Clinical Challenges in Therapeutic Drug Monitoring Book

Clinical Challenges in Therapeutic Drug Monitoring


  • Author : William Clarke
  • Publisher : Elsevier
  • Release Date : 2016-07-21
  • Genre: Medical
  • Pages : 376
  • ISBN 10 : 9780128020524

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Clinical Challenges in Therapeutic Drug Monitoring Excerpt :

Clinical Challenges in Therapeutic Drug Monitoring: Special Populations, Physiological Conditions and Pharmacogenomics focuses on critical issues in therapeutic drug monitoring including special requirements of therapeutic drug monitoring important to special populations (infants and children, pregnant women, elderly patients, and obese patients). The book also covers issues of free drug monitoring and common interferences in using immunoassays for therapeutic drug monitoring. This book is essential reading for any clinician, fellow, or trainee who wants to gain greater insight into the process of therapeutic drug monitoring for individual dosage adjustment and avoiding drug toxicity for certain drugs within a narrow therapeutic window. The book is written specifically for busy clinicians, fellows, and trainees who order therapeutic drug monitoring and need to get more familiar with testing methodologies, issues of interferences, and interpretation of results in certain patient populations. Offers busy clinicians, pathologists, and trainees a concise resource on the key aspects and critical issues in therapeutic drug monitoring Focuses on patient populations such as infants and children, pregnant women, elderly patients, and obese patients, who have special requirements in therapeutic drug monitoring Explores special topics in therapeutic drug monitoring including free drug monitoring and common immunoassay interference Explains how individual dosage adjustments can prevent drug toxicity for certain drugs within a narrow therapeutic window

Therapeutic Drug Monitoring Book

Therapeutic Drug Monitoring


  • Author : Amitava Dasgupta
  • Publisher : Academic Press
  • Release Date : 2012-06-07
  • Genre: Medical
  • Pages : 468
  • ISBN 10 : 9780123854681

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Therapeutic Drug Monitoring Excerpt :

Therapeutic Drug Monitoring: Newer Drugs and Biomarkers features timely topics such as the monitoring of classical and newer drugs, pharmacogenomics and the application of biomarkers in therapeutic drug monitoring. This reference also discusses the limitations of current commercially available immunoassays for therapeutic monitoring. It presents new and sophisticated techniques used for proper determination of blood levels and the clinical utility of therapeutic drug monitoring of contemporary drugs. Written by leading international experts and geared toward clinical pathologists, toxicologists, clinical chemists, laboratory professionals and physicians, this book is an essential resource on the current practice of therapeutic drug monitoring in improving patient safety. Includes both the technical and clinical issues associated with therapeutic drug monitoring Discusses the utility of therapeutic drug monitoring of newer drugs such as antiretroviral agents, anticonvulsants, antidepressants etc. Provides up-to-date information on issues in pharmacogenomics and personalized medicine with emphasis on therapy with warfarin, certain anticancer drugs and antidepressants Covers important content on the limitations of commercially available immunoassays (chemical tests) for therapeutic drug monitoring and additional analytical techniques

Therapeutic Drug Monitoring Data Book

Therapeutic Drug Monitoring Data


  • Author : Amitava Dasgupta
  • Publisher : Academic Press
  • Release Date : 2019-09-14
  • Genre: Science
  • Pages : 382
  • ISBN 10 : 9780128158500

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Therapeutic Drug Monitoring Data Excerpt :

Therapeutic Drug Monitoring Data: A Concise Guide, Fourth Edition serves as a ready resource of information on commonly monitored drugs that will help readers make decisions relating to the monitoring and interpretation of results. It is an easy-to-read source of information on intended use, pharmacokinetics, therapeutic range, and toxic concentrations, as well as bioavailability, disposition, metabolism and the excretion of commonly monitored therapeutic drugs. This fully updated fourth edition includes sections on new anticonvulsants, anti-depressant and anti-HIV drugs, new drugs for advanced cancer treatment, and thoroughly updated chapters that address new pitfalls and problems in the lab. Serves as a ready resource of information for commonly monitored drugs Presents a useful, quick guide for those making decisions related to monitoring and interpretation of results Provides concise, easily digestible content for clinical laboratory scientists, toxicologists and clinicians

Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology Book

Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology


  • Author : Seth Kwabena Amponsah
  • Publisher : Springer
  • Release Date : 2022-11-12
  • Genre: Medical
  • Pages : 0
  • ISBN 10 : 3031123972

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Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology Excerpt :

This book gives an overview of therapeutic drug monitoring (TDM) and its clinical application. It also highlights recent advances in toxicological studies, as they relate to therapeutic drug monitoring. This is one of the few books available on the market that covers TDM. Therapeutic drug monitoring (TDM) is a clinical decision-making tool that enables dosage regimen adjustments based on clinical and laboratory measurements. TDM not only involves the measuring of drug concentrations but also interpretation of the results. There is a strong correlation between drug concentrations in body fluids and outcome than between dose and outcome. The chapters include coverage of analytical techniques, pharmacokinetics, therapeutic indices, artificial intelligence and recent advances in toxicological studies. The book fills a gap in published literature and provides reliable information on; Analytical techniques in TDM and clinical toxicology TDM and pharmacokinetic studies TDM of drugs with narrow therapeutic indices Artificial intelligence in TDM and clinical toxicology Future directions and challenges

Improving and Accelerating Therapeutic Development for Nervous System Disorders Book

Improving and Accelerating Therapeutic Development for Nervous System Disorders


  • Author : Institute of Medicine
  • Publisher : National Academies Press
  • Release Date : 2014-02-06
  • Genre: Medical
  • Pages : 118
  • ISBN 10 : 9780309292498

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Improving and Accelerating Therapeutic Development for Nervous System Disorders Excerpt :

Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.

Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology Book

Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology


  • Author : Seth Kwabena Amponsah
  • Publisher : Springer Nature
  • Release Date : 2022-10-25
  • Genre: Medical
  • Pages : 384
  • ISBN 10 : 9783031123986

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Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology Excerpt :

This book gives an overview of therapeutic drug monitoring (TDM) and its clinical application. It also highlights recent advances in toxicological studies, as they relate to therapeutic drug monitoring. This is one of the few books available on the market that covers TDM. Therapeutic drug monitoring (TDM) is a clinical decision-making tool that enables dosage regimen adjustments based on clinical and laboratory measurements. TDM not only involves the measuring of drug concentrations but also interpretation of the results. There is a strong correlation between drug concentrations in body fluids and outcome than between dose and outcome. The chapters include coverage of analytical techniques, pharmacokinetics, therapeutic indices, artificial intelligence and recent advances in toxicological studies. The book fills a gap in published literature and provides reliable information on; Analytical techniques in TDM and clinical toxicology TDM and pharmacokinetic studies TDM of drugs with narrow therapeutic indices Artificial intelligence in TDM and clinical toxicology Future directions and challenges

Clinical Pharmacy Education  Practice and Research Book

Clinical Pharmacy Education Practice and Research


  • Author : Dixon Thomas
  • Publisher : Elsevier
  • Release Date : 2018-11-23
  • Genre: Business & Economics
  • Pages : 540
  • ISBN 10 : 9780128142776

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Clinical Pharmacy Education Practice and Research Excerpt :

Clinical Pharmacy Education, Practice and Research offers readers a solid foundation in clinical pharmacy and related sciences through contributions by 83 leading experts in the field from 25 countries. This book stresses educational approaches that empower pharmacists with patient care and research competencies. The learning objectives and writing style of the book focus on clarifying the concepts comprehensively for a pharmacist, from regular patient counseling to pharmacogenomics practice. It covers all interesting topics a pharmacist should know. This book serves as a basis to standardize and coordinate learning to practice, explaining basics and using self-learning strategies through online resources or other advanced texts. With an educational approach, it guides pharmacy students and pharmacists to learn quickly and apply. Clinical Pharmacy Education, Practice and Research provides an essential foundation for pharmacy students and pharmacists globally. Covers the core information needed for pharmacy practice courses Includes multiple case studies and practical situations with 70% focused on practical clinical pharmacology knowledge Designed for educational settings, but also useful as a refresher for advanced students and researchers

Voriconazole Book

Voriconazole


  • Author : Andrea Angelini
  • Publisher : Unknown
  • Release Date : 2015
  • Genre: Antifungal agents
  • Pages : 208
  • ISBN 10 : 1634639405

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Voriconazole Excerpt :

In the last twenty years, the incidence of invasive fungal infections (IFI) has risen dramatically due to the prolongation of survival of patients with multiple risk factors for fungal infections and due to the increase of infection associated with travel. Moreover IFI in infants admitted to the neonatal intensive care unit are common and often fatal. Amphotericin B was for more than 40 years the gold standard for almost all IFI, but toxicity and resistance, especially of new and emerging pathogens remained important issues. Fluconazole and itraconazole have also the same disadvantage of resistance. After a long period of relative inactivity in the introduction of new antifungals, more recently a few new drugs of already existing classes have been introduced as important agents in the treatment and prevention of IFI. These represent small or large advantages and differences compared with existing available alternative therapy for deep and systemic mycoses. Voriconazole is a second-generation triazole antifungal drug, often prescribed as first-line therapy for candidemia, in non-neutropenic hosts, for invasive pulmonary aspergillosis and as prophylaxis of many systemic mycoses. In-vitro and in-vivo studies showed that voriconazole has broad-spectrum activity against most Candida species, Aspergillus species, fusariosis or scedosporiosis. Voriconazole has non-linear pharmacokinetics and, as substrate and inhibitor of cytochrome P450, it undergoes extensive hepatic metabolism that depends on age, genetic factors, and interactions with other drugs, which may lead to enhanced toxicity of the concomitant medication(s) or ineffective antifungal treatment. This book presents an update on voriconazole research, particularly its pharmacology, microbiology, toxicology, and clinical outcomes in order to optimize its use in daily clinical practice.

Individualized Drug Therapy for Patients Book

Individualized Drug Therapy for Patients


  • Author : Roger W Jelliffe
  • Publisher : Academic Press
  • Release Date : 2016-11-15
  • Genre: Medical
  • Pages : 434
  • ISBN 10 : 9780128033494

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Individualized Drug Therapy for Patients Excerpt :

Individualized Drug Therapy for Patients: Basic Foundations, Relevant Software and Clinical Applications focuses on quantitative approaches that maximize the precision with which dosage regimens of potentially toxic drugs can hit a desired therapeutic goal. This book highlights the best methods that enable individualized drug therapy and provides specific examples on how to incorporate these approaches using software that has been developed for this purpose. The book discusses where individualized therapy is currently and offers insights to the future. Edited by Roger Jelliffe, MD and Michael Neely, MD, renowned authorities in individualized drug therapy, and with chapters written by international experts, this book provides clinical pharmacologists, pharmacists, and physicians with a valuable and practical resource that takes drug therapy away from a memorized ritual to a thoughtful quantitative process aimed at optimizing therapy for each individual patient. Uses pharmacokinetic approaches as the tools with which therapy is individualized Provides examples using specific software that illustrate how best to apply these approaches and to make sense of the more sophisticated mathematical foundations upon which this book is based Incorporates clinical cases throughout to illustrate the real-world benefits of using these approaches Focuses on quantitative approaches that maximize the precision with which dosage regimens of potentially toxic drugs can hit a desired therapeutic goal

Handbook of Drug Monitoring Methods Book

Handbook of Drug Monitoring Methods


  • Author : Amitava Dasgupta
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-10-23
  • Genre: Medical
  • Pages : 441
  • ISBN 10 : 9781588297808

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Handbook of Drug Monitoring Methods Excerpt :

In Handbook of Drug Monitoring Methods: Therapeutics and Drug Abuse, authors discuss the different analytical techniques used in today’s practice of therapeutic drug monitoring and drugs of abuse as well as alcohol testing with relevant theory, mechanism, and in-depth scientific discussion on each topic. This volume is the perfect handbook and quick reference for any clinical laboratory, allowing clinicians to find the potential source of a false-positive or a false-negative result in the daily operation of a toxicology laboratory. At the same time, this book can also be used as a reference for medical technologists, supervisors, laboratory directors, clinical chemists, toxicologists, and pathologists to find in-depth cause of a potential interference and what tests can be ordered to circumvent such problem. The volume’s first half focuses on various issues of therapeutic drug monitoring. Additional chapters cover analysis of heavy metals, alcohol testing, and issues of drugs of abuse testing. These chapters are written by experts in their relative sub-specialties and also by the editor. Comprehensive and timely, Handbook of Drug Monitoring Methods: Therapeutics and Drug Abuse is the ideal text for clinicians and researchers monitoring alcohol and drug testing and other important tasks of toxicological laboratory services.

Pocket Guide to Diagnostic Tests  Sixth Edition Book

Pocket Guide to Diagnostic Tests Sixth Edition


  • Author : Diana Nicoll
  • Publisher : McGraw Hill Professional
  • Release Date : 2012-06-22
  • Genre: Medical
  • Pages : 528
  • ISBN 10 : 9780071766241

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Pocket Guide to Diagnostic Tests Sixth Edition Excerpt :

A quick reference guide to the selection and interpretation of more than 450 commonly used diagnostic tests COVERS: Basic principles of diagnostic testing, common blood, urine and cerebrospinal fluid laboratory tests, therapeutic drug monitoring, microbiologic test selection and interpretation and diagnostic imaging tests by body system , electrocardiography, and differential diagnosis tables & algorithms Tests used in internal medicine, pediatrics, surgery, neurology and obstetrics and gynecology INCLUDES: Costs and risks of diagnostic tests Evidence-based information Diseases associated with abnormal test results, including test sensitivities Full literature citations with PubMed (PMID) numbers included for each reference More than 24 NEW clinical laboratory test entries, 6 NEW differential diagnosis tables 5 NEW diagnostic algorithms NEW sections on point-of-care testing, provider-performed microscopy, pharmacogenetic testing, and diagnostic echocardiography

Antiepileptic Drug Interactions Book
Score: 5
From 1 Ratings

Antiepileptic Drug Interactions


  • Author : Philip Patsalos
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-03
  • Genre: Medical
  • Pages : 437
  • ISBN 10 : 9781447124344

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Antiepileptic Drug Interactions Excerpt :

Antiepileptic Drug Interactions: A Clinical Guide, Second Edition provides a pocket-sized, systematic description of the most clinically relevant drug interactions that occur between AEDs and also between AEDs and non-AEDs. AEDs are presented alphabetically and by drug class in three sections for easy access: Drug interactions between AEDs; Drug interactions between AEDs and non-AEDs: Interactions affecting AEDs; and Drug interactions between AEDs and non-AEDs: Interactions affected by AEDs. Antiepileptic Drug Interactions: A Clinical Guide, Second Edition should help physicians make more rational choices when polytherapy regimens are indicated and should be of interest to all who treat patients with epilepsy: neurologists and neurosurgeons, trainees at all levels, general practitioners and epilepsy nurse specialists.

Antibiotic Pharmacokinetic Pharmacodynamic Considerations in the Critically Ill Book

Antibiotic Pharmacokinetic Pharmacodynamic Considerations in the Critically Ill


  • Author : Andrew A. Udy
  • Publisher : Springer
  • Release Date : 2017-09-18
  • Genre: Medical
  • Pages : 275
  • ISBN 10 : 9789811053368

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Antibiotic Pharmacokinetic Pharmacodynamic Considerations in the Critically Ill Excerpt :

This book provides unique insights into the issues that drive modified dosing regimens for antibiotics in the critically ill. Leading international authors provide their commentary alongside a summary of existing evidence on how to effectively dose antibiotics. Severe infection frequently necessitates admission to the intensive care unit (ICU). Equally, nosocomial sepsis often complicates the clinical course in ICU. Early, appropriate application of antibiotic therapy remains a cornerstone of effective management. However, this is challenging in the critical care environment, given the significant changes in patient physiology and organ function frequently encountered. Being cognisant of these factors, prescribers need to consider modified dosing regimens, not only to ensure adequate drug exposure, and therefore the greatest chance of clinical cure, but also to avoid encouraging drug resistance.

Mass Spectrometry for the Clinical Laboratory Book

Mass Spectrometry for the Clinical Laboratory


  • Author : Hari Nair
  • Publisher : Academic Press
  • Release Date : 2016-11-02
  • Genre: Medical
  • Pages : 304
  • ISBN 10 : 9780128009925

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Mass Spectrometry for the Clinical Laboratory Excerpt :

Mass Spectrometry for the Clinical Laboratory is an accessible guide to mass spectrometry and the development, validation, and implementation of the most common assays seen in clinical labs. It provides readers with practical examples for assay development, and experimental design for validation to meet CLIA requirements, appropriate interference testing, measuring, validation of ion suppression/matrix effects, and quality control. These tools offer guidance on what type of instrumentation is optimal for each assay, what options are available, and the pros and cons of each. Readers will find a full set of tools that are either directly related to the assay they want to adopt or for an analogous assay they could use as an example. Written by expert users of the most common assays found in a clinical laboratory (clinical chemists, toxicologists, and clinical pathologists practicing mass spectrometry), the book lays out how experts in the field have chosen their mass spectrometers, purchased, installed, validated, and brought them on line for routine testing. The early chapters of the book covers what the practitioners have learned from years of experience, the challenges they have faced, and their recommendations on how to build and validate assays to avoid problems. These chapters also include recommendations for maintaining continuity of quality in testing. The later parts of the book focuses on specific types of assays (therapeutic drugs, Vitamin D, hormones, etc.). Each chapter in this section has been written by an expert practitioner of an assay that is currently running in his or her clinical lab. Provides readers with the keys to choosing, installing, and validating a mass spectrometry platform Offers tools to evaluate, validate, and troubleshoot the most common assays seen in clinical pathology labs Explains validation, ion suppression, interference testing, and quality control design to the detail that is required for implementation in the lab