Carbonic Anhydrases as Biocatalysts Book

Carbonic Anhydrases as Biocatalysts


  • Author : Claudiu T Supuran
  • Publisher : Elsevier
  • Release Date : 2015-01-14
  • Genre: Technology & Engineering
  • Pages : 398
  • ISBN 10 : 9780444632630

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Carbonic Anhydrases as Biocatalysts Excerpt :

Carbonic anhydrases (CAs, EC 4.2.1.1) are ubiquitous metalloenzymes, present throughout most living organisms and encoded by five evolutionarily unrelated gene families. The Carbonic Anhydrases as Biocatalysts: From Theory to Medical and Industrial Applications presents information on the growing interest in the study of this enzyme family and their applications to both medicine and biotechnology. Offers comprehensive coverage of the carbonic anhydrases enzyme family and their properties as biocatalysts Includes current applications of carbonic anhydrases in biotechnology on the basis of their catalytic efficiency, including new technologies for CO2 capture processes Identifies new targets for drug design studies Provides a selectivity profile for the different carbonic anhydrases and their related biomedical applications

Carbonic Anhydrases Book

Carbonic Anhydrases


  • Author : Claudiu T. Supuran
  • Publisher : Academic Press
  • Release Date : 2019-07-17
  • Genre: Science
  • Pages : 560
  • ISBN 10 : 9780128167458

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Carbonic Anhydrases Excerpt :

Carbonic Anhydrases provides an interdisciplinary review of the burgeoning carbonic anhydrase (CA) research area, spanning from CAs classification (biochemical and structural features) to drug design and pharmacology of CA inhibitors and activators, finally touching on the biotechnological applications of these metalloenzymes. The book adopts a clear step-by-step approach and introduction to this intricate and highly interdisciplinary field. A diverse range of chapters from international experts speak to CA classification and distribution, the mechanisms of action and drug design of inhibitors and activators, the druggability of the various isoforms in the treatment of a multitude of diseases, and threats to human health. Carbonic Anhydrases provides biology, biochemistry, and medicinal chemistry students and researchers a thorough discussion and update on the evergreen and expanding research area of CAs. Offers a full overview of CAs’ biochemical and structural features, as well as drug design and pharmacology of inhibitors and activators Provides a thorough update on the newly identified isoforms, modulating chemotypes, and innovative biomedical applications Describes the current biotechnological applications of CAs, including processes for CO2 capture Features chapter contributions from international leaders in CA biology, medicinal chemistry, and pharmacology

Carbonic Anhydrases and Metabolism Book

Carbonic Anhydrases and Metabolism


  • Author : Claudiu T. Supuran
  • Publisher : MDPI
  • Release Date : 2019-04-08
  • Genre: Science
  • Pages : 184
  • ISBN 10 : 9783038978008

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Carbonic Anhydrases and Metabolism Excerpt :

Carbonic anhydrases (CAs; EC 4.2.1.1) are metalloenzymes present in all kingdoms of life, as they equilibrate the reaction between three simple but essential chemical species: CO2, bicarbonate, and protons. Discovered more than 80 years ago, in 1933, these enzymes have been extensively investigated due to the biomedical application of their inhibitors, but also because they are an extraordinary example of convergent evolution, with seven genetically distinct CA families that evolved independently in Bacteria, Archaea, and Eukarya. CAs are also among the most efficient enzymes known in nature, due to the fact that the uncatalyzed hydration of CO2 is a very slow process and the physiological demands for its conversion to ionic, soluble species is very high. Inhibition of the CAs has pharmacological applications in many fields, such as antiglaucoma, anticonvulsant, antiobesity, and anticancer agents/diagnostic tools, but is also emerging for designing anti-infectives, i.e., antifungal, antibacterial, and antiprotozoan agents with a novel mechanism of action. Mitochondrial CAs are implicated in de novo lipogenesis, and thus selective inhibitors of such enzymes may be useful for the development of new antiobesity drugs. As tumor metabolism is diverse compared to that of normal cells, ultimately, relevant contributions on the role of the tumor-associated isoforms CA IX and XII in these phenomena have been published and the two isoforms have been validated as novel antitumor/antimetastatic drug targets, with antibodies and small-molecule inhibitors in various stages of clinical development. CAs also play a crucial role in other metabolic processes connected with urea biosynthesis, gluconeogenesis, and so on, since many carboxylation reactions catalyzed by acetyl-coenzyme A carboxylase or pyruvate carboxylase use bicarbonate, not CO2, as a substrate. In organisms other than mammals, e.g., plants, algae, and cyanobacteria, CAs are involved in photosynthesis, whereas in many

The Carbonic Anhydrases  Current and Emerging Therapeutic Targets Book

The Carbonic Anhydrases Current and Emerging Therapeutic Targets


  • Author : W. Richard Chegwidden
  • Publisher : Springer Nature
  • Release Date : 2021-12-01
  • Genre: Medical
  • Pages : 288
  • ISBN 10 : 9783030795115

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The Carbonic Anhydrases Current and Emerging Therapeutic Targets Excerpt :

This volume assembles and integrates the wealth of diverse information that is now accumulating in this burgeoning field. The existing and potential therapeutic applications of targeting CA cover a remarkably wide-range of diseases and disorders and have generated increasing and extensive interest in recent years. Its inter-disciplinary approach embraces both the most up-to-date therapeutic application of CA-targeting and the latest research data that will provide a platform for the development of novel applications. The interested audience comprises scientists and clinicians from many relevant disciplines within science and medicine.

Antiprotozoal Drug Development and Delivery Book

Antiprotozoal Drug Development and Delivery


  • Author : Alane Beatriz Vermelho
  • Publisher : Springer Nature
  • Release Date : 2022-06-24
  • Genre: Science
  • Pages : 331
  • ISBN 10 : 9783031068508

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Antiprotozoal Drug Development and Delivery Excerpt :

This book reviews new promising drug targets for Neglected Tropical Diseases (NTDs), with a special focus on antiprotozoal drugs against trpyanosomatids Trypanosoma cruzi and Leishmania spp. The book offers a comprehensive overview of the most recent studied targets, and it outlines classical and new treatments and delivery strategies. Expert contributors describe new methods of analysis and bio-prospecting for new compounds, and provide a critical perspective of the translational process used in the research and development of new drug candidates. The book will appeal not only to researchers, students and professionals interested in drug development to protozoan diseases, but also to medicinal chemists in general.

Neutron Crystallography in Structural Biology Book

Neutron Crystallography in Structural Biology


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2020-02-22
  • Genre: Science
  • Pages : 408
  • ISBN 10 : 9780128192153

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Neutron Crystallography in Structural Biology Excerpt :

Neutron Crystallography in Structural Biology, Volume 634, the latest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this updated release include Fundamentals of neutron crystallography in structural biology, Large crystal growth for neutron protein crystallography, Prospects for membrane protein crystals in NMX, IMAGINE: The neutron protein crystallography beamline at the high flux isotope reactor, The macromolecular neutron diffractometer at the spallation neutron source, Current status and near future plan of neutron protein crystallography at J-PARC, Neutron macromolecular crystallography at the European spallation source, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series Includes the latest information on neutron crystallography in structural biology

Biocatalysis for Practitioners Book

Biocatalysis for Practitioners


  • Author : Gonzalo de Gonzalo
  • Publisher : John Wiley & Sons
  • Release Date : 2021-04-13
  • Genre: Science
  • Pages : 528
  • ISBN 10 : 9783527824458

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Biocatalysis for Practitioners Excerpt :

This reference book originates from the interdisciplinary research cooperation between academia and industry. In three distinct parts, latest results from basic research on stable enzymes are explained and brought into context with possible industrial applications. Downstream processing technology as well as biocatalytic and biotechnological production processes from global players display the enormous potential of biocatalysts. Application of "extreme" reaction conditions (i.e. unconventional, such as high temperature, pressure, and pH value) - biocatalysts are normally used within a well defined process window - leads to novel synthetic effects. Both novel enzyme systems and the synthetic routes in which they can be applied are made accessible to the reader. In addition, the complementary innovative process technology under unconventional conditions is highlighted by latest examples from biotech industry.

Industrial Biocatalysis Book

Industrial Biocatalysis


  • Author : Peter Grunwald
  • Publisher : CRC Press
  • Release Date : 2014-12-11
  • Genre: Medical
  • Pages : 1232
  • ISBN 10 : 9789814463898

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Industrial Biocatalysis Excerpt :

Biocatalysis has become an essential tool in the chemical industry and is the core of industrial biotechnology, also known as white biotechnology, making use of biocatalysts in terms of enzymes or whole cells in chemical processes as an alternative to chemical catalysts. This shift can be seen in the many areas of daily life where biocatalysts—with their environmentally friendly properties—are currently employed. Drivers are the big societal challenges resulting from concerns about the global climate change and the need for an assured energy supply. Modern biocatalysis relies to a large extent on the tremendous advances in the so-called omics techniques and the structural elucidation of biomolecules, which have led to synthetic biology and metabolic engineering as new research fields with high application potential for the rational design of enzymes and microbial production strains. In this book, renowned scientists discuss the actual developments in these research fields together with a variety of application-oriented topics.

Immobilized Biocatalysts Book

Immobilized Biocatalysts


  • Author : Peter Grunwald
  • Publisher : MDPI
  • Release Date : 2018-11-14
  • Genre: Electronic books
  • Pages : 511
  • ISBN 10 : 9783038973188

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Immobilized Biocatalysts Excerpt :

This book is a printed edition of the Special Issue "Immobilized Biocatalysts" that was published in Catalysts

Modern Biocatalysis Book

Modern Biocatalysis


  • Author : Gavin Williams
  • Publisher : Royal Society of Chemistry
  • Release Date : 2018-05-31
  • Genre: Science
  • Pages : 574
  • ISBN 10 : 9781782627265

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Modern Biocatalysis Excerpt :

The synergy between synthetic biology and biocatalysis is emerging as an important trend for future sustainable processes. This book reviews all modern and novel techniques successfully implemented in biocatalysis, in an effort to provide better performing enzymatic systems and novel biosynthetic routes to (non-)natural products. This includes the use of molecular techniques in protein design and engineering, construction of artificial metabolic pathways, and application of computational methods for enzyme discovery and design. Stress is placed on current 'hot' topics in biocatalysis, where recent advances in research are defining new grounds in enzyme-catalyzed processes. With contributions from leading academics around the world, this book makes a ground-breaking contribution to this progressive field and is essential reading for graduates and researchers investigating (bio)catalysis, enzyme engineering, chemical biology, and synthetic biology.

Novel Materials for Carbon Dioxide Mitigation Technology Book

Novel Materials for Carbon Dioxide Mitigation Technology


  • Author : Bryan Morreale
  • Publisher : Elsevier
  • Release Date : 2015-06-01
  • Genre: Science
  • Pages : 414
  • ISBN 10 : 9780444632616

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Novel Materials for Carbon Dioxide Mitigation Technology Excerpt :

Materials for Carbon Dioxide Mitigation Technology offers expert insight and experience from recognized authorities in advanced material development in carbon mitigation technology and constitutes a comprehensive guide to the selection and design of a wide range of solvent/sorbent/catalyst used by scientists globally. It appeals to chemical scientists, material scientists and engineers, energy researchers, and environmental scientists from academia, industry, and government in their research directed toward greener, more efficient carbon mitigation processes. Emphasizes material development for carbon mitigation technologies rather than regulations Provides a fundamental understanding of the underpinning science as well as technological approaches to implement carbon capture, utilization and storage technologies Introduces the driving force behind novel materials, their performance and applications for carbon dioxide mitigation Contains figures, tables and an abundance of examples clearly explaining the development, characterization and evaluation of novel carbon mitigation materials Includes hundreds of citations drawing on the most recent published works on the subject Provides a wealth of real-world examples, illustrating how to bridge nano-scale materials to bulk carbon mitigation properties

Biocatalysis Book

Biocatalysis


  • Author : Gonzalo de Gonzalo
  • Publisher : Royal Society of Chemistry
  • Release Date : 2017-11-02
  • Genre: Science
  • Pages : 532
  • ISBN 10 : 9781782626190

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Biocatalysis Excerpt :

Implementing biocatalytic strategies in an industrial setting is a challenging task, especially when commercial scale necessitates a balance between industrial need and economic viability. With invited contributions from a wide range of chemical and pharmaceutical companies, this book bridges the gap between academia and industry. Contributors discuss current processes, types of biocatalysts and improvements, industrial motivation and the key aspects needed for economic success. Focussing on industry related issues, this book will be a useful tool for future research by both practitioners and academics.

Essentials of Chemical Biology Book

Essentials of Chemical Biology


  • Author : Andrew D. Miller
  • Publisher : John Wiley & Sons
  • Release Date : 2013-05-03
  • Genre: Science
  • Pages : 592
  • ISBN 10 : 9781118687833

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Essentials of Chemical Biology Excerpt :

“This excellent work fills the need for an upper-level graduate course resource that examines the latest biochemical, biophysical, and molecular biological methods for analyzing the structures and physical properties of biomolecules... This reviewer showed [the book] to several of his senior graduate students, and they unanimously gave the book rave reviews. Summing Up: Highly recommended...” CHOICE Chemical biology is a rapidly developing branch of chemistry, which sets out to understand the way biology works at the molecular level. Fundamental to chemical biology is a detailed understanding of the syntheses, structures and behaviours of biological macromolecules and macromolecular lipid assemblies that together represent the primary constituents of all cells and all organisms. The subject area of chemical biology bridges many different disciplines and is fast becoming an integral part of academic and commercial research. This textbook is designed specifically as a key teaching resource for chemical biology that is intended to build on foundations lain down by introductory physical and organic chemistry courses. This book is an invaluable text for advanced undergraduates taking biological, bioorganic, organic and structural chemistry courses. It is also of interest to biochemists and molecular biologists, as well as professionals within the medical and pharmaceutical industry. Key Features: A comprehensive introduction to this dynamic area of chemistry, which will equip chemists for the task of understanding and studying the underlying principles behind the functioning of biological macro molecules, macromolecular lipid assemblies and cells. Covers many basic concepts and ideas associated with the study of the interface between chemistry and biology. Includes pedagogical features such as: key examples, glossary of equations, further reading and links to websites. Clearly written and richly illustrated in full colour.

Biocatalysis in Green Solvents Book

Biocatalysis in Green Solvents


  • Author : Pedro Lozano
  • Publisher : Academic Press
  • Release Date : 2022-08-02
  • Genre: Science
  • Pages : 562
  • ISBN 10 : 9780323914253

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Biocatalysis in Green Solvents Excerpt :

Biocatalysis in Green Solvents offers a pragmatic overview and instruction in biocatalysis and enzymology of green solvents for sustainable industries and medicine, running from concept to application. Here, international experts in the field discuss structure-function relationships of enzymes in ionic liquids (ILs) and examine how enzymes act as selective catalysts for fine biochemical synthesis in non-aqueous environments. Several integral green biochemical processes of biocatalytic transformation and pure product separation are described in detail. Application focused chapters discuss the role of biocatalysis in creating and implementing deep eutectic solvents, biomass derived solvents, sub and supercritical fluids, carbon dioxide biphasic systems, and enzymatic membrane reactors, as well as applying these biocatalytic processes in drug discovery and production. Examines the structure-function relationships of enzymes in ionic liquids and biocatalytic processes for various applications across industry and medicine Includes clear instruction in core green biochemical processes—of (bio)catalytic transformation—and pure product separation Features chapter contributions from international experts across academia and industry