Comparative Toxicogenomics Book

Comparative Toxicogenomics


  • Author :
  • Publisher : Elsevier
  • Release Date : 2008-07-11
  • Genre: Science
  • Pages : 352
  • ISBN 10 : 0080560024

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Comparative Toxicogenomics Book Description :

Functional genomics has come of age. No longer is it an adventure for the avant garde scientist, but it has become an increasingly standardized mainstream tool accessible to any modern biological laboratory. Toxicogenomics studies are now generating an avalanche of data that, with the aid of established informatics methodology, is being translated into biologically meaningful information. This is enabling us to start harvesting the benefits from years of investment in terms of technology, time, and (of course) money. It is therefore timely to bring together leading toxicologists with a wide variety of scientific aims in this book to demonstrate how microarray technology can be successfully applied to different research areas. This book transects biology from bacteria to human, from ecologically relevant sentinel organisms to well-characterized model species, and represents the full toxicogenomics arena from exploratory "blue sky" science to the prospects for incorporation into regulatory frameworks. * Reviews some of the first really fruitful studies made in this area * Covers different organisms ranging from humans to model species and environmental sentinels * Provides a broad view of the area, increasing its attractiveness to researchers working in a variety of specialties

Information Resources in Toxicology Book

Information Resources in Toxicology


  • Author : Steve Gilbert
  • Publisher : Academic Press
  • Release Date : 2020-05-16
  • Genre: Medical
  • Pages : 1054
  • ISBN 10 : 9780128137253

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Information Resources in Toxicology Book Description :

This new fifth edition of Information Resources in Toxicology offers a consolidated entry portal for the study, research, and practice of toxicology. Both volumes represents a unique, wide-ranging, curated, international, annotated bibliography, and directory of major resources in toxicology and allied fields such as environmental and occupational health, chemical safety, and risk assessment. The editors and authors are among the leaders of the profession sharing their cumulative wisdom in toxicology’s subdisciplines. This edition keeps pace with the digital world in directing and linking readers to relevant websites and other online tools. Due to the increasing size of the hardcopy publication, the current edition has been divided into two volumes to make it easier to handle and consult. Volume 1: Background, Resources, and Tools, arranged in 5 parts, begins with chapters on the science of toxicology, its history, and informatics framework in Part 1. Part 2 continues with chapters organized by more specific subject such as cancer, clinical toxicology, genetic toxicology, etc. The categorization of chapters by resource format, for example, journals and newsletters, technical reports, organizations constitutes Part 3. Part 4 further considers toxicology’s presence via the Internet, databases, and software tools. Among the miscellaneous topics in the concluding Part 5 are laws and regulations, professional education, grants and funding, and patents. Volume 2: The Global Arena offers contributed chapters focusing on the toxicology contributions of over 40 countries, followed by a glossary of toxicological terms and an appendix of popular quotations related to the field. The book, offered in both print and electronic formats, is carefully structured, indexed, and cross-referenced to enable users to easily find answers to their questions or serendipitously locate useful knowledge they were not originally aware they needed. Among the many timely topics receiving incre

OMICS Book

OMICS


  • Author : Debmalya Barh
  • Publisher : CRC Press
  • Release Date : 2016-04-19
  • Genre: Medical
  • Pages : 622
  • ISBN 10 : 9781439850091

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OMICS Book Description :

A reflection of the explosion of research and development in this field, OMICS: Biomedical Perspectives and Applications explores applications of omics in bioinformatics, cancer research and therapy, diabetes research, plant science, molecular biology, and neurosciences. A select editorial panel of experts discusses their cutting edge omics research and novel technologies, supplying a basic platform of methods and applications and a resource for enhanced cross-pollination in a multiomics approach to future endeavors in the fertile fields of omics research. After an introduction on the omics universe, the book presents modern omics and its applications in nanotechnology, genomics, proteomics, metagenomics, toxicogenomics, immunomics, nutrigenomics, diabetes, neurology, cardiology, and cancer to name just a few. The book begins with an overview of omics and omic technologies such as cellomics, glycomics, and lipidomics. It also discusses bioinformatics, demonstrating how it can be a tool in omics, and examines the various approaches of omics technology in toxicology research and applications in biomedical sciences. While there are a long list of omics books available, most focus narrowly on one area. Presenting a wide view of the current status of integrative omics, this resource contains complete coverage of omics in research and therapy, ranging from neuroscience to cardiology. It collates recent developments in the field into a state-of-the-art framework for this discipline.

Applications of Toxicogenomics in Safety Evaluation and Risk Assessment Book

Applications of Toxicogenomics in Safety Evaluation and Risk Assessment


  • Author : Darrell R. Boverhof
  • Publisher : John Wiley & Sons
  • Release Date : 2011-10-11
  • Genre: Science
  • Pages : 392
  • ISBN 10 : 1118008987

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Applications of Toxicogenomics in Safety Evaluation and Risk Assessment Book Description :

This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process – including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how toxicogenomics and complementary technologies can reframe the current risk assessment paradigm.

Genomic Approaches for Cross Species Extrapolation in Toxicology Book

Genomic Approaches for Cross Species Extrapolation in Toxicology


  • Author : William H. Benson
  • Publisher : CRC Press
  • Release Date : 2006-12-13
  • Genre: Mathematics
  • Pages : 216
  • ISBN 10 : 1420043641

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Genomic Approaches for Cross Species Extrapolation in Toxicology Book Description :

The latest tools for investigating stress response in organisms, genomic technologies provide great insight into how different organisms respond to environmental conditions. However, their usefulness needs to be tested, verified, and codified. Genomic Approaches for Cross-Species Extrapolation in Toxicology provides a balanced discussion drawn from

Clinical Genetics in Nursing Practice Book

Clinical Genetics in Nursing Practice


  • Author : Felissa R. Lashley, PhD, RN, FABMGG
  • Publisher : Springer Publishing Company
  • Release Date : 2005-04-15
  • Genre: Medical
  • Pages : 584
  • ISBN 10 : 0826123678

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Clinical Genetics in Nursing Practice Book Description :

Designated a Doody's Core Title! The third edition of this award-winning text provides new and updated knowledge about genetics issues relevant to nursing practice. Read in sequence or used as a reference, this is a comprehensive overview of how genetics affetcs the care that nurses provide. In addition to a summary of basic human genetics and discussion of the Human Genome Project, this new edition includes the latest research findings and implications about inheritance, major genetic disorders (cytogenetics or chromosomal, inherited biochemical, and congenital anomalies), and genetics in twin studies. A consideration of the ethical impact of genetics on society and future generations, as well as information on assisted reproduction round out the overview. Includes over 100 illustrations and photos of specific genetic disorders; tables and figures on the distribution of disease; and an extensive appendix listing associations, organizations, and websites relevant to genetics.

An Introduction to Toxicogenomics Book

An Introduction to Toxicogenomics


  • Author : Michael E. Burczynski
  • Publisher : CRC Press
  • Release Date : 2003-03-26
  • Genre: Medical
  • Pages : 348
  • ISBN 10 : 020350481X

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An Introduction to Toxicogenomics Book Description :

Since the advent of cDNA microarrays, oligonucleotide array technology, and gene chip analysis, genomics has revolutionized the entire field of biomedical research. A byproduct of this revolution, toxicogenomics is a fast-rising star within toxicological analysis. Gathering together leading authors and scientists at the forefront of the field, An Introduction to Toxicogenomics provides a comprehensive overview of this new discipline. With a focus on toxicology, it introduces the basic principles of microarray/oligonucleotide array-based genomic analysis and explains how it fits into the field of biomedical research. These discussions provide an overview to the actual mechanics of the analyses themselves and offer insights on handling and quality control. Then the book features an important section on the basics of data analysis and clustering methods such as genetic algorithms. Finally, it covers the application of expression profiling in the field of toxicology and addresses the two fundamental types of analysis in detail, with sections dedicated to both mechanistic and predictive studies. Although toxicogenomics promises fast, efficient techniques and information-rich data, much of its potential remains untapped. An Introduction to Toxicogenomics consolidates the concepts underlying the field to provide a solid foundation from which to begin your research endeavors.

Biological Data Mining in Protein Interaction Networks Book
Score: 5
From 1 Ratings

Biological Data Mining in Protein Interaction Networks


  • Author : Li, Xiao-Li
  • Publisher : IGI Global
  • Release Date : 2009-05-31
  • Genre: Technology & Engineering
  • Pages : 450
  • ISBN 10 : 9781605663999

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Biological Data Mining in Protein Interaction Networks Book Description :

"The goal of this book is to disseminate research results and best practices from cross-disciplinary researchers and practitioners interested in, and working on bioinformatics, data mining, and proteomics"--Provided by publisher.

Annual Review of Nursing Research  Volume 29 Book

Annual Review of Nursing Research Volume 29


  • Author : Ginette A. Pepper, PhD, RN, FAAN
  • Publisher : Springer Publishing Company
  • Release Date : 2012-05-29
  • Genre: Medical
  • Pages : 400
  • ISBN 10 : 9780826157553

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Annual Review of Nursing Research Volume 29 Book Description :

This landmark annual review has provided three decades of knowledge, insight, and research on topics critical to the continued advancement of the nursing profession. This latest edition is a compilation of the most significant nursing research in genetics and genomics. Articles have been carefully selected by the editors, highly respected scholars and researchers in the field of genetics, to bring together current research that has particular relevance for translation into a clinical setting or expansion into other research areas. The review provides authoritative information of the highest caliber not only to researchers, but also to clinicians and undergraduate and graduate nursing students. Key Topics: The current status of genomic molecular science Ethical, legal, and social issues in genomics Genetics of diseases and symptoms Genomics across the lifespan

Antitargets and Drug Safety Book

Antitargets and Drug Safety


  • Author : Laszlo Urban
  • Publisher : John Wiley & Sons
  • Release Date : 2015-02-23
  • Genre: Medical
  • Pages : 528
  • ISBN 10 : 9783527673667

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Antitargets and Drug Safety Book Description :

With its focus on emerging concerns of kinase and GPCR-mediated antitarget effects, this vital reference for drug developers addresses one of the hot topics in drug safety now and in future. Divided into three major parts, the first section deals with novel technologies and includes the utility of adverse event reports to drug discovery, the translational aspects of preclinical safety findings, broader computational prediction of drug side-effects, and a description of the serotonergic system. The main part of the book looks at some of the most common antitarget-mediated side effects, focusing on hepatotoxicity in drug safety, cardiovascular toxicity and signaling effects via kinase and GPCR anti-targets. In the final section, several case studies of recently developed drugs illustrate how to prevent anti-target effects and how big pharma deals with them if they occur. The more recent field of systems pharmacology has gained prominence and this is reflected in chapters dedicated to the utility in deciphering and modeling anti-targets. The final chapter is concerned with those compounds that inadvertently elicit CNS mediated adverse events, including a pragmatic description of ways to mitigate these types of safety risks. Written as a companion to the successful book on antitargets by Vaz and Klabunde, this new volume focuses on recent progress and new classes, methods and case studies that were not previously covered.

Smart Health Book

Smart Health


  • Author : Andreas Holzinger
  • Publisher : Springer
  • Release Date : 2015-02-24
  • Genre: Medical
  • Pages : 275
  • ISBN 10 : 9783319162263

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Smart Health Book Description :

Prolonged life expectancy along with the increasing complexity of medicine and health services raises health costs worldwide dramatically. Whilst the smart health concept has much potential to support the concept of the emerging P4-medicine (preventive, participatory, predictive, and personalized), such high-tech medicine produces large amounts of high-dimensional, weakly-structured data sets and massive amounts of unstructured information. All these technological approaches along with “big data” are turning the medical sciences into a data-intensive science. To keep pace with the growing amounts of complex data, smart hospital approaches are a commandment of the future, necessitating context aware computing along with advanced interaction paradigms in new physical-digital ecosystems. The very successful synergistic combination of methodologies and approaches from Human-Computer Interaction (HCI) and Knowledge Discovery and Data Mining (KDD) offers ideal conditions for the vision to support human intelligence with machine learning. The papers selected for this volume focus on hot topics in smart health; they discuss open problems and future challenges in order to provide a research agenda to stimulate further research and progress.

Nonalcoholic Fatty Liver Disease  An Issue of Clinics in Liver Disease   E Book Book

Nonalcoholic Fatty Liver Disease An Issue of Clinics in Liver Disease E Book


  • Author : Arun J. Sanyal
  • Publisher : Elsevier Health Sciences
  • Release Date : 2012-08-12
  • Genre: Medical
  • Pages : 240
  • ISBN 10 : 9781455747368

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Nonalcoholic Fatty Liver Disease An Issue of Clinics in Liver Disease E Book Book Description :

Dr. Sanyal's expertise as Chairman of the Division of Hepatology at Virginia Commonwealth University and the breadth of his published articles in hepatology make him the perfect person to compile state-of-the-art reviews on the topic of NASH/fatty liver. The articles in this issue address the following topics: The Genetic Epidemiology of Nonalcoholic Fatty Liver Disease; Relevance of Liver Histology to Predict Clinically Meaningful Outcomes in NASH; Mechanisms of Simple Hepatic Steatosis; Cellular and Molecular Basis for Phenotype of Steatohepatitis; Mechanisms of Disease Progression in NASH: New Paradigms; Can NASH Be Diagnosed, Graded and Staged Non-Invasively?; Is NAFLD in Children the Same Disease as in Adults?; The Cardiovascular Link to NAFLD: A Critical Analysis; Impact of Behavioral Disturbances and Their Treatment on Obesity and NAFLD; and Management of NASH.

Safety Pharmacology in Pharmaceutical Development Book

Safety Pharmacology in Pharmaceutical Development


  • Author : Shayne C. Gad
  • Publisher : CRC Press
  • Release Date : 2012-04-26
  • Genre: Medical
  • Pages : 213
  • ISBN 10 : 9781439845677

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Safety Pharmacology in Pharmaceutical Development Book Description :

Safety pharmacology is the evaluation and study of the pharmacological effects of a potential drug that are unrelated to the desired therapeutic effect. These effects often present a hazard—particularly in individuals with compromised or limited organ system functions. Safety Pharmacology in Pharmaceutical Development: Approval and Post Marketing Surveillance, Second Edition covers safety pharmacology from the regulatory requirements down to the studies that must be done to justify them. Using the author’s more than 30 years of direct experience, the book incorporates tricks and practical insights for making studies work and understanding why they fail. The second edition includes current regulations, including USFDA and those from Europe and Japan. Presenting a clear description of what is needed and why for supporting drug development, the book focuses on updated test methods, interpretation, and science. It covers the core and supplemental batteries of test procedures and how to do them and provides an overview of available facilities and contract organizations for performing studies.