Biometals in Neurodegenerative Diseases Book

Biometals in Neurodegenerative Diseases


  • Author : Anthony R. White
  • Publisher : Academic Press
  • Release Date : 2017-04-28
  • Genre: Nervous system
  • Pages : 462
  • ISBN 10 : 0128045620

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Biometals in Neurodegenerative Diseases Excerpt :

Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics is an authoritative and timely resource bringing together the major findings in the field for ease of access to those working in the field or with an interest in metals and their role in brain function, disease, and as therapeutic targets. Chapters cover metals in Alzheimer's Disease, Parkinson's Disease, Motor Neuron Disease, Autism and lysosomal storage disorders. This book is written for academic researchers, clinicians and advanced graduate students studying or treating patients in neurodegeneration, neurochemistry, neurology and neurotoxicology. The scientific literature in this field is advancing rapidly, with approximately 300 publications per year adding to our knowledge of how biometals contribute to neurodegenerative diseases. Despite this rapid increase in our understanding of biometals in brain disease, the fields of biomedicine and neuroscience have often overlooked this information. The need to bring the research on biometals in neurodegeneration to the forefront of biomedical research is essential in order to understand neurodegenerative disease processes and develop effective therapeutics. Authoritative and timely resource bringing together the major findings in the field for those with an interest in metals and their role in the brain function, disease, and as therapeutic targets Written for academic researchers, clinicians, and advanced graduate students studying, or treating, patients in neurodegeneration, neurochemistry, neurology and neurotoxicology Edited by international leaders in the field who have contributed greatly to the study of metals in neurodegenerative diseases

Metals and Neurodegeneration  Restoring the Balance Book

Metals and Neurodegeneration Restoring the Balance


  • Author : Anthony R. White
  • Publisher : Frontiers Media SA
  • Release Date : 2016-02-02
  • Genre: Electronic book
  • Pages : 134
  • ISBN 10 : 9782889197392

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Metals and Neurodegeneration Restoring the Balance Excerpt :

Biometals such as copper, zinc and iron have key biological functions, however, aberrant metabolism can lead to detrimental effects on cell function and survival. These biometals have important roles in the brain, driving cellular respiration, antioxidant activity, intracellular signaling and many additional structural and enzymatic functions. There is now considerable evidence that abnormal biometal homeostasis is a key feature of many neurodegenerative diseases and may have an important role in the onset and progression of disorders such as Alzheimer’s, Parkinson’s, prion and motor neuron diseases. Recent studies also support biometal roles in a number of less common neurodegenerative disorders. The role of biometals in a growing list of brain disorders is supported by evidence from a wide range of sources including molecular genetics, biochemical studies and biometal imaging. These studies have spurred a growing interest in understanding the role of biometals in brain function and disease as well as the development of therapeutic approaches that may be able to restore the altered biometal chemistry of the brain. These approaches range from genetic manipulation of biometal transport to chelation of excess metals or delivery of metals where levels are deficient. A number of these approaches are offering promising results in cellular and animal models of neurodegeneration with successful translation to pre-clinical and clinical trials. At a time of aging populations and slow progress in development of neurotherapeutics to treat age-related neurodegenerative diseases, there is now a critical need to further our understanding of biometals in neurodegeneration. This issue covers a broad range of topics related to biometals and their role in neurodegeneration. It is hoped that this will inspire greater discussion and exchange of ideas in this crucial area of research and lead to positive outcomes for sufferers of these neurodegenerative diseases.

Biometals in Neurodegenerative Diseases Book

Biometals in Neurodegenerative Diseases


  • Author : Anthony R. White
  • Publisher : Academic Press
  • Release Date : 2017-04-28
  • Genre: Medical
  • Pages : 462
  • ISBN 10 : 9780128045633

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Biometals in Neurodegenerative Diseases Excerpt :

Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics is an authoritative and timely resource bringing together the major findings in the field for ease of access to those working in the field or with an interest in metals and their role in brain function, disease, and as therapeutic targets. Chapters cover metals in Alzheimer’s Disease, Parkinson’s Disease, Motor Neuron Disease, Autism and lysosomal storage disorders. This book is written for academic researchers, clinicians and advanced graduate students studying or treating patients in neurodegeneration, neurochemistry, neurology and neurotoxicology. The scientific literature in this field is advancing rapidly, with approximately 300 publications per year adding to our knowledge of how biometals contribute to neurodegenerative diseases. Despite this rapid increase in our understanding of biometals in brain disease, the fields of biomedicine and neuroscience have often overlooked this information. The need to bring the research on biometals in neurodegeneration to the forefront of biomedical research is essential in order to understand neurodegenerative disease processes and develop effective therapeutics. Authoritative and timely resource bringing together the major findings in the field for those with an interest in metals and their role in the brain function, disease, and as therapeutic targets Written for academic researchers, clinicians and advanced graduate students studying, or treating, patients in neurodegeneration, neurochemistry, neurology and neurotoxicology Edited by international leaders in the field who have contributed greatly to the study of metals in neurodegenerative diseases

Metal Related Neurodegenerative Disease Book

Metal Related Neurodegenerative Disease


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2013-11-07
  • Genre: Medical
  • Pages : 434
  • ISBN 10 : 9780124105355

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Metal Related Neurodegenerative Disease Excerpt :

This issue reviews the role of metals in neurodegenerative diseases; including Parkinson’s and Huntington’s disease; restless leg syndrome and NBIA disorders; and Wilson’s disease and manganese and calcium accumulation disorders. An update on advances in neuroimaging and pathology of metal related disease is also presented. This volume of International Review of Neurobiology brings together cutting-edge research on metal related neurodegenerative disease It reviews the role of metals in neurodegenerative diseases, including Parkinson’s and Huntington’s disease; restless leg syndrome and NBIA disorders; and Wilson’s disease and manganese and calcium accumulation disorders An update on advances in neuroimaging and pathology of metal related disease is also presented

Nervous System Diseases   Advances in Research and Treatment  2013 Edition Book

Nervous System Diseases Advances in Research and Treatment 2013 Edition


  • Author : Anonim
  • Publisher : ScholarlyEditions
  • Release Date : 2013-06-21
  • Genre: Medical
  • Pages : 491
  • ISBN 10 : 9781481678001

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Nervous System Diseases Advances in Research and Treatment 2013 Edition Excerpt :

Nervous System Diseases—Advances in Research and Treatment: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Neuromuscular Diseases. The editors have built Nervous System Diseases—Advances in Research and Treatment: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Neuromuscular Diseases in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Nervous System Diseases—Advances in Research and Treatment: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Metal Based Neurodegeneration Book

Metal Based Neurodegeneration


  • Author : Robert Crichton
  • Publisher : John Wiley & Sons
  • Release Date : 2013-09-04
  • Genre: Medical
  • Pages : 440
  • ISBN 10 : 9781118553510

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Metal Based Neurodegeneration Excerpt :

Neurodegenerative diseases of the human brain appear in variousforms, resulting in disorders of movement and coordination,cognitive deterioration and psychiatric disturbances. Many of thekey factors leading to neurodegenerative diseases are similar,including the dysfunction of metal ion homeostasis, redox-activemetal ions generating oxidative stress, and intracellular inclusionbodies. Metal-based Neurodegeneration presents a detailed surveyof the molecular origins of neurodegenerative diseases. Eachchapter is dedicated to a specific disease, presenting the latestscientific findings, including details of their biochemicalactors (proteins or peptides), their normal and pathologicalconformations, and a description of the diseases characteristics,with an emphasis on the role of metal-induced oxidative stress,which can result in the production of intracellular aggregates oftarget proteins and peptides. Topics covered include: Brain function, physiology and the blood-brain barrier Immune system and neuroinflammation Aging and mild cognitive impairment, MCI Parkinson’s Disease Alzheimer’s Disease Creutzfelt-Jakob and related prion diseases Alcoholic Brain Damage Therapeutic strategies to combat the onset and progression ofneurological diseases This extensively updated, full colour, second edition ofMetal-based Neurodegeneration is an essential text forresearch scientists and clinicians working in gerontology,neuropathology, neurochemistry, and metalloprotein mechanisms.

Combustion Emissions Book

Combustion Emissions


  • Author : Keith Schofield
  • Publisher : Academic Press
  • Release Date : 2020-01-10
  • Genre: Science
  • Pages : 612
  • ISBN 10 : 9780128191279

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Combustion Emissions Excerpt :

Combustion Emissions: Formation, Reaction, and Removal of Trace Metals in Combustion Products presents the latest scientific knowledge on combustion, with a particular focus on the behavior of elements in this high temperature method of energy generation. The book describes methods of control and establishes a solid base of understanding for future research. Encyclopedic in style and consistent in format, each chapter systematically presents a complete analysis of the combustion behavior of each element and guides the reader in resolving specific problems. This includes source levels in fuels and fuel usage, emission and pollutant release into the environment and environmental effects, and more. Societal impacts and environmental concerns are considered throughout, highlighting sustainability aspects across a diverse range of applications, such as within power plants, automobiles and propulsion. Presents the latest research in a very systematic way Includes methods of control and establishes a base of understanding for future research in energy systems Analyzes the individual behavior of 34 elements, considering their chemistry, nature and environmental impacts

Frontiers in Clinical Drug Research   Dementia  Volume 1 Book

Frontiers in Clinical Drug Research Dementia Volume 1


  • Author : Atta-ur-Rahman
  • Publisher : Bentham Science Publishers
  • Release Date : 2020-06-02
  • Genre: Science
  • Pages : 261
  • ISBN 10 : 9789811410932

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Frontiers in Clinical Drug Research Dementia Volume 1 Excerpt :

Frontiers in Clinical Drug Research - Dementia is a book series which presents comprehensive reviews about research on Dementia, - the loss of brain function associated with Alzheimer’s disease and other related medical conditions. The disease affects the parts of the brain that deal with memory, thought, and language. Chapters in each volume focus on drug research with special emphasis on clinical trials, research on drugs in advanced stages of development and cure for dementia and related disorders. This volume includes the following reviews: - Meeting the Challenges of Falls and Hip Fractures in People with Alzheimer’s Disease - Cholesterol in Brain Health and Pathologies - Advances in the Treatment of Mild Cognitive Impairment (MCI) and Dementia - Analytical Methods in Alzheimer’s Disease Drug Discovery - Targeting Alzheimer’s Disease through Nanomedicine - Current Challenges in Alzheimer’s Disease Research - Metals Linked to Alzheimer's Disease

Human and Animal Models for Translational Research on Neurodegeneration  Challenges and Opportunities From South America Book

Human and Animal Models for Translational Research on Neurodegeneration Challenges and Opportunities From South America


  • Author : Agustín Ibáñez
  • Publisher : Frontiers Media SA
  • Release Date : 2018-06-21
  • Genre: Uncategoriezed
  • Pages : 217
  • ISBN 10 : 9782889454945

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Human and Animal Models for Translational Research on Neurodegeneration Challenges and Opportunities From South America Excerpt :

Neurodegenerative diseases are the most frequent cause of dementia, representing a burden for public health systems (especially in middle and middle-high income countries). Although most research on this issue is concentrated in first-world centers, growing efforts in South America are affording important breakthroughs. This emerging agenda poses new challenges for the region but also new opportunities for the field. This book aims to integrate the community of experts across the globe and the region, and to establish new challenges and developments for future investigation. We present research focused on neurodegenerative research in South America. We introduce studies assessing the interplay among genetic, neural, and behavioral dimensions of these diseases, as well as articles on vulnerability factors, comparisons of findings from various countries, and works promoting multicenter and collaborative networking. More generally, our book covers a broad scope of human-research approaches (behavioral assessment, neuroimaging, electromagnetic techniques, brain connectivity, peripheral measures), animal methodologies (genetics, epigenetics, proteomics, metabolomics, other molecular biology tools), species (all human and non-human animals, sporadic, and genetic versions), and article types (original research, review, and opinion papers). Through this wide-ranging proposal, we hope to introduce a fresh approach to the challenges and opportunities of research on neurodegeneration in South America.

Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases Book

Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases


  • Author : Akhlaq A. Farooqui
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-09-02
  • Genre: Medical
  • Pages : 401
  • ISBN 10 : 9781441966520

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Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases Excerpt :

Collectively, neurodegenerative diseases are characterized by chronic and progressive loss of neurons in discrete areas of the brain, producing debilitating symptoms such as dementia, loss of memory, loss of sensory or motor capability, decreased overall quality of life eventually leading to premature death. Two types of cell death are known to occur during neurodegeneration: (a) apoptosis and (b) necrosis. The necrosis is characterized by the passive cell swelling, intense mitochondrial damage with rapid loss of ATP, alterations in neural membrane permeability, high calcium influx, and disruption of ion homeostasis. This type of cell death leads to membrane lysis and release of intracellular components that induce inflammatory reactions. Necrotic cell death normally occurs at the core of injury site. In contrast, apoptosis is an active process in which caspases (a group of endoproteases with specificity for aspartate residues in protein) are stimulated. Apoptotic cell death is accompanied by cell shrinkage, dynamic membrane blebbing, chromatin condensation, DNA laddering, loss of phospholipids asymmetry, low ATP levels, and mild calcium overload. This type of cell death normally occurs in penumbral region at the ischemic injury site and in different regions in various neurodegenerative diseases.

Magnesium in the Central Nervous System Book

Magnesium in the Central Nervous System


  • Author : Robert Vink
  • Publisher : University of Adelaide Press
  • Release Date : 2011
  • Genre: Medical
  • Pages : 354
  • ISBN 10 : 9780987073051

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Magnesium in the Central Nervous System Excerpt :

The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have

Antioxidants and Functional Foods for Neurodegenerative Disorders Book

Antioxidants and Functional Foods for Neurodegenerative Disorders


  • Author : Abhai Kumar
  • Publisher : CRC Press
  • Release Date : 2021-01-07
  • Genre: Health & Fitness
  • Pages : 472
  • ISBN 10 : 9781000282740

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Antioxidants and Functional Foods for Neurodegenerative Disorders Excerpt :

Neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, are a growing problem across the world’s aging population. Oxidative stress in the brain plays a central role in a common pathophysiology of these diseases. This book presents scientific research on the potential of antioxidant therapy in the prevention and treatment of neurodegenerative disorders. This book outlines the roles of oxidative stress and diabetes mellitus in neurodegeneration, describes the molecular mechanisms of neurodegenerative disorders including the roles of environmental pollutants and inflammatory responses, and explores mitochondrial dysfunction. It then describes the protective abilities of antioxidants – including vitamin D, tocotrienol and coenzyme Q10 – against neurodegeneration. The book demonstrates the therapeutic potential of ketogenic diets, and highlights the roles of medicinal plants, phytopharmaceuticals, traditional medicines and food nutrients in neuroprotection. Key Features: Explains damage caused by numerous neurodegenerative disorders and the possible protection offered by antioxidants and functional foods. Describes molecular mechanisms of neurodegeneration by oxidative stress, advancing age, diabetes and mitochondrial dysfunctions. Demonstrates protection offered by nutraceuticals, antioxidants, botanical extracts and functional foods. The book contains twenty-three chapters divided into six sections written by leading researchers. This book is essential reading for health professionals, dietitians, food and nutrition scientists and anyone wanting to improve their knowledge of etiology of neurodegenerative diseases.

Iron and Neurodegeneration Book

Iron and Neurodegeneration


  • Author : Isabella Zanella
  • Publisher : Frontiers Media SA
  • Release Date : 2020-01-23
  • Genre: Uncategoriezed
  • Pages : 369
  • ISBN 10 : 9782889634514

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Iron and Neurodegeneration Excerpt :

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Research Anthology on Diagnosing and Treating Neurocognitive Disorders Book

Research Anthology on Diagnosing and Treating Neurocognitive Disorders


  • Author : Management Association, Information Resources
  • Publisher : IGI Global
  • Release Date : 2020-08-30
  • Genre: Medical
  • Pages : 671
  • ISBN 10 : 9781799834427

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Research Anthology on Diagnosing and Treating Neurocognitive Disorders Excerpt :

Cognitive impairment, through Alzheimer’s disease or other related forms of dementia, is a serious concern for afflicted individuals and their caregivers. Understanding patients’ mental states and combatting social stigmas are important considerations in caring for cognitively impaired individuals. Technology is playing an increasing role in the lives of the elderly. One of the most prevalent developments for the aging population is the use of technological innovations for intervention and treatment of individuals with mental impairments. Research Anthology on Diagnosing and Treating Neurocognitive Disorders examines the treatment, diagnosis, prevention, and therapeutic and technological interventions of neurodegenerative disorders. It also describes programs and strategies that professional and family caregivers can implement to engage and improve the quality of life of persons suffering from cognitive impairment. Highlighting a range of topics such as dementia, subjective wellbeing, and cognitive decline, this publication is an ideal reference source for speech pathologists, social workers, occupational therapists, psychologists, psychiatrists, neurologists, pediatricians, researchers, clinicians, and academicians seeking coverage on neurocognitive disorder identification and strategies for clinician support and therapies.