Design and Development of New Nanocarriers Book

Design and Development of New Nanocarriers


  • Author : Alexandru Mihai Grumezescu
  • Publisher : William Andrew
  • Release Date : 2017-12-12
  • Genre: Science
  • Pages : 766
  • ISBN 10 : 9780128136287

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Design and Development of New Nanocarriers Excerpt :

Design and Development of New Nanocarriers focuses on the design and development of new nanocarriers used in pharmaceutical applications that have emerged in recent years. In particular, the pharmaceutical uses of microfluidic techniques, supramolecular design of nanocapsules, smart hydrogels, polymeric micelles, exosomes and metal nanoparticles are discussed in detail. Written by a diverse group of international researchers, this book is a valuable reference resource for those working in both biomaterials science and the pharmaceutical industry. Shows how nanomanufacturing techniques can help to create more effective, cheaper pharmaceutical products Explores how nanofabrication techniques developed in the lab have been translated to commercial applications in recent years Explains safety and regulatory aspects of the use of nanomanufacturing processes in the pharmaceutical industry

Design and Development of New Nanocarriers Book

Design and Development of New Nanocarriers


  • Author : Alexandru Mihai Grumezescu
  • Publisher : William Andrew
  • Release Date : 2017-11-28
  • Genre: Uncategoriezed
  • Pages : 766
  • ISBN 10 : 0128136278

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Design and Development of New Nanocarriers Excerpt :

Design and Development of New Nanocarriers focuses on the design and development of new nanocarriers used in pharmaceutical applications that have emerged in recent years. In particular, the pharmaceutical uses of microfluidic techniques, supramolecular design of nanocapsules, smart hydrogels, polymeric micelles, exosomes and metal nanoparticles are discussed in detail. Written by a diverse group of international researchers, this book is a valuable reference resource for those working in both biomaterials science and the pharmaceutical industry. Shows how nanomanufacturing techniques can help to create more effective, cheaper pharmaceutical products Explores how nanofabrication techniques developed in the lab have been translated to commercial applications in recent years Explains safety and regulatory aspects of the use of nanomanufacturing processes in the pharmaceutical industry

Lipid Nanocarriers for Drug Targeting Book

Lipid Nanocarriers for Drug Targeting


  • Author : Alexandru Mihai Grumezescu
  • Publisher : William Andrew
  • Release Date : 2018-04-16
  • Genre: Science
  • Pages : 674
  • ISBN 10 : 9780128136881

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Lipid Nanocarriers for Drug Targeting Excerpt :

Lipid Nanocarriers for Drug Targeting presents recent advances in the area of lipid nanocarriers. The book focuses on cationic lipid nanocarriers, solid lipid nanocarriers, liposomes, thermosensitive vesicles, and cubosomes, with applications in phototherapy, cosmetic and others. As the first book related to lipid nanocarriers and their direct implication in pharmaceutical nanotechnology, this important reference resource is ideal for biomaterials scientists and those working in the medical and pharmaceutical industries that want to learn more on how lipids can be used to create more effective drug delivery systems. Highlights the most commonly used types of lipid nanocarriers and explains how they are applied in pharmacy Shows how lipid nanocarriers are used in different types of treatment, including oral medicine, skin repair and cancer treatment Assesses the pros and cons of using different lipid nanocarriers for different therapies

Organic Materials as Smart Nanocarriers for Drug Delivery Book

Organic Materials as Smart Nanocarriers for Drug Delivery


  • Author : Alexandru Mihai Grumezescu
  • Publisher : William Andrew
  • Release Date : 2018-03-26
  • Genre: Science
  • Pages : 768
  • ISBN 10 : 9780128136645

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Organic Materials as Smart Nanocarriers for Drug Delivery Excerpt :

Organic Materials as Smart Nanocarriers for Drug Delivery presents the latest developments in the area of organic frameworks used in pharmaceutical nanotechnology. An up-to-date overview of organic smart nanocarriers is explored, along with the different types of nanocarriers, including polymeric micelles, cyclodextrins, hydrogels, lipid nanoparticles and nanoemlusions. Written by a diverse range of international academics, this book is a valuable reference for researchers in biomaterials, the pharmaceutical industry, and those who want to learn more about the current applications of organic smart nanocarriers. Explores the most recent molecular- and structure-based applications of organic smart nanocarriers in drug delivery Highlights different smart nanocarriers and assesses their intricate organic structural properties for improving drug delivery Assesses how molecular organic frameworks lead to more effective drug delivery systems

Medicinal Chemistry with Pharmaceutical Product Development Book

Medicinal Chemistry with Pharmaceutical Product Development


  • Author : Debarshi Kar Mahapatra
  • Publisher : CRC Press
  • Release Date : 2019-02-04
  • Genre: Medical
  • Pages : 368
  • ISBN 10 : 9780429947155

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Medicinal Chemistry with Pharmaceutical Product Development Excerpt :

This volume focuses on novel therapeutics and strategies for the development of pharmaceutical products, keeping the drug molecule as the central component. It discusses current theoretical and practical aspects of pharmaceuticals for the discovery and development of novel therapeutics for health problems. Explaining the necessary features essential for pharmacological activity, it takes an interdisciplinary approach by including a unique combination of pharmacy, chemistry, and medicine along with clinical aspects. It takes into consideration the therapeutic regulations of the USP along with all the latest therapeutic guidelines put forward by WHO, and the US Food and Drug Administration.

Intracellular Delivery III Book

Intracellular Delivery III


  • Author : Aleš Prokop
  • Publisher : Springer
  • Release Date : 2016-10-31
  • Genre: Medical
  • Pages : 453
  • ISBN 10 : 9783319435251

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Intracellular Delivery III Excerpt :

A critical review is attempted to assess the status of nanomedicine entry onto the market. The emergence of new potential therapeutic entities such as DNA and RNA fragments requires that these new “drugs” will need to be delivered in a cell-and organelle-specific manner. Although efforts have been made over the last 50 years or so to develop such delivery technology, no effective and above all clinically approved protocol for cell-specific drug delivery in humans exists as yet. Various particles, macromolecules, liposomes and most recently “nanomaterials” have been said to “show promise” but none of these promises have so far been “reduced” to human clinical practice. The focus of this volume is on cancer indication since the majority of published research relates to this application; within that, we focus on solid tumors (solid malignancies). Our aim is critically to evaluate whether nanomaterials, both non-targeted and targeted to specific cells, could be of therapeutic benefit in clinical practice. The emphasis of this volume will be on pharmacokinetics (PK) and pharmacodynamics (PD) in animal and human studies. Apart from the case of exquisitely specific antibody-based drugs, the development of target-specific drug–carrier delivery systems has not yet been broadly successful at the clinical level. It can be argued that drugs generated using the conventional means of drug development (i.e., relying on facile biodistribution and activity after (preferably) oral administration) are not suitable for a target-specific delivery and would not benefit from such delivery even when a seemingly perfect delivery system is available. Therefore, successful development of site-selective drug delivery systems will need to include not only the development of suitable carriers, but also the development of drug entities that meet the required PK/PD profile.

Nanostructures for the Engineering of Cells  Tissues and Organs Book

Nanostructures for the Engineering of Cells Tissues and Organs


  • Author : Alexandru Mihai Grumezescu
  • Publisher : William Andrew
  • Release Date : 2018-02-14
  • Genre: Science
  • Pages : 630
  • ISBN 10 : 9780128136669

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Nanostructures for the Engineering of Cells Tissues and Organs Excerpt :

Nanostructures for the Engineering of Cells: Tissues and Organs showcases recent advances in pharmaceutical nanotechnology, with particular emphasis on tissue engineering, organ and cell applications. The book provides an up-to-date overview of organ targeting and cell targeting using nanotechnology. In addition, tissue engineering applications, such as skin regeneration are also discussed. Written by a diverse range of international academics, this book is a valuable research resource for researchers working in the biomaterials, medical and pharmaceutical industries. Explains how nanomaterials regulate different cell behavior and function as a carrier for different biomolecules Shows how nanobiomaterials and nanobiodevices are used in a range of treatment areas, such as skin tissue, wound healing and bone regeneration Discusses nanomaterial preparation strategies for pharmaceutical application and regenerative medicine

Fullerens  Graphenes and Nanotubes Book

Fullerens Graphenes and Nanotubes


  • Author : Alexandru Mihai Grumezescu
  • Publisher : William Andrew
  • Release Date : 2018-05-28
  • Genre: Science
  • Pages : 724
  • ISBN 10 : 9780128136928

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Fullerens Graphenes and Nanotubes Excerpt :

Fullerens, Graphenes and Nanotubes: A Pharmaceutical Approach shows how carbon nanomaterials are used in the pharmaceutical industry. While there are various books on the carbonaceous nanomaterials available on the market, none approach the subject from a pharmaceutical point-of-view. In this context, the book covers different applications of carbonaceous nanomaterials. Chapters examine different types of carbon nanomaterials and explore how they are used in such areas as cancer treatments, pulse sensing and prosthetics. Readers will find this book to be a valuable reference resource for those working in the areas of carbon materials, nanomaterials and pharmaceutical science. Explains how the unique properties of carbon-based nanomaterials allow them to be used to create effective drug delivery systems Covers how carbon-based nanomaterials should be prepared for use in pharmaceutical applications Discusses the relative toxicity of a range of carbon-based nanomaterials Considers the safety of their use in different types of drugs

Drug Targeting and Stimuli Sensitive Drug Delivery Systems Book

Drug Targeting and Stimuli Sensitive Drug Delivery Systems


  • Author : Alexandru Mihai Grumezescu
  • Publisher : William Andrew
  • Release Date : 2018-05-21
  • Genre: Science
  • Pages : 836
  • ISBN 10 : 9780128136904

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Drug Targeting and Stimuli Sensitive Drug Delivery Systems Excerpt :

Drug Targeting and Stimuli Sensitive Drug Delivery Systems covers recent advances in the area of stimuli sensitive drug delivery systems, providing an up-to-date overview of the physical, chemical, biological and multistimuli-responsive nanosystems. In addition, the book presents an analysis of clinical status for different types of nanoplatforms. Written by an internationally diverse group of researchers, it is an important reference resource for both biomaterials scientists and those working in the pharmaceutical industry who are looking to help create more effective drug delivery systems. Shows how the use of nanomaterials can help target a drug to specific tissues and cells Explores the development of stimuli-responsive drug delivery systems Includes case studies to showcase how stimuli responsive nanosystems are used in a variety of therapies, including camptothecin delivery, diabetes and cancer therapy

Inorganic Frameworks as Smart Nanomedicines Book

Inorganic Frameworks as Smart Nanomedicines


  • Author : Alexandru Mihai Grumezescu
  • Publisher : William Andrew
  • Release Date : 2018-04-09
  • Genre: Science
  • Pages : 726
  • ISBN 10 : 9780128136621

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Inorganic Frameworks as Smart Nanomedicines Excerpt :

Inorganic Frameworks as Smart Nanocarriers for Drug Delivery brings together recent research in the area of inorganic frameworks for drug delivery. Different types of nanocarriers are presented and discussed in detail, providing an up-to-date overview on inorganic nanoparticles with pharmaceutical applications. Written by a diverse range of international academics, this book is a valuable reference resource for researchers in biomaterials, the pharmaceutical industry, and those who want to learn more about the current applications of inorganic smart nanocarriers. Includes assembly methods for a variety of smart nanocarrier systems, also showing how they are applied Highlights how metal-oxide nanoparticles are effectively used in drug delivery Assesses the pros and cons of different metallic nanomaterials as drug carriers

Nanoscale Fabrication  Optimization  Scale up and Biological Aspects of Pharmaceutical Nanotechnology Book

Nanoscale Fabrication Optimization Scale up and Biological Aspects of Pharmaceutical Nanotechnology


  • Author : Alexandru Mihai Grumezescu
  • Publisher : William Andrew
  • Release Date : 2017-12-11
  • Genre: Science
  • Pages : 696
  • ISBN 10 : 9780128136300

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Nanoscale Fabrication Optimization Scale up and Biological Aspects of Pharmaceutical Nanotechnology Excerpt :

Nanoscale Fabrication, Optimization, Scale-up and Biological Aspects of Pharmaceutical Nanotechnology focuses on the fabrication, optimization, scale-up and biological aspects of pharmaceutical nanotechnology. In particular, the following aspects of nanoparticle preparation methods are discussed: the need for less toxic reagents, simplification of the procedure to allow economic scale-up, and optimization to improve yield and entrapment efficiency. Written by a diverse range of international researchers, the chapters examine characterization and manufacturing of nanomaterials for pharmaceutical applications. Regulatory and policy aspects are also discussed. This book is a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about how nanomaterials can best be utilized. Shows how nanomanufacturing techniques can help to create more effective, cheaper pharmaceutical products Explores how nanofabrication techniques developed in the lab have been translated to commercial applications in recent years Explains safety and regulatory aspects of the use of nanomanufacturing processes in the pharmaceutical industry

Mixed Polymeric Micelles for Osteosarcoma Therapy  Development and Characterization Book

Mixed Polymeric Micelles for Osteosarcoma Therapy Development and Characterization


  • Author : Catarina Melim
  • Publisher : Bentham Science Publishers
  • Release Date : 2022-03-09
  • Genre: Medical
  • Pages : 120
  • ISBN 10 : 9789815040388

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Mixed Polymeric Micelles for Osteosarcoma Therapy Development and Characterization Excerpt :

Osteosarcoma is a rare bone tumor that has a high incidence amongchildren and young adults. Despite recent therapeutic developments, osteosarcomastill presents major hurdles to achieving successful results, mainly due to thepresence of multi-drug-resistant cells.This monograph primarily aims to provide information about the basicscience behind the treatment of osteosarcoma along with experimental resultsfor a novel formulation that overcomes multidrug resistance, and therefore, mayserve as a viable treatment option. The book starts with an updated and conciseguide to the pathophysiology of the disease, while also introducing the readerto new therapies and materials (specifically chitosan, polyethyleneimine, poloxamers,poloxamines, and Pluronics®) used in the treatment process along with the aimsof the experiments present subsequently. Next, the book documents the materialsand methods used in developing polymeric micelles for delivering drugs toosteosarcoma sites. By explaining the basics of nanomedicine as a startingpoint, readers will understand how polymeric micelles act as facilitators ofdrug transport to cancer cells, and how one can synthesize a small stablemicelle (by creating derivatives of base nanomaterials), capable of activelytargeting osteosarcoma cells and overcoming multi-drug resistance. The chapterexplains the synthesis and characterization techniques of the materials used todevelop polymeric micelles.The results, a reflection of the conjugation of different experimentalsolutions initiated here, point to a modern route towards the search for a therapeutic solution for osteosarcoma.The simple, structured presentation coupled with relevant informationon the subject of micelle-based nanotherapeutic drug delivery make thismonograph an essential handbook for pharmaceutical scientists involved in thefield of nanomedicine, drug delivery, cancer therapy and any researchersassisting specialists in clinical oncology for the treatment of osteosarcoma.

Drug Delivery Using Nanomaterials Book

Drug Delivery Using Nanomaterials


  • Author : Yasser Shahzad
  • Publisher : CRC Press
  • Release Date : 2022-01-19
  • Genre: Medical
  • Pages : 430
  • ISBN 10 : 9781000529494

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Drug Delivery Using Nanomaterials Excerpt :

After the drug discovery and development process, designing suitable formulations to safely deliver the optimum dose, while avoiding side effects, has been a constant challenge, especially when drugs are very toxic and have poor solubility and undesirable clearance profiles. With recent advances in synthetic technologies, nanoparticles can be custom-made from a variety of advanced materials to mimic the bioenvironment and can be equipped with various targeting and imaging moieties for site-specific delivery and real-time imaging. Drug Delivery Using Nanomaterials covers advancements in the field of nanoparticle-based drug-delivery systems, along with all the aspects needed for a successful and marketable nanoformulation. FEATURES Offers a general overview of the entire process involved in the synthesis and characterization of pharmaceutical nanoparticles Covers a broad range of synthetic materials for developing nanoformulations customized for specific disease states, target organs, and drugs Every chapter sequentially builds, providing a progressive pathway from classical nanoparticles to the more advanced to be used as a full drug product by consumers Provides information in a bottom-up manner in that definitions and explanations of relevant background information serve as a framework for understanding advanced concepts This user-friendly reference is aimed at materials engineers, chemical engineers, biomedical engineers, pharmaceutical scientists, chemists, and others working on advanced drug delivery, from academia as well as industry.

Advances in Sustainable Polymers Book

Advances in Sustainable Polymers


  • Author : Vimal Katiyar
  • Publisher : Springer Nature
  • Release Date : 2020-03-03
  • Genre: Technology & Engineering
  • Pages : 404
  • ISBN 10 : 9789811512513

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Advances in Sustainable Polymers Excerpt :

This book discusses synthesis and characterization of sustainable polymers. The book covers opportunities and challenges of using sustainable polymers to replace existing petroleum based feedstock. This volume provides insights into the chemistry of polymerization, and discusses tailoring the properties of the polymers at the source in order fit requirements of specific applications. The book also covers processing of these polymers and their critical assessment. The book will be of use to chemists and engineers in the industry and academia working on sustainable polymers and their commercialization to replace dependence on petroleum-based polymers.

Nanomaterials in Clinical Therapeutics Book

Nanomaterials in Clinical Therapeutics


  • Author : Mainak Mukhopadhyay
  • Publisher : John Wiley & Sons
  • Release Date : 2022-09-01
  • Genre: Technology & Engineering
  • Pages : 548
  • ISBN 10 : 9781119857723

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Nanomaterials in Clinical Therapeutics Excerpt :

NANOMATERIALS IN CLINICAL THERAPEUTICS In this rapidly developing field, the book focuses on the practical elements of nanomaterial creation, characterization, and development, as well as their usage in clinical research. Nanotechnology-based applications is a rapidly growing field encompassing a diverse range of disciplines that impact our daily lives. Nanotechnology is being used to carry out large-scale reactions in practically every field of biotechnology and healthcare. The incredible progress being made in these applications is particularly true for the healthcare sector, where they are used in cancer detection and treatment, medical implants, tissue engineering, and so forth. Expansions in this discipline are expected to continue in the future, resulting in the creation of a variety of life-saving medical technology and treatment procedures. The primary goal of this book is to disseminate information on nanotechnology’s applications in the biological sciences. A broad array of nanotechnological approaches utilized in different biological applications are highlighted in the book’s 17 chapters, including the employment of nanotechnology in drug delivery. The first three chapters provide an overview of the history and principles of nanotechnology. The synthesis, characterization, and applications of nanomaterials are covered in the next 10 chapters. The last four chapters discuss the use of nanomaterials in clinical research. Audience The book will be useful for researchers and graduate students in the many areas of science such as biomedicine, environmental biotechnology, bioprocess engineering, renewable energy, chemical engineering, nanotechnology, biotechnology, microbiology, etc.