Computational Modeling in Bioengineering and Bioinformatics Book

Computational Modeling in Bioengineering and Bioinformatics

  • Author : Nenad Filipovic
  • Publisher : Academic Press
  • Release Date : 2019-10-09
  • Genre: Science
  • Pages : 442
  • ISBN 10 : 9780128195840
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Computational Modeling in Bioengineering and Bioinformatics promotes complementary disciplines that hold great promise for the advancement of research and development in complex medical and biological systems, and in the environment, public health, drug design, and so on. It provides a common platform by bridging these two very important and complementary disciplines into an interactive and attractive forum. Chapters cover biomechanics and bioimaging, biomedical decision support system, data mining, personalized diagnoses, bio-signal processing, protein structure prediction, tissue and cell engineering, biomedical image processing, analysis and visualization, high performance computing and sports bioengineering. The book's chapters are the result of many international projects in the area of bioengineering and bioinformatics done at the Research and Development Center for Bioengineering BioIRC and by the Faculty of Engineering at the University of Kragujevac, Serbia. Presents recent advances at the crossroads of biomedical engineering and bioinformatics, one of the hottest areas in biomedical and clinical research Discusses a wide range of leading-edge research topics, including biomechanics and bioimaging, biomedical decision support systems, data mining, personalized diagnoses, bio-signal processing, protein structure prediction, tissue and cell engineering, amongst others Includes coverage of biomechanical, bioengineering and computational methods of treatment and diagnosis

Computational Bioengineering and Bioinformatics Book

Computational Bioengineering and Bioinformatics

  • Author : Nenad Filipovic
  • Publisher : Springer Nature
  • Release Date : 2020-03-11
  • Genre: Technology & Engineering
  • Pages : 169
  • ISBN 10 : 9783030436582
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This book explores the latest and most relevant topics in the field of computational bioengineering and bioinformatics, with a particular focus on patient-specific, disease-progression modeling. It covers computational methods for cardiovascular disease prediction, with an emphasis on biomechanics, biomedical decision support systems, data mining, personalized diagnostics, bio-signal processing, protein structure prediction, biomedical image processing, analysis and visualization, and high-performance computing. It also discusses state-of-the-art tools for disease characterization, and recent advances in areas such as biomechanics, cardiovascular engineering, patient-specific modeling, population-based modeling, multiscale modeling, image processing, data mining, biomedical decision-support systems, signal processing, biomaterials and dental biomechanics, tissue and cell engineering, computational chemistry and high-performance computing. As such, it is a valuable resource for researchers, medical and bioengineering students, and medical device and software experts

Uncertainty in Biology Book

Uncertainty in Biology

  • Author : Liesbet Geris
  • Publisher : Springer
  • Release Date : 2015-10-26
  • Genre: Technology & Engineering
  • Pages : 478
  • ISBN 10 : 9783319212968
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Computational modeling allows to reduce, refine and replace animal experimentation as well as to translate findings obtained in these experiments to the human background. However these biomedical problems are inherently complex with a myriad of influencing factors, which strongly complicates the model building and validation process. This book wants to address four main issues related to the building and validation of computational models of biomedical processes: 1. Modeling establishment under uncertainty 2. Model selection and parameter fitting 3. Sensitivity analysis and model adaptation 4. Model predictions under uncertainty In each of the abovementioned areas, the book discusses a number of key-techniques by means of a general theoretical description followed by one or more practical examples. This book is intended for graduate students and researchers active in the field of computational modeling of biomedical processes who seek to acquaint themselves with the different ways in which to study the parameter space of their model as well as its overall behavior.

Computational Modeling and Simulation Examples in Bioengineering Book

Computational Modeling and Simulation Examples in Bioengineering

  • Author : Nenad Filipovic
  • Publisher : John Wiley & Sons
  • Release Date : 2021-11-30
  • Genre: Science
  • Pages : 384
  • ISBN 10 : 9781119563914
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A systematic overview of the quickly developing field of bioengineering—with state-of-the-art modeling software! Computational Modeling and Simulation Examples in Bioengineering provides a comprehensive introduction to the emerging field of bioengineering. It provides the theoretical background necessary to simulating pathological conditions in the bones, muscles, cardiovascular tissue, and cancers, as well as lung and vertigo disease. The methodological approaches used for simulations include the finite element, dissipative particle dynamics, and lattice Boltzman. The text includes access to a state-of-the-art software package for simulating the theoretical problems. In this way, the book enhances the reader's learning capabilities in the field of biomedical engineering. The aim of this book is to provide concrete examples of applied modeling in biomedical engineering. Examples in a wide range of areas equip the reader with a foundation of knowledge regarding which problems can be modeled with which numerical methods. With more practical examples and more online software support than any competing text, this book organizes the field of computational bioengineering into an accessible and thorough introduction. Computational Modeling and Simulation Examples in Bioengineering: Includes a state-of-the-art software package enabling readers to engage in hands-on modeling of the examples in the book Provides a background on continuum and discrete modeling, along with equations and derivations for three key numerical methods Considers examples in the modeling of bones, skeletal muscles, cartilage, tissue engineering, blood flow, plaque, and more Explores stent deployment modeling as well as stent design and optimization techniques Generates different examples of fracture fixation with respect to the advantages in medical practice applications Computational Modeling and Simulation Examples in Bioengineering is an excellent textbook for students of bioengineering, as well

Computational Modeling of Gene Regulatory Networks Book

Computational Modeling of Gene Regulatory Networks

  • Author : Hamid Bolouri
  • Publisher : World Scientific Publishing Company
  • Release Date : 2008
  • Genre: Medical
  • Pages : 326
  • ISBN 10 : 1848162219
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"This book serves as an introduction to the myriad computational approaches to gene regulatory modeling and analysis, and is written specifically with experimental biologists in mind. Mathematical jargon is avoided and explanations are given in intuitive terms. In cases where equations are unavoidable, they are derived from first principles or, at the very least, an intuitive description is provided. Extensive examples and a large number of model descriptions are provided for use in both classroom exercises as well as self-guided exploration and learning. As such, the book is ideal for self-learning and also as the basis of a semester-long course for undergraduate and graduate students in molecular biology, bioengineering, genome sciences, or systems biology."--Jacket.

Computational Models for Biomedical Reasoning and Problem Solving Book

Computational Models for Biomedical Reasoning and Problem Solving

  • Author : Chen, Chung-Hao
  • Publisher : IGI Global
  • Release Date : 2019-04-12
  • Genre: Computers
  • Pages : 353
  • ISBN 10 : 9781522574682
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The results of computational model simulations allow researchers and clinicians to make predictions about what will happen in the biological systems that are being studied in response to changing conditions for a disease or disorder. With a well-developed computational model, researchers and clinicians can better understand the cause of a disease or a disorder and predict treatment results. Computational Models for Biomedical Reasoning and Problem Solving is a critical scholarly publication that provides insightful strategies to developing computational models that allow for the better understanding and treatment of various diseases and disorders. Featuring topics such as biomedicine, neuroscience, and artificial intelligence, this book is ideal for practitioners, clinicians, researchers, psychologists, and engineers.

Bioinformatics and Computational Biology Book

Bioinformatics and Computational Biology

  • Author : Basant K. Tiwary
  • Publisher : Springer Nature
  • Release Date : 2021-11-23
  • Genre: Medical
  • Pages : 234
  • ISBN 10 : 9789811642418
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This textbook introduces fundamental concepts of bioinformatics and computational biology to the students and researchers in biology, medicine, veterinary science, agriculture, and bioengineering . The respective chapters provide detailed information on biological databases, sequence alignment, molecular evolution, next-generation sequencing, systems biology, and statistical computing using R. The book also presents a case-based discussion on clinical, veterinary, agricultural bioinformatics, and computational bioengineering for application-based learning in the respective fields. Further, it offers readers guidance on reconstructing and analysing biological networks and highlights computational methods used in systems medicine and genome-wide association mapping of diseases. Given its scope, this textbook offers an essential introductory book on bioinformatics and computational biology for undergraduate and graduate students in the life sciences, botany, zoology, physiology, biotechnology, bioinformatics, and genomic science as well as systems biology, bioengineering and the agricultural, and veterinary sciences.

Computer Modeling in Bioengineering Book

Computer Modeling in Bioengineering

  • Author : Miloš Kojić
  • Publisher : John Wiley & Sons
  • Release Date : 2008-09-15
  • Genre: Science
  • Pages : 466
  • ISBN 10 : 9780470751756
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Bioengineering is a broad-based engineering discipline that appliesengineering principles and design to challenges in human health andmedicine, dealing with bio-molecular and molecular processes,product design, sustainability and analysis of biological systems.Applications that benefit from bioengineering include medicaldevices, diagnostic equipment and biocompatible materials, amongstothers. Computer Modeling in Bioengineering offers acomprehensive reference for a large number of bioengineeringtopics, presenting important computer modeling problems andsolutions for research and medical practice. Starting with basictheory and fundamentals, the book progresses to more advancedmethods and applications, allowing the reader to become familiarwith different topics to the desired extent. It includes unique andoriginal topics alongside classical computational modeling methods,and each application is structured to explain the physiologicalbackground, phenomena that are to be modeled, the computationalmethods used in the model, and solutions of typical cases. Theaccompanying software contains over 80 examples, enabling thereader to study a topic using the theory and examples, then run thesoftware to solve the same, or similar examples, varying the modelparameters within a given range in order to investigate the problemat greater depth. Tutorials also guide the user in furtherexploring the modeled problem; these features promote easierlearning and will help lecturers with presentations. Computer Modeling in Bioengineering includescomputational methods for modelling bones, tissues, muscles,cardiovascular components, cartilage, cells and cancernanotechnology as well as many other applications. It bridges thegap between engineering, biology and medicine, and will appeal notonly to bioengineering students, lecturers and researchers, butalso medical students and clinical researchers.

Computational Systems Bioinformatics Book

Computational Systems Bioinformatics

  • Author : Xiaobo Zhou
  • Publisher : World Scientific
  • Release Date : 2008
  • Genre: Science
  • Pages : 398
  • ISBN 10 : 9789812707048
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Computational systems biology is a new and rapidly developing field of research, concerned with understanding the structure and processes of biological systems at the molecular, cellular, tissue, and organ levels through computational modeling as well as novel information theoretic data and image analysis methods. By focusing on either information processing of biological data or on modeling physical and chemical processes of biosystems, and in combination with the recent breakthrough in deciphering the human genome, computational systems biology is guaranteed to play a central role in disease prediction and preventive medicine, gene technology and pharmaceuticals, and other biotechnology fields. This book begins by introducing the basic mathematical, statistical, and data mining principles of computational systems biology, and then presents bioinformatics technology in microarray and sequence analysis step-by-step. Offering an insightful look into the effectiveness of the systems approach in computational biology, it focuses on recurrent themes in bioinformatics, biomedical applications, and future directions for research.

Modeling in Computational Biology and Biomedicine Book

Modeling in Computational Biology and Biomedicine

  • Author : Frédéric Cazals
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-11-06
  • Genre: Mathematics
  • Pages : 318
  • ISBN 10 : 9783642312083
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Computational biology, mathematical biology, biology and biomedicine are currently undergoing spectacular progresses due to a synergy between technological advances and inputs from physics, chemistry, mathematics, statistics and computer science. The goal of this book is to evidence this synergy by describing selected developments in the following fields: bioinformatics, biomedicine and neuroscience. This work is unique in two respects - first, by the variety and scales of systems studied and second, by its presentation: Each chapter provides the biological or medical context, follows up with mathematical or algorithmic developments triggered by a specific problem and concludes with one or two success stories, namely new insights gained thanks to these methodological developments. It also highlights some unsolved and outstanding theoretical questions, with a potentially high impact on these disciplines. Two communities will be particularly interested in this book. The first one is the vast community of applied mathematicians and computer scientists, whose interests should be captured by the added value generated by the application of advanced concepts and algorithms to challenging biological or medical problems. The second is the equally vast community of biologists. Whether scientists or engineers, they will find in this book a clear and self-contained account of concepts and techniques from mathematics and computer science, together with success stories on their favorite systems. The variety of systems described represents a panoply of complementary conceptual tools. On a practical level, the resources listed at the end of each chapter (databases, software) offer invaluable support for getting started on a specific topic in the fields of biomedicine, bioinformatics and neuroscience.

Computational Models in Biomedical Engineering Book

Computational Models in Biomedical Engineering

  • Author : Milos Kojic
  • Publisher : Academic Press
  • Release Date : 2022-09-11
  • Genre: Science
  • Pages : 402
  • ISBN 10 : 9780323906692
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Computational Models in Biomedical Engineering: Finite Element Models Based on Smeared Physical Fields: Theory, Solutions, and Software discusses novel computational methodologies developed by the authors that address a variety of topics in biomedicine, with concepts that rely on the so-called smeared physical field built into the finite element method. A new and straightforward methodology is represented by their Kojic Transport Model (KTM), where a composite smeared finite element (CSFE) as a FE formulation contains different fields (e.g., drug concentration, electrical potential) in a composite medium, such as tissue, which includes the capillary and lymphatic system, different cell groups and organelles. The continuum domains participate in the overall model according to their volumetric fractions. The governing laws and material parameters are assigned to each of the domains. Furthermore, the continuum fields are coupled at each FE node by connectivity elements which take into account biological barriers such as vessel walls and cells. Provides a methodology based on the smeared concept within the finite element method which is simple, straightforward and easy to use Enables the modeling of complex physical field problems and the mechanics of biological systems Includes features that are illustrated in chapters devoted to applications surrounding tissue, heart and lung Includes a methodology that can serve as a basis for further enhancements by including additional phenomena which can be described by relevant relationships, derived theoretically or experimentally observed in laboratories and clinics

Computational Modeling of Biological Systems Book

Computational Modeling of Biological Systems

  • Author : Nikolay V Dokholyan
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-02-12
  • Genre: Science
  • Pages : 360
  • ISBN 10 : 9781461421450
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Computational modeling is emerging as a powerful new approach to study and manipulate biological systems. Multiple methods have been developed to model, visualize, and rationally alter systems at various length scales, starting from molecular modeling and design at atomic resolution to cellular pathways modeling and analysis. Higher time and length scale processes, such as molecular evolution, have also greatly benefited from new breeds of computational approaches. This book provides an overview of the established computational methods used for modeling biologically and medically relevant systems.

Patient Specific Computational Modeling Book

Patient Specific Computational Modeling

  • Author : Begoña Calvo Lopez
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-05-20
  • Genre: Technology & Engineering
  • Pages : 193
  • ISBN 10 : 9789400745520
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This book addresses patient-specific modeling. It integrates computational modeling, experimental procedures, imagine clinical segmentation and mesh generation with the finite element method (FEM) to solve problems in computational biomedicine and bioengineering. Specific areas of interest include cardiovascular problems, ocular and muscular systems and soft tissue modeling. Patient-specific modeling has been the subject of serious research over the last seven years and interest in the area is continually growing and this area is expected to further develop in the near future.

Cardiovascular and Respiratory Bioengineering Book

Cardiovascular and Respiratory Bioengineering

  • Author : Nenad Filipovic
  • Publisher : Academic Press
  • Release Date : 2022-05-27
  • Genre: Technology & Engineering
  • Pages : 312
  • ISBN 10 : 9780128242292
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Cardiovascular and Respiratory Bioengineering focuses on computational tools and modeling techniques in cardiovascular and respiratory systems that help develop bioengineered solutions. The book demonstrates how these technologies can be utilized in order to tackle diseases and medical issues. It provides practical guidance on how a bioengineering or medical problem can be modeled, along with which computational models can be used. Topics include computer modeling of Purkinje fibers with different electrical potential applied, modeling of cardiomyopathies caused by sarcomeric gene mutations, altered sarcomere function, perturbations in intracellular ion homeostasis, impaired myocardial energetics at reduced costs, and more. The book also discusses blood flow through deformable blood vessels in human aorta, abdominal aortic aneurysm, carotid artery, coronary artery and plaque formation, along with content on stent deployment modeling and stent design and optimization techniques. Features practical applications of cardiovascular and respiratory technology to counteract diseases Includes detailed steps for the modeling of cardiovascular and respiratory systems Explores a range of different modeling methods, including computational modeling, predictive modeling and multi-scale modeling Covers biological processes and biomechanics relevant to cardiovascular and respiratory bioengineering