Clinical Studies and Therapies in Parkinson s Disease Book

Clinical Studies and Therapies in Parkinson s Disease


  • Author : Juan Segura-Aguilar
  • Publisher : Academic Press
  • Release Date : 2021-06-12
  • Genre: Medical
  • Pages : 306
  • ISBN 10 : 9780128221587

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Clinical Studies and Therapies in Parkinson s Disease Excerpt :

More than 50 years have passed since the use of L-dopa in the palliative treatment of Parkinson’s disease, but it remains the most common treatment despite inducing severe side effects such as dyskinesia after 4–6 years of use. Numerous preclinical investigations based on endogenous neurotoxin models have promised various therapies for Parkinson’s disease, but these efforts have failed when attempting to transfer these successful results to preclinical studies. Although several publications have warned of these failures, the scientific community remains mostly unaware, and there is a need to focus their efforts on potential therapeutics that can slow or halt development of the disease. Clinical Studies and Therapies in Parkinson’s Disease: Translations from Preclinical Models analyzes preclinical models based on exogenous neurotoxins and why they have failed. Neuroscientists, neurologists, and neuropharmacologists will benefit greatly from the book’s discussion of these newer models, their benefits, and the need for their implementation. This book also provides the basic concepts of dopamine metabolism for students taking courses in neurochemistry, neuroscience, neuropharmacology, biochemistry, and medicine. Reviews Parkinson's disease classification, pharmacological therapies, and nonmotor and motor symptoms Analyzes preclinical models of Parkinson’s disease therapies based on exogenous neurotoxins and why they have failed Reviews genetic preclinical models based on genetic mutations and endogenous neurotoxins Proposes a more physiological model directly related to the metabolism of dopaminergic neurons Provides the basic concepts and mechanisms of dopamine metabolism

Parkinson s Disease Book

Parkinson s Disease


  • Author : National Collaborating Centre for Chronic Conditions (Great Britain)
  • Publisher : Royal College of Physicians
  • Release Date : 2006
  • Genre: Parkinson's disease
  • Pages : 237
  • ISBN 10 : 9781860162831

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Clinical Trials In Parkinson s Disease Book

Clinical Trials In Parkinson s Disease


  • Author : Santiago Perez-Lloret
  • Publisher : Humana
  • Release Date : 2021-09-02
  • Genre: Medical
  • Pages : 396
  • ISBN 10 : 1071609149

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Clinical Trials In Parkinson s Disease Excerpt :

This volume looks at major clinical trials for motor and non-motor symptoms in Parkinson’s Disease (PD) and covers important aspects, including trial design, sample selection, and outcome selection. Chapters in this book discuss topics such as toxin-based rodent or genetic models of PD; clinical trials for motor symptoms, L-DOPA related motor complications, and gait disorders; clinical trials for mood disorders, troubled sleep, autonomic dysfunction; and clinical trials for disease modifying therapies. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory or research center. Cutting-edge and authoritative, Clinical Trials in Parkinson’s Disease is a valuable resource for clinicians and researchers who want to enhance their interpretation of results from clinical trials and to design their own high-quality trials.

Restorative Therapies in Parkinson s Disease Book

Restorative Therapies in Parkinson s Disease


  • Author : Patrik Brundin
  • Publisher : Springer Science & Business Media
  • Release Date : 2006-08-31
  • Genre: Medical
  • Pages : 365
  • ISBN 10 : 9780387328232

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Restorative Therapies in Parkinson s Disease Excerpt :

In this exciting and timely book new approaches to repairing the parkinsonian brain are described by leading experts. Never in history has there been greater hope that novel experimental therapies can support significant restoration of brain function. This book gives an overview of the current state-of-the-art research for brain repair, what the challenges are and an indication of what research can provide for the next generation of people with Parkinson’s disease. The comprehensive chapters are geared to an audience of neuroscientists, neurologists, neurosurgeons and anyone interested in how findings in the research laboratory can effectively be transferred to the clinic.

Towards New Therapies for Parkinson s Disease Book

Towards New Therapies for Parkinson s Disease


  • Author : David Finkelstein
  • Publisher : BoD – Books on Demand
  • Release Date : 2011-11-02
  • Genre: Medical
  • Pages : 410
  • ISBN 10 : 9789533074634

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Towards New Therapies for Parkinson s Disease Excerpt :

Parkinson's disease (PD) is characterised clinically by various non-motor and progressive motor symptoms, pathologically by loss of dopamine producing cells and intraneuronal cytoplasmic inclusions composed primarily of ?-synuclein. By the time a patient first presents with symptoms of Parkinson's disease at the clinic, a significant proportion of the cells in the substantia nigra have already been destroyed. This degeneration progresses despite the current therapies until the cell loss is so great that the quality of normal life is compromised. The dopamine precursor levodopa is the most valuable drug currently available for the treatment of PD. However for most PD patients, the optimal clinical benefit from levodopa decreases around five to six years of treatment. The aim of the chapters of this book is to work towards an understanding in the mechanisms of degeneration and to develop disease modifying therapies.

Diagnosis and Treatment of Parkinson s Disease Book

Diagnosis and Treatment of Parkinson s Disease


  • Author : Cindy Levine
  • Publisher : Department of Health and Human Services Pu Ncy for Healthcare Res
  • Release Date : 2003-01-01
  • Genre: Evidence-based medicine
  • Pages : 306
  • ISBN 10 : 1587630885

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Non Motor Symptoms of Parkinson s Disease Book

Non Motor Symptoms of Parkinson s Disease


  • Author : K. Ray Chaudhuri
  • Publisher : Oxford University Press, USA
  • Release Date : 2014-10
  • Genre: Medical
  • Pages : 500
  • ISBN 10 : 9780199684243

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Non Motor Symptoms of Parkinson s Disease Excerpt :

Patients with Parkinson's disease (PD) are known to suffer from motor symptoms of the disease, but they also experience non-motor symptoms (NMS) that are often present before diagnosis or that inevitably emerge with disease progression. The motor symptoms of Parkinson's disease have been extensively researched, and effective clinical tools for their assessment and treatment have been developed and are readily available. In contrast, researchers have only recently begun to focus on the NMS of Parkinson's Disease, which are poorly recognized and inadequately treated by clinicians. The NMS of PD have a significant impact on patient quality of life and mortality and include neuropsychiatric, sleep-related, autonomic, gastrointestinal, and sensory symptoms. While some NMS can be improved with currently available treatments, others may be more refractory and will require research into novel (non-dopaminergic) drug therapies for the future. Edited by members of the UK Parkinson's Disease Non-Motor Group (PD-NMG) and with contributions from international experts, this new edition summarizes the current understanding of NMS symptoms in Parkinson's disease and points the way towards future research.

The New Parkinson s Disease Treatment Book Book

The New Parkinson s Disease Treatment Book


  • Author : J. Eric Ahlskog, PhD, MD
  • Publisher : Oxford University Press
  • Release Date : 2015-08-03
  • Genre: Health & Fitness
  • Pages : 544
  • ISBN 10 : 9780190231880

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The New Parkinson s Disease Treatment Book Excerpt :

The fundamental guide to the most effective treatments for Parkinson's Disease, from a Mayo Clinic doctor with thirty years of clinical and research experience. In this second edition follow-up to the extremely successful first edition, Dr. Ahlskog draws on thirty years of clinical experience to present the definitive guide to dealing with all aspects of Parkinson's Disease, from treatment options and side effects to the impact of the disease on caregivers and family. Dr. Ahlskog's goal is to educate patients so that they can better team up with their doctors to do battle with the disease, streamlining the decision-making process and enhancing their treatment. To do this, Dr. Ahlskog offers a gold mine of information, distilled from his years of experience treating people with Parkinson's at the Mayo Clinic. In addition to providing a comprehensive account of Parkinson's medications, this book also examines additional aspects of treatment, such as the role of nutrition, exercise, and physical therapy. Although many commendable texts have been written on the subject of Parkinson's Disease, their discussions of treatment have not been in depth. Dr. Ahlskog sifts through aspects of the disease in order to give the reader a comprehensive sense of Parkinson's and the best available treatment options. With a broader understanding of the disease and the available options, patients are able to make more informed choices, and doctors are able to provide more tailored care. This book delivers hopeful, helpful, and extensive information to all parties concerned: patients, caregivers, and doctors. The ultimate guide to symptoms and treatment, this thoroughly updated second edition is the first place patients should turn for reliable, easy-to-grasp information on Parkinson's Disease.

Rating Scales in Parkinson s Disease Book

Rating Scales in Parkinson s Disease


  • Author : Cristina Sampaio
  • Publisher : Oxford University Press
  • Release Date : 2012-05-01
  • Genre: Medical
  • Pages : 328
  • ISBN 10 : 9780199783151

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Rating Scales in Parkinson s Disease Excerpt :

For many years, the need to develop valid tools to evaluate signs and symptoms of Parkinson Disease (PD) has been present. However the understanding of all intricacies of rating scales development was not widely available and the first attempts were relatively crude. In 2002, the Movement Disorders Society created a task force to systemize the measurement of Parkinson's Disease. Since then, the Task Force has produced and published several critiques to the available rating scales addressing both motor and non-motor domains of Parkinson Disease. Additionally the task force initiated a project to develop a new version of the UPDRS, the MDS-UPDRS. But none of this was made available in one convenient source. Until now. Rating Scales in Parkinson's Disease: Clinical Practice and Research is written for researchers from the medical and social sciences, and for health professionals wishing to evaluate the progress of their patients suffering from Parkinson's Disease. The book is both exhaustive in the description of the scales and informative on the advantages and limitations of each scale. As such, the text clearly guides readers on how to choose and use the instruments available. Extensive cross-referenced tables and charts closely integrate the parts of the book to facilitate readers in moving from one symptom domain to another.

Recent Advances in Parkinson s Disease Book

Recent Advances in Parkinson s Disease


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2020-04-02
  • Genre: Science
  • Pages : 574
  • ISBN 10 : 9780444642615

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Recent Advances in Parkinson s Disease Excerpt :

Recent Advances in Parkinson ́s Disease Research, Volume 252, represents a follow-up on two previous volumes presented in the Progress in Brain Research series, Volumes 193 and 193, both published in 2010. It contains a collection of overview articles written by leading researchers in Parkinson's, discussing the most important advances made in basic, translational and clinical research. Topics of note in this new release include What can we learn from iPS cell models of PD, What can we learn from animal models of PD?, Molecular basis of selective neuronal vulnerability in PD, Role of innate and adaptive immunity in Parkinson ́s disease, and much more. Covers all key aspects of current research on Parkinson ́s disease Includes topics that range from basic studies on disease models and pathogenic pathways (e.g., protein misfolding, immune and glial mechanisms) to clinical studies on disease features, microbiome, pathophysiology and therapeutic approaches Presents articles authored by world leaders in their respective fields

Leucine Rich Repeat Kinase 2  LRRK2  Book

Leucine Rich Repeat Kinase 2 LRRK2


  • Author : Hardy J. Rideout
  • Publisher : Springer
  • Release Date : 2017-03-28
  • Genre: Medical
  • Pages : 271
  • ISBN 10 : 9783319499697

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Leucine Rich Repeat Kinase 2 LRRK2 Excerpt :

This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It also discusses the current state of the field after a decade of research, putative normal physiological roles of LRRK2, and the various pathways that have been identified in the search for the mechanism(s) of its induction of neurodegeneration.

Levodopa Induced Dyskinesia in Parkinson s Disease Book

Levodopa Induced Dyskinesia in Parkinson s Disease


  • Author : Susan H. Fox
  • Publisher : Springer
  • Release Date : 2014-10-08
  • Genre: Medical
  • Pages : 368
  • ISBN 10 : 9781447165033

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Levodopa Induced Dyskinesia in Parkinson s Disease Excerpt :

This book aims to provide a single reference source on levodopa-induced dyskinesias (LID) from ‘bench to bedside’. Initial chapters review the clinical features and phenomenology of LID with video examples; epidemiology and genetic risk factors for LID are covered as a background to understanding risk factors for developing LID. The following chapters cover the latest preclinical studies aiming to understand the pathophysiology of LID at the cellular, neurochemical, neurophysiological and circuitry level with detailed discussion of mechanisms and future directions to take the field forward; clinical studies from phase II to phase IV; on going RCTs in LID and evidence-based medicine reviews of treatment options. Levodopa-Induced Dyskinesia in Parkinson’s Disease is aimed at an international audience of movement disorder neurologists; neuroscientists; trainees and graduate and post-graduate students.

Therapeutics of Parkinson s Disease and Other Movement Disorders Book

Therapeutics of Parkinson s Disease and Other Movement Disorders


  • Author : Mark Hallett
  • Publisher : John Wiley & Sons
  • Release Date : 2008-10-13
  • Genre: Medical
  • Pages : 520
  • ISBN 10 : 9780470714003

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Therapeutics of Parkinson s Disease and Other Movement Disorders Excerpt :

Provides a comprehensive update on therapies for Parkinson’s disease and other movement disorders Describes the basic mechanisms of neurodegeneration, pharmacologic interventions for motor and non-motor symptoms, and surgical management Features summary tables and algorithms that serve as a quick reference guide for practical treatment decisions The expert guidance of recognised authorities will enable readers of this book to plan their patients’ care with greater confidence

The NINCDS Parkinson s Disease Research Program Book

The NINCDS Parkinson s Disease Research Program


  • Author : National Institute of Neurological and Communicative Disorders and Stroke
  • Publisher : Unknown
  • Release Date : 1978
  • Genre: Medicine
  • Pages : null
  • ISBN 10 : STANFORD:36105214599602

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The NINCDS Parkinson s Disease Research Program Excerpt :