Cancer Immunotherapy Book

Cancer Immunotherapy


  • Author : George C. Prendergast
  • Publisher : Elsevier
  • Release Date : 2011-04-28
  • Genre: Medical
  • Pages : 428
  • ISBN 10 : 0080521851

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Cancer Immunotherapy Book Description :

There has been major growth in understanding immune suppression mechanisms and its relationship to cancer progression and therapy. This book highlights emerging new principles of immune suppression that drive cancer and it offers radically new ideas about how therapy can be improved by attacking these principles. Following work that firmly establishes immune escape as an essential trait of cancer, recent studies have now defined specific mechanisms of tumoral immune suppression. It also demonstrates how attacking tumors with molecular targeted therapeutics or traditional chemotherapeutic drugs can produce potent anti-tumor effects in preclinical models. This book provides basic, translational, and clinical cancer researchers an indispensable overview of immune escape as a critical trait in cancer and how applying specific combinations of immunotherapy and chemotherapy to attack this trait may radically improve the treatment of advanced disease. * Offers a synthesis of concepts that are useful to cancer immunologists and pharmacologists, who tend to work in disparate fields with little cross-communication * Drs Prendergast and Jaffee are internationally recognized leaders in cancer biology and immunology who have created a unique synthesis of fundamental and applied concepts in this important new area of cancer research * Summarizes the latest insights into how immune escape defines an essential trait of cancer * Includes numerous illustrations including: how molecular-targeted therapeutic drugs or traditional chemotherapy can be combined with immunotherapy to improve anti-tumor efficacy; and how reversing immune suppression by the tumor can cause tumor regression

Vaccines for Cancer Immunotherapy Book

Vaccines for Cancer Immunotherapy


  • Author : Nima Rezaei
  • Publisher : Academic Press
  • Release Date : 2018-10-17
  • Genre: Medical
  • Pages : 198
  • ISBN 10 : 9780128140406

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Vaccines for Cancer Immunotherapy Book Description :

Therapeutic cancer vaccines represent a type of active cancer immunotherapy. Clinicians, scientists, and researchers working on cancer treatment require evidence-based and up-to-date resources relating to therapeutic cancer vaccines. Vaccines for Cancer Immunotherapy provides a reference for cancer treatment for clinicians and presents a well-organized resource for determining high-potential research areas. The book considers that this promising modality can be made more feasible as a treatment for cancer. Chapters cover cancer immunology, general approaches to cancer immunotherapy, vaccines, tumor antigens, the strategy of allogeneic and autologous cancer vaccines, personalized vaccines, whole-tumor antigen vaccines, protein and peptide vaccines, dendritic cell vaccines, genetic vaccines, candidate cancers for vaccination, obstacles to developing therapeutic cancer vaccines, combination therapy, future perspectives and concluding remarks on therapeutic cancer vaccines. Introduces the feasible immunotherapeutic vaccines for patients with different types of cancer Presents the status of past and current vaccines for cancer treatment Considers advantages and disadvantages of different therapeutic cancer vaccines Looks at the combination of vaccines and other modalities, including immunotherapeutic and conventional methods Analyzes obstacles to development of therapeutic cancer vaccines Gives a view on future perspectives in the application of therapeutic cancer vaccines

The Basics of Cancer Immunotherapy Book

The Basics of Cancer Immunotherapy


  • Author : Haidong Dong
  • Publisher : Springer
  • Release Date : 2018-01-05
  • Genre: Medical
  • Pages : 160
  • ISBN 10 : 9783319706221

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The Basics of Cancer Immunotherapy Book Description :

This book provides patients and their physicians (especially “non-oncologist” health care providers) with a clear and concise introduction to cancer immunotherapy, which, unlike traditional forms of cancer therapy, acts by boosting the patient’s own immune system to fight cancer. The unique features of cancer immunotherapy make its management, monitoring and side-effects different from those of traditional cancer therapy. Especially novel are the side effects of cancer immunotherapy, necessitating greater awareness for both patients and physicians in order to minimize complications of therapy. The patient-friendly, concise, easy-to-understand, and up-to-date knowledge presented in this book will inform patients about the benefits and risks of cancer immunotherapy, and help them and their care providers to understand how immunotherapy would control their unique disease. Researchers and academic professionals in the field of cancer immunotherapy will also find clear and useful information to help them communicate with patients or address unresolved problems. Some key features of the book are: Expertise. All editors and authors are scientists and oncologists specializing in cancer immunotherapy, and are involved in scientific discovery from the early stage of immune-checkpoint inhibitors to today’s daily patient care. Their insights, expertise and experience guarantee the high quality and authority in the science, medicine and practice of cancer immunotherapy. Patient-friendly. This book is written for cancer patients in order to meet their needs when considering immunotherapy. As an educational tool, this book will help the reader balance the risks and benefits based on both science and clinical facts, and therefore to make the best choice in receiving or withdrawing from immunotherapy. Disease Specificity. Cancer is a complicated disease involving multiple stages and pathology. Its response to immunotherapy is individualized and varies depending on cancer typ

Immunotherapy of Cancer Book

Immunotherapy of Cancer


  • Author : Mary L. Disis
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-10-28
  • Genre: Medical
  • Pages : 516
  • ISBN 10 : 9781597450119

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Immunotherapy of Cancer Book Description :

Expert bench and clinical scientists join forces to concurrently review both the state-of-the-art in tumor immunology and its clinical translation into promising practical treatments. The authors explain in each chapter the scientific basis behind such therapeutic agents as monoclonal antibodies, cytokines, vaccines, and T-cells, and illustrate their clinical manipulation to combat cancer. Additional chapters address statistical analysis-both of clinical trials and assay evaluations-methods for the discovery of antigens, adoptive T cell therapy, and adaptive and innate immunity. The challenges in clinical trial design, the need for biomarkers of response-such as novel imaging techniques and immunologic monitoring-and the new advances and directions in cancer immunotherapy are also fully examined.

Autophagy in Immune Response  Impact on Cancer Immunotherapy Book

Autophagy in Immune Response Impact on Cancer Immunotherapy


  • Author : Salem Chouaib
  • Publisher : Academic Press
  • Release Date : 2020-05
  • Genre: Science
  • Pages : 400
  • ISBN 10 : 9780128196090

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Autophagy in Immune Response Impact on Cancer Immunotherapy Book Description :

Autophagy in Immune Response: Impact on Cancer Immunotherapy focuses on the status and future directions of autophagy with respect to different aspects of its interaction with the immune system and immunotherapy. The book takes scientific research in autophagy a step further by presenting reputable information on the topic and offering integrated content with advancements in autophagy, from cell biology and biochemical research, to clinical treatments. This book is a valuable source for cancer researchers, oncologists, graduate students and several members of biomedical field who are interested in learning more on the relationship between autophagy and immunotherapies.

Tumor Immunology and Immunotherapy Book

Tumor Immunology and Immunotherapy


  • Author : Robert C. Rees
  • Publisher : Oxford University Press, USA
  • Release Date : 2014-05-20
  • Genre: Medical
  • Pages : 442
  • ISBN 10 : 9780199676866

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Tumor Immunology and Immunotherapy Book Description :

Patients are beginning to benefit from antibody based, cellular and vaccine approaches that are effective against genetically diverse and therapy-resistance cancers. BCG immunotherapy is now being used as a first line treatment for human bladder cancer and the introduction of prophylactic vaccination against Hepatitis B and HPV cancers is starting to show positive results. Following recent FDA approval for a vaccination against prostate cancer, and optimistic results in clinical trials for a vaccine targeting cancer antigens in lung cancer, cancer immunotherapy is now significantly impacting patient clinical management. Tumor Immunology and Immunotherapy provides an up-to-date and comprehensive account of cancer immunity and immunotherapy. It discusses our adaptive and innate immunity to cancer, the mechanisms underpinning our immune response, current approaches to cancer immunotherapy, and how tumour and host responses can circumvent effective anti-cancer immunity. The book examines recent results, publications and current areas of interest including 'immune editing' and the specific issues that are affecting the research and development of vaccines, providing insight into how these problems may be overcome, as viewed by world leaders in the field. Tumor Immunology and Immunotherapy will appeal to clinicians working in oncology and cancer immunotherapy, and research scientists including PhD and masters students, post-doctoral researchers and senior investigators.

Cancer Immunology and Immunotherapy Book

Cancer Immunology and Immunotherapy


  • Author : Glenn Dranoff
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-04-11
  • Genre: Medical
  • Pages : 306
  • ISBN 10 : 3642141366

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Cancer Immunology and Immunotherapy Book Description :

The interplay between tumors and their immunologic microenvironment is complex, difficult to decipher, but its understanding is of seminal importance for the development of novel prognostic markers and therapeutic strategies. The present review discusses tumor-immune interactions in several human cancers that illustrate various aspects of this complexity and proposes an integrated scheme of the impact of local immune reactions on clinical outcome. Current active immunotherapy trials have shown durable tumor regressions in a fraction of patients. However, clinical efficacy of current vaccines is limited, possibly because tumors skew the immune system by means of myeloid-derived suppressor cells, inflammatory type 2 T cells and regulatory T cells (Tregs), all of which prevent the generation of effector cells. To improve the clinical efficacy of cancer vaccines in patients with metastatic disease, we need to design novel and improved strategies that can boost adaptive immunity to cancer, help overcome Tregs and allow the breakdown of the immunosuppressive tumor microenvironment.

Cancer Immunotherapy Book

Cancer Immunotherapy


  • Author : Marij J.P. Welters
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-06-04
  • Genre: Medical
  • Pages : 684
  • ISBN 10 : 9780128059128

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Cancer Immunotherapy Book Description :

Immunotherapy exploits the effector mechanisms of the immune system to combat cancer. A number of immunotherapeutic compounds are now firmly anchored in current treatment of cancer patients. For newly developed therapeutic entities, the study of the patient’s immune response to treatment remains an essential component of clinical trials. Under ideal circumstances, this analysis is accomplished by various laboratory assays that measure differences in wanted and unwanted immune parameters before, during, and after treatment, at both systemic and local levels, with the ultimate aim of identifying immune correlates of biological activity as well as clinical outcome. The biomarker identification process is assisted by a harmonization of assays and data reporting, because this enables a comparison of datasets obtained by testing similar therapeutic products in different trials. Moreover, a systematic use of the datasets to better understand the strengths, weaknesses and efficacy of various treatment modalities can guide decision making with regard to further clinical development, possibly encouraging investigators to move forward into larger trials or to further optimize immunotherapeutic compounds or approach. This chapter provides an overview of immunomonitoring principles to promote the clinical development of effective immunotherapeutics for cancer treatment.

Cancer Immunotherapy Book

Cancer Immunotherapy


  • Author : Alberto Mantovani
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-06-04
  • Genre: Medical
  • Pages : 684
  • ISBN 10 : 9780128059234

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Cancer Immunotherapy Book Description :

Tumor development and progression are strongly linked to inflammation and macrophage infiltration is a major component of the inflammatory reactions associated with neoplasia. Plasticity is a hallmark of mononuclear phagocytes, which undergo polarized diverse forms of activation. Metabolic adaptation is a key component of macrophage plasticity and polarization, instrumental to their function in homeostasis, immunity and inflammation. Tumor-associated macrophages (TAM) and related immature myeloid suppressor cells generally have properties of an M2-like population. TAM produce growth factors, have immunoregulatory and immunosuppressive activity, stimulate angiogenesis and provide tissue remodeling, invasion and metastasis. Thus, TAM are a key component of cancer-promoting inflammatory reactions.

Cancer Immunotherapy Book

Cancer Immunotherapy


  • Author : Mariacristina Chioda
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-06-04
  • Genre: Medical
  • Pages : 684
  • ISBN 10 : 9780128059302

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Cancer Immunotherapy Book Description :

In higher organisms, the control of amino acid metabolism has been identified as an evolutionarily preserved strategy for limiting the expansion of actively proliferating cells, including antigen-activated T lymphocytes, and tumor cells have surreptitiously adopted it to avoid or restrain attack by the immune system. Tumor growth is often associated with an altered metabolism of the amino acid L-arginine (L-Arg) by the enzymes nitric oxide synthase (NOS) and arginase (ARG). In tumor-recruited myeloid cells or in cancerous cells the consequence of their activities causes L-Arg deprivation or release of NO, which have been shown to have profound effects directly on tumor outgrowth as well as on the regulation of antitumor T-cell-mediated immune responses. Experimental findings indicate that when either one of the two enzymes is active, the net effect on T lymphocytes can be attributed to cell cycle arrest whereas the concomitant activation of both enzymes within the same environment can lead to T-cell death by apoptosis. Moreover, an increasing amount of evidence reveals an intricate system of circuits controlling either pathway or their crosstalk in cancer and in immune cells. This highlights the broad range of cellular processes that might be affected by ARG and NOS activity. In general, immune regulation by L-Arg metabolism is not antigen specific but requires that T cells are activated through their clonotypic T-cell receptor in order to be susceptible to these inhibitory circuits. In this chapter, the main processes of tumor immunity influenced by L-Arg metabolism will be discussed, along with the description of novel compounds that can deactivate these metabolic pathways in tumor-bearing hosts and thus help to restore immune reactivity against cancer.

Cancer Immunotherapy Book

Cancer Immunotherapy


  • Author : Michele W.L. Teng
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-06-04
  • Genre: Medical
  • Pages : 684
  • ISBN 10 : 9780128059036

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Cancer Immunotherapy Book Description :

In 1957 Burnet and Thomas formulated the cancer immunosurveillance theory by hypothesizing that lymphocytes act as sentinels in recognizing and eliminating continuously arising, nascent transformed cells. Cancer immunosurveillance is one of several important host protection processes that inhibit carcinogenesis and maintain regular cellular homeostasis. More recently, it has been proposed that immunosurveillance primarily functions as a component of a more general process of cancer immunoediting, which involves three phases, elimination (surveillance), equilibrium and escape. These stages have largely been formulated on the basis of experimental data accumulated in mice over the past decade. In parallel, convincing correlative clinical data from human patients have provided unequivocal evidence that cells of the immune system, both innate and adaptive, are required for prevention of cancer. This chapter summarizes the principles of cancer immunoediting and focuses on the relevant clinical data that best support the role of immunity in cancer initiation, growth and spread.

Cancer Immunotherapy Book

Cancer Immunotherapy


  • Author : James Allison
  • Publisher : Elsevier
  • Release Date : 2006-05-19
  • Genre: Medical
  • Pages : 400
  • ISBN 10 : 9780080463377

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Cancer Immunotherapy Book Description :

For some time immunotherapy has been heralded as a breakthrough approach for cancer treatment. Although the potential of this strategy remains solid, the approach needs considerable refinement. Whilst some programmes are looking to increase the understanding of molecular and cellular mechanisms underlying the stimulation of antitumor immunity, others are trying to find the most appropriate clinical setting that will reveal the role of the immune system in combating cancer. Among the most important discoveries have been tumor-specific antigens. This thematic volume highlights some key issues and discusses where they may move forward. It has been put together by two leading cancer immunotherapists from two eminent institutions that focus on cancer research.

Cancer Immunotherapy Book

Cancer Immunotherapy


  • Author : W. Joost Lesterhuis
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-06-04
  • Genre: Medical
  • Pages : 684
  • ISBN 10 : 9780128059203

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Cancer Immunotherapy Book Description :

Studies over the past few years have caused a gestalt in thinking about chemotherapy and tumor immunity. Rather than regarding chemotherapy as an immunosuppressive inevitability, it is now recognized that chemotherapeutics can direct and amplify an immune response against cancer. In this chapter, we will review this field with emphasis on the mechanisms behind the immunopotentiating features of classic cytotoxic chemotherapeutics. We will discuss the most recent clinical translations in this field and review the current gaps in our knowledge. In addition we will outline the difficulties that lie ahead in optimally exploiting the immunopotentiating action of classical chemotherapeutics, and describe the way we think this field can move forward.

Cancer Immunotherapy Book

Cancer Immunotherapy


  • Author : Jeffrey Schlom
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-06-04
  • Genre: Medical
  • Pages : 684
  • ISBN 10 : 9780128059166

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Cancer Immunotherapy Book Description :

This article reviews progress made in the design and development of recombinant poxviral-based vaccines that express transgenes for tumor-associated antigens (TAAs) and human T-cell co-stimulatory molecules (designated TRICOM). The TRICOM vaccine platform consists of priming with a recombinant vaccinia (rV-) vector and multiple boosts with a replication defective fowlpox (rF-) vector. The rV, rF-PSA-TRICOM (PROSTVAC) has demonstrated survival benefit in randomized trials. rV, rF-CEA-MUC1-TRICOM (PANVAC) has demonstrated evidence of benefit in patients with colorectal, breast and ovarian cancers. Preclinical studies with TRICOM-based vaccines have demonstrated their ability to be used in combination with anti-CTLA4 monoclonal antibody, radiation, chemotherapeutics, and small molecule targeted therapies to enhance vaccine-mediated immune responses and antitumor activity. Randomized clinical studies have been completed, are ongoing, and are planned employing several of these TRICOM vaccine combination therapies. The importance of trial design in terms of patient population and clinical trial endpoint has been demonstrated in these studies.

Cancer Immunotherapy Book

Cancer Immunotherapy


  • Author : Saul J. Priceman
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-06-04
  • Genre: Medical
  • Pages : 684
  • ISBN 10 : 9780128059227

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Cancer Immunotherapy Book Description :

Tumor-associated immune cells, in particular myeloid cells, have opposing roles during cancer development by facilitating antitumor immune responses and driving cancer-promoting inflammation. Defective antitumor immunity is prevalent in cancers, and it is now clear that overcoming the myeloid cell-mediated immunosuppressive microenvironment poses tremendous interest for future cancer therapies. JAK/STAT signaling has come to the forefront as a crucial pathway to induce immunosuppression and procancer inflammation. Specifically, STAT3 activation is critical for the phenotype of myeloid cells by regulating immunosuppressive and prometastatic factors, thereby providing myeloid cells with a multitude of tumor-promoting functions. Genetic ablation of STAT3 in the myeloid compartment induces potent innate and adaptive antitumor immunity along with an inhibition of tumor growth and metastasis. Recently, therapeutic targeting of JAK/STAT3 has shown great promise in blocking immunosuppression in preclinical models. One such example is the use of novel siRNA to selectively target STAT3 in myeloid cells, through conjugation to CpG oligonucleotides that agonize Toll receptor TLR9 on myeloid cells. Along with other novel therapeutic strategies to inhibit JAK/STAT signaling, it seems likely that future efforts to target this pathway will be made in single and combination approaches for effective anticancer immunotherapy.

Cancer Immunotherapy Book

Cancer Immunotherapy


  • Author : Cathryn Nagler
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-06-04
  • Genre: Medical
  • Pages : 684
  • ISBN 10 : 9780128059029

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Cancer Immunotherapy Book Description :

Mucosal surfaces form the interface of the body with the external environment and play a central role in immune surveillance and protection against infection. The surface areas that comprise the mucosa are defined by the presence of a semipermeable epithelial barrier that is reinforced by a variety of innate and adaptive immune mechanisms. Large numbers of lymphocytes that reside below the epithelium serve to protect against microbial invasion and mediate immunity to disease. Mucosal surfaces are also the home of the commensal microbiome, a diverse community of bacteria that contributes to the health of the host but must also be contained and controlled by the immune system at these sites. Overall, mucosal surfaces provide an essential barrier between the host and the outside environment and are characterized by the novel adaptations required to protect this barrier.

Cancer Immunotherapy Book

Cancer Immunotherapy


  • Author : Margaret K. Callahan
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-06-04
  • Genre: Medical
  • Pages : 684
  • ISBN 10 : 9780128059159

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Cancer Immunotherapy Book Description :

Ipilimumab is the first drug to show a survival benefit for patients with advanced melanoma and was approved by the US Food and Drug Administration in March of 2011. Ipilimumab enhances antitumor immunity by enhancing T-cell function by blocking the negative regulatory molecule, cytotoxic T-lymphocyte antigen 4 (CTLA-4). Unlike traditional cancer therapy, ipilimumab’s effects may be delayed and occur after initial apparent disease progression. A distinct set of side effects have been described, and ongoing efforts continue to characterize immunologic changes associated with patients who benefit from therapy. Efforts to characterize ipilimumab’s clinical activity in malignancies other than melanoma are ongoing.

Cancer Immunotherapy Book

Cancer Immunotherapy


  • Author : Ende Zhao
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-06-04
  • Genre: Medical
  • Pages : 684
  • ISBN 10 : 9780128059067

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Cancer Immunotherapy Book Description :

As a new member of the helper T cell subsets, Th17 cells have triggered more and more interest in exploring their development, regulation, function and therapeutic manipulation in distinct context since they were identified in 2005. This also causes a lot of confusion and debate about the generation and function of Th17 cells, especially their activity in the tumor immunopathology as our understanding grows. However, it is worth asserting that the most confusing part arises from the Th17-associated cytokines including IL-17 and IL-23 rather than the Th17 cells. IL-17 cytokine is not synonymous with Th17-cell subset, although IL-17 is the lineage-signature cytokine for Th17 cells. We will discuss the generation, cytokine profile, genetic control, plasticity and stemness of Th17 cells and address the role of Th17 cells and their associated cytokines in tumor immunity, and further explore the potential immunotherapy by targeting Th17 cells and their cytokines.

Part I  Understanding Cancer Immunotherapy  A brief Review  Part II     What is Chimeric Antigen Receptor  CAR  T  Cell Therapy     An Emerging Cancer Treatment Modality  Book

Part I Understanding Cancer Immunotherapy A brief Review Part II What is Chimeric Antigen Receptor CAR T Cell Therapy An Emerging Cancer Treatment Modality


  • Author : Dr. Hakim Saboowala
  • Publisher : Dr.Hakim Saboowala
  • Release Date : 2020-05-12
  • Genre: Medical
  • Pages :
  • ISBN 10 :

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Part I Understanding Cancer Immunotherapy A brief Review Part II What is Chimeric Antigen Receptor CAR T Cell Therapy An Emerging Cancer Treatment Modality Book Description :

Part I- Understanding Cancer Immunotherapy: A brief Review. Immunotherapy, also called biologic therapy, is a type of cancer treatment that boosts the body's natural defenses to fight cancer. It uses substances made by the body or in a laboratory to improve or restore immune system function. Immunotherapy may work by: Stopping or slowing the growth of cancer cells Stopping cancer from spreading to other parts of the body Helping the immune system work better at destroying cancer cells There are several types of immunotherapy, including: Monoclonal antibodies and tumor-agnostic therapies Non-specific immunotherapies Oncolytic virus therapy T-cell therapy Cancer vaccines Part II- “What is Chimeric Antigen Receptor (CAR) T- Cell Therapy?” An Emerging Cancer Treatment Modality. Chimeric antigen receptor (CAR) T-cell therapy is an emerging cancer treatment modality in which the patients’ own immune cells are collected, genetically engineered to recognize a tumor-related target, expanded in vitro, and then reinfused to produce responses and prevent progression in a variety of malignancies (ie, adoptive cell transfer) Several types of adoptive cell transfer(ACT) are under investigation, but CAR T-cell therapy is the first to enter clinical practice. Like other technologies, CAR-T cell therapy has undergone a long development process in the past. Chimeric antigen receptor- (CAR-) T cell therapy is one of the most recent innovative immunotherapies and is rapidly evolving. At present, CAR-T cell therapy is developing rapidly, and many clinical trials have been established on a global scale, which has great commercial potential. I have endeavored to compile this E- Booklet into Two Parts i.e. Part I & Part II for better understanding of Chimeric antigen receptor (CAR) T-cell therapy, an emerging cancer treatment modality. In Part I, an effort has been made to describe Cancer Immunotherapy briefly whereas in Part II know about of CAR T-Cell Therapy-the first to enter clin

Cancer Immunotherapy Book

Cancer Immunotherapy


  • Author : David B. Teplow
  • Publisher : Academic Press
  • Release Date : 2019
  • Genre: Cancer
  • Pages : 335
  • ISBN 10 : OCLC:1112114468

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Cancer Immunotherapy Book Description :

Cancer Immunotherapy, Volume 164 in the Progress in Molecular Biology and Translational Science series, provides informative monographs on a variety of research topics related to different approaches to cancer immunotherapy, with this release focusing on TNFR2 in cancer immunology and immunotherapy, From the Hellstrom paradox towards cancer cure, CAR T-cell treatment of T-cell malignancy, Immunotherapy of pancreatic cancer, Cancer stem cell immunology/immunotherapy, Cytokine release syndrome, Tumor cell-based mechanisms of resistance to immune attack, and Mushroom compounds in cancer immunotherapy. --