Chelation Therapy in the Treatment of Metal Intoxication Book

Chelation Therapy in the Treatment of Metal Intoxication

  • Author : Jan Aaseth
  • Publisher : Academic Press
  • Release Date : 2016-04-18
  • Genre: Medical
  • Pages : 388
  • ISBN 10 : 9780128030738

Chelation Therapy in the Treatment of Metal Intoxication Excerpt :

Chelation Therapy in the Treatment of Metal Intoxication presents a practical guide to the use of chelation therapy, from its basic chemistry, to available chelating antidotes, and the application of chelating agents. Several metals have long been known to be toxic to humans, and continue to pose great difficulty to treat. These challenges pose particular problems in industrial settings, with lead smelting known to be associated with hemopoietic alterations and paralyses, and the inhalation of mercury vapor in mercury mining being extremely detrimental to the central nervous system. Clinical experience has demonstrated that acute and chronic human intoxications with a range of metals can be treated efficiently by administration of chelating agents. Chelation Therapy in the Treatment of Metal Intoxication describes the chemical and biological principles of chelation in the treatment of these toxic metal compounds, including new chelators such as meso-2,3-dimercaptosuccinic acid (DMSA) and D,L-2,3-dimercapto-1-propanesulfonic acid (DMPS). Presents all the current findings on the potential for chelation as a therapy for metal intoxication Presents practical guidelines for selecting the most appropriate chelating agent Includes coverage on radionuclide exposure and metal storage diseases Describes the chemical and biological principles of chelation in the treatment of toxic metal compounds

Evidence Based Clinical Chelation Book

Evidence Based Clinical Chelation

  • Author : Dr. Eleonore Blaurock-Busch, PhD
  • Publisher : BoD – Books on Demand
  • Release Date : 2020-06-02
  • Genre: Medical
  • Pages : 120
  • ISBN 10 : 9783750428676

Evidence Based Clinical Chelation Excerpt :

This is an easy-to-read manual about chelation therapy. It contains specific protocols for the treatment of chronic metal overexposure, all of which are evidence-based, aiding the inexperienced and the experienced therapist in selecting the optimal chelating agent for the metal(s) in question. Expert chemists and chelation therapists have contributed invaluable knowledge and experience to this book. Most importantly, this is not a book promoting personal views or preferences. In fact, the information presents and explains different approaches, and allows the reader to draw his own conclusion. All the protocols listed have been modified for the treatment of chronic metal intoxication, included are oral and intravenous treatment plans. The authors explain in simple terms how a chelating agent ́s bioavailability affects metal binding and how various protocols such as the Cutler Protocol affect the detoxification process, why DMPS binds mercury and which chelators are useful for the detoxification of certain organ system. Also discussed is the importance and effect of treatment pauses. Diagnostic tests are discussed, and which are useful under certain conditions. Shown are tables comparing the average metal binding ability of the various EDTAs, DMPS, DMSA and other chelating agents. Detailed information explains which chelator binds which metal and why, all of which aids the therapist in finding optimal treatment schedules. Novel chelating agents are presented such as MIADMSA, a new oral chelator specifically designed for arsenic intoxication, or how natural Pectin may be used an alternative for gadolinium intoxication, which metals are bound by lipoic acid and why a slightly alkaline environment supports metal binding, even preventing the often-feared metal redistribution. All in all, this evidence-based chelation "cookbook" should be in medical libraries and on the bookshelf of every physician treating environmental disease.

Hepatotoxicity Book
Score: 5
From 1 Ratings


  • Author : Hyman J. Zimmerman
  • Publisher : Lippincott Williams & Wilkins
  • Release Date : 1999
  • Genre: Medical
  • Pages : 789
  • ISBN 10 : 0781719526

Hepatotoxicity Excerpt :

Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.

Iron Chelation Therapy Book

Iron Chelation Therapy

  • Author : Chaim Hershko
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-06
  • Genre: Science
  • Pages : 277
  • ISBN 10 : 9781461505938

Iron Chelation Therapy Excerpt :

Within the last few years, iron research has yielded exciting new insights into the under standing of normal iron homeostasis. However, normal iron physiology offers little protec tion from the toxic effects of pathological iron accumulation, because nature did not equip us with effective mechanisms of iron excretion. Excess iron may be effectively removed by phlebotomy in hereditary hemochromatosis, but this method cannot be applied to chronic anemias associated with iron overload. In these diseases, iron chelating therapy is the only method available for preventing early death caused mainly by myocardial and hepatic iron toxicity. Iron chelating therapy has changed the quality of life and life expectancy of thalassemic patients. However, the high cost and rigorous requirements of deferoxamine therapy, and the significant toxicity of deferiprone underline the need for the continued development of new and improved orally effective iron chelators. Such development, and the evolution of improved strategies of iron chelating therapy require better understanding of the pathophysiology of iron toxicity and the mechanism of action of iron chelating drugs. The timeliness of the present volume is underlined by several significant develop ments in recent years. New insights have been gained into the molecular basis of aberrant iron handling in hereditary disorders and the pathophysiology of iron overload (Chapters 1-5).

Metallothionein IV Book

Metallothionein IV

  • Author : C. Klaasen
  • Publisher : Birkhäuser
  • Release Date : 2012-11-05
  • Genre: Science
  • Pages : 650
  • ISBN 10 : 3034897995

Metallothionein IV Excerpt :

The Proceedings of the Fourth International Metallothionein Meeting (MT-97) feature the latest research on metallothionein. The book covers a broad range of topics which provide important information for both basic and clinical investigators. The selected 94 articles in this book are written by the leading scientists in the field around the world. This is an increasingly important, multi-disciplinary area of study that has benefitted from recent advances in concepts and methodologies from other fields.

Handbook of Arsenic Toxicology Book
Score: 5
From 1 Ratings

Handbook of Arsenic Toxicology

  • Author : Swaran Jeet Singh Flora
  • Publisher : Academic Press
  • Release Date : 2014-12-26
  • Genre: Medical
  • Pages : 752
  • ISBN 10 : 9780124199552

Handbook of Arsenic Toxicology Excerpt :

Throughout history, arsenic has been used as an effective and lethal poison. Today, arsenic continues to present a real threat to human health all over the world, as it contaminates groundwater and food supplies. Handbook of Arsenic Toxicology presents the latest findings on arsenic, its chemistry, its sources and its acute and chronic effects on the environment and human health. The book takes readings systematically through the target organs, before detailing current preventative and counter measures. This reference enables readers to effectively assess the risks related to arsenic, and provide a comprehensive look at arsenic exposure, toxicity and toxicity prevention. Brings together current findings on the effects of arsenic on the environment and human health Includes state-of-the-art techniques in arsenic toxicokinetics, speciation and molecular mechanisms Provides all the information needed for effective risk assessment, prevention and countermeasure

Introduction to Basics of Pharmacology and Toxicology Book

Introduction to Basics of Pharmacology and Toxicology

  • Author : Gerard Marshall Raj
  • Publisher : Springer Nature
  • Release Date : 2019-11-16
  • Genre: Medical
  • Pages : 417
  • ISBN 10 : 9789813297791

Introduction to Basics of Pharmacology and Toxicology Excerpt :

This book illustrates, in a comprehensive manner, the most crucial principles involved in pharmacology and allied sciences. The title begins by discussing the historical aspects of drug discovery, with up to date knowledge on Nobel Laureates in pharmacology and their significant discoveries. It then examines the general pharmacological principles - pharmacokinetics and pharmacodynamics, with in-depth information on drug transporters and interactions. In the remaining chapters, the book covers a definitive collection of topics containing essential information on the basic principles of pharmacology and how they are employed for the treatment of diseases. Readers will learn about special topics in pharmacology that are hard to find elsewhere, including issues related to environmental toxicology and the latest information on drug poisoning and treatment, analytical toxicology, toxicovigilance, and the use of molecular biology techniques in pharmacology. The book offers a valuable resource for researchers in the fields of pharmacology and toxicology, as well as students pursuing a degree in or with an interest in pharmacology.

Toxicological Profile for Arsenic  Update  Book

Toxicological Profile for Arsenic Update

  • Author : Selene Chou
  • Publisher : DIANE Publishing
  • Release Date : 2010-08
  • Genre: Uncategoriezed
  • Pages : 447
  • ISBN 10 : 9781437930689

Toxicological Profile for Arsenic Update Excerpt :

Characterizes the toxicologic and adverse health effects for arsenic, which has been found in many sites targeted for long-term fed. cleanup activities. Contents: (1) The examination, summary, and interpretation of available toxicologic info. and epidemiologic evaluations on arsenic to ascertain the levels of significant human exposure for the substance and the associated chronic health effects; (2) A determination of whether adequate info. on the health effects of arsenic is available to determine levels of exposure that present a significant risk to human health of chronic health effects; and (3) Identification of toxicologic testing needed to identify the types or levels of exposure that may present significant risk of adverse health effects in humans. Illus.

Cancer Causing Substances Book

Cancer Causing Substances

  • Author : Faik Atroshi
  • Publisher : BoD – Books on Demand
  • Release Date : 2018-05-16
  • Genre: Medical
  • Pages : 80
  • ISBN 10 : 9781789231403

Cancer Causing Substances Excerpt :

Cancer risk factors include exposure to certain substances, which may contribute to the development of cancer. However, substances can have different levels of cancer-causing potential, and the risk of developing cancer is dependent on several factors, including individual genetic background and the amount and duration of the exposure. This book focuses on various cancer risk factors, covering numerous known, probable, and possible carcinogens; their role in carcinogenesis; mechanisms of carcinogenicity; and methods for detecting carcinogens. And due to the growing concerns over the effects that substances and environmental exposures can have on human health, the chapters also emphasize on the vital need for further topic-related research as well as development and implementation of beneficial approaches.

Lead Toxicity Book

Lead Toxicity

  • Author : Sarah E. Royce
  • Publisher : Unknown
  • Release Date : 2000
  • Genre: Lead
  • Pages : 55
  • ISBN 10 : UOM:39015051606617

Lead Toxicity Excerpt :

Metal Chelation in Medicine Book

Metal Chelation in Medicine

  • Author : Robert Crichton
  • Publisher : Royal Society of Chemistry
  • Release Date : 2016-10-26
  • Genre: Uncategoriezed
  • Pages : 322
  • ISBN 10 : 9781782620648

Metal Chelation in Medicine Excerpt :

Metal chelators are emerging as versatile tool with many medical applications. Their versatility allows them to be used in chelation therapy for treating diseases caused by toxic and heavy metal poisoning, chelating agents are capable of binding to toxic metal ions to form complex structures which are easily excreted from the body removing them from intracellular or extracellular spaces. In addition, metal chelators can also be applied as contrast agents in MRI scanning. Metal Chelation in Medicine provides a clear and timely perspective on the role of chelating agents in the management of metal intoxications and storage diseases. Written by leaders in the field of chelators, this publication is at the cutting-edge of the subject. It covers a broad range of topics such as the use of metal chelators in non-invasive assessment of brain iron overload, and the treatment of systemic iron overload and neurodegenerative diseases. As such it is particularly valuable to clinicians treating metal poisonings and metal storage diseases. However, it is also a useful text for researchers, industry professionals and university students with a specific interest in medicinal chemistry, chelation, metal ions, imaging and non-invasive techniques.

The Therapeutic Use of N Acetylcysteine  NAC  in Medicine Book

The Therapeutic Use of N Acetylcysteine NAC in Medicine

  • Author : Richard Eugene Frye
  • Publisher : Springer
  • Release Date : 2018-09-20
  • Genre: Medical
  • Pages : 394
  • ISBN 10 : 9789811053115

The Therapeutic Use of N Acetylcysteine NAC in Medicine Excerpt :

Focusing on the practical use of N-Acetyl-Cysteine (NAC) in medicine, this book provides a comprehensive review of the basic biological and clinical studies documenting its benefits in treating medical disease. NAC is perhaps best known as an antidote for acetaminophen, but its therapeutic effect in a wide range of medical diseases has recently been realized. In addition to its well recognized use in radiological contrast prophylaxis for renal disease and pulmonary disorders, studies have suggested significant promise in psychiatric and neurological disorders such as addiction, Alzheimer’s disease, ataxia, autism, bipolar disorder, depression, epilepsy, neuropathy, obsessive-compulsive disorder, schizophrenia, traumatic brain injury and trichotillomania in addition to promising studies in audiology, cardiology, exercise physiology, gastroenterology, hematology, infectious disease, infertility and ophthalmology. Given the promising studies for a wide range of medical conditions, coupled with a excellent safety profile, the potential for NAC in the treatment of human disease appears considerable. Dr Leonore A Herzenberg from Stanford University, a pioneer of redox physiology and the use of NAC, provides a succinct history of the development of the therapeutic use of NAC for medical disease. This is followed by a series of basic science chapters outlining the role of NAC in important physiological processes, including modulation of dopamine and glutamate neurotransmitter systems, redox and mitochondrial metabolism, apoptosis and inflammation. The last section of the book is dedicated to clinically oriented chapters that comprehensively review the literature on medical disorders in which NAC has been found to be effective, including toxicity and cardiovascular, gastrointestinal, neurological, psychiatric, pulmonary and renal disorders. Each chapter reviews the theoretical biological mechanisms of NAC for the specific diseases reviewed, rates the clinical studies using

Heavy Metals and Health Book

Heavy Metals and Health

  • Author : Lance Castillo
  • Publisher : Unknown
  • Release Date : 2016-11-13
  • Genre: Uncategoriezed
  • Pages : 202
  • ISBN 10 : 1634856104

Heavy Metals and Health Excerpt :

Heavy metals are persistent in the environment and their elevated emission during longer periods of time can cause contamination of the environment. They are emitted in all environmental media, but can also be easily transported between them due to the atmospheric deposition, water runoff, etc., and thus accumulate in the environment or penetrate the food chains. The main routes of human exposure to heavy metals are through ingestion, inhalation or via dermal contact. Hence, there is a need for better understanding of absorption, distribution and deposition of heavy metals in the human body. This information is of a crucial importance for the evaluation of heavy metal potential health implications. In this book, Chapter One provides an overview of the heavy metal health hazards, presented as a consequence of heavy metal pollution, their availability and cycling between different media in the environment. Chapter Two comprehensively discusses the roles and harmful effects of heavy metals on human health, as well as the sources and techniques of removing heavy metals from the environment. Chapter Three explores the mechanisms of mercury cardiovascular toxicity, with a particular emphasis on its effects toward endothelial cells. Chapter Four focuses on the effects of exposure to soil contaminated by metals. Chapter Five examines antimicrobial functionalized textiles. Chapter Six discusses thallium poisoning. Chapter Seven provides a review of heavy metal pollution, human exposure and public health implications in Nigeria.

Biomedical Applications of Metals Book

Biomedical Applications of Metals

  • Author : Mahendra Rai
  • Publisher : Springer
  • Release Date : 2018-02-24
  • Genre: Medical
  • Pages : 325
  • ISBN 10 : 9783319748146

Biomedical Applications of Metals Excerpt :

Focused more specifically on the recent advances in applications of various metals and their complexes used in biomedicine, particularly in the diagnosis and treatment of chronic diseases. The editors give equal importance to other key aspects such as toxicological issues and safety concerns. The application of metals in the biomedical field is highly interdisciplinary and has a broad appeal across all biomedical specialties. Biomedical Applications of Metals is particularly focused on covering the role of metals in medicine and the development of novel therapeutic products and solutions in the form of alternative medicines, and some topics on Indian traditional medicine i.e., “Ayurveda”. In Section I, the book discusses the role of metals in medicines and include chapters on nanoparticles, noble metals, medical devices, copper. selenium, silver, and microbial pathogens; while Section II includes topics on metals toxicity including heavy metals, carcinogens, cancer therapy, Bhasma’s and chelating agents used in Ayurveda, and biochemical and molecular targets including actions of metals. These new and emerging concepts of applications of metals in medicine, their crucial role in management of microbial resistance, and their use in the treatment of various chronic diseases is essential information for toxicologists, and clinical and biomedical researchers.

Medicinal Applications of Coordination Chemistry Book

Medicinal Applications of Coordination Chemistry

  • Author : Chris J Jones
  • Publisher : Royal Society of Chemistry
  • Release Date : 2007-10-31
  • Genre: Science
  • Pages : 366
  • ISBN 10 : 9781847557759

Medicinal Applications of Coordination Chemistry Excerpt :

Metals in pharmaceuticals have played an increasingly important role in medicine over the last century, particularly in cancer therapy and diagnostic imaging methods. Medicinal Applications of Coordination Chemistry focuses on the role that transition metals play in clinical applications. Medicinal Applications of Coordination Chemistry begins with a brief historical review and an introduction to the chemistry of d- and f- block metals. Subsequent sections discuss metallodrugs for a number of different applications, the design of new drugs and the relationship between structure and function. Key sections include diagnostic applications of metal compounds in anatomical and functional imaging, and therapeutic applications of metals compounds. This book is ideal for researchers in academia and industry and comes complete with examples of real life applications.