Coronavirus Drug Discovery Book

Coronavirus Drug Discovery


  • Author : Chukwuebuka Egbuna
  • Publisher : Elsevier
  • Release Date : 2022-05-25
  • Genre: Science
  • Pages : 388
  • ISBN 10 : 9780323851787

DOWNLOAD BOOK
Coronavirus Drug Discovery Excerpt :

Coronavirus Drug Discovery: SARS-CoV-2 (Covid 19) Prevention, Diagnosis, and Treatment presents comprehensive information on antiviral drug discovery from medicinal plants, animals, marine organisms and microorganisms. This book present special chapters on the COVID-19 disease outbreak and detailed information on drug discovery for the COVID-19 virus, including its diagnosis and prevention strategies. Subsequent chapters present drug discovery opportunities for the treatment and management of respiratory viral diseases, gastrointestinal viral diseases, exanthematous viral diseases, hepatic viral diseases, cutaneous viral diseases, hemorrhagic viral diseases and neurologic viral diseases. The book's contributors are specialists from key institutions around the world, making this a key resource for drug developers, medicinal chemists, public health scientists, molecular biologists, biochemists, and toxicologists, among others. Details the various natural bioactive compounds for antiviral drug discoveries surrounding treatments for the coronavirus Discuses recent drug discovery for covid-19 treatment and drug discovery from natural sources Focuses on the discovery of drugs against acute viral diseases of world importance Reviews recent advances in research tools for the discovery of new antiviral drugs

Coronavirus Drug Discovery Book

Coronavirus Drug Discovery


  • Author : Chukwuebuka Egbuna
  • Publisher : Elsevier
  • Release Date : 2022-07-20
  • Genre: Business & Economics
  • Pages : 406
  • ISBN 10 : 9780323955799

DOWNLOAD BOOK
Coronavirus Drug Discovery Excerpt :

Coronavirus Drug Discovery, Volume Three: Druggable Targets and In Silico Update presents comprehensive information on drug discovery against COVID-19. Chapters in Part One of this volume describe the various druggable targets and associated signaling pathways for effective targeting of SARS-CoV-2. In Part Two, chapters discuss the various computational approaches and in silico studies against SARS-CoV-2. Written by global team of experts, this book is an excellent resource that will be extremely useful to drug developers, medicinal chemists, pharmaceutical companies in R&D, research institutes in both academia and industry, and the National Library of Medicines and Health. In addition, agencies such as the National Institutes of Health, Centers for Disease Control and Prevention, World Health Organization, European Medicines Agency, the US Food and Drug Administration, and all others involved in drug discovery against COVID-19 will find this book useful. Discusses the pathogenic mechanisms of SARS-CoV-2 and druggable targets Reviews the various signaling pathways associated with SAR-CoV-2 as possible druggable targets Presents computational approaches and in silico studies against SARS-CoV-2

Coronavirus Drug Discovery Book

Coronavirus Drug Discovery


  • Author : Chukwuebuka Egbuna
  • Publisher : Elsevier
  • Release Date : 2022-07-20
  • Genre: Medical
  • Pages : 382
  • ISBN 10 : 9780323955751

DOWNLOAD BOOK
Coronavirus Drug Discovery Excerpt :

Coronavirus Drug Discovery, Volume Two: Antiviral Agents from Natural Products and Nanotechnological Applications presents detailed information on drug discovery against COVID-19. Sections in this volume present chapters that focus on the various antiviral agents from natural products that have the propensity to be used as chemical scaffolds for the development of drugs against COVID-19. Also captured are the dietary sources of antioxidant bioactives that may help boost the immune system for the management of COVID-19. Other chapters describe the application of nanotechnology for efficient and effective delivery of drugs against COVID-19. Written by global team of experts, this book is an excellent resource for drug developers, medicinal chemists, pharmaceutical companies in R&D and research institutes in both academia and industry. Presents the various antiviral bioactive compounds from natural products Discusses the roles of antioxidant in the prevention and management of COVID-19 Details the application of nanotechnology for efficient and effective drug delivery

Modeling  Control and Drug Development for COVID 19 Outbreak Prevention Book

Modeling Control and Drug Development for COVID 19 Outbreak Prevention


  • Author : Ahmad Taher Azar
  • Publisher : Springer
  • Release Date : 2021-11-02
  • Genre: Computers
  • Pages : 1122
  • ISBN 10 : 3030728331

DOWNLOAD BOOK
Modeling Control and Drug Development for COVID 19 Outbreak Prevention Excerpt :

This book is well-structured book which consists of 31 full chapters. The book chapters' deal with the recent research problems in the areas of modeling, control and drug development, and it presents various techniques of COVID-19 outbreak prevention modeling. The book also concentrates on computational simulations that may help speed up the development of drugs to counter the novel coronavirus responsible for COVID-19.

Novel Coronavirus 2019 Book

Novel Coronavirus 2019


  • Author : Amit Kumar
  • Publisher : Springer Nature
  • Release Date : 2020-09-26
  • Genre: Science
  • Pages : 78
  • ISBN 10 : 9789811579189

DOWNLOAD BOOK
Novel Coronavirus 2019 Excerpt :

This book highlights the genomic findings, observations, and analysis of DNA/RNA sequences and protein structure of the dreadful virus of this decade- COVID-19. The Corona group of viruses though known species, the strain that caused the Pandemic of 2019 is a completely new strain, belonging to the same corona family with a novel genetic make-up. This makes it a new pathogen which is causing the current outbreak leaving the global scientific community clueless of any therapeutic breakthrough. NCOV enjoys life threatening pathogenicity with mysterious genetic annotations. This book details and offers insights into its viral genetic arrangement, Virulence factors, probable mutations leading to the evolution of this new strain and more. It contains chapters on Virus evolutionary status and Genetic makeup leading to its pathogenicity which can be a new insight in understanding the nature of this clever microorganism and can pave way to the development of new drugs and Vaccines or a novel diagnostic approach for the early prognosis of the disease. A dedicated chapter on annotation of NCOV-19 virulence genes, translation of the genes to protein product, annotation of the antigenic sites on these proteins is also included. In all, this brief is a complete genomic annotation insight of NCOV-19 using AI, Data analytics and Bioinformatics analysis. In the current situation, this book is an extensive preliminary resource for Medical practitioners, Researchers, Academicians, Scientists, Biochemists, Bioinformaticians and other professionals interested in understanding the genetics of Novel Coronavirus 19, the best possible drug targets, ideal vaccine candidates and novel prognostic and diagnostic biomarkers.

Coronavirus Therapeutics     Volume II Book

Coronavirus Therapeutics Volume II


  • Author : Alexzander A. A. Asea
  • Publisher : Springer Nature
  • Release Date : 2022-02-08
  • Genre: Medical
  • Pages : 242
  • ISBN 10 : 9783030851132

DOWNLOAD BOOK
Coronavirus Therapeutics Volume II Excerpt :

The book Coronavirus Therapeutics Volume II provides the most comprehensive review on contemporary knowledge on the consequences during the outbreak of Coronavirus. This also describes the clinical features, diagnostic evaluation and management of Coronavirus patients. Using an integrative approach to the understanding of paradigm gap in host-pathogen interaction studies to the management of Coronavirus patients in the Intensive Care Unit to the current challenges for the effective management of Coronavirus pandemic risk factors including diabetes, hypertension, obesity and repercussion on the central and peripheral nervous system. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed articles that review present research activity on the role of heat shock proteins in human diseases and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Cancer Biology, Oncology, Cardiovascular Diseases, Microbiology, Inflammation, Translational Medicine, Clinical Research, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.

Coronavirus Therapeutics     Volume I Book

Coronavirus Therapeutics Volume I


  • Author : Alexzander A. A. Asea
  • Publisher : Springer Nature
  • Release Date : 2022-02-24
  • Genre: Medical
  • Pages : 222
  • ISBN 10 : 9783030851095

DOWNLOAD BOOK
Coronavirus Therapeutics Volume I Excerpt :

The book Coronavirus Therapeutics Volume I provides the most comprehensive review on contemporary knowledge on the origin and structural biology and molecular aspects of Coronaviruses. This also describes the etiology and pathogeny and therapeutic targets including vaccine drug candidates against Coronaviruses in the light of current scientific knowledge. Using an integrative approach to the understanding of Coronaviruses structure, function and immunobiology, the contributors provide a synopsis of novel mechanisms by which Coronaviruses can be treated. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed articles that review present research activity on the role of heat shock proteins in human diseases and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Cancer Biology, Oncology, Cardiovascular Diseases, Microbiology, Inflammation, Translational Medicine, Clinical Research, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.

In Silico Modeling of Drugs Against Coronaviruses Book

In Silico Modeling of Drugs Against Coronaviruses


  • Author : Kunal Roy
  • Publisher : Unknown
  • Release Date : 2021
  • Genre: Coronavirus infections
  • Pages : 788
  • ISBN 10 : 1071613669

DOWNLOAD BOOK
In Silico Modeling of Drugs Against Coronaviruses Excerpt :

This essential volume explores a variety of tools and protocols of structure-based (homology modeling, molecular docking, molecular dynamics, protein-protein interaction network) and ligand-based (pharmacophore mapping, quantitative structure-activity relationships or QSARs) drug design for ranking and prioritization of candidate molecules in search of effective treatment strategy against coronaviruses. Beginning with an introductory section that discusses coronavirus interactions with humanity and COVID-19 in particular, the book then continues with sections on tools and methodologies, literature reports and case studies, as well as online tools and databases that can be used for computational anti-coronavirus drug research. Written for the Methods in Pharmacology and Toxicology series, chapters include the kind of practical detail and implementation advice that ensures high quality results in the lab. Comprehensive and timely, In Silico Modeling of Drugs Against Coronaviruses: Computational Tools and Protocols is an ideal reference for researchers working on the development of novel anti-coronavirus drugs for SARS-CoV-2 and for coronaviruses that will likely appear in the future.

Discovery of Small Molecule Modulators of Protein   RNA Interactions for Treating Cancer and COVID 19 Book

Discovery of Small Molecule Modulators of Protein RNA Interactions for Treating Cancer and COVID 19


  • Author : Wan Gi Byun
  • Publisher : Springer Nature
  • Release Date : 2022-12-13
  • Genre: Science
  • Pages : 156
  • ISBN 10 : 9789811978142

DOWNLOAD BOOK
Discovery of Small Molecule Modulators of Protein RNA Interactions for Treating Cancer and COVID 19 Excerpt :

This book describes the development of novel protein–RNA-binding assays and their applications in a high-throughput manner for the identification of small-molecule modulators of protein–RNA interactions to treat cancer and COVID-19. Modulating protein–RNA interactions with small molecules is expected to provide novel biological insights of the interrelation of diseases with the protein–RNA interactome. The modulations may also be exploited therapeutically. For these reasons, the development of a simple, reliable, and sensitive protein–RNA-binding assay is necessary for high-throughput screening to discover new effective chemical entities capable of acting on diverse protein–RNA interactions. This book discusses the discovery of small-molecule modulators targeting protein–RNA interactions that are potentially valuable to treat cancer and COVID-19 by constructing novel high-throughput screening methods. The results of this dissertation provide valuable insights into the regulation of protein–RNA interactions in chemical biology and drug development.

New Drug Development for Known and Emerging Viruses Book

New Drug Development for Known and Emerging Viruses


  • Author : Helga Rübsamen-Schaeff
  • Publisher : John Wiley & Sons
  • Release Date : 2021-11-30
  • Genre: Medical
  • Pages : 528
  • ISBN 10 : 9783527810703

DOWNLOAD BOOK
New Drug Development for Known and Emerging Viruses Excerpt :

Discusses how to fight Ebola, SARS Corona, and other known or emerging human viruses by building on the successes in antiviral therapy of the past decades Written by leading medicinal chemists from academia and industry, this book discusses the entire field of antiviral drug discovery and development from a medicinal chemistry perspective, focusing on antiviral drugs, targets, and viral disease mechanisms. It provides an outlook on emerging pathogens such as Ebola, Zika, West Nile, Lassa, and includes a chapter on SARS Coronoavirus-2 causing the present pandemic. New Drug Development for Known and Emerging Viruses describes the discovery and development process for antiviral agents for different classes of viruses and targets based on the experiences from the nine human viruses for which approved drugs are on the market (HIV, HCV, Influenza, RSV, HBV, HPV, HCMV, HSV, and VZV). It covers the properties and potential of 20 classes of currently approved antivirals, including combination drugs, and looks at novel antiviral strategies against emerging viruses. Covers the entire field of antiviral drug discovery and development Addresses the need for antiviral drugs to combat major health threats such as Ebola, Zika, West Nile, and SARS Coronavirus-2 Summarizes the successes of the past 15 years in developing ground-breaking medicines against 9 major human viruses, both from the medicinal chemistry and the pharmacological angle Discusses practical and strategic challenges in the drug discovery and development process, including screening technologies, latency, and toxicity issues New Developments in Antiviral Drugs is an important book for medicinal chemists, pharmaceutical chemists, virologists, and epidemiologists, and will be of great interest to those in the pharmaceutical industry and public health agencies.

In Silico Modeling of Drugs Against Coronaviruses Book

In Silico Modeling of Drugs Against Coronaviruses


  • Author : Kunal Roy
  • Publisher : Humana
  • Release Date : 2021-09-12
  • Genre: Medical
  • Pages : 788
  • ISBN 10 : 1071613650

DOWNLOAD BOOK
In Silico Modeling of Drugs Against Coronaviruses Excerpt :

This essential volume explores a variety of tools and protocols of structure-based (homology modeling, molecular docking, molecular dynamics, protein-protein interaction network) and ligand-based (pharmacophore mapping, quantitative structure-activity relationships or QSARs) drug design for ranking and prioritization of candidate molecules in search of effective treatment strategy against coronaviruses. Beginning with an introductory section that discusses coronavirus interactions with humanity and COVID-19 in particular, the book then continues with sections on tools and methodologies, literature reports and case studies, as well as online tools and databases that can be used for computational anti-coronavirus drug research. Written for the Methods in Pharmacology and Toxicology series, chapters include the kind of practical detail and implementation advice that ensures high quality results in the lab. Comprehensive and timely, In Silico Modeling of Drugs Against Coronaviruses: Computational Tools and Protocols is an ideal reference for researchers working on the development of novel anti-coronavirus drugs for SARS-CoV-2 and for coronaviruses that will likely appear in the future.

Antiviral Drug Discovery and Development Book

Antiviral Drug Discovery and Development


  • Author : Xinyong Liu
  • Publisher : Springer Nature
  • Release Date : 2021-07-13
  • Genre: Medical
  • Pages : 357
  • ISBN 10 : 9789811602672

DOWNLOAD BOOK
Antiviral Drug Discovery and Development Excerpt :

This book summarizes state-of-the-art antiviral drug design and discovery approaches starting from natural products to de novo design, and provides a timely update on recently approved antiviral drugs and compounds in advanced clinical development. Special attention is paid to viral infections with a high impact on the world population or highly relevant from the public health perspective (HIV, hepatitis C, influenza virus, etc.). In these chapters, limitations associated with adverse effects and emergence of drug resistance are discussed in detail. In addition to classical antiviral strategies, chapters will be dedicated to discuss the non-classical drug development strategies to block viral infection, for instance, allosteric inhibitors, covalent antiviral agents, or antiviral compounds targeting protein–protein interactions. Finally, current prospects for producing broad-spectrum antiviral inhibitors will be also addressed. The book is distinctive in providing the most recent update in the rapidly evolving field of antiviral therapeutics. Authoritative reviews are written by international scientists well known for their contributions in their topics of research, which makes this book suitable for researchers not only within the antiviral research community but also attractive to a broad audience in the drug discovery field. This book covers molecular structures and biochemical mechanisms mediating the antiviral effects, while discussing various ligand design strategies, which include traditional medicinal chemistry, computational chemistry, and chemical biology approaches. The book provides a comprehensive review of antiviral drug discovery and development approaches, particularly focusing on current innovations and future trends.

Modeling  Control and Drug Development for COVID 19 Outbreak Prevention Book

Modeling Control and Drug Development for COVID 19 Outbreak Prevention


  • Author : Ahmad Taher Azar
  • Publisher : Springer Nature
  • Release Date : 2021-11-01
  • Genre: Computers
  • Pages : 1115
  • ISBN 10 : 9783030728342

DOWNLOAD BOOK
Modeling Control and Drug Development for COVID 19 Outbreak Prevention Excerpt :

This book is well-structured book which consists of 31 full chapters. The book chapters' deal with the recent research problems in the areas of modeling, control and drug development, and it presents various techniques of COVID-19 outbreak prevention modeling. The book also concentrates on computational simulations that may help speed up the development of drugs to counter the novel coronavirus responsible for COVID-19. This is an open access book.

Viral Proteases and Their Inhibitors Book

Viral Proteases and Their Inhibitors


  • Author : Satya Prakash Gupta
  • Publisher : Academic Press
  • Release Date : 2017-07-03
  • Genre: Science
  • Pages : 516
  • ISBN 10 : 9780128096826

DOWNLOAD BOOK
Viral Proteases and Their Inhibitors Excerpt :

Viral Proteases and Their Inhibitors provides a thorough examination of viral proteases from their molecular components, to therapeutic applications. As information on three dimensional structures and biological functions of these viral proteases become known, unexpected protein folds and unique mechanisms of proteolysis are realized. This book investigates how this facilitates the design and development of potent antiviral agents used against life-threatening viruses. Users will find descriptions of each virus that detail the structure and function of viral proteases, discuss the design and development of inhibitors, and analyze the structure-activity relationships of inhibitors. This book is ideal biochemists, virologists and those working on antiviral agents. Provides comprehensive, state-of-the-art coverage of virus infections, the virus lifecycle, and mechanisms of protease inhibition Analyzes structure-activity relationships of inhibitors of each viral protease Presents an in-depth view of the structure and function of viral proteases