Cancer Stem Cells Book

Cancer Stem Cells


  • Author : Huiping Liu
  • Publisher : Elsevier
  • Release Date : 2016-08-16
  • Genre: Science
  • Pages : 542
  • ISBN 10 : 9780128039342

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Cancer Stem Cells Excerpt :

Cancer Stem Cells: Targeting the Roots of Cancer, Seeds of Metastasis, and Sources of Therapy Resistance introduces the basic concepts and advanced understanding of cancer stem cells, covering general overviews, organ-specific identifications, and their characteristic mechanisms. The book also explores innovative therapeutic strategies in preclinical and clinical trials to target cancer stem cells, remove the roots of cancer, eliminate the seeds of metastasis, overcome the resistance of therapies, and contribute to the eradication of cancer. The book includes contributions from leading, worldwide experts in the field, helping readers embrace new hope in their quest to eradicate cancer with emerging clinical trials on treating cancer stem cells in combination with other therapies. Provides an authoritative and complete overview of cancer stem cells Includes comprehensive coverage of current therapeutic strategies targeting cancer stem cells Deepens a reader’s technical expertise in cancer stem cell biology

Cancer Stem Cells Book

Cancer Stem Cells


  • Author : Lucie Laplane
  • Publisher : Harvard University Press
  • Release Date : 2016-06-06
  • Genre: Medical
  • Pages : 252
  • ISBN 10 : 9780674088740

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Cancer Stem Cells Excerpt :

A new therapeutic strategy could break the stalemate in the war on cancer by targeting not all cancerous cells but the small fraction that lie at the root of cancers. Lucie Laplane offers a comprehensive analysis of cancer stem cell theory, based on an original interdisciplinary approach that combines biology, biomedical history, and philosophy.

Cancer Stem Cells Book

Cancer Stem Cells


  • Author : Vinagolu K. Rajasekhar
  • Publisher : John Wiley & Sons
  • Release Date : 2014-01-27
  • Genre: Science
  • Pages : 552
  • ISBN 10 : 9781118356173

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Cancer Stem Cells Excerpt :

Cancer Stem Cells covers a wide range of topics incancer stem cell biology, including the functional characteristicsof cancer stem cells and how they're generated, where they arelocalized, the means by which cancer stem cells can be targeted,and how cancer stem cells can be reprogrammed back to normal tissuestem cells. Each chapter begins with a brief historical note andconcept summary, followed by a description of the latest basic orclinical advance associated with the topic. Cancer Stem Cells builds systematically fromcoverage of the basic research stage to an advanced research level,from clinical relevance to therapeutic potential, and will be avaluable resource for professionals in the fields of cancerresearch and stem cell biology.

Cancer Stem Cells  New Horizons in Cancer Therapies Book

Cancer Stem Cells New Horizons in Cancer Therapies


  • Author : Surajit Pathak
  • Publisher : Springer Nature
  • Release Date : 2020-10-17
  • Genre: Medical
  • Pages : 369
  • ISBN 10 : 9789811551208

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Cancer Stem Cells New Horizons in Cancer Therapies Excerpt :

This book discusses the recent developments in the therapeutic implications of cancer stem cells for the effective diagnosis, prognosis, and treatment of cancer. It summarizes the various stem cells of common cancers including colon, pancreas, lungs, prostate, melanoma, and glioblastoma, and reviews the potential role of cancer stem cells in tissue aggressiveness, examining the functional contribution of cancer stem cells in the establishment and recurrence of cancerous tumors. Further, it explores the potential of cancer stem cells as novel therapeutic targets for the treatment and prevention of tumor progression. The book also discusses the various approaches for detecting, isolating, and characterizing different cancer stem cells and signaling pathways that control their replication, survival, and differentiation. Lastly, it explores the key features and mechanisms of drug resistance, chemo-resistance, and radio-resistance in cancer stem cells to improve therapeutic rationale.

Role of Cancer Stem Cells in Cancer Biology and Therapy Book

Role of Cancer Stem Cells in Cancer Biology and Therapy


  • Author : Thomas Dittmar
  • Publisher : CRC Press
  • Release Date : 2016-04-19
  • Genre: Medical
  • Pages : 332
  • ISBN 10 : 9781466577367

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Role of Cancer Stem Cells in Cancer Biology and Therapy Excerpt :

This book summarizes the latest findings about the role of cancer stem cells (CSCs) in cancer biology and how this knowledge could be used for novel anticancer therapies. It provides an overview of CSCs in selected malignancies with particular emphasis on hematopoietic neoplasias. It then reviews the role of CSCs in metastasis formation and initiation of cancer relapses. It also examines the dark side of cancer therapy such as conventional cancer therapies that may lead to the origin of recurrence CSCs. Finally, it supplies a brief overview of current concepts that may allow for a selective eradication of CSCs.

The Cancer Stem Cell Niche Book

The Cancer Stem Cell Niche


  • Author : Susie Prof. Nilsson
  • Publisher : Academic Press
  • Release Date : 2021-01-23
  • Genre: Science
  • Pages : 246
  • ISBN 10 : 9780323853262

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The Cancer Stem Cell Niche Excerpt :

The Cancer Stem Cell Niche, Volume Five in the Advances in Stem Cells and their Niches series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Acute lymphoblastic leukemia and the bone marrow microenvironment, Stem cell niches in bone and their roles in cancer metastasis, The role of vasculature in cancer stem cell niches, The lung cancer stem cell niche, The prostate cancer stem cell niche: Genetic drivers and therapeutic approaches, Impact of prostate cancer stem cell niches on prostate cancer tumorigenesis and progression, The testicular cancer stem cell niche. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Advances in Stem Cells and their Niches series Includes the latest information on the Cancer Stem Cell Niche

Principles of Stem Cell Biology and Cancer Book

Principles of Stem Cell Biology and Cancer


  • Author : Tarik Regad
  • Publisher : John Wiley & Sons
  • Release Date : 2015-05-06
  • Genre: HEALTH & FITNESS
  • Pages : 376
  • ISBN 10 : 9781118670620

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Principles of Stem Cell Biology and Cancer Excerpt :

Principles of Stem Cell Biology and Cancer: Future Applications and Therapeutics Tarik Regad, The John van Geest Cancer Research Centre, Nottingham Trent University, UK, Thomas J. Sayers, Centre for Cancer Research, National Cancer Institute, Frederick, USA and Robert Rees The John van Geest Cancer Research Centre, Nottingham Trent University, UK The field of cancer stem cells is expanding rapidly, with many groups focusing on isolating and identifying cancer stem cell populations. Although some progress has been made developing efficient cancer therapies, targeting cancer stem cells remains one of the important challenges facing the growing stem cell research community. Principles of Stem Cell Biology and Cancer brings together original contributions from international experts in the field to present the very latest information linking stem cell biology and cancer. Divided into two parts, the book begins with a detailed introduction to stem cell biology with a focus on the characterization of these cells, progress that has been made in their identification, as well as future therapeutic applications of stem cells. The second part focuses on cancer stem cells and their role in cancer development, progression and chemo-resistance. This section of the book includes an overview of recent progress concerning therapies targeting cancer stem cells. Features: An authoritative introduction to the link between stem cell biology and cancer. Includes contributions from leading international experts in the field. Well-illustrated with full colour figures throughout. This book will prove an invaluable resource for basic and applied researchers and clinicians working on the development of new cancer treatments and therapies, providing a timely publication of high quality reviews outlining the current progress and exciting future possibilities for stem cell research.

Advances in Cancer Stem Cell Biology Book

Advances in Cancer Stem Cell Biology


  • Author : Roberto Scatena
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-10-06
  • Genre: Medical
  • Pages : 343
  • ISBN 10 : 1461408091

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Advances in Cancer Stem Cell Biology Excerpt :

In recent years, cancer stem cells have been recognized as important component in carcinogenesis and they seem to form the basis of many (if not all) tumor types. Cancer stem cells or "cancer cell like stem cells" have been isolated from various cancers of different origin (blood, breast, brain, skin, head and neck, thyroid, cervix, lung, retina, colon, pancreas and so on). Cancer stem cells - rare cells with indefinite proliferative potential that drive the formation and growth of tumours- seem to show intriguing relationships with physiological stem cells. Specifically, these cancer cells show significant similarities in the mechanisms that regulate self-renewal of normal stem cells. Moreover, tumour cells might directly arise from normal stem cells. Further, the cellular biology of cancer stem cells show a lot of similarities with normal stem cells.

The Heterogeneity of Cancer Metabolism Book

The Heterogeneity of Cancer Metabolism


  • Author : Anne Le
  • Publisher : Springer
  • Release Date : 2018-06-26
  • Genre: Medical
  • Pages : 183
  • ISBN 10 : 9783319777368

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The Heterogeneity of Cancer Metabolism Excerpt :

Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

Stem Cells and Cancer in Hepatology Book

Stem Cells and Cancer in Hepatology


  • Author : Yun-Wen Zheng
  • Publisher : Academic Press
  • Release Date : 2018-05-18
  • Genre: Science
  • Pages : 382
  • ISBN 10 : 9780128123027

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Stem Cells and Cancer in Hepatology Excerpt :

Stem Cells and Cancer in Hepatology: From the Essentials to Application offers basic scientists and clinicians in the fields of stem cells, hepatology and oncology an overview of the interaction between liver biology, stem cells and cancer. It discusses how the liver performs regeneration and repair, the role stem cells play in these processes, and the mechanisms by which liver cancers are initiated and developed. As the field of stem cells and cancer stem cells in hepatology is new and dynamic, thus making it difficult for researchers and clinicians to understand the most relevant historic and novel studies, this volume addresses that challenge. Addresses both the basic and clinical perspectives of the topic, including sections on normal and cancer stem cells of the liver Provides coverage of the molecular mechanisms of liver development, the proliferation of hepatic progenitor cells during development, epithelial cell plasticity, generation of hepatocytes by transdifferentiation, liver tissue engineering, and more Presents a study of hepatic stem cells that will help readers understand critical events during development, stem cell differentiation towards functional liver cell fate, and tumor initiation

Cancer Stem Cells in Solid Tumors Book
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Cancer Stem Cells in Solid Tumors


  • Author : Alison L. Allan
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-08-12
  • Genre: Science
  • Pages : 478
  • ISBN 10 : 9781617792465

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Cancer Stem Cells in Solid Tumors Excerpt :

The “cancer stem cell” hypothesis postulates that cancer arises from a subpopulation of tumor-initiating cells or cancer stem cells (CSCs). While the idea of cancer stem cells has been around for more than a hundred years, evidence from the fields of hematology and cancer biology has now demonstrated the critical role of stem cells in hematological malignancies and suggested that these same mechanisms are also central to the initiation, progression, and treatment of solid cancers. Clinical and experimental studies have shown that CSCs exhibit many classical properties of normal stem cells, including a high self-renewal capacity and the ability to generate heterogeneous lineages; the requirement for a specific “niche”/microenvironment to grow; and an increased capacity for self-protection against harsh environments, toxins, and drugs. Cancer Stem Cells in Solid Tumors represents a detailed overview of cancer stem cells and their role in solid cancers. Comprised of 24 chapters, this volume will provide readers with a comprehensive understanding of this important and evolving field. Topics covered include: Introduction of the CSC hypothesis Historical perspectives and the contributing lessons from leukemia Current knowledge regarding the identification and role of CSCs in various forms of solid cancer including breast, brain, colorectal, pancreatic, prostate, melanoma, lung, ovarian, hepatocellular, and head and neck cancer Molecular pathways involved in driving CSC function, with a particular focus on the novel convergence of embryonic and tumorigenic signaling pathways In vitro and in vivo assays, model systems, and imaging modalities for studying CSCs The clinical importance of CSCs for cancer management and treatment, including important implications for prognosis, prediction, and treatment resistance Consideration of the controversy surrounding the CSC hypothesis and important unanswered questions in this field This collective work was written by a group o

Stem Cells     From Hype to Real Hope Book

Stem Cells From Hype to Real Hope


  • Author : Khawaja Husnain Haider
  • Publisher : Walter de Gruyter GmbH & Co KG
  • Release Date : 2018-12-17
  • Genre: Medical
  • Pages : 220
  • ISBN 10 : 9783110586916

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Stem Cells From Hype to Real Hope Excerpt :

This book is a compilation of the bench experience of leading experts from various research labs involved in the cutting edge area of research. The authors describe the use of stem cells both as part of the combinatorial therapeutic intervention approach and as tools (disease model) during drug development, highlighting the shift from a conventional symptomatic treatment strategy to addressing the root cause of the disease process. The book is a continuum of the previously published book entitled "Stem Cells: from Drug to Drug Discovery" which was published in 2017.

Prominin 1  CD133   New Insights on Stem   Cancer Stem Cell Biology Book

Prominin 1 CD133 New Insights on Stem Cancer Stem Cell Biology


  • Author : Denis Corbeil
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-11-19
  • Genre: Medical
  • Pages : 252
  • ISBN 10 : 9781461458944

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Prominin 1 CD133 New Insights on Stem Cancer Stem Cell Biology Excerpt :

​​​​​​​Prominin-1 or otherwise known as CD133 is a glycoprotein that is present in humans and mice. Since the first description of prominin in 1997, in mouse neuroepithelial cells and in human hematopoietic stem cells as AC133 antigen, this molecule has aroused a large interest especially, as a stem cell marker, that gave rise to an ever growing body of publications and more recently its expression in cancer stem cells. Controversies as to its role as a cancer stem and its detection in different models, as well as its use as a prognostic marker have emerged. Yet, beyond its use as a stem cell and cancer stem cell marker, prominin-1/CD133 displays unique biological features and appears of importance in other processes like for example in retinal biogenesis. Indeed, this five-transmembrane plasma membrane glycoprotein, which marks membrane protrusions is associated with several essential processes like cell polarity, asymmetric cell division and membrane remodeling. We propose to review current knowledge about this intriguing molecule and present pertinent information to determine the biological role of prominins and assess their importance in medicine and cancer research. The primary audience for this book is geared towards scientists and researchers with interest in cancer stem cells, stem cells, cell biology, neurobiology, and regenerative medicine.

Stem Cells and Cancer Stem Cells  Volume 4 Book

Stem Cells and Cancer Stem Cells Volume 4


  • Author : M.A. Hayat
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-02-07
  • Genre: Medical
  • Pages : 319
  • ISBN 10 : 9789400728288

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Stem Cells and Cancer Stem Cells Volume 4 Excerpt :

Vast therapeutic applications of the following specific stem cells in disease and tissue injury are discussed: embryonic stem cells, induced pluripotent stem cells, human hair follicle stem cells, bone marrow-derived human mesenchymal stem cells, adipose-derived stem cells, periodontal/progenitor cells, cancer stem cells, and breast cancer stem cells. Because human embryonic stem cells possess the potential to produce unlimited quantities of any human cell type, considerable focus is placed on this type of stem cells in this volume. The role of cancer stem cells, specifically in breast cancer is explained. Transplantation of mesenchymal stem cells to aid the injured brain is included. Immune recovery after stem cells transplantation in severe combined immunodeficiency patients is described. The role of mesenchymal stem cells in enhancing the growth and metastasis of colon cancer is discussed. Clinical application of human follicle stem cells is presented. Treatment of malignant gliomas using genetically-modified neural stem cells as a marker is discussed. The impact of cancer stem cell hypothesis on designing new cancer therapies is explained. In the field of regenerative medicine, the use of stem cells in the repair of the central nervous system, tendon injury, and as a cardiac regenerative medicine is described. The role of DNA methylation in maintaining stemness induced pluripotent stem cells from human extraembryonic amnion cells is discussed. Insights on the understanding of molecular pathways involved in tumor biology are explained, which lead to the development of effective drugs. Information on pathways, such as hedgehog, facilitates targeted therapies in cancer.