Clinical Decision Support for Pharmacogenomic Precision Medicine Book

Clinical Decision Support for Pharmacogenomic Precision Medicine


  • Author : Beth Devine
  • Publisher : Academic Press
  • Release Date : 2022-06-01
  • Genre: Medical
  • Pages : 424
  • ISBN 10 : 9780128244548

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Clinical Decision Support for Pharmacogenomic Precision Medicine Excerpt :

Clinical Decision Support for Pharmacogenomic Precision Medicine: Foundations and Implementation offers overviews, methods and strategies for translating genomic medicine to clinical practice. The book's authors explore incorporating pharmacogenetics into electronic health records, CDS methods and infrastructure for delivery, economic evaluation, the hospital administrations’ role and needs in integration, and patient counseling aspects. The book empowers clinicians, researchers, translational scientists, and data and IT experts to effectively navigate the complex landscape of CDS for pharmacogenomic precision medicine. Illustrative case studies of existing gene networks include CSER, eMERGE, the IGNITE network, DIGITIZE, the CDS Learning Network (RTI), ClinGen, Ubiquitous and CDS Hooks. Offers an applied, case-driven discussion of CDS for pharmacogenomic precision medicine Illustrates key concepts, contemporary developments, and future directions using examples of existing gene networks Features contributions from leading voices in precision medicine and clinical decision support

Clinical Decision Support for Pharmacogenomic Precision Medicine Book

Clinical Decision Support for Pharmacogenomic Precision Medicine


  • Author : Richard David Boyce
  • Publisher : Academic Press
  • Release Date : 2022-06-15
  • Genre: Medical
  • Pages : 424
  • ISBN 10 : 0128244534

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Clinical Decision Support for Pharmacogenomic Precision Medicine Excerpt :

Clinical Decision Support for Pharmacogenomic Precision Medicine: Foundations and Implementation offers overviews, methods and strategies for translating genomic medicine to clinical practice. The book's authors explore incorporating pharmacogenetics into electronic health records, CDS methods and infrastructure for delivery, economic evaluation, the hospital administrations' role and needs in integration, and patient counseling aspects. The book empowers clinicians, researchers, translational scientists, and data and IT experts to effectively navigate the complex landscape of CDS for pharmacogenomic precision medicine. Illustrative case studies of existing gene networks include CSER, eMERGE, the IGNITE network, DIGITIZE, the CDS Learning Network (RTI), ClinGen, Ubiquitous and CDS Hooks. Offers an applied, case-driven discussion of CDS for pharmacogenomic precision medicine Illustrates key concepts, contemporary developments, and future directions using examples of existing gene networks Features contributions from leading voices in precision medicine and clinical decision support

Personalized and Precision Medicine Informatics Book

Personalized and Precision Medicine Informatics


  • Author : Terrence Adam
  • Publisher : Springer Nature
  • Release Date : 2019-09-17
  • Genre: Medical
  • Pages : 349
  • ISBN 10 : 9783030186265

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Personalized and Precision Medicine Informatics Excerpt :

This book adopts an integrated and workflow-based treatment of the field of personalized and precision medicine (PPM). Outlined within are established, proven and mature workflows as well as emerging and highly-promising opportunities for development. Each workflow is reviewed in terms of its operation and how they are enabled by a multitude of informatics methods and infrastructures. The book goes on to describe which parts are crucial to discovery and which are essential to delivery and how each of these interface and feed into one-another. Personalized and Precision Medicine Informatics provides a comprehensive review of the integrative as well as interpretive nature of the topic and brings together a large body of literature to define the topic and ensure that this is the key reference for the topic. It is an unique contribution that is positioned to be an essential guide for both PPM experts and non-experts, and for both informatics and non-informatics professionals.

Reinventing Clinical Decision Support Book

Reinventing Clinical Decision Support


  • Author : Paul Cerrato
  • Publisher : Taylor & Francis
  • Release Date : 2020-01-15
  • Genre: Business & Economics
  • Pages : 166
  • ISBN 10 : 9781000055559

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Reinventing Clinical Decision Support Excerpt :

This book takes an in-depth look at the emerging technologies that are transforming the way clinicians manage patients, while at the same time emphasizing that the best practitioners use both artificial and human intelligence to make decisions. AI and machine learning are explored at length, with plain clinical English explanations of convolutional neural networks, back propagation, and digital image analysis. Real-world examples of how these tools are being employed are also discussed, including their value in diagnosing diabetic retinopathy, melanoma, breast cancer, cancer metastasis, and colorectal cancer, as well as in managing severe sepsis. With all the enthusiasm about AI and machine learning, it was also necessary to outline some of criticisms, obstacles, and limitations of these new tools. Among the criticisms discussed: the relative lack of hard scientific evidence supporting some of the latest algorithms and the so-called black box problem. A chapter on data analytics takes a deep dive into new ways to conduct subgroup analysis and how it’s forcing healthcare executives to rethink the way they apply the results of large clinical trials to everyday medical practice. This re-evaluation is slowly affecting the way diabetes, heart disease, hypertension, and cancer are treated. The research discussed also suggests that data analytics will impact emergency medicine, medication management, and healthcare costs. An examination of the diagnostic reasoning process itself looks at how diagnostic errors are measured, what technological and cognitive errors are to blame, and what solutions are most likely to improve the process. It explores Type 1 and Type 2 reasoning methods; cognitive mistakes like availability bias, affective bias, and anchoring; and potential solutions such as the Human Diagnosis Project. Finally, the book explores the role of systems biology and precision medicine in clinical decision support and provides several case studies of how next genera

Pharmacogenomics in Psychiatry Book

Pharmacogenomics in Psychiatry


  • Author : M. Schwab
  • Publisher : Karger Medical and Scientific Publishers
  • Release Date : 2010-06-25
  • Genre: Medical
  • Pages : 148
  • ISBN 10 : 9783805594998

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Pharmacogenomics in Psychiatry Excerpt :

In recent years, there have been major developments in the fields of pharmacogenetics and pharmacogenomics, with the potential to make drug treatments in psychiatric medicine more effective. However, improvements in drug efficacy and tolerability, as well as finding the optimal dosage, can only be realized if in vivo mechanisms of drug action and ADME (absorption, distribution, metabolism, excretion) processes (pharmacokinetics) of psychopharmacological agents are better understood. In this volume, current progress and perspectives in pharmacogenetic testing of drug-metabolizing enzymes, drug transporters and other drug targets involved in the response to psychotropic agents are described extensively. This provides a timely overview of what has been achieved in the area of psychiatric pharmacogenomics alongside some promising directions and perspectives for future research.Psychiatrists, general medical doctors as well as pharmacologists and clinical pharmacologists will find new insights into the development and applications of pharmacogenomics in psychiatry.

Pharmacogenomics in Precision Medicine Book

Pharmacogenomics in Precision Medicine


  • Author : Weimin Cai
  • Publisher : Springer Nature
  • Release Date : 2020-06-12
  • Genre: Medical
  • Pages : 289
  • ISBN 10 : 9789811538957

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Pharmacogenomics in Precision Medicine Excerpt :

This book provides an introduction to the principles of pharmacogenomics and precision medicine, followed by the pharmacogenomics aspects of major therapeutic areas such as cardiovascular disease, cancer, organ transplantation, psychiatry, infection, antithrombotic drugs. It also includes genotyping technology and therapeutic drug monitoring in Pharmacogenomics; ethical, Legal and Regulatory Issues; cost-effectiveness of pharmacogenetics-guided treatment; application of pharmacogenomics in drug discovery and development and clinical Implementation of Pharmacogenomics for Personalized Precision Medicine. The contributors of Pharmacogenomics in Precision Medicine come from a team of experts, including professors from academic institutions and practitioner from hospital. It will give an in-depth overview of the current state of pharmacogenomics in drug therapy for all health care professionals and graduate students in the era of precision medicine.

Clinical Precision Medicine Book

Clinical Precision Medicine


  • Author : Judy S. Crabtree
  • Publisher : Academic Press
  • Release Date : 2019-11-15
  • Genre: Medical
  • Pages : 112
  • ISBN 10 : 9780128204023

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Clinical Precision Medicine Excerpt :

Clinical Precision Medicine: A Primer offers clinicians, researchers and students a practical, up-to-date resource on precision medicine, its evolving technologies, and pathways towards clinical implementation. Early chapters address the fundamentals of molecular biology and gene regulation as they relate to precision medicine, as well as the foundations of heredity and epigenetics. Oncology, an early adopter of precision approaches, is considered with its relationship to genetic variation in drug metabolism, along with tumor immunology and the impact of DNA variation in clinical care. Contributions by Stephanie Kramer, a Clinical Genetic Counselor, also provide current information on prenatal diagnostics and adult genetics that highlight the critical role of genetic counselors in the era of precision medicine. Includes applied discussions of chromosomes and chromosomal abnormalities, molecular genetics, epigenetic regulation, heredity, clinical genetics, pharmacogenomics and immunogenomics Features chapter contributions from leaders in the field Consolidates fundamental concepts and current practices of precision medicine in one convenient resource

Toward Precision Medicine Book

Toward Precision Medicine


  • Author : National Research Council
  • Publisher : National Academies Press
  • Release Date : 2012-01-16
  • Genre: Medical
  • Pages : 142
  • ISBN 10 : 9780309222228

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Toward Precision Medicine Excerpt :

Motivated by the explosion of molecular data on humans-particularly data associated with individual patients-and the sense that there are large, as-yet-untapped opportunities to use this data to improve health outcomes, Toward Precision Medicine explores the feasibility and need for "a new taxonomy of human disease based on molecular biology" and develops a potential framework for creating one. The book says that a new data network that integrates emerging research on the molecular makeup of diseases with clinical data on individual patients could drive the development of a more accurate classification of diseases and ultimately enhance diagnosis and treatment. The "new taxonomy" that emerges would define diseases by their underlying molecular causes and other factors in addition to their traditional physical signs and symptoms. The book adds that the new data network could also improve biomedical research by enabling scientists to access patients' information during treatment while still protecting their rights. This would allow the marriage of molecular research and clinical data at the point of care, as opposed to research information continuing to reside primarily in academia. Toward Precision Medicine notes that moving toward individualized medicine requires that researchers and health care providers have access to very large sets of health- and disease-related data linked to individual patients. These data are also critical for developing the information commons, the knowledge network of disease, and ultimately the new taxonomy.

Progress and Challenges in Precision Medicine Book

Progress and Challenges in Precision Medicine


  • Author : Mukesh Verma
  • Publisher : Academic Press
  • Release Date : 2016-12-22
  • Genre: Medical
  • Pages : 344
  • ISBN 10 : 9780128095027

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Progress and Challenges in Precision Medicine Excerpt :

Progress and Challenges in Precision Medicine presents an insightful overview to the myriad factors of personalized and precision medicine. The availability of the human genome, large amounts of data on individual genetic variations, environmental interactions, influence of lifestyle, and cutting-edge tools and technologies for big-data analysis have led to the age of personalized and precision medicine. Bringing together a global range of experts on precision medicine, this book collects previously scattered information into one concise volume which covers the most important developments so far in precision medicine and also suggests the most likely avenues for future development. The book includes clinical information, informatics, public policy implications, and information on case studies. It is a useful reference and background work for students, researchers, and clinicians working in the biomedical and medical fields, as well as policymakers in the health sciences. Provides an overview of the growing field of precision medicine Contains chapters from geographically diverse experts in their field Explores important aspects of precision medicine, including applications, ethics, and development

Pharmacogenomics Book

Pharmacogenomics


  • Author : Yui-Wing Francis Lam
  • Publisher : Academic Press
  • Release Date : 2018-11-27
  • Genre: Medical
  • Pages : 442
  • ISBN 10 : 9780128126271

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Pharmacogenomics Excerpt :

Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation, Second Edition, provides comprehensive coverage of the challenges and opportunities facing the therapeutic implications of pharmacogenomics from academic, regulatory, pharmaceutical, socio-ethical and economic perspectives. While emphasis is on the limitations in moving the science into drug development and direct therapeutic applications, this book also focuses on clinical areas with successful applications and important initiatives that have the ability to further advance the discipline. New chapters cover important topics such as pharmacogenomic data technologies, clinical testing strategies, cost-effectiveness, and pharmacogenomic education and practice guidelines. The importance of ethnicity is also discussed, which highlights phar,acogenomic diversity across Latin American populations. With chapters written by interdisciplinary experts and insights into the future direction of the field, this book is an indispensable resource for academic and industry scientists, graduate students and clinicians engaged in pharmacogenomics research and therapeutic implementation. Provides viewpoints that focus on the scientific and translational challenges and opportunities associated with advancing the field of pharmacogenomics Highlights progress in both the research and clinical areas of pharmacogenomics, as well as relevant implementation experience, challenges, and perspectives on direct-to-consumer genetic testing Includes, where applicable, discussion points, review questions, and cases for self-assessment purposes and to facilitate in-depth discussion

Genomic and Precision Medicine Book

Genomic and Precision Medicine


  • Author : Geoffrey S. Ginsburg
  • Publisher : Academic Press
  • Release Date : 2022-04-09
  • Genre: Science
  • Pages : 378
  • ISBN 10 : 9780128006535

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Genomic and Precision Medicine Excerpt :

Genomic and Precision Medicine: Oncology, Third Edition focuses on the applications of genome discovery as research points to personalized cancer therapies. Each chapter is organized to cover the application of genomics and personalized medicine tools and technologies to a) Risk Assessment and Susceptibility, b) Diagnosis and Prognosis, c) Pharmacogenomics and Precision Therapeutics, and d) Emerging and Future Opportunities in the field. Provides a comprehensive volume written and edited by oncology genomic specialists for oncology health providers Includes succinct commentary and key learning points that will assist providers with their local needs for implementation of genomic and personalized medicine into practice Presents an up-to-date overview on major opportunities for genomic and personalized medicine in practice Covers case studies that highlight the practical use of genomics in the management of patients

Economic Dimensions of Personalized and Precision Medicine Book

Economic Dimensions of Personalized and Precision Medicine


  • Author : Ernst R. Berndt
  • Publisher : National Bureau of Economic Re
  • Release Date : 2019-04-22
  • Genre: Business & Economics
  • Pages : 392
  • ISBN 10 : 9780226611068

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Economic Dimensions of Personalized and Precision Medicine Excerpt :

Personalized and precision medicine (PPM)--the targeting of therapies according to an individual's genetic, environmental, or lifestyle characteristics--is becoming an increasingly important approach in health care treatment and prevention. The advancement of PPM is a challenge in traditional clinical, reimbursement, and regulatory landscapes because it is costly to develop and introduces a wide range of scientific, clinical, ethical, and socioeconomic issues. PPM raises a multitude of economic issues, including how information on accurate diagnosis and treatment success will be disseminated and who will bear the cost; changes to physician training to incorporate genetics, probability and statistics, and economic considerations; questions about whether the benefits of PPM will be confined to developed countries or will diffuse to emerging economies with less developed health care systems; the effects of patient heterogeneity on cost-effectiveness analysis; and opportunities for PPM's growth beyond treatment of acute illness, such as prevention and reversal of chronic conditions. This volume explores the intersection of the scientific, clinical, and economic factors affecting the development of PPM, including its effects on the drug pipeline, on reimbursement of PPM diagnostics and treatments, and on funding of the requisite underlying research; and it examines recent empirical applications of PPM.

The UKU Side Effect Rating Scale Book

The UKU Side Effect Rating Scale


  • Author : O. Lingjaerde
  • Publisher : Unknown
  • Release Date : 1987
  • Genre: Psychotropic drugs
  • Pages : 100
  • ISBN 10 : IND:30000114243979

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The UKU Side Effect Rating Scale Excerpt :

Precision Public Health Book

Precision Public Health


  • Author : Tarun Weeramanthri
  • Publisher : Frontiers Media SA
  • Release Date : 2018-06-25
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : 9782889455010

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Precision Public Health Excerpt :

Precision Public Health is a new and rapidly evolving field, that examines the application of new technologies to public health policy and practice. It draws on a broad range of disciplines including genomics, spatial data, data linkage, epidemiology, health informatics, big data, predictive analytics and communications. The hope is that these new technologies will strengthen preventive health, improve access to health care, and reach disadvantaged populations in all areas of the world. But what are the downsides and what are the risks, and how can we ensure the benefits flow to those population groups most in need, rather than simply to those individuals who can afford to pay? This is the first collection of theoretical frameworks, analyses of empirical data, and case studies to be assembled on this topic, published to stimulate debate and promote collaborative work.