release. It was also the intent both, to focus on material properties from the perspectives of therapeutic and diagnostic use, and to address questions relevant to state-of-the-art research endeavors. Reviews the current status of nearly all biomaterials in the field by analyzing their strengths and weaknesses, performance as well as future prospects Presents appropriate analytical methods and testing procedures in addition to potential device applications Provides strategic insights for those working on diverse application areas such as R&D, regulatory management, and commercial development

Stem Cells and Revascularization Therapies Book

Stem Cells and Revascularization Therapies

  • Author : Hyunjoon Kong
  • Publisher : CRC Press
  • Release Date : 2011-12-13
  • Genre: Medical
  • Pages : 345
  • ISBN 10 : 9781439803233

Stem Cells and Revascularization Therapies Excerpt :

In the last few decades, significant advancements in the biology and engineering of stem cells have enabled progress in their clinical application to revascularization therapies. Some strategies involve the mobilization of endogenous stem cell populations, and others employ cell transplantation. However, both techniques have benefited from multidisciplinary efforts to create biomaterials and other biomedical tools that can improve and control the fate of stem cells, and advance our understanding of them. Stem Cells and Revascularization Therapies focuses on the fundamentals and applied studies in stem cell biology, and provides perspectives associated with the development of revascularization strategies. To help readers understand the multidisciplinary issues associated with this topic, this book has been divided into four sections: Section 1: Explores how to define, isolate, and characterize various stem and progenitor cell populations for neovascularization Section 2: Summarizes some especially useful model systems and approaches used to regulate angiogenesis, vasculogenesis, and arteriogenesis, and explores their impact on formation of functional vessels in vivo Section 3: Focuses on stem cell homing to sites of injury and inflammation, as well as strategies to exploit this mobilization phenomenon Section 4: Covers stem cell transplantation topics, including recreating features of endogenous stem cell niches to maintain the multipotency of transplanted cells and combinatorial delivery of cells and molecular factors Intended to inspire new contributions to improve the therapeutic efficacy, Stem Cells and Revascularization Therapies outlines emergent findings and challenges regarding the use of stem cells in revascularization therapies. Overcoming the significant hurdles to our understanding of stem cell biology will enhance their utility in promoting new blood vessel formation.

Integrated Biomaterials in Tissue Engineering Book

Integrated Biomaterials in Tissue Engineering

  • Author : Murugan Ramalingam
  • Publisher : John Wiley & Sons
  • Release Date : 2012-04-03
  • Genre: Science
  • Pages : 325
  • ISBN 10 : 9781118311981

Integrated Biomaterials in Tissue Engineering Excerpt :

This book acts as a self-contained resource for understanding the current technological advancement of biomaterials towards tissue engineering applications. It covers impact of biomaterials at different length scales such as macro/micro/nano/ level and offers extensive discussion on cell-biomaterial interactions with illustrative examples. This resource offer a multi-disciplinary approach for the adaptability of integrated biomaterials in tissue repair and reconstruction.