Cellular Senescence in Disease Book

Cellular Senescence in Disease


  • Author : Manuel Serrano
  • Publisher : Academic Press
  • Release Date : 2021-11-27
  • Genre: Science
  • Pages : 472
  • ISBN 10 : 9780128225158

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Cellular Senescence in Disease Excerpt :

Research in the field of senescence has boomed recently due to the gradual realization that senescent cells are associated with a significant number of diseases. The genetic or pharmacological elimination of senescent cells can cause widespread benefits and improves outcomes for most of those diseases. Cellular Senescence in Diseases presents an updated review of the role of cellular senescence in multiple pathologies. Focus is given to those diseases where the implication of senescence has been more extensively documented, such as (cancer, lung and liver diseases, diabetes, Neurodegenerative diseases and others). The Editors recruited a group of worldwide experts in each individual pathology to review the role of cellular senescence in each one of them, aiming at identifying potential therapeutic pathways. The first two chapters provide an overview of the cellular senescence principles. Next, the chapters are divided into specific diseases. Cancer, including premalignant lesions (OIS), Advanced disease (TIS), and Metastasis are covered. The following condition covered is Lund diseases, including IPF, COPD, and Pulmonary Hypertension. Next Liver Diseases are covered, including Fibrosis and Cirrhosis, and Fatty liver disease. Next there is coverage for Kidney implications, including fibrosis and transplantation. Vascular diseases are covered next including infarction and hear fibrosis, and atherosclerosis. Both diabetes types 1 and 2 are covered next. Following chapters cover Obesity, Sarcopenia, and Bone and Cartilage disorders, respectively. Neurodegenerative diseases are covered next, focusing on Alzheimer and Parkinson. The next chapter discusses accumulation of senescent cell in tissues during aging. The two final chapters cover current developments and conclusions. Cellular Senescence in Diseases is designed for researchers and clinicians with a focus on the cellular mechanisms of diseases. All chapters cover current experimental therapeutic approaches to elimi

Cellular Ageing and Replicative Senescence Book

Cellular Ageing and Replicative Senescence


  • Author : Suresh I.S. Rattan
  • Publisher : Springer
  • Release Date : 2016-05-09
  • Genre: Medical
  • Pages : 364
  • ISBN 10 : 9783319262390

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Cellular Ageing and Replicative Senescence Excerpt :

This book covers the origins and subsequent history of research results in which attempts have been made to clarify issues related to cellular ageing, senescence, and age-related pathologies including cancer. Cellular Ageing and Replicative Senescence revisits more than fifty-five years of research based on the discovery that cultured normal cells are mortal and the interpretation that this phenomenon is associated with the origins of ageing. The mortality of normal cells and the immortality of cancer cells were also reported to have in vivo counterparts. Thus began the field of cytogerontology. Cellular Ageing and Replicative Senescence is organized into five sections: history and origins; serial passaging and progressive ageing; cell cycle arrest and senescence; system modulation; and recapitulation and future expectations. These issues are discussed by leading thinkers and researchers in biogerontology and cytogerontology. This collection of articles provides state-of-the-art information, and will encourage students, teachers, health care professionals and others interested in the biology of ageing to explore the fascinating and challenging question of why and how our cells age, and what can and cannot be done about it.

Innovative Medicine Book

Innovative Medicine


  • Author : Kazuwa Nakao
  • Publisher : Springer
  • Release Date : 2015-10-13
  • Genre: Medical
  • Pages : 339
  • ISBN 10 : 9784431556510

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Innovative Medicine Excerpt :

This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.

Cellular Senescence in Health  Disease and Aging Book

Cellular Senescence in Health Disease and Aging


  • Author : Markus Riessland
  • Publisher : Mdpi AG
  • Release Date : 2021-11-08
  • Genre: Science
  • Pages : 112
  • ISBN 10 : 3036521755

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Cellular Senescence in Health Disease and Aging Excerpt :

Dear Colleagues, When Hayflick and Moorhead coined the term "cellular senescence" (CS) almost 60 years ago, this phenomenon was understood as a mechanism, usually induced by activation of the DNA-repair machinery, to prevent uncontrolled proliferation. Meanwhile, additional beneficial roles for CS have been identified, such as embryonic development and wound healing. The senescence associated secretory phenotype (SASP) activated in most senescent cells (SC) signals to the immune system "come here and remove me". In organisms with young and functional immune systems, occurring SC are usually detected and removed. If SC remain in the tissue expressing the SASP, this will cause not just a damaging local inflammation but can also induce remodeling and regeneration of the surrounding tissue as well as spreading of senescence. Old organisms show reduced regenerative potential and immune function which leads to accumulation of SC. Accordingly, accumulation of SC was observed in tissues of aged individuals, but importantly also in the context of age-related disorders, neurodegenerative, or cardiovascular diseases and others. Because of its detrimental effect of the surrounding tissue, accumulation of SC is not just a consequence, but can rather been understood as a major driver of aging. In line with this, recent studies described that removal of SC showed beneficial effects on healthspan and lifespan. This exciting research led to the discovery of "senolytics", drugs which can kill SC. Given the heterogeneity of cell types that show senescence-like phenotypes, including heart muscle and post-mitotic neuronal cells, further research is required to unravel the molecular background that renders a cell type vulnerable to senesce. Additionally, it will be important to understand how senescence is cell type-specifically induced and which molecules serve as drug targets to prevent senescence and its spreading, or actively kill SC. This special issue will shed light on the molecul

Senolytics in Disease  Ageing and Longevity Book

Senolytics in Disease Ageing and Longevity


  • Author : Daniel Muñoz-Espin
  • Publisher : Springer
  • Release Date : 2021-05-12
  • Genre: Science
  • Pages : 222
  • ISBN 10 : 303044905X

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Senolytics in Disease Ageing and Longevity Excerpt :

This book offers comprehensive information on the new and rapidly evolving science of identifying and targeting senescent cells, and on the exciting prospect of new diagnostic and therapeutic opportunities for stopping, and even reversing, the progression of disease and the deterioration of the human body due to ageing. According to recent United Nations data, by 2050 one in six people worldwide will be older than age 65, with peaks rising to one in four people in Europe and North America. Remarkably, the number of persons aged 80 years or older is expected to triple, from 143 million in 2019 to 426 million in 2050. First documented in the 1960s, the concept of cellular senescence as an underlying cause of ageing has been established in the course of the last decade. Using genetically engineered mouse models, researchers have demonstrated that the selective elimination of senescent cells can block and even reverse a number of age-related dysfunctions and pathologies, promoting both better health and longer life in the elderly. These include cardiovascular diseases; neurological disorders; type 1 and type 2 diabetes; inflammatory diseases; fibrosis; geriatric syndromes; chronic diseases resulting in organ dysfunction; the integrity of the musculoskeletal system; and cancer. Some senolytic agents have already progressed into trials. These include UBX0101 for the treatment of osteoarthritis (now in phase II), a cocktail of dasatinib and quercetin for the management of idiopathic pulmonary fibrosis and chronic kidney disease, and ABT-263 in combination with senescence-inducing chemotherapies for the treatment of advanced solid tumours. In addition, the book discusses pathways to early phase clinical trials and translational approaches in medicine and ageing, highlighting new opportunities as well as current limitations, challenges and alternatives. Given its scope, it will benefit a broad audience of advanced educators, researchers, graduate students and practitioners.

Endothelial Dysfunction Book

Endothelial Dysfunction


  • Author : Helena Lenasi
  • Publisher : BoD – Books on Demand
  • Release Date : 2018-10-24
  • Genre: Medical
  • Pages : 432
  • ISBN 10 : 9781789842531

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Endothelial Dysfunction Excerpt :

The endothelium enables communication between blood and tissues and is actively involved in cardiovascular homeostasis. Endothelial dysfunction has been recognized as an early step in the development of cardiovascular diseases: respectively, endothelium represents a potential therapeutic niche with multiple targets. The purpose of the book is to point out some recent findings of endothelial physiology and pathophysiology emphasizing various aspects of endothelial dysfunction connected to the body's internal and external environment. While basic features of the endothelium are presented in an introductory chapter, the authors of the following 17 chapters have provided extensive insight into some selected topics of endothelial (dys)function. The book would hopefully be useful for anyone interested in recapitulating endothelial (patho)physiology and expanding knowledge of molecular mechanisms involved in endothelial dysfunction, relevant also for further clinical investigations.

Senolytics in Disease  Ageing and Longevity Book

Senolytics in Disease Ageing and Longevity


  • Author : Daniel Muñoz-Espin
  • Publisher : Springer Nature
  • Release Date : 2020-04-27
  • Genre: Science
  • Pages : 222
  • ISBN 10 : 9783030449032

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Senolytics in Disease Ageing and Longevity Excerpt :

This book offers comprehensive information on the new and rapidly evolving science of identifying and targeting senescent cells, and on the exciting prospect of new diagnostic and therapeutic opportunities for stopping, and even reversing, the progression of disease and the deterioration of the human body due to ageing. According to recent United Nations data, by 2050 one in six people worldwide will be older than age 65, with peaks rising to one in four people in Europe and North America. Remarkably, the number of persons aged 80 years or older is expected to triple, from 143 million in 2019 to 426 million in 2050. First documented in the 1960s, the concept of cellular senescence as an underlying cause of ageing has been established in the course of the last decade. Using genetically engineered mouse models, researchers have demonstrated that the selective elimination of senescent cells can block and even reverse a number of age-related dysfunctions and pathologies, promoting both better health and longer life in the elderly. These include cardiovascular diseases; neurological disorders; type 1 and type 2 diabetes; inflammatory diseases; fibrosis; geriatric syndromes; chronic diseases resulting in organ dysfunction; the integrity of the musculoskeletal system; and cancer. Some senolytic agents have already progressed into trials. These include UBX0101 for the treatment of osteoarthritis (now in phase II), a cocktail of dasatinib and quercetin for the management of idiopathic pulmonary fibrosis and chronic kidney disease, and ABT-263 in combination with senescence-inducing chemotherapies for the treatment of advanced solid tumours. In addition, the book discusses pathways to early phase clinical trials and translational approaches in medicine and ageing, highlighting new opportunities as well as current limitations, challenges and alternatives. Given its scope, it will benefit a broad audience of advanced educators, researchers, graduate students and practitioners.

Handbook on Immunosenescence Book
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Handbook on Immunosenescence


  • Author : Tamas Fulop
  • Publisher : Springer Science & Business Media
  • Release Date : 2009-02-27
  • Genre: Medical
  • Pages : 1693
  • ISBN 10 : 9781402090639

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Handbook on Immunosenescence Excerpt :

This authoritative handbook covers all aspects of immunosenescence, with contributions from experts in the research and clinical areas. It examines methods and models for studying immunosenescence; genetics; mechanisms including receptors and signal transduction; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; and much more.

Frailty and Cardiovascular Diseases Book

Frailty and Cardiovascular Diseases


  • Author : Nicola Veronese
  • Publisher : Springer Nature
  • Release Date : 2020-01-01
  • Genre: Medical
  • Pages : 154
  • ISBN 10 : 9783030333300

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Frailty and Cardiovascular Diseases Excerpt :

This book aims to clarify the potential association between frailty and cardiovascular disease in older people. Covering the biological as well as the clinical point of view, it allows researchers and clinicians to discover the significance of this topic. The contributions cover the most important aspects in the potential relationship between frailty and cardiovascular disease. In particular, authoritative authors in this field have clarified the definition and the epidemiology of frailty and cardiovascular disease in older people. A large part of the volume is dedicated to the biological mechanisms of frailty and cardiovascular disease, trying to find those in common between these two conditions. Since this book is dedicated to both researchers and clinicians, we have proposed some chapters to the importance of comprehensive geriatric assessment in the evaluation and treatment of cardiovascular diseases and frailty. In this regard, the importance of geriatric evaluation in cardiac surgery for older people is well covered. Finally, the importance of cardiac rehabilitation and physical exercise is summarized, being, actually, the most important treatments for both frailty and cardiovascular disease. Written by many well-known and widely published experts in their respective fields, this book will appeal to a wide readership such as researchers in the field and clinicians, especially suited in geriatric medicine and cardiology who, every day, face frail older patients.

Frailty Book

Frailty


  • Author : R.A. Fielding
  • Publisher : Unknown
  • Release Date : 2015
  • Genre: Electronic books
  • Pages : 124
  • ISBN 10 : 3318054771

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Frailty Excerpt :

Cover -- Contents -- Preface -- Foreword -- Contributors -- Connecting Age-Related Biological Decline to Frailty and Late-Life Vulnerability -- Abstract -- Introduction -- Frailty Conceptualization -- Frailty Measurement -- The Biology That Underlies Frailty -- Disease States and Frailty -- Physiological System Dysregulation and Frailty -- Age-Related Cellular and Molecular Changes and Frailty -- Disclosure Statement -- References -- Cellular Senescence and the Biology of Aging, Disease, and Frailty -- Abstract -- Introduction -- Cellular Senescence, the Senescence-Associated Secretory Phenotype, and Aging -- Cellular Senescence and Age-Related Disease and Frailty -- Interventions Targeting Senescent Cells and the Senescence-Associated Secretory Phenotype -- Conclusions -- Acknowledgments -- Disclosure Statement -- References -- The Role of Genome Instability in Frailty: Mitochondria versus Nucleus -- Abstract -- Introduction -- Cellular and Mitochondrial Mechanisms of Nuclear Genome Instability -- Mitochondrial Quality Control and Nuclear Genome Stability -- Concluding Remarks -- Acknowledgments -- Disclosure Statement -- References -- Determinants of Frailty and Longevity: Are They the Same Ones? -- Abstract -- Introduction -- Longevity and Functional Reserve -- Disease, Functional Reserve, and Frailty -- Longevity and Frailty: Biological Background -- Disclosure Statement -- References -- Psychological Frailty in the Aging Patient -- Abstract -- Introduction -- Frailty -- Psychological Frailty -- Disclosure Statement -- References -- Frailty Clinical Phenotype: A Physical and Cognitive Point of View -- Abstract -- Introduction -- Physical Frailty: From Concept to Clinical Practice -- Cognitive Frailty: From Concept to Operational Definition -- Redefining Frailty: Emerging Definitions -- Conclusion -- Acknowledgments -- Disclosure Statement.

Telomere Book

Telomere


  • Author : Marcelo Larramendy
  • Publisher : BoD – Books on Demand
  • Release Date : 2016-11-23
  • Genre: Medical
  • Pages : 228
  • ISBN 10 : 9789535127529

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Telomere Excerpt :

This book, Telomere - A Complex End of a Chromosome, is organized into nine chapters containing the latest aspects of the current knowledge about the structure of telomeres and the crucial role that telomerase plays not only in maintaining chromosomal stability but also in relation to cell immortality, cell instability, and cancer biology. We now appreciate that these unusual complexes of DNA and proteins we all know as "telomeres" are dynamic and key structures that depend on telomerase and other cellular factors for continuance. Regulation of telomere activity is a dynamic area of current research, and new insights into telomeres and their role in aging and cancer, among other biological functions and pathologies, appear regularly in the scientific world. However, one fact is more than understandable in this difficult biological conundrum: the end of the telomere story is far from being totally unraveled.

MiRNAs in Aging and Cancer Book

MiRNAs in Aging and Cancer


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2017-08-22
  • Genre: Science
  • Pages : 354
  • ISBN 10 : 9780128118696

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MiRNAs in Aging and Cancer Excerpt :

MiRNAs in Aging and Cancer, Volume 334, the latest in the International Review of Cell and Molecular Biology series, reviews and details current advances in cell and molecular biology. This new release includes chapters on a variety of timely topics, including the Regulation of autophagy by miRNAs, the Impact of miRNAs in cellular senescence, miRNAs in hematopoiesis, stem cell biology and hematological disorders, the Impact of miRNAs on longevity, miRNA deregulation in cardiovascular aging and associated disorders, miRNA deregulation in aging-associated pathologies of the skeletal muscle, and miRNAs and neurodegeneration. The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics that are authored by prominent cell and molecular biologists. The articles published in IRCMB have a high impact and an average cited half-life of 9 years. This great resource ranks high amongst scientific journals dealing with cell biology. Publishes only invited review articles on selected topics Authored by established and active cell and molecular biologists Offers a wide range of perspectives on specific subjects

Hepatocellular Carcinoma Book

Hepatocellular Carcinoma


  • Author : Costin Teodor Streba
  • Publisher : BoD – Books on Demand
  • Release Date : 2018-11-28
  • Genre: Medical
  • Pages : 201
  • ISBN 10 : 9781789842739

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Hepatocellular Carcinoma Excerpt :

Hepatocellular carcinoma (HCC) currently ranks as the third most common cause of death. As the primary malignancy of the liver is directly related to an underlying liver condition, its incidence and profile are expected to change soon. While effective prevention programs and antiviral therapies for hepatitis B and C will lower the incidence of HCC, emerging socioeconomic issues will deliver new at-risk populations. Moreover, diagnostic techniques and protocols have undergone significant advancements. Reliance on contrast enhanced ultrasound has been re-evaluated, imaging methods being considered as sufficient diagnostic tools. Molecular characterization remains desirable, since chemotherapeutic agents still have limited applicability. In light of recent diagnostic advancements and novel therapeutic solutions, it is our belief that a comprehensive update on recent paradigm shifts and interesting upcoming developments is highly needed.

Oxidative Stress in Heart Diseases Book

Oxidative Stress in Heart Diseases


  • Author : Sajal Chakraborti
  • Publisher : Springer Nature
  • Release Date : 2019-11-06
  • Genre: Science
  • Pages : 596
  • ISBN 10 : 9789811382734

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Oxidative Stress in Heart Diseases Excerpt :

This book bridges the gap between fundamental and translational research in the area of heart disease. It describes a multidisciplinary approach, and demonstrates biochemical mechanisms associated with dysregulation of redox signaling, which leads heart disease. Presenting recent studies on improved forms of ROS scavenging enzymes; specific inhibitors for different ROS generating enzymes; and oxidant induced signaling pathways and their antagonists that allow subtle modulation of redox signaling, it also discusses the spatial and temporal aspects of oxidative stress in the cardiovascular system, which are of vital importance in developing better strategies for treating heart disease. Each chapter offers researchers valuable insights into identifying targets for drug development for different types of heart disease.

Metabolic and Bioenergetic Drivers of Neurodegenerative Disease  Treating Neurodegenerative Diseases as Metabolic Diseases Book

Metabolic and Bioenergetic Drivers of Neurodegenerative Disease Treating Neurodegenerative Diseases as Metabolic Diseases


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2020-08-25
  • Genre: Medical
  • Pages : 322
  • ISBN 10 : 9780128231227

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Metabolic and Bioenergetic Drivers of Neurodegenerative Disease Treating Neurodegenerative Diseases as Metabolic Diseases Excerpt :

Metabolic Drivers and Bioenergetic Components of Neurodegenerative Disease reviews how the different aspects of metabolic dysfunction and consequent pathology associated with neurodegenerative diseases, including Alzheimer’s and Parkinson’s, can be targeted by novel treatment approaches. Topics covered include Cellular Senescence in Aging and Age-Related Disorders: Implications for Neurodegenerative Diseases; Repurposing GLP1 agonists for Neurodegenerative Diseases; Ketotherapeutics for Neurodegenerative Diseases; Enhancing Mitophagy as a Therapeutic Approach for Neurodegenerative Diseases; Harnessing Neurogenesis in the Adult Brain – A Role in Type 2 Diabetes Mellitus and Alzheimer’s disease; and much more. Summarizes the impact of the metabolic hypothesis on underlying mechanisms of neurodegenerative diseases Presents novel, potential treatment strategies based on the metabolic hypothesis for neurodegenerative diseases.