Bispecific Antibodies Book

Bispecific Antibodies


  • Author : Roland E. Kontermann
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-07-21
  • Genre: Medical
  • Pages : 373
  • ISBN 10 : 3642209106

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Bispecific Antibodies Excerpt :

The concept of using bispecific antibodies for cancer therapy by retargeting immune effector cells was developed several years ago. Initial clinical studies were rather disappointing mainly due to low efficacy, severe side effects and the immunogenicity of the bispecific antibodies. The progress in antibody engineering finally led to the generation of new classes of bispecific antibodies lacking these obstacles. In addition, new applications were established, such as pre-targeting strategies in radioimmunotherapy and dual targeting approaches in order to improve binding, selectivity and efficacy. In this book, the different ways of generating bispecific antibodies are described, with emphasis on recombinant formats. The various applications of bispecific antibodies, e.g. in cellular cancer immunotherapy, radioimmunotherapy and pretargeting strategies are covered, and emerging applications such as dual targeting strategies, which involve the simultaneous inhibition of two targets, are addressed.

Bispecific Antibodies for T Cell Based Immunotherapy Book

Bispecific Antibodies for T Cell Based Immunotherapy


  • Author : Brian H. Santich
  • Publisher : Frontiers Media SA
  • Release Date : 2021-01-21
  • Genre: Medical
  • Pages : null
  • ISBN 10 : 9782889664153

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Bispecific Antibodies for T Cell Based Immunotherapy Excerpt :

CK is affiliated with the Roche Innovation Center Zurich, holds stocks and has patents with Hoffmann-La Roche company. NKC reports receiving commercial research grants from Y-mabs Therapeutics and Abpro-Labs Inc.; holding ownership interest/equity/options in Y-Mabs Therapeutics Inc., and in Abpro-Labs, and owning stock options in Eureka Therapeutics. NKC is the inventor of pending and issued patents filed by MSK, including hu3F8 and 8H9 licensed to Ymabs Therapeutics, beta-glucan to Biotec Pharmacon, and HER2 bispecific antibody to Abpro-labs. NKC is an advisory board member for Abpro-Labs and Eureka Therapeutics

Approaches to the Purification  Analysis and Characterization of Antibody Based Therapeutics Book

Approaches to the Purification Analysis and Characterization of Antibody Based Therapeutics


  • Author : Allan Matte
  • Publisher : Elsevier
  • Release Date : 2020-09-07
  • Genre: Business & Economics
  • Pages : 222
  • ISBN 10 : 9780081030196

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Approaches to the Purification Analysis and Characterization of Antibody Based Therapeutics Excerpt :

Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics provides the interested and informed reader with an overview of current approaches, strategies and considerations relating to the purification, analytics and characterization of therapeutic antibodies and related molecules. While there are obviously other books published in and around this subject area, they seem to be either older (c.a. year 2000 publication date) or are more limited in scope. The book will include an extensive bibliography of the published literature in the respective areas covered. It is not, however, intended to be a how-to methods book. Covers the vital new area of R&D on therapeutic antibodies Written by leading scientists and researchers Up-to-date coverage and includes a detailed bibliography

Monoclonal Antibodies Book

Monoclonal Antibodies


  • Author : Mary A. Ritter
  • Publisher : Cambridge University Press
  • Release Date : 1995-01-26
  • Genre: Medical
  • Pages : 480
  • ISBN 10 : 0521425034

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Monoclonal Antibodies Excerpt :

Monoclonal antibodies have a very important and wide-ranging role in many areas of biomedical research and this volume is amongst the very first to combine technical and clinical aspects of the subject.

Handbook of Therapeutic Antibodies Book

Handbook of Therapeutic Antibodies


  • Author : Stefan Dübel
  • Publisher : John Wiley & Sons
  • Release Date : 2014-12-03
  • Genre: Science
  • Pages : 2544
  • ISBN 10 : 9783527329373

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Handbook of Therapeutic Antibodies Excerpt :

Still the most comprehensive reference source on the development, production and therapeutic application of antibodies, this second edition is thoroughly updated and now has 30% more content. Volume I covers selection and engineering strategies for new antibodies, while the second volume look at novel therapeutic concepts and antibodies in clinical trial phases, as well as their potential. Volume III features detailed and specific information about each antibody currently approved for therapeutic purposes, including the clinical data. Beyond providing current knowledge, the authors discuss emerging technologies, future developments, and intellectual property issues, such that this handbook meets the needs of academic researchers, decision makers in industry and healthcare professionals in the clinic.

Structure and Function of Antibodies Book

Structure and Function of Antibodies


  • Author : Roy Jefferis
  • Publisher : MDPI
  • Release Date : 2021-02-05
  • Genre: Science
  • Pages : 440
  • ISBN 10 : 9783039438976

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Structure and Function of Antibodies Excerpt :

This book provides a detailed description of all kinds of therapeutic antibodies including IgGs, IgAs, IgEs, and IgMs, bispecific antibodies, chimeric antigen receptor antibodies, and antibody fragments. Details about how each of these antibodies interact with their ligands, the immune system, and their targets are provided. Additionally, this book delves into the details of antibody, Fc, and variable chain structures, and how subtle changes in structure, charge, flexibility, post-translational modification, and the ability to bind to natural antibody ligands can result in a significant impact on antibody activity and functionality. Finally, the book explains the critical quality attributes of modern therapeutic antibodies and how to ensure that antibodies entering development have the best possible chance of success.

Apoptotic Pathways as Targets for Novel Therapies in Cancer and Other Diseases Book

Apoptotic Pathways as Targets for Novel Therapies in Cancer and Other Diseases


  • Author : Marek Los
  • Publisher : Springer Science & Business Media
  • Release Date : 2006-06-20
  • Genre: Medical
  • Pages : 395
  • ISBN 10 : 9780387236957

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Apoptotic Pathways as Targets for Novel Therapies in Cancer and Other Diseases Excerpt :

As our understanding of apoptotic pathway expands, we are coming to realize the great potential of utilizing this pathway to treat diseases such as cancer. The book attempts to review, summarize, and speculate on the apoptotic pathways, how are they regulated and how targeted therapies are being used to treat a wide variety of diseases. Special emphasis is placed on cancer since new treatments either being developed or currently in the clinical setting are showing great promise to increase survival rates for cancer patients. Chapters will address the biology behind regulating the apoptotic pathways and what goes wrong in disease states whereas other chapters will concentrate on new therapies targeting apoptotic pathways. The reader by the end of the book should have greater insight into the understanding and utilization of apoptotic pathways to fight diseases such as cancer.

Single Domain Antibodies  Biology  Engineering and Emerging Applications Book

Single Domain Antibodies Biology Engineering and Emerging Applications


  • Author : Kevin A. Henry
  • Publisher : Frontiers Media SA
  • Release Date : 2018-03-19
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : 9782889454327

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Single Domain Antibodies Biology Engineering and Emerging Applications Excerpt :

Single-domain antibodies (sdAbs) represent the minimal antigen binding-competent form of the immunoglobulin domain and have unique properties and applications. SdAbs are naturally produced as the variable domains of the heavy chain-only antibodies of camelid ruminants and cartilaginous fishes, but can also be engineered synthetically from autonomous human or mouse VH or VL domains. The scope of this research topic and associated e-book covers current understanding and new developments in (i) the biology, immunology and immunogenetics of sdAbs in camelids and cartilaginous fishes, (ii) strategies for sdAb discovery, (iii) protein engineering approaches to increase the solubility, stability and antigen-binding affinity of sdAbs and (iv) specialized applications of sdAbs in areas such diagnostics, imaging and therapeutics.

Antibody Engineering Book
Score: 3
From 1 Ratings

Antibody Engineering


  • Author : Benny K. C. Lo
  • Publisher : Springer Science & Business Media
  • Release Date : 2004
  • Genre: Medical
  • Pages : 561
  • ISBN 10 : 9781592596669

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Antibody Engineering Excerpt :

A core collection of diverse cutting-edge techniques for the generation, expression, optimization, and characterization of recombinant antibodies. Readily reproducible protocols for lead generation range from the cloning of human immunoglobulin genes to the selection and generation of human recombinant antibodies by humanization approaches, molecular display technologies and transgenic animals. Procedures are also described on restructuring antibody leads into monovalent, multivalent, and bispecific binding fragments for a wide variety of in vivo applications. State-of-the-art technologies are described for the characterization of antigen-binding affinity and specificity with novel applications in radioimmunotargeting, cancer immunotherapy, drug abuse, and proteomics. Use cutting-edge techniques for generating and optimizing recombinant antibodies Generate antibodies by humanization, molecular display technologies and transgenic mice Perform epitope mapping with mass spectrometry, bioinformatics, and array technologies Learn about novel applications in cancer, drug addiction, and proteomics Express recombinant antibodies in bacterial, yeast, insect, mammalian and plant systems.

Encyclopedia of Cancer Book

Encyclopedia of Cancer


  • Author : Manfred Schwab
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-10-14
  • Genre: Medical
  • Pages : 3984
  • ISBN 10 : 9783642164828

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Encyclopedia of Cancer Excerpt :

The merging of different basic and clinical science disciplines towards the common goal of fighting against cancer has long ago called for the establishment of a comprehensive reference source both as a tool to close the language gap between clinical and basic science investigators and as a platform of information for students and informed laymen alike. The Encyclopedia of Cancer provides rapid access to focused information on all topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the Second Edition, which appeared in 2009, and fast recent development in the different fields of cancer research, it has been decided to publish a third fully revised and expanded edition, following the principal concept of the first edition that has proven so successful. Recent developments are seeing a dynamic progress in basic and clinical cancer science, with translational research increasingly becoming a new paradigm in cancer research. In particular, new approaches to both Personalized Cancer Medicine and Targeted Therapies have made promising progress. While the Second Edition featured scholarly contributions from approximately 1.000 scientists/clinicians in four Volumes, the Third Edition includes 1.300 contributors in 7 Volumes with an A-Z format of approx. 7000 entries. It provides definitions of common acronyms and short definitions of related terms and processes in the form of keyword entries. In addition, there are detailed essays, which provide comprehensive information on syndromes, genes and molecules, and processes and methods. Each essay is well-structured, with extensive cross-referencing between all entries. In the Third Edition, topical Essays present a comprehensive picture of major cancers, such as Breast Cancer, Colorectal Cancer, Prostate Cancer, Ovarian Cancer, Renal Cancer, Lung Cancer, and Hematological Maligancies, Leukemias and Lymphomas. For each of these cancers, different authoritative Es

Applications And Engineering Of Monoclonal Antibodies Book

Applications And Engineering Of Monoclonal Antibodies


  • Author : David J. King
  • Publisher : CRC Press
  • Release Date : 1998-11-27
  • Genre: Medical
  • Pages : 249
  • ISBN 10 : 0748404228

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Applications And Engineering Of Monoclonal Antibodies Excerpt :

A valuable resource for researchers and workers in the fields of both pharmaceuticals and biotechnology as well as undergraduates in biochemistry, applied biology, biomedical sciences and pharmacy, this book compares established techniques of antibody production with the new. Antibody structure and the implications of antibody engineering are fully discussed, and a case study approach illustrates how antibodies are finding increasing use in the diagnosis and treatment of disease. The volume ends with commercial expression, purification and large-scale manufacture of antibodies and their future potential, particularly as therapeutic agents.

Animal Biotechnology Book

Animal Biotechnology


  • Author : Ashish S. Verma
  • Publisher : Academic Press
  • Release Date : 2020-07-03
  • Genre: Medical
  • Pages : 798
  • ISBN 10 : 9780128117101

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Animal Biotechnology Excerpt :

Animal Biotechnology: Models in Discovery and Translation, Second Edition, provides a helpful guide to anyone seeking a thorough review of animal biotechnology and its application to human disease and welfare. This updated edition covers vital fundamentals, including animal cell cultures, genome sequencing analysis, epigenetics and animal models, gene expression, and ethics and safety concerns, along with in-depth examples of implications for human health and prospects for the future. New chapters cover animal biotechnology as applied to various disease types and research areas, including in vitro fertilization, human embryonic stem cell research, biosensors, enteric diseases, biopharming, organ transplantation, tuberculosis, neurodegenerative disorders, and more. Highlights the latest biomedical applications of genetically modified and cloned animals, with a focus on cancer and infectious diseases Offers first-hand accounts of the use of biotechnology tools, including molecular markers, stem cells, animal cultures, tissue engineering, ADME and CAM Assay Includes case studies that illustrate safety assessment issues, ethical considerations, and intellectual property rights associated with the translation of animal biotechnology studies

Adoptive Immunotherapy Book

Adoptive Immunotherapy


  • Author : Burkhard Ludewig
  • Publisher : Springer Science & Business Media
  • Release Date : 2005
  • Genre: Cancer
  • Pages : 500
  • ISBN 10 : 9781592598625

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Adoptive Immunotherapy Excerpt :

Over the last decade, major advances in our understanding of the immune system and its mechanisms have led to promising new treatment strategies. In Adoptive Immunotherapy: Methods and Protocols, leading experts describe in detail their optimal techniques for producing and characterizing the immunologically active cells and effector molecules now gaining wide use in the clinical treatment of patients. Taking advantage of the latest technologies, the authors present readily reproducible experimental protocols for the study of dendritic cells, T-cells, monoclonal antibodies, and bone marrow transplantation. The emphasis is on preclinicical and clinical applications and on the progress of selected approaches in clinical trials. Additional chapters cover the molecular definition of target antigens, mathematical modeling approaches to immonotherapy, and the utilization of regulatory T-cells. Theoretical overviews and discussion of future directions for the improvement of adoptive immunotherapy complete the volume. The protocols follow the successful Methods in Molecular MedicineTM series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and state-of-the-art, Adoptive Immunotherapy: Methods and Protocols offers an authoritative collection of novel techniques to study the adoptive transfer of tailored antigen-specific immune cells and to improve their clinical application.

Antibody Therapeutics Book

Antibody Therapeutics


  • Author : William J. Harris
  • Publisher : CRC Press
  • Release Date : 2019-10-10
  • Genre: Medical
  • Pages : 366
  • ISBN 10 : 9780429535987

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Antibody Therapeutics Excerpt :

Published in 1997: Antibody Therapeutics is a comprehensive evaluation of progress toward using humanized antibodies as a new generation of therapeutics. The humanized antibodies that have led the way in product approval are discussed as case studies, offering an insight into the preclinical and clinical data acquired during the regulatory approval process. Leading experts offer their findings as examples of what works and what does not, saving you time and making your research more cost effective. This book is essential reading for researchers, clinicians, development and regulatory staff in pharmaceutical and biotechnology companies, and hospital staff, including policy and decision makers. It also provides postgraduate and medical students with an authoritative overview of the field.

Continuous Processing in Pharmaceutical Manufacturing Book

Continuous Processing in Pharmaceutical Manufacturing


  • Author : Ganapathy Subramanian
  • Publisher : John Wiley & Sons
  • Release Date : 2015-02-09
  • Genre: Medical
  • Pages : 528
  • ISBN 10 : 9783527335954

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Continuous Processing in Pharmaceutical Manufacturing Excerpt :

With contributions from biotechnologists and bioengineers, this ready reference describes the state of the art in industrial biopharmaceutical production, with a strong focus on continuous processes. Recent advances in single-use technology as well as application guidelines for all types of biopharmaceutical products, from vaccines to antibodies, and from bacterial to insect to mammalian cells are covered. The efficiency, robustness, and quality control of continuous production processes for biopharmaceuticals are reviewed and compared to traditional batch processes for a range of different production systems.