Combination Therapy Against Multidrug Resistance Book

Combination Therapy Against Multidrug Resistance


  • Author : Mohmmad Younus Wani
  • Publisher : Academic Press
  • Release Date : 2020-04-30
  • Genre: Business & Economics
  • Pages : 268
  • ISBN 10 : 9780128205785

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Combination Therapy Against Multidrug Resistance Excerpt :

Combination Therapy against Multidrug Resistance explores the potential of combination therapy as an efficient strategy to combat multi-drug resistance. Multidrug resistance (MDR) occurs when microorganisms such as bacteria, fungi, viruses, and parasites are excessively exposed to antimicrobial drugs such as antibiotics, antifungals, or antivirals, and in response the microorganism undergoes mutations or develops different resistance mechanisms to combat the drug for its survival. MDR is becoming an increasingly serious problem in both developed and developing nations. Bacterial resistance to antibiotics has developed faster than the production of new antibiotics, making bacterial infections increasingly difficult to treat, and the same is true for a variety of other diseases. Combination therapy proves to be a promising strategy as it offers potential benefits such as a broad spectrum of efficacy, greater potency than the drugs used in monotherapy, improved safety and tolerability, and reduction in the number of resistant organisms. This book considers how combination therapy can be applied in multiple situations, including cancer, HIV, tuberculosis, fungal infections, and more. Combination Therapy Against Multidrug Resistance gathers the most relevant information on the prospects of combination therapy as a strategy to combat multridrug resistance and helping to motivate the industrial sector and government agencies to invest more in research and development of this strategy as a weapon to tackle the multidrug resistance problem. It will be useful to academics and researchers involved in the development of new antimicrobial or antiinfective agents and treatment strtategies to combat multidrug resistance. Clinicians and medical nurses working in the field of infection prevention and control (IPC) will also find the book relevant Explores strategic methods with investigation of both short- and long-term goals to combat multidrug resistance Presents a broad scope to

Fighting Multidrug Resistance with Herbal Extracts  Essential Oils and Their Components Book

Fighting Multidrug Resistance with Herbal Extracts Essential Oils and Their Components


  • Author : Mahendra Rai
  • Publisher : Academic Press
  • Release Date : 2013-05-24
  • Genre: Medical
  • Pages : 296
  • ISBN 10 : 9780124017085

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Fighting Multidrug Resistance with Herbal Extracts Essential Oils and Their Components Excerpt :

Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and their Components offers scientists a single source aimed at fighting specific multidrug-resistant (MDR) microorganisms such as bacteria, protozoans, viruses and fungi using natural products. This essential reference discusses herbal extracts and essential oils used or under investigation to treat MDR infections, as well as those containing antimicrobial activity that could be of potential interest in future studies against MDR microorganisms. The need to combat multidrug-resistant microorganisms is an urgent one and this book provides important coverage of mechanism of action, the advantages and disadvantages of using herbal extracts, essential oils and their components and more to aid researchers in effective antimicrobial drug discovery Addresses the need to develop safe and effective approaches to coping with resistance to all classes of antimicrobial drugs Provides readers with current evidence-based content aimed at using herbal extracts and essential oils in antimicrobial drug development Includes chapters devoted to the activity of herbal products against herpes, AIDS, tuberculosis, drug-resistant cancer cells and more

Antibiotics and Bacterial Resistance Book

Antibiotics and Bacterial Resistance


  • Author : Wiley
  • Publisher : John Wiley & Sons
  • Release Date : 2013-01-14
  • Genre: Medical
  • Pages : 146
  • ISBN 10 : 9781118580912

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Antibiotics and Bacterial Resistance Excerpt :

The need for novel antibiotics is greater now than perhaps anytime since the pre-antibiotic era. Indeed, the recent collapse ofmany pharmaceutical antibacterial groups, combined with theemergence of hypervirulent and pan-antibiotic-resistant bacteriahas severely compromised infection treatment options and led todramatic increases in the incidence and severity of bacterialinfections. This collection of reviews and laboratory protocols gives thereader an introduction to the causes of antibiotic resistance, thebacterial strains that pose the largest danger to humans (i.e.,streptococci, pneumococci and enterococci) and the antimicrobialagents used to combat infections with these organisms. Some newavenues that are being investigated for antibiotic development arealso discussed. Such developments include the discovery of agentsthat inhibit bacterial RNA degradation, the bacterial ribosome, andstructure-based approaches to antibiotic drug discovery. Two laboratory protocols are provided to illustrate differentstrategies for discovering new antibiotics. One is a bacterialgrowth inhibition assay to identify inhibitors of bacterial growththat specifically target conditionally essential enzymes in thepathway of interest. The other protocol is used to identifyinhibitors of bacterial cell-to-cell signaling. This e-book — a curated collection from eLS, WIREs, andCurrent Protocols — offers a fantastic introduction to thefield of antibiotics and antibiotic resistance for students orinterdisciplinary collaborators. Table of Contents: Introduction Antibiotics and the Evolution of Antibiotic Resistance eLS Jose L Martinez, Fernando Baquero Antimicrobials Against Streptococci, Pneumococci andEnterococci eLS Susan Donabedian, Adenike Shoyinka Techniques & Applications RNA decay: a novel therapeutic target in bacteria WIREs RNA Tess M. Eidem, Christelle M. Roux, Paul M. Dunman Antibiotics that target protein synthesis WIREs RNA Lisa S. McCoy, Yun Xie, Yitzhak Tor Methods High-Throug

Drug Discovery Targeting Drug Resistant Bacteria Book

Drug Discovery Targeting Drug Resistant Bacteria


  • Author : Prashant Kesharwani
  • Publisher : Academic Press
  • Release Date : 2020-05
  • Genre: Uncategoriezed
  • Pages : 350
  • ISBN 10 : 9780128184806

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Drug Discovery Targeting Drug Resistant Bacteria Excerpt :

Drug Discovery Targeting Drug-Resistant Bacteria explores the status and possible future of developments in fighting drug-resistant bacteria. The book covers the majority of microbial diseases and the drugs targeting them. In addition, it discusses the potential targeting strategies and innovative approaches to address drug resistance. It brings together academic and industrial experts working on discovering and developing drugs targeting drug-resistant (DR) bacterial pathogens. New drugs active against drug-resistant pathogens are discussed, along with new strategies being used to discover molecules acting via new modes of action. In addition, alternative therapies such as peptides and phages are included. Pharmaceutical scientists, microbiologists, medical professionals, pathologists, researchers in the field of drug discovery, infectious diseases and microbial drug discovery both in academia and in industrial settings will find this book helpful.

Drug Resistance in Bacteria  Fungi  Malaria  and Cancer Book

Drug Resistance in Bacteria Fungi Malaria and Cancer


  • Author : Gunjan Arora
  • Publisher : Springer
  • Release Date : 2017-03-21
  • Genre: Medical
  • Pages : 630
  • ISBN 10 : 9783319486833

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Drug Resistance in Bacteria Fungi Malaria and Cancer Excerpt :

This book is a compilation of past and recent knowledge in the field of emerging drug resistance. The book covers major aspects of drug resistance in bacteria, fungi, malaria, and cancer.Human survival on earth is constantly threatened by disease and syndrome. From the early days, the aim of research in medicine was to find therapeutic agents that can improve the quality of human life. Although humans are dependent on natural compounds from early days their dependence of drugs increased excessively in last century. The advances in chemistry and biology have helped researchers to identify the drugs that have improved treatment of many diseases. The primary factor for treatment of these diseases is dependent on the efficacy of drugs available. The development of resistance to these drugs is one of the major hindrances. Although there are number of books available on this topic, “drug resistance” biology across kingdoms has never been discussed in a coherent way.

Optimizing Polymyxin Antibiotics Using Combination Therapy and Mechanism based Models Book

Optimizing Polymyxin Antibiotics Using Combination Therapy and Mechanism based Models


  • Author : Neang S. Ly
  • Publisher : Unknown
  • Release Date : 2014
  • Genre: Uncategoriezed
  • Pages : 443
  • ISBN 10 : OCLC:961274163

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Optimizing Polymyxin Antibiotics Using Combination Therapy and Mechanism based Models Excerpt :

The emergence of multidrug-resistant (MDR) Gram-negative 'superbugs' coupled with a rapid decline in the development of new antibiotics has led to a serious, global health crisis. Polymyxin antibiotics, which include polymyxin E (colistin) and polymyxin B, were introduced over 50 years ago and were seldom used due to nephrotoxicity. However, recently, the polymyxins have re-emerged in the clinic as an antibiotic of last-resort. There are increasing reports of polymyxin resistance and failure during polymyxin monotherapy. While polymyxin based combination therapies are a promising alternative, there are significant gaps regarding the optimal use of such combinations. The primary goal of this dissertation is to rationally optimize polymyxin combination therapy based on pharmacokinetic/pharmacodynamic (PK/PD) principles. Menchanism-based (PK/PD) models (MBMs) were employed to evaluate mechanisms of antibiotic synergy. A secondary goal is to define the mechanisms of polymyxin tolerance and resistance utilizing genetically modified knockout strains and to develop MBMs that quantify the impact of bacterial regulatory systems including quorum sensing mechanisms on antibiotic PD.

Combination Therapy of Aids Book

Combination Therapy of Aids


  • Author : Erik De Clercq
  • Publisher : Springer Science & Business Media
  • Release Date : 2004
  • Genre: Medical
  • Pages : 243
  • ISBN 10 : 3764366001

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Combination Therapy of Aids Excerpt :

An extensive assessment of combination therapy of AIDS. Main focus is put on the Highly Active Antiretroviral Therapy (HAART) but other therapies like salvage therapy are also discussed. The chapters cover efficacy, treatment, causes of treatment failure, clinical care, guidelines, pharmacology. The volume closes with an outlook on future perspectives.

Antibiotics in Laboratory Medicine Book

Antibiotics in Laboratory Medicine


  • Author : Daniel Amsterdam
  • Publisher : Lippincott Williams & Wilkins
  • Release Date : 2014-08-08
  • Genre: Medical
  • Pages : 832
  • ISBN 10 : 9781469883632

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Antibiotics in Laboratory Medicine Excerpt :

Antibiotics in Laboratory Medicine has been a mainstay resource for practitioners/providers, investigators, and pharmaceutical researchers of new anti-infective compounds for the past 30 years. This edition includes new chapters on the predictive value of in vitro laboratory testing and the improvement of patient care in the hospital environment through antimicrobial stewardship.

Introduction to Basics of Pharmacology and Toxicology Book

Introduction to Basics of Pharmacology and Toxicology


  • Author : Abialbon Paul
  • Publisher : Springer Nature
  • Release Date : 2021-03-13
  • Genre: Medical
  • Pages : 1175
  • ISBN 10 : 9789813360099

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Introduction to Basics of Pharmacology and Toxicology Excerpt :

This book explains the pharmacological relationships between the various systems in the human body. It offers a comprehensive overview of the pharmacology concerning the autonomic, central, and peripheral nervous systems. Presenting up-to-date information on chemical mediators and their significance, it highlights the therapeutic aspects of several diseases affecting the cardiovascular, renal, respiratory, gastrointestinal, endocrinal, and hematopoietic systems. The book also includes drug therapy for microbial and neoplastic diseases. It also comprises sections on immunopharmacology, dermatological, and ocular pharmacology providing valuable insights into these emerging and recent topics. Covering the diverse groups of drugs acting on different systems, the book reviews their actions, clinical uses, adverse effects, interactions, and subcellular mechanisms of action. It is divided into 11 parts, subdivided into several chapters that evaluate the basic pharmacological principles that govern the different types of body systems. This book is intended for academicians, researchers, and clinicians in industry and academic institutions in pharmaceutical, pharmacological sciences, pharmacy, medical sciences, physiology, neurosciences, biochemistry, molecular biology and other allied health sciences.

Antibiofilm Agents Book

Antibiofilm Agents


  • Author : Kendra P. Rumbaugh
  • Publisher : Springer Science & Business Media
  • Release Date : 2014-05-08
  • Genre: Science
  • Pages : 497
  • ISBN 10 : 9783642538339

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Antibiofilm Agents Excerpt :

This book provides a survey of recent advances in the development of antibiofilm agents for clinical and environmental applications. The fact that microbes exist in structured communities called biofilms has slowly become accepted within the medical community. We now know that over 80% of all infectious diseases are biofilm-related; however, significant challenges still lie in our ability to diagnose and treat these extremely recalcitrant infections. Written by experts from around the globe, this book offers a valuable resource for medical professionals seeking to treat biofilm-related disease, academic and industry researchers interested in drug discovery and instructors who teach courses on microbial pathogenesis and medical microbiology.

Fighting Multidrug Resistance with Herbal Extracts  Essential Oils and Their Components Book

Fighting Multidrug Resistance with Herbal Extracts Essential Oils and Their Components


  • Author : Kalpna D. Rakholiya
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-24
  • Genre: Medical
  • Pages : 296
  • ISBN 10 : 9780128066829

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Fighting Multidrug Resistance with Herbal Extracts Essential Oils and Their Components Excerpt :

Antibiotics are antimicrobial agents that are used to treat infectious diseases. The outbreak of pathogenic antibiotic-resistant strains illustrates our urgent need to search for new alternative sources of treatment. Hence, an attempt has been made in this review to list some plant extracts, essential/volatile oils, and their antimicrobial activity against different microorganisms using different methods, as well as synergistic effects (plant extract-plant extract, plant extract-essential oils, plant extract-conventional antibiotics, phytochemical-antibiotics, and essential oil-essential oil). Plant products and their active constituents are useful in the treatment of infectious diseases caused by multidrug-resistant microbes, food borne diseases caused by food spoiling microbes, and oral pathogens. Products derived from plants have the potential to control microbial growth in diverse situations, and specifically in the treatment of disease. The various aspects of this review may be helpful for the food, cosmetic, and pharmaceutical industries.