Cell Death Signaling in Cancer Biology and Treatment Book

Cell Death Signaling in Cancer Biology and Treatment


  • Author : Daniel Johnson
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-11-19
  • Genre: Science
  • Pages : 408
  • ISBN 10 : 9781461458470

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Cell Death Signaling in Cancer Biology and Treatment Excerpt :

A key goal in the treatment of cancer is to achieve selective and efficient killing of tumor cells. The aim of Cell Death Signaling in Cancer Biology and Treatment is to describe state-of-the-art approaches and future opportunities for achieving this goal by targeting mechanisms and pathways that regulate cancer cell death. In this book, molecular defects in cell death signaling that characterize cancer cells, including dysregulation of cell death due to overexpression/hyperactivation of oncoproteins, as well as the loss of tumor suppressor proteins will be described. The potential for targeting microRNAs will be discussed. Multiple chapters will describe preclinical and clinical approaches that are currently being used to target epigenetic modifications, DNA repair pathways, and protein chaperones, as a means of provoking tumor cell death. Finally, the development and application of novel agents and approaches for targeting specific components of cell death signaling pathways and machinery will be reviewed.

Mechanisms of Cell Death and Opportunities for Therapeutic Development Book

Mechanisms of Cell Death and Opportunities for Therapeutic Development


  • Author : Diaqing Liao
  • Publisher : Academic Press
  • Release Date : 2021-10-26
  • Genre: Science
  • Pages : 296
  • ISBN 10 : 9780128142097

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Mechanisms of Cell Death and Opportunities for Therapeutic Development Excerpt :

Mechanisms of Cell Death and Opportunities for Therapeutic Development, volume four in the Perspectives in Translational Cell Biology series, offers content for professors, students and researchers across basic and translational biology. The book covers fundamental mechanisms, ranging from different forms of cell death and drug development, to efforts for treating disease, providing a valuable resource for readers interested in understanding cell death and relevant translational research. The book's editor, Diaqing Liao, has over twenty years’ experience teaching topics of cell death. Provides a comprehensive overview of current knowledge on the process of apoptosis, its potential role in health and disease, and a discussion of potential alternative forms, such as autophagy Covers fundamental mechanisms and relevant translational research

Apoptosis and Cancer Book

Apoptosis and Cancer


  • Author : Seamus J. Martin
  • Publisher : S Karger Ag
  • Release Date : 1997-01-01
  • Genre: Health & Fitness
  • Pages : 265
  • ISBN 10 : 3805565798

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Apoptosis and Cancer Excerpt :

Apoptosis and Cancer is an up-to-date overview of our understanding of apoptosis and how it effects cancer development and cancer treatment. Written by leading researchers in the field of apoptosis, this book provides an extremely valuable reference for those already familiar with apoptosis as well as a jumping-off point for those new to the field. It will appeal to scientists interested in mechanisms of cell transformation that lead to cancer and to oncologists interested in investigating and understanding new cancer therapies.

Autophagy in tumor and tumor microenvironment Book

Autophagy in tumor and tumor microenvironment


  • Author : Sujit Kumar Bhutia
  • Publisher : Springer Nature
  • Release Date : 2020-10-24
  • Genre: Medical
  • Pages : 280
  • ISBN 10 : 9789811569302

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Autophagy in tumor and tumor microenvironment Excerpt :

This book deals with the paradoxical role of autophagy in tumor suppression and tumor promotion in cancer cells. Autophagy plays opposing, context-dependent roles in tumors; accordingly, strategies based on inhibiting or stimulating autophagy could offer as potential cancer therapies. The book elucidates the physiological role of autophagy in modulating cancer metastasis, which is the primary cause of cancer-associated mortality. Further, it reviews its role in the differentiation, development, and activation of multiple immune cells, and its potential applications in tumor immunotherapy. In addition, it examines the effect of epigenetic modifications of autophagy-associated genes in regulating tumor growth and therapeutic response and summarizes autophagy’s role in the development of resistance to a variety of anti-cancer drugs in cancer cells. In closing, it assesses autophagy as a potential therapeutic target for cancer treatment. Given its scope, the book offers a valuable asset for all oncologists and researchers who wish to understand the potential role of autophagy in tumor biology.

The Molecular Biology of Cancer Book

The Molecular Biology of Cancer


  • Author : Stella Pelengaris
  • Publisher : John Wiley & Sons
  • Release Date : 2013-03-13
  • Genre: Science
  • Pages : 632
  • ISBN 10 : 9781118430859

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The Molecular Biology of Cancer Excerpt :

The Molecular Biology of Cancer, Stella Pelengaris& Michael Khan This capturing, comprehensive text, extensively revisedand updated for its second edition, provides a detailed overview ofthe molecular mechanisms underpinning the development of cancer andits treatment. “Bench to Bedside”: A key strength of thisbook that sets it apart from general cancer biology references isthe interweaving of all aspects of cancer biology from the causes,development and diagnosis through to the treatment and care ofcancer patients – essential for providing a broader view ofcancer and its impact. The highly readable presentation of a complex field,written by an international panel of researchers, specialists andpractitioners, would provide an excellent text for graduate andundergraduate courses in the biology of cancer, medical studentsand qualified practitioners in the field preparing for higherexams, and for researchers and teachers in the field. For the teaching of cancer biology, special features havebeen included to facilitate this use: bullet points at thebeginning of each chapter explaining key concepts and controversialareas; each chapter builds on concepts learned in previouschapters, with a list of key outstanding questions remaining in thefield, suggestions for further reading, and questions for studentreview. All chapters contain text boxes that provide additional andrelevant information. Key highlights are listed below: An overview of the cancer cell and important newconcepts. Selected human cancers: lung, breast, colorectal, prostate,renal, skin, cervix, and hematological malignancies. Key cellular processes in cancer biology including (a)traditionally important areas such as cell cycle control, growthregulation, oncogenes and tumour suppressors apoptosis, as well as(b) more highly topical areas of apoptosis, telomeres, DNA damageand repair, cell adhesion, angiogenesis, immunity, epigenetics, andthe proteasome. Clinical oncology: In-depth coverage of important con

Cell Death Regulation in Health and Disease   Part B Book

Cell Death Regulation in Health and Disease Part B


  • Author : Johan K. E. Spetz
  • Publisher : Academic Press
  • Release Date : 2020-05
  • Genre: Uncategoriezed
  • Pages : 277
  • ISBN 10 : 9780128199299

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Cell Death Regulation in Health and Disease Part B Excerpt :

Cell Death Regulation in Health and Disease - Part B, Volume 352, the latest release in the International Review of Cell and Molecular Biology, reviews and details current advances in cell and molecular biology. Chapters in this updated release include Regulation of cell death signaling in insects, Bcl-2 family proteins, Cell death signaling in prokaryotes, Parthanatos in neurodegenerative diseases, Cell death regulation in yeast, Mutual regulation of autophagy and necroptosis, Therapeutic inhibition of cell death by autophagy induction, and Necroptosis in neurodegenerative diseases.

Cell Biology Book

Cell Biology


  • Author : Stevo Najman
  • Publisher : BoD – Books on Demand
  • Release Date : 2016-01-20
  • Genre: Science
  • Pages : 206
  • ISBN 10 : 9789535122425

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Cell Biology Excerpt :

Cell biology is a multidisciplinary scientific field that its modern expansion in new knowledge and applications owes to important support of new technologies with the rapid development, such as ICTs. By integrating knowledge from nano-, molecular, micro-, and macroareas, it represents a strong foundation for almost all biological sciences and disciplines, as well as for biomedical research and application. This book is a compilation of inspiring reviews/original studies, which are divided into sections: New Methods in Cell Biology, Molecular and Cellular Regulatory Mechanisms, and Cellular Basis of Disease and Therapy. The book will be very useful for students and beginners to gain insight into new area, as well as for experts and scientists to find new facts and expand their scientific horizons through biological sciences and biomedicine.

Clinical Perspectives and Targeted Therapies in Apoptosis Book

Clinical Perspectives and Targeted Therapies in Apoptosis


  • Author : Rupinder K. Sodhi
  • Publisher : Academic Press
  • Release Date : 2020-10-15
  • Genre: Medical
  • Pages : 432
  • ISBN 10 : 9780128157633

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Clinical Perspectives and Targeted Therapies in Apoptosis Excerpt :

Clinical Perspectives and Targeted Therapies in Apoptosis: Drug Discovery, Drug Delivery, and Disease Prevention provides comprehensive coverage, from basic cell biology, to modern assessment techniques for apoptosis in all major disease areas. Chapters provide an introduction to the fundamentals of cell biology, biochemical mechanisms, and the pathophysiological consequences of apoptosis. In addition, the book covers the tools and techniques used to quantify apoptosis and the significance of apoptosis in drug discovery, drug delivery, and its applications in disease prevention. Finally, the book provides a comprehensive compilation of the apoptosis targeting drugs that recently underwent clinical trials. This combination of fundamentals, along with applications in drug discovery, drug delivery, and clinical research make this book a useful resource for those in both academia and industry who are engaged in pharmaceutical, biomedical and biotechnology research. Offers standard and innovative therapeutic approaches to modulate apoptosis in clinical interventions, such as cardiovascular diseases, immune disorders, cancer chemotherapy and neurological ailments Covers cutting-edge laboratory techniques and traditional protocols to determine apoptosis, both in vitro and in vivo Examines clinical study reports of new drug moieties that are explored for various pathological conditions associated with apoptosis

Basic Radiotherapy Physics and Biology Book

Basic Radiotherapy Physics and Biology


  • Author : David S. Chang
  • Publisher : Springer
  • Release Date : 2014-09-19
  • Genre: Medical
  • Pages : 348
  • ISBN 10 : 9783319068411

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Basic Radiotherapy Physics and Biology Excerpt :

This book is a concise and well-illustrated review of the physics and biology of radiation therapy intended for radiation oncology residents, radiation therapists, dosimetrists, and physicists. It presents topics that are included on the Radiation Therapy Physics and Biology examinations and is designed with the intent of presenting information in an easily digestible format with maximum retention in mind. The inclusion of mnemonics, rules of thumb, and reader-friendly illustrations throughout the book help to make difficult concepts easier to grasp. Basic Radiotherapy Physics and Biology is a valuable reference for students and prospective students in every discipline of radiation oncology.

Advances in Cancer Research Book

Advances in Cancer Research


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2018-02-07
  • Genre: Medical
  • Pages : 198
  • ISBN 10 : 0128151234

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Advances in Cancer Research Excerpt :

Advances in Cancer Research, Volume 137, the latest release in this ongoing, well-regarded serial provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents original reviews on research bridging oncology and gene expression, with this volume covering unconventional approaches to modulating the immunogenicity of tumor cells, tumor dormancy and immunoediting, the emerging role of anti-apoptotic Bcl-2 family proteins in chemoresistance, Beclin-1 and autophagy, MDA-7/IL-24, and nanotechnology and medicine. Provides information on cancer research Offers outstanding and original reviews on a range of cancer research topics Serves as an indispensable reference for researchers and students alike

Necrotic Cell Death Book

Necrotic Cell Death


  • Author : Han-Ming Shen
  • Publisher : Springer Science & Business Media
  • Release Date : 2014-03-29
  • Genre: Science
  • Pages : 397
  • ISBN 10 : 9781461482208

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Necrotic Cell Death Excerpt :

Starting with discussion of basic concepts and the molecular mechanisms of necrosis, this book looks first at several forms of necrotic cell death that have been identified, including necroptosis, autophagic cell death, and PARP-mediated cell death. As necrotic cell death is increasingly known to play a critical role in many physiological processes, the next chapters discuss its effect on metabolism, inflammation, immunity, and development. Necrotic cell death is closely implicated in human diseases like cancer, so the next chapters examine its relevance to human diseases, and final chapters cover methodologies for measuring necrosis. This book presents comprehensive coverage of necrosis from recognized experts from leading academic and medical institutions around the world. ​In contrast to apoptosis, well-defined as a form of programmed cell death, necrosis used to be considered as accidental (i.e., non-programmed) cell death, usually in response to a severe injury. Accumulating evidence now suggests, however, that necrosis is also programmed and controlled by distinctive "death machinery" in response to various stimuli like oxidative stress or DNA damage.

Regulated Cell Death Part A Book

Regulated Cell Death Part A


  • Author : Avi Ashkenazi
  • Publisher : Elsevier
  • Release Date : 2014-06-25
  • Genre: Science
  • Pages : 504
  • ISBN 10 : 9780124171756

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Regulated Cell Death Part A Excerpt :

Regulated Cell Death Part A & Part B of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in apoptosis focusing on the important areas of intrinsic pathway, extrinsic pathway, caspases, cellular assays and post-apoptotic effects and model organisms; as well as topics on necroptosis and screening approaches. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods in biomineralization science Regulated Cell Death Part A & Part B contains sections on such topics as apoptosis focusing on the important areas of intrinsic pathway, extrinsic pathway, caspases, cellular assays and post-apoptotic effects and model organisms; as well as topics on necroptosis and screening approaches

Cancer Signaling  Enhanced Edition Book

Cancer Signaling Enhanced Edition


  • Author : Christoph Wagener
  • Publisher : John Wiley & Sons
  • Release Date : 2016-08-17
  • Genre: Science
  • Pages : 360
  • ISBN 10 : 9783527800469

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Cancer Signaling Enhanced Edition Excerpt :

Cancer, which has become the second-most prevalent health issue globally, is essentially a malfunction of cell signaling. Understanding how the intricate signaling networks of cells and tissues allow cancer to thrive - and how they can be turned into potent weapons against it - is the key to managing cancer in the clinic and improving the outcome of cancer therapies. In their ground-breaking textbook, the authors provide a compelling story of how cancer works on the molecular level, and how targeted therapies using kinase inhibitors and other modulators of signaling pathways can contain and eventually cure it. The first part of the book gives an introduction into the cell and molecular biology of cancer, focusing on the key mechanisms of cancer formation. The second part of the book introduces the main signaling transduction mechanisms responsible for carcinogenesis and compares their function in healthy versus cancer cells. In contrast to the complexity of its topic, the text is easy to read. 32 specially prepared teaching videos on key concepts and pathways in cancer signaling are available online for users of the print edition and have been integrated into the text in the enhanced e-book edition.

Application of Apoptosis to Cancer Treatment Book

Application of Apoptosis to Cancer Treatment


  • Author : Mels Sluyser
  • Publisher : Springer Science & Business Media
  • Release Date : 2005-12-05
  • Genre: Medical
  • Pages : 370
  • ISBN 10 : 9781402033025

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Application of Apoptosis to Cancer Treatment Excerpt :

Novel drugs are being developed which interact with the programmed cell death (apoptotic) machinery in cancer cells, thereby causing these cells to commit suicide and to be removed from the body. Research is also directed to investigate why the cancer cells sometimes lose the ability to undergo apoptosis after a certain period of time and methods are being developed to reactivate this cell death process. This book is intended for workers in the field and clinicians as a useful guide of the state of affairs in this exciting field which may offer more effective possibilities for treatment of cancer patients. Mels Sluyser is the Editor of the journals APOPTOSIS and ANTI-CANCER DRUGS. He brings together a collection of papers written by the world’s leading experts in these fields.

Systems Biology of Apoptosis Book

Systems Biology of Apoptosis


  • Author : Inna N. Lavrik
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-09-10
  • Genre: Science
  • Pages : 204
  • ISBN 10 : 9781461440086

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Systems Biology of Apoptosis Excerpt :

Systems Biology of Apoptosis summarizes all current achievements in this emerging field. Apoptosis is a process common to all multicellular organisms. Apoptosis leads to the elimination of cells via a complex but highly defined cellular programme. Defects in the regulation of apoptosis result in serious diseases such as cancer, autoimmunity, AIDS and neurodegeneration. Recently, a substantial step forward in understanding the complex apoptotic pathways has been made by utilising systems biology approaches. Systems biology combines rigorous mathematical modelling with experimental approaches in a closed loop cycle for advancing our knowledge about complex biological processes. In this book, the editor describes the contemporary systems biology studies devoted to apoptotic signaling and focuses on the question how systems biology helps to understand life/death decisions made in the cell and to develop new approaches to rational treatment strategies.