Delivery of Therapeutics for Biogerontological Interventions Book

Delivery of Therapeutics for Biogerontological Interventions


  • Author : Wing-Fu Lai
  • Publisher : Academic Press
  • Release Date : 2019-07-02
  • Genre: Medical
  • Pages : 204
  • ISBN 10 : 9780128172766

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Delivery of Therapeutics for Biogerontological Interventions Excerpt :

Delivery of Therapeutics for Biogerontological Interventions: From Concepts to Experimental Design provides tactics on how to facilitate planning and research in interventive biogerontology. The book helps create clearer directions for the translation of existing advances in delivery technologies, from lab to practice. It is ideal as a starting point for scientists, clinicians and those interested in the field of biogerontology, biomedicine or nanotechnology, comprehensively discussing how to translate bench works to practicable tactics that retard the aging process. Using support from recent advances reported in literature, this title takes advantage of delivery technologies to develop biogerontological interventions, from concept to experimental design. Provides the first comprehensive reference to guide researchers through the process of intervention development, from concepts, to practicable interventions Covers the information needed to exploit the use of delivery technologies in intervention biogerontology Presents complete coverage of advances in the field, all of which are supported by full color photographs, figures and references

Systemic Delivery Technologies in Anti Aging Medicine  Methods and Applications Book

Systemic Delivery Technologies in Anti Aging Medicine Methods and Applications


  • Author : Wing-Fu Lai
  • Publisher : Springer Nature
  • Release Date : 2020-10-19
  • Genre: Medical
  • Pages : 511
  • ISBN 10 : 9783030544904

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Systemic Delivery Technologies in Anti Aging Medicine Methods and Applications Excerpt :

This book presents a multidisciplinary assessment of the state of science in the use of systemic delivery technologies to deliver anti-aging therapeutics now under development. There is a gap between basic aging research and the development of intervention technologies. This major obstacle must be overcome before biogerontological interventions can be put into clinical practice. As biogerontology comes to understand aging as a systemic degenerative process, it is clear that there is a pressing need for technologies that enable cells and tissues in a fully developed adult body to be manipulated systemically to combat aging. The authors review advances in the chemistry and engineering of systemic delivery methods and analyze the strengths and limitations of each. The book is organized into six sections. The first offers an overview of the need for systemic delivery technologies alongside the development of anti-aging therapies and describes approaches that will be required for studying the properties and efficiency of carriers for systemic delivery. Sections II, III and IV describe recent advances in a range of strategies that may enable systemic delivery to help combat aging conditions ranging from cell senescence to decline in immune function and hormonal secretion. Section V discusses practical strategies to engineer and optimize the performance of delivery technologies for applications in systemic delivery, along with their working principles. The final section discusses technical and biological barriers that must be overcome as systemic delivery technologies move from research laboratory to clinical applications aimed at tackling aging and age-associated diseases. Benefiting scholars, students and a broader audience of interested readers, the book includes helpful glossary sections in each chapter, as well as sidebars that highlight important notes, and questions for future research.

Biotechnology of Microbial Enzymes Book

Biotechnology of Microbial Enzymes


  • Author : Goutam Brahmachari
  • Publisher : Academic Press
  • Release Date : 2016-07-21
  • Genre: Medical
  • Pages : 632
  • ISBN 10 : 9780128037461

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Biotechnology of Microbial Enzymes Excerpt :

Biotechnology of Microbial Enzymes: Production, Biocatalysis and Industrial Applications provides a complete survey of the latest innovations on microbial enzymes, highlighting biotechnological advances in their production and purification along with information on successful applications as biocatalysts in several chemical and industrial processes under mild and green conditions. Applications of microbial enzymes in food, feed, and pharmaceutical industries are given particular emphasis. The application of recombinant DNA technology within industrial fermentation and the production of enzymes over the last 20 years have produced a host of useful chemical and biochemical substances. The power of these technologies results in novel transformations, better enzymes, a wide variety of applications, and the unprecedented development of biocatalysts through the ongoing integration of molecular biology methodology, all of which is covered insightfully and in-depth within the book. Features research on microbial enzymes from basic science through application in multiple industry sectors for a comprehensive approach Includes information on metabolic pathway engineering, metagenomic screening, microbial genomes, extremophiles, rational design, directed evolution, and more Provides a holistic approach to the research of microbial enzymes

Encyclopedia of Biomedical Gerontology Book

Encyclopedia of Biomedical Gerontology


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2019-11-20
  • Genre: Medical
  • Pages : 1640
  • ISBN 10 : 9780128160763

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Encyclopedia of Biomedical Gerontology Excerpt :

Encyclopedia of Biomedical Gerontology presents a wide range of topics, ranging from what happens in the body during aging, the reasons and mechanisms relating to those age-related changes, and their clinical, psychological and social modulators and determinants. The book covers the biological and medical aspects of gerontology within the general framework of the biological basis of assessing age, biological mechanisms of aging, age-related changes in biological systems, human age-related diseases, the biomedical practicality and impracticality of interventions, and finally, the ethics of intervention. Provides a ‘one-stop’ resource to information written by world-leading scholars in the field of biomedical gerontology Fills a critical gap of information in a field that has seen significant progress in the last 10 years

Handbook of the Biology of Aging Book

Handbook of the Biology of Aging


  • Author : Matt Kaeberlein
  • Publisher : Academic Press
  • Release Date : 2015-08-20
  • Genre: Medical
  • Pages : 576
  • ISBN 10 : 9780124116207

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Handbook of the Biology of Aging Excerpt :

Handbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of ‘big data’ approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems. The book includes discussions on longevity pathways and interventions that modulate aging, innovative new tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, new strategies to pharmacologically modulate the mTOR pathway to delay aging, the importance of sirtuins and the hypoxic response in aging, and how various pathways interact within the context of aging as a complex genetic trait, amongst others. Covers the key areas in biological gerontology research in one volume, with an 80% update from the previous edition Edited by Matt Kaeberlein and George Martin, highly respected voices and researchers within the biology of aging discipline Assists basic researchers in keeping abreast of research and clinical findings outside their subdiscipline Presents information that will help medical, behavioral, and social gerontologists in understanding what basic scientists and clinicians are discovering New chapters on genetics, evolutionary biology, bone aging, and epigenetic control Provides a close examination of the diverse research being conducted today in the study of the biology of aging, detailing recent breakthroughs and potential new directions

Evidence Based Physical Therapy for the Pelvic Floor Book

Evidence Based Physical Therapy for the Pelvic Floor


  • Author : Kari Bo
  • Publisher : Elsevier Health Sciences
  • Release Date : 2014-11-04
  • Genre: Medical
  • Pages : 448
  • ISBN 10 : 9780702060731

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Evidence Based Physical Therapy for the Pelvic Floor Excerpt :

Bridging the gap between evidence-based research and clinical practice, Physical Therapy for the Pelvic Floor has become an invaluable resource to practitioners treating patients with disorders of the pelvic floor. The second edition is now presented in a full colour, hardback format, encompassing the wealth of new research in this area which has emerged in recent years. Kari Bø and her team focus on the evidence, from basic studies (theories or rationales for treatment) and RCTs (appraisal of effectiveness) to the implications of these for clinical practice, while also covering pelvic floor dysfunction in specific groups, including men, children, elite athletes, the elderly, pregnant women and those with neurological diseases. Crucially, recommendations on how to start, continue and progress treatment are also given with detailed treatment strategies around pelvic floor muscle training, biofeedback and electrical stimulation. aligns scientific research with clinical practice detailed treatment strategies innovative practice guidelines supported by a sound evidence base colour illustrations of pelvic floor anatomy and related neuroanatomy/ neurophysiology MRIs and ultrasounds showing normal and dysfunctional pelvic floor

Critical Reviews of Oxidative Stress and Aging Book

Critical Reviews of Oxidative Stress and Aging


  • Author : Richard G. Cutler
  • Publisher : World Scientific
  • Release Date : 2003
  • Genre: FAMILY & RELATIONSHIPS
  • Pages : 1624
  • ISBN 10 : 9789812775733

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Critical Reviews of Oxidative Stress and Aging Excerpt :

This two-volume reference examines the translational research field of oxidative stress and ageing. It focuses on understanding the molecular basis of oxidative stress and its associated age-related diseases, with the goal of developing new methods for treating the human ageing processes.

Anti aging Drugs Book

Anti aging Drugs


  • Author : Alexander M Vaiserman
  • Publisher : Royal Society of Chemistry
  • Release Date : 2017-02-01
  • Genre: Medical
  • Pages : 570
  • ISBN 10 : 9781782624356

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Anti aging Drugs Excerpt :

Aging is a natural phenomenon that is peculiar to all living things. However, accumulating findings indicate that senescence could be postponed or prevented by certain approaches. Substantial evidence has emerged supporting the possibility of radical human health and lifespan extension, in particular through pharmacological modulation of aging. A number of natural dietary ingredients and synthetic drugs have been assumed to have geroprotective potential. In the development of anti-aging therapeutics, several cell, insect, and animal models may provide useful starting points prior to human studies. This book provides an overview of current research aimed to search for life-extending medications and describes pharmacological aspects of anti-aging medicine. Readers are introduced to the fascinating historical background of geroprotection in the first chapter. In-depth information on models for investigating geroprotective drugs precedes a section covering anti-aging properties of pharmaceutical compounds, such as calorie restriction mimetics, autophagy inducers, senolytics and mitochondrial antioxidants. Finally, strategies to translate discoveries from aging research into drugs and healthcare policy perspectives on anti-ageing medicine are provided to give a complete picture of the field. A timely and carefully edited collection of chapters by leading researchers in the field, this book will be a fascinating and useful resource for pharmacologists, gerontologists and any scientifically interested person wishing to know more about the current status of research into anti-aging remedies, challenges and opportunities.

Epigenetics of Aging and Longevity Book

Epigenetics of Aging and Longevity


  • Author : Alexey Moskalev
  • Publisher : Academic Press
  • Release Date : 2017-11-17
  • Genre: Medical
  • Pages : 544
  • ISBN 10 : 9780128110836

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Epigenetics of Aging and Longevity Excerpt :

Epigenetics of Aging and Longevity provides an in-depth analysis of the epigenetic nature of aging and the role of epigenetic factors in mediating the link between early-life experiences and life-course health and aging. Chapters from leading international contributors explore the effect of adverse conditions in early-life that may result in disrupted epigenetic pathways, as well as the potential to correct these disrupted pathways via targeted therapeutic interventions. Intergenerational epigenetic inheritance, epigenetic drug discovery, and the role of epigenetic mechanisms in regulating specific age-associated illnesses—including cancer and cardiovascular, metabolic, and neurodegenerative diseases—are explored in detail. This book will help researchers in genomic medicine, epigenetics, and biogerontology better understand the epigenetic determinants of aging and longevity, and ultimately aid in developing therapeutics to extend the human life-span and treat age-related disease. Offers a comprehensive overview of the epigenetic nature of aging, as well as the impact of epigenetic factors on longevity and regulating age-related disease Provides readers with clinical and epidemiological evidence for the role of epigenetic mechanisms in mediating the link between early-life experiences, life-course health and aging trajectory Applies current knowledge of epigenetic regulatory pathways towards developing therapeutic interventions for age-related diseases and extending the human lifespan

Polymers and Nanomaterials for Gene Therapy Book

Polymers and Nanomaterials for Gene Therapy


  • Author : Ravin Narain
  • Publisher : Woodhead Publishing
  • Release Date : 2016-01-09
  • Genre: Science
  • Pages : 302
  • ISBN 10 : 9780081005217

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Polymers and Nanomaterials for Gene Therapy Excerpt :

Polymers and Nanomaterials for Gene Therapy provides the latest information on gene therapy, a topic that has attracted significant attention over the past two decades for the treatment of inherited and acquired genetic diseases. Major research efforts are currently focused on designing suitable carrier vectors that compact and protect oligonucleotides for gene therapy. The book explores the most recent developments in the field of polymer science and nanotechnology, and how these advancements have helped in the design of advanced materials. Non-viral vector systems, including cationic lipids, polymers, dendrimers, peptides and nanoparticles, are potential routes for compacting DNA for systemic delivery. However, unlike viral analogues that have no difficulty in overcoming cellular barriers and immune defense mechanisms, non-viral gene carriers consistently exhibit significant reduced transfection efficiency due to numerous extra- and intracellular obstacles. Therefore, biocompatibility and potential for large-scale production make these compounds increasingly attractive for gene therapy. This book contains chapters on the engineering of polymers and nanomaterials for gene therapy, and how they can form complexes with DNA and avoid both in vitro and in vivo barriers. Other chapters describe in vitro, ex vivo, in vivo gene therapy studies, and the current issues affecting non-viral gene therapy. Explores current challenges in the research of genetic diseases Discusses polymers for gene therapy and their function in designing advanced materials Provides examples of organic and inorganic nanomaterials for gene therapy Includes labeling, targeting, and assays Looks at characterization, physico-(bio)chemical properties, and applications

The Science of Hormesis in Health and Longevity Book

The Science of Hormesis in Health and Longevity


  • Author : Suresh I. S. Rattan
  • Publisher : Academic Press
  • Release Date : 2018-10-23
  • Genre: Medical
  • Pages : 326
  • ISBN 10 : 9780128142547

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The Science of Hormesis in Health and Longevity Excerpt :

The Science of Hormesis in Health and Longevity provides a comprehensive review of mild stress-induced physiological hormesis and its role in the maintenance and promotion of health. Coverage includes the underlying mechanisms of hormesis, including details of stress-response signaling, an enriched environment, positive challenges and dose-response mechanisms, amongst others. Research from top experts is presented to provide suggestions for developing novel therapeutic strategies, along with lifestyle interventions to promote health and homoeostasis. Researchers in aging and physiology, gerontologists, clinicians and medical students will find this a valuable addition for their work. Provides a comprehensive, scholarly review of the current state of hormesis in physiology, health, disease and aging Includes multiple perspectives and in-depth analysis by top experts involved in cutting-edge research to provide developing, novel therapeutic strategies, as well as lifestyle interventions Offers a clear understanding of hormesis’ underlying mechanisms, including details of stress-response signaling, an enriched environment, positive challenges, dose-response mechanisms, and more

World Report on Ageing and Health Book

World Report on Ageing and Health


  • Author : World Health Organization
  • Publisher : World Health Organization
  • Release Date : 2015-10-22
  • Genre: Family & Relationships
  • Pages : 246
  • ISBN 10 : 9789241565042

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World Report on Ageing and Health Excerpt :

The WHO World report on ageing and health is not for the book shelf it is a living breathing testament to all older people who have fought for their voice to be heard at all levels of government across disciplines and sectors. - Mr Bjarne Hastrup President International Federation on Ageing and CEO DaneAge This report outlines a framework for action to foster Healthy Ageing built around the new concept of functional ability. This will require a transformation of health systems away from disease based curative models and towards the provision of older-person-centred and integrated care. It will require the development sometimes from nothing of comprehensive systems of long term care. It will require a coordinated response from many other sectors and multiple levels of government. And it will need to draw on better ways of measuring and monitoring the health and functioning of older populations. These actions are likely to be a sound investment in society's future. A future that gives older people the freedom to live lives that previous generations might never have imagined. The World report on ageing and health responds to these challenges by recommending equally profound changes in the way health policies for ageing populations are formulated and services are provided. As the foundation for its recommendations the report looks at what the latest evidence has to say about the ageing process noting that many common perceptions and assumptions about older people are based on outdated stereotypes. The report's recommendations are anchored in the evidence comprehensive and forward-looking yet eminently practical. Throughout examples of experiences from different countries are used to illustrate how specific problems can be addressed through innovation solutions. Topics explored range from strategies to deliver comprehensive and person-centred services to older populations to policies that enable older people to live in comfort and safety to ways to correct the problems a

Veterinary Herbal Medicine Book
Score: 5
From 1 Ratings

Veterinary Herbal Medicine


  • Author : Susan G. Wynn
  • Publisher : Elsevier Health Sciences
  • Release Date : 2007
  • Genre: Health & Fitness
  • Pages : 714
  • ISBN 10 : 9780323029988

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Veterinary Herbal Medicine Excerpt :

This full-color text and practical clinical reference provides comprehensive information on herbal remedies for both large and small animal species. Key coverage includes clinical uses of medicinal plants, specific information on how to formulate herbal remedies, a systems-based review of plant-based medicine, and in-depth information on the different animal species--dog, cat, avian and exotic, equine, food animal, and poultry.

The Changing Role of the Hospital in European Health Systems Book

The Changing Role of the Hospital in European Health Systems


  • Author : Martin McKee
  • Publisher : Cambridge University Press
  • Release Date : 2020-08-13
  • Genre: Health & Fitness
  • Pages : 324
  • ISBN 10 : 9781108790055

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The Changing Role of the Hospital in European Health Systems Excerpt :

A team of world-leading policy experts and clinicians analyse the changing role of the hospital across Europe.

A Materia Medica for Chinese Medicine Book
Score: 5
From 1 Ratings

A Materia Medica for Chinese Medicine


  • Author : Carl-Hermann Hempen
  • Publisher : Elsevier Health Sciences
  • Release Date : 2009
  • Genre: Medical
  • Pages : 1007
  • ISBN 10 : 9780443100949

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A Materia Medica for Chinese Medicine Excerpt :

Phytotherapy or herbal medicine is the most important therapy within Chinese medicine and is being used increasingly in the West. A Materia Medica for Chinese Medicine: plants, minerals and animal products describes 400 of the most important plants, minerals and animal substances used as treatments by Chinese medical practitioners. The items included have been selected according to their degree of clinical relevance. Each remedy is clearly described and illustrated on two facing pages, making this an easily accessible reference for both students and practitioners of Chinese herbal medicine. The clearly laid out text presents the following details for each herb or substance included: a detailed description of the characteristic features indictions for safe use medicinal and toxic effects possible combinations with other substances full-colour illustrations, generally two for each substance, showing the detailed characterisitcs of the item described A Materia Medica for Chinese Medicine has been written by two medically trained doctors who have worked as TCM therapists specializing in the use of Chinese herbs for more than 30 years. Based on their many years of teaching and practice, the book has been carefully compiled and designed to provide a concise and accurate practice-based reference for both students and practitioners.