Brain Targeted Drug Delivery Systems Book

Brain Targeted Drug Delivery Systems


  • Author : Huile Gao
  • Publisher : Academic Press
  • Release Date : 2018-09-20
  • Genre: Medical
  • Pages : 499
  • ISBN 10 : 9780128140024

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Brain Targeted Drug Delivery Systems Excerpt :

Brain Targeted Drug Delivery Systems: A Focus on Nanotechnology and Nanoparticulates provides a guide on nanoparticulates to both academic and industry researchers. The book discusses key points in the development of brain targeted drug delivery, summarizes available strategies, and considers the main problems and pitfalls evidenced in current studies on brain targeted drug delivery systems. As the brain is the most important organ in the human body, and disorders of the central nervous system (CNS) are the most serious threat to human life, this book highlights advances and new research in drug delivery methods to the brain. Provides an overview of brain targeting drug delivery that is useful to both academic and industry-based researchers Discusses key points in developing brain targeting drug delivery systems Summarizes and presents currently available strategies for brain targeting drug delivery Covers not only current studies and their strengths, but also gives insight into the pitfalls of current research

Nanotechnology Based Targeted Drug Delivery Systems for Brain Tumors Book
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Nanotechnology Based Targeted Drug Delivery Systems for Brain Tumors


  • Author : Prashant Kesharwani
  • Publisher : Academic Press
  • Release Date : 2018-04-20
  • Genre: Medical
  • Pages : 478
  • ISBN 10 : 9780128122495

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Nanotechnology Based Targeted Drug Delivery Systems for Brain Tumors Excerpt :

Nanotechnology-Based Targeted Drug Delivery Systems for Brain Tumors addresses brain anatomy and tumors and the progress and challenges in delivering drugs across the blood brain barrier. Several chapters are devoted to the latest technologies and advances in nanotechnology, along with practical solutions on how to design more effective nanocarriers for drug and gene delivery. This valuable resource prepares readers to develop novel drug delivery systems for the treatment of brain tumors that further promote the latest nanomedical technologies. Addresses the progress and challenges inherent in delivering drugs across the blood brain barrier and offers strategies to maximize effectiveness Draws upon the experience and expertise of international scientists working in the fields of drug delivery and nanomedicine Considers the future possibilities of nanotechnology for delivering nanocarriers that better diagnose and treat brain tumors

Nanopharmaceuticals  Principles and Applications Vol  3 Book

Nanopharmaceuticals Principles and Applications Vol 3


  • Author : Vinod Kumar Yata
  • Publisher : Springer Nature
  • Release Date : 2020-08-19
  • Genre: Technology & Engineering
  • Pages : 340
  • ISBN 10 : 9783030471200

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Nanopharmaceuticals Principles and Applications Vol 3 Excerpt :

This book is the third volume on this subject and focuses on the recent advances of nanopharmaceuticals in cancer, dental, dermal and drug delivery applications and presents their safety, toxicity and therapeutic efficacy. The book also includes the transport phenomenon of nanomaterials and important pathways for drug delivery applications. It goes on to explain the toxicity of nanoparticles to different physiological systems and methods used to assess this for different organ systems using examples of in vivo systems.

Nanocarriers for Brain Targeting Book

Nanocarriers for Brain Targeting


  • Author : Raj K. Keservani
  • Publisher : CRC Press
  • Release Date : 2019-08-27
  • Genre: Medical
  • Pages : 512
  • ISBN 10 : 9780429877537

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Nanocarriers for Brain Targeting Excerpt :

This new volume, Nanocarriers for Brain Targeting: Principles and Applications, covers recent research on brain physiology and the development of drug delivery systems. It explores a diverse variety of strategies that can be employed to achieve drug targeting to the brain. The nanocarriers that are discussed include nanoparticles, vesicular carriers, carriers having carbon as a core constituent, dispersed systems, and more. The inherent anatomy and physiology of the brain renders it different from other organs. The past few decades have witnessed significant research on brain ailments in response to a majority of hospitalizations that occur due to age-related central nervous system disorders. The prevalence of diverse diseases such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, multiple sclerosis, HIV-dementia, etc., affect about 1.5 billion people globally, which is further anticipated to reach 1.9 billion by the year 2020. Nanocarriers for drug delivery to the brain are seen as one of the answers to this growing problem.

Drug Delivery to the Brain Book

Drug Delivery to the Brain


  • Author : Margareta Hammarlund-Udenaes
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-12-03
  • Genre: Medical
  • Pages : 731
  • ISBN 10 : 9781461491057

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Drug Delivery to the Brain Excerpt :

The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood –brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics are dynamic and often changed by disease/trauma. Knowledge of all these factors and their interplay in different conditions is of utmost importance for proper CNS drug development and disease treatment. In recent years much information has become available for a better understanding of the many factors important for CNS drug delivery and how they interact to affect drug action. This book describes small and large drug delivery to the brain with an emphasis on the physiology of the BBB and the principles and concepts for drug delivery across the BBB and distribution within the brain. It contains methods descriptions for studying drug delivery, routes and approaches of administering drugs into the brain, the influence of disease, and drug industry perspectives. Therewith, it contributes to an in-depth understanding of the interplay between brain (patho)-physiology and drug characteristics. Furthermore, the content is designed to be both cutting-edge and educational, so that the book can be used in high-level training of academic and industry scientists with full references to original publications. ​

Direct Nose to Brain Drug Delivery Book

Direct Nose to Brain Drug Delivery


  • Author : Chandrakantsing Pardeshi
  • Publisher : Academic Press
  • Release Date : 2021-06-16
  • Genre: Business & Economics
  • Pages : 554
  • ISBN 10 : 9780128225233

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Direct Nose to Brain Drug Delivery Excerpt :

Direct Nose-to-Brain Drug Delivery provides the reader with precise knowledge about the strategies and approaches for enhanced nose-to-brain drug delivery. It highlights the development of novel nanocarrier-based drug delivery systems for targeted drug delivery to the brain microenvironments with a focus on the technological advances in the development of the novel drug delivery devices for intranasal administration, including special emphasis on brain targeting through nose. This book explores the various quantification parameters to assess the brain targeting efficiency following intranasal administration and includes an overview on the toxicity aspects of the various materials used to develop the direct nose-to-brain drug delivery vehicles and of the regulatory aspects including patents and current clinical status of the potential neurotherapeutics for the effective management of neuro-ailments. Technological advances in new drug delivery systems with diverse applications in pharmaceutical, biomedical, biomaterials, and biotechnological fields are also explained. This book is a crucial source that will assist the veteran scientists, industrial technologists, and clinical research professionals to develop new drug delivery systems and novel drug administration devices for the treatment of neuro-ailments. Explains the targeting approaches for enhanced brain targeting following intranasal drug administration Explores the various nanocarriers developed to date for neurotherapeutic delivery via nose-to-brain Discusses pharmaceutical and biomedical applications after nose-to-brain delivery of therapeutic pharmaceuticals and biologicals

Nanotechnology Methods for Neurological Diseases and Brain Tumors Book

Nanotechnology Methods for Neurological Diseases and Brain Tumors


  • Author : Yasemin Gürsoy Özdemir
  • Publisher : Academic Press
  • Release Date : 2017-07-14
  • Genre: Medical
  • Pages : 378
  • ISBN 10 : 9780128038000

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Nanotechnology Methods for Neurological Diseases and Brain Tumors Excerpt :

Nanotechnology Methods for Neurological Diseases and Brain Tumors: Drug Delivery across the Blood-Brain Barrier compiles the latest (and future potential) treatment strategies for brain tumors and neurological diseases, in particular Alzheimer’s, Parkinson’s and stroke, those that bypass the blood/brain barrier. The current understanding of brain drug delivery and access is discussed in Chapter One, with the next section focusing on the implementation of the nose-to-brain intranasal route in brain-targeted drug delivery. In addition, nanotechnology-based brain drug delivery is covered in Chapter Three. This avenue offers impressive improvement in the treatment of neurological diseases and brain tumors by using bio-engineered systems that interact with biological systems at a molecular level. In Chapter Four, emphasis is placed on the need for brain-targeted experimental models that mimic disease conditions. Final chapters discuss the very latest advances in targeted treatment strategies for neurological diseases and brain tumors. Comprehensive guide for up-to-date views on the latest advances in targeted treatment strategies for brain tumors and neurological diseases Designed with a multidisciplinary approach that links neurology, neuro-oncology and nanoscience to drug delivery to the brain with an emphasis on the blood-brain-barrier Written in a language that makes it easy to understand nanotechnology drug delivery techniques Presents a unique book that also covers advanced treatment approaches of neurological diseases and brain tumors

Advanced Drug Delivery Systems in the Management of Cancer Book

Advanced Drug Delivery Systems in the Management of Cancer


  • Author : Kamal Dua
  • Publisher : Elsevier
  • Release Date : 2021-06-24
  • Genre: Business & Economics
  • Pages : 572
  • ISBN 10 : 9780323900799

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Advanced Drug Delivery Systems in the Management of Cancer Excerpt :

Advanced Drug Delivery Systems in the Management of Cancer discusses recent developments in nanomedicine and nano-based drug delivery systems used in the treatment of cancers affecting the blood, lungs, brain, and kidneys. The research presented in this book includes international collaborations in the area of novel drug delivery for the treatment of cancer. Cancer therapy remains one of the greatest challenges in modern medicine, as successful treatment requires the elimination of malignant cells that are closely related to normal cells within the body. Advanced drug delivery systems are carriers for a wide range of pharmacotherapies used in many applications, including cancer treatment. The use of such carrier systems in cancer treatment is growing rapidly as they help overcome the limitations associated with conventional drug delivery systems. Some of the conventional limitations that these advanced drug delivery systems help overcome include nonspecific targeting, systemic toxicity, poor oral bioavailability, reduced efficacy, and low therapeutic index. This book begins with a brief introduction to cancer biology. This is followed by an overview of the current landscape in pharmacotherapy for the cancer management. The need for advanced drug delivery systems in oncology and cancer treatment is established, and the systems that can be used for several specific cancers are discussed. Several chapters of the book are devoted to discussing the latest technologies and advances in nanotechnology. These include practical solutions on how to design a more effective nanocarrier for the drugs used in cancer therapeutics. Each chapter is written with the goal of informing readers about the latest advancements in drug delivery system technologies while reinforcing understanding through various detailed tables, figures, and illustrations. Advanced Drug Delivery Systems in the Management of Cancer is a valuable resource for anyone working in the fields of cancer biology and d

The Blood Brain Barrier  BBB  Book

The Blood Brain Barrier BBB


  • Author : Gert Fricker
  • Publisher : Springer
  • Release Date : 2014-10-24
  • Genre: Science
  • Pages : 163
  • ISBN 10 : 9783662437872

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The Blood Brain Barrier BBB Excerpt :

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

Recent Development in Brain Targeted Drug Delivery System Book

Recent Development in Brain Targeted Drug Delivery System


  • Author : Sanket Gandhi
  • Publisher : LAP Lambert Academic Publishing
  • Release Date : 2012-06
  • Genre: Uncategoriezed
  • Pages : 60
  • ISBN 10 : 3659159107

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Recent Development in Brain Targeted Drug Delivery System Excerpt :

The brain is a delicate organ, and evolution built very efficient ways to protect it. Unfortunately, the same mechanisms that protect it against intrusive chemicals can also frustrate therapeutic interventions. Many existing pharmaceuticals are rendered ineffective in the treatment of cerebral diseases due to our inability to effectively deliver and sustain them within the brain. General methods that can enhance drug delivery to the brain are, therefore, of great interest. The clinical failure of much potentially effective therapeutics is often not due to a lack of drug potency but rather to shortcomings in the method by which the drug is delivered. In response to the insufficiency in conventional delivery mechanisms, aggressive research efforts have recently focused on the development of new strategies to more effectively deliver drug molecules to the CNS.

Surface Modification of Nanoparticles for Targeted Drug Delivery Book

Surface Modification of Nanoparticles for Targeted Drug Delivery


  • Author : Yashwant V Pathak
  • Publisher : Springer
  • Release Date : 2019-03-11
  • Genre: Medical
  • Pages : 499
  • ISBN 10 : 9783030061159

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Surface Modification of Nanoparticles for Targeted Drug Delivery Excerpt :

This unique book is the only one to discuss various new techniques developed to enhance the application of nanoparticulate drug delivery systems using surface modification of nanoparticles. The understanding of the surface characteristics nano-particles is growing significantly with the advent of new analytical techniques. Polymer chemistry is contributing to the development of many new versatile polymers which have abilities to accommodate many different, very reactive chemical groups, and can be used as a diagnostic tool, for better targeting, for more effective therapeutic results as well as for reducing the toxic and side effects of the drugs. Surface modification of such polymeric nanoparticles has been found by many scientists to enhance the application of nanoparticles and also allows the nano particles to carry specific drug molecule and disease /tumor specific antibodies which refine and improve drug delivery. Surface Modification of Nanoparticles for Targeted Drug Delivery is a collection essential information with various applications of surface modification of nanoparticles and their disease specific applications for therapeutic purposes.

In Vitro and In Vivo Tools in Drug Delivery Research for Optimum Clinical Outcomes Book

In Vitro and In Vivo Tools in Drug Delivery Research for Optimum Clinical Outcomes


  • Author : Ambikanandan Misra
  • Publisher : CRC Press
  • Release Date : 2018-06-22
  • Genre: Medical
  • Pages : 332
  • ISBN 10 : 9781351368728

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In Vitro and In Vivo Tools in Drug Delivery Research for Optimum Clinical Outcomes Excerpt :

This book covers the essentials of drug delivery research and provides a unique forum for scientific experimental methods that are exclusively focused by the in-vitro, ex-vivo, and in-vivo methodologies of drug delivery research and felicitates translational research. The book includes recent and novel approaches in evaluation methods of transdermal, nasal, ocular, oral and intraoral, gastro-retentive, colon-targeted, and brain-targeted drug delivery systems. Providing up to date and comprehensive information, this text is invaluable to students, teachers, scientists, and others employed in the field of drug delivery.

Nanoparticles for Brain Drug Delivery Book

Nanoparticles for Brain Drug Delivery


  • Author : Carla Vitorino
  • Publisher : CRC Press
  • Release Date : 2021-03-16
  • Genre: Medical
  • Pages : 504
  • ISBN 10 : 9781000245639

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Nanoparticles for Brain Drug Delivery Excerpt :

In an era wherein nanotechnology has sparked a huge research interest, brain drug delivery is not an exception. Aiming at fighting several central nervous system (CNS) conditions, tailored nanoparticles open new avenues to address several challenges in the fields of drug delivery and brain targeting. This book gathers contributions from experts in different, complementary fields, having in common their interest in developing new strategies for brain delivery based on nanotechnologies. The book encompasses general aspects pertaining to fundamental development, including tripartite in silico–in vitro–in vivo approaches. It also covers a diversity of nanomedicines applied in treatment and/or diagnosis and monitoring of CNS disorders. Aspects concerning their translation from the bench to clinical practice are also seamlessly discussed. This book will inspire readers to discover possible approaches to holistically delivering drugs into the brain. Edited by Carla Vitorino, Andreia Jorge and Alberto Pais, this book will appeal to anyone involved in nanomedicine, pharmaceutics, neurological and cancer therapies, drug delivery research and computational and regulatory sciences.

Targeted Drug Delivery   Concepts and Design Book

Targeted Drug Delivery Concepts and Design


  • Author : Padma V. Devarajan
  • Publisher : Springer
  • Release Date : 2014-12-08
  • Genre: Medical
  • Pages : 790
  • ISBN 10 : 9783319113555

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Targeted Drug Delivery Concepts and Design Excerpt :

This authoritative volume explores the fundamental concepts and numerous applications of targeted delivery of drugs to the body. This compilation has been divided into eight sections comprised of the basic principles of drug targeting, disease and organ/organelle-based targeting, passive and active targeting strategies, and various advanced drug delivery tools such as functionalized lipidic, polymeric and inorganic nanocarriers. Together, the twenty-three chapters cover a wide range of topics in the field, including tumor and hepatic targeting, polymer-drug conjugates, nanoemulsion, physical and biophysical characteristics of nanoparticles, and in vivo imaging techniques, among others. The book also examines advanced characterization techniques, regulatory hurdles and toxicity-related issues that are key features for successful commercialization of targeted drug delivery system products. Targeted Drug Delivery is a comprehensive reference guide for drug delivery researchers, both beginners and those already working in the field.