Clinical and Translational Science Book

Clinical and Translational Science


  • Author : David Robertson
  • Publisher : Academic Press
  • Release Date : 2016-11-25
  • Genre: Science
  • Pages : 808
  • ISBN 10 : 9780128021118

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Clinical and Translational Science Excerpt :

Clinical and Translational Science: Principles of Human Research, Second Edition, is the most authoritative and timely resource for the broad range of investigators taking on the challenge of clinical and translational science, a field that is devoted to investigating human health and disease, interventions, and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. This updated second edition has been prepared with an international perspective, beginning with fundamental principles, experimental design, epidemiology, traditional and new biostatistical approaches, and investigative tools. It presents complete instruction and guidance from fundamental principles, approaches, and infrastructure, especially for human genetics and genomics, human pharmacology, research in special populations, the societal context of human research, and the future of human research. The book moves on to discuss legal, social, and ethical issues, and concludes with a discussion of future prospects, providing readers with a comprehensive view of this rapidly developing area of science. Introduces novel physiological and therapeutic strategies for engaging the fastest growing scientific field in both the private sector and academic medicine Brings insights from international leaders into the discipline of clinical and translational science Addresses drug discovery, drug repurposing and development, innovative and improved approaches to go/no-go decisions in drug development, and traditional and innovative clinical trial designs

Designing and Conducting Mixed Methods Research Book

Designing and Conducting Mixed Methods Research


  • Author : John W. Creswell
  • Publisher : SAGE Publications
  • Release Date : 2017-08-31
  • Genre: Social Science
  • Pages : 520
  • ISBN 10 : 9781506394671

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Designing and Conducting Mixed Methods Research Excerpt :

Combining the latest thinking in the field with practical, step-by-step guidance, the Third Edition of John W. Creswell and Vicki L. Plano Clark’s Designing and Conducting Mixed Methods Research now includes seven mixed methods designs with accompanying journal articles illustrating each design. The authors walk readers through the entire research process and present updated examples from published mixed methods studies drawn from multiple disciplines. In addition, this new edition includes information about the dynamic and evolving nature of the field of mixed methods research, four additional methodological approaches, and coverage of new directions in mixed methods.

The Design and Conduct of Meaningful Experiments Involving Human Participants Book

The Design and Conduct of Meaningful Experiments Involving Human Participants


  • Author : R. Barker Bausell
  • Publisher : Oxford University Press
  • Release Date : 2015-01-29
  • Genre: Psychology
  • Pages : 288
  • ISBN 10 : 9780199385256

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The Design and Conduct of Meaningful Experiments Involving Human Participants Excerpt :

Designing and conducting experiments involving human participants requires a skillset different from that needed for statistically analyzing the resulting data. The Design and Conduct of Meaningful Experiments Involving Human Participants combines an introduction to scientific culture and ethical mores with specific experimental design and procedural content. Author R. Barker Bausell assumes no statistical background on the part of the reader, resulting in a highly accessible text. Clear instructions are provided on topics ranging from the selection of a societally important outcome variable to potentially efficacious interventions to the conduct of the experiment itself. Early chapters introduce the concept of experimental design in an intuitive manner involving both hypothetical and real-life examples of how people make causal inferences. The fundamentals of formal experimentation, randomization, and the use of control groups are introduced in the same manner, followed by the presentation and explanation of common (and later, more advanced) designs. Replete with synopses of examples from the journal literature and supplemented by 25 experimental principles, this book is designed to serve as an interdisciplinary supplementary text for research-methods courses in the educational, psychological, behavioral, social, and health sciences. It also serves as an excellent primary text for methods seminar courses.

Translational and Experimental Clinical Research Book

Translational and Experimental Clinical Research


  • Author : Daniel P. Schuster
  • Publisher : Lippincott Williams & Wilkins
  • Release Date : 2005
  • Genre: Medical
  • Pages : 490
  • ISBN 10 : 0781755654

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Translational and Experimental Clinical Research Excerpt :

This volume is a comprehensive textbook for investigators entering the rapidly growing field of translational and experimental clinical research. The book offers detailed guidelines for designing and conducting a study and analyzing and reporting results and discusses key ethical and regulatory issues. Chapters address specific types of studies such as clinical experiments in small numbers of patients, pharmacokinetics and pharmacodynamics, and gene therapy and pharmacogenomic studies. A major section describes modern techniques of translational clinical research, including gene expression, identifying mutations and polymorphisms, cloning, transcriptional profiling, proteomics, cell and tissue imaging, tissue banking, evaluating substrate metabolism, and in vivo imaging.

Clinical and Translational Science Book

Clinical and Translational Science


  • Author : David Robertson
  • Publisher : Academic Press
  • Release Date : 2009-03-02
  • Genre: Medical
  • Pages : 600
  • ISBN 10 : 0080920195

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Clinical and Translational Science Excerpt :

Clinical or translational science is the field of study devoted to investigating human health and disease, interventions and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. New molecular tools and diagnostic technologies based on clinical and translational research have lead to a better understanding of human disease and the application of new therapeutics for enhanced health. Clinical and Translational Science is designed as the most authoritative and modern resource for the broad range of investigators in various medical specialties taking on the challenge of clinical research. Prepared with an international perspective, this resource begins with experimental design and investigative tools to set the scene for readers. It then moves on to human genetics and pharmacology with a focus on statistics, epidemiology, genomic information, drug discovery and development, and clinical trials. Finally, it turns to legal, social, and ethical issues of clinical research concluding with a discussion of future prospects to provide readers with a comprehensive view of the this developing area of science. Clinical research is one of the fastest growing fields in private practice and academic medicine with practical biological, physiological, cellular, and therapeutic applications Contributions from international leaders provide insight into background and future understanding for clinical and translational science Provides the structure for complete instruction and guidance on the subject from fundamental principles, approaches and infrastructure to human genetics, human pharmacology, research in special populations, the societal context of human research, and the future of human research

Designing Clinical Research Book
Score: 5
From 2 Ratings

Designing Clinical Research


  • Author : Stephen B. Hulley
  • Publisher : Lippincott Williams & Wilkins
  • Release Date : 2011-11-30
  • Genre: Medical
  • Pages : 384
  • ISBN 10 : 9781451165852

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Designing Clinical Research Excerpt :

Designing Clinical Research sets the standard for providing a practical guide to planning, tabulating, formulating, and implementing clinical research, with an easy-to-read, uncomplicated presentation. This edition incorporates current research methodology—including molecular and genetic clinical research—and offers an updated syllabus for conducting a clinical research workshop. Emphasis is on common sense as the main ingredient of good science. The book explains how to choose well-focused research questions and details the steps through all the elements of study design, data collection, quality assurance, and basic grant-writing. All chapters have been thoroughly revised, updated, and made more user-friendly.

Departments of Labor  Health and Human Services  Education  and Related Agencies Appropriations for 2006  National Institutes of Health Book

Departments of Labor Health and Human Services Education and Related Agencies Appropriations for 2006 National Institutes of Health


  • Author : United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies
  • Publisher : Unknown
  • Release Date : 2005
  • Genre: Government publications
  • Pages : null
  • ISBN 10 : MINN:31951D02480528T

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Departments of Labor Health and Human Services Education and Related Agencies Appropriations for 2006 National Institutes of Health Excerpt :

Design and Development of Smart Surgical Assistant Technologies Book

Design and Development of Smart Surgical Assistant Technologies


  • Author : Jeff J.H. Kim
  • Publisher : CRC Press
  • Release Date : 2022-06-23
  • Genre: Technology & Engineering
  • Pages : 88
  • ISBN 10 : 9781000685558

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Design and Development of Smart Surgical Assistant Technologies Excerpt :

Are Amazon Alexa and Google Home limited to our bedrooms, or can they be used in hospitals? Do you envision a future where physicians work hand-in-hand with voice AI to revolutionize healthcare delivery? In the near future, clinical smart assistants will be able to automate many manual hospital tasks—and this will be only the beginning of the changes to come. Voice AI is the future of physician-machine interaction and this Focus book provides invaluable insight on its next frontier. It begins with a brief history and current implementations of voice-activated assistants and illustrates why clinical voice AI is at its inflection point. Next, it describes how the authors built the world’s first smart surgical assistant using an off-the-shelf smart home device, outlining the implementation process in the operating room. From quantitative metrics to surgeons’ feedback, the authors discuss the feasibility of this technology in the surgical setting. The book then provides an in-depth development guideline for engineers and clinicians desiring to develop their own smart surgical assistants. Lastly, the authors delve into their experiences in translating voice AI into the clinical setting and reflect on the challenges and merits of this pursuit. The world’s first smart surgical assistant has not only reduced surgical time but eliminated major touch points in the operating room, resulting in positive, significant implications for patient outcomes and surgery costs. From clinicians eager for insight on the next digital health revolution to developers interested in building the next clinical voice AI, this book offers a guide for both audiences.

The State of the Science in Universal Design Book

The State of the Science in Universal Design


  • Author : Jordana L. Maisel
  • Publisher : Bentham Science Publishers
  • Release Date : 2010-08-03
  • Genre: Health & Fitness
  • Pages : 160
  • ISBN 10 : 9781608050635

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The State of the Science in Universal Design Excerpt :

"Emerging Research and Developments - The Rehabilitation Engineering Research Center on Universal Design and the Built Environment (RERC-UD), a federally funded research center located in The University at Buffalo, hosted a series of State of the Science ("

The CTSA Program at NIH Book

The CTSA Program at NIH


  • Author : Institute of Medicine
  • Publisher : National Academies Press
  • Release Date : 2013-10-09
  • Genre: Medical
  • Pages : 178
  • ISBN 10 : 9780309284745

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The CTSA Program at NIH Excerpt :

In 2006 the National Institutes of Health (NIH) established the Clinical and Translational Science Awards (CTSA) Program, recognizing the need for a new impetus to encourage clinical and translational research. At the time it was very difficult to translate basic and clinical research into clinical and community practice; making it difficult for individual patients and communities to receive its benefits. Since its creation the CTSA Program has expanded, with 61 sites spread across the nation's academic health centers and other institutions, hoping to provide catalysts and test beds for policies and practices that can benefit clinical and translation research organizations throughout the country. The NIH contracted with the Institute of Medicine (IOM) in 2012 to conduct a study to assess and provide recommendations on appropriateness of the CTSA Program's mission and strategic goals and whether changes were needed. The study was also address the implementation of the program by the National Center for Advancing Translational Sciences (NCATS) while exploring the CTSA's contributions in the acceleration of the development of new therapeutics. A 13-member committee was established to head this task; the committee had collective expertise in community outreach and engagement, public health and health policy, bioethics, education and training, pharmaceutical research and development, program evaluation, clinical and biomedical research, and child health research. The CTSA Program at NIH: Opportunities for Advancing Clinical and Translational Research is the result of investigations into previous program evaluations and assessments, open-session meetings and conference class, and the review of scientific literature. Overall, the committee believes that the CTSA Program is significant to the advancement of clinical and translational research through its contributions. The Program would benefit from a variety of revisions, however, to make it more efficient and effective.

Design and Living Well Book

Design and Living Well


  • Author : Gjoko Muratovski
  • Publisher : Intellect Books
  • Release Date : 2019-07-10
  • Genre: Design
  • Pages : 196
  • ISBN 10 : 9781789381474

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Design and Living Well Excerpt :

Just as the term design has been going through change, growth and expansion of meaning, and interpretation in practice and education – the same can be said for design research. The traditional boundaries of design are dissolving and connections are being established with other fields at an exponential rate. Based on the proceedings from the IASDR 2017 Conference, Re:Research is an edited collection that showcases a curated selection of 83 papers – just over half of the works presented at the conference. With topics ranging from the introduction of design in the primary education sector to designing information for Artificial Intelligence systems, this book collection demonstrates the diverse perspectives of design and design research. Divided into seven thematic volumes, this collection maps out where the field of design research is now. Using Frameworks to Cross Interdisciplinary Boundaries: Addressing Wellness • Traci Rose Rider Increasing interest is seen at the intersection of architecture and health. The built environment has become associated with a number of negative health outcomes including obesity, cancers and diabetes. Engaging design students in these inquiries surrounding health is integral in preparing them for future practice. This paper reviews the conceptual development and tested implementation of an interdisciplinary course focusing on the well-being and overall health of the occupant, using primary and secondary framework structures in the vein of Groat and Wang’s logical argumentation. The reviewed course engages interdisciplinary teams composed of students from the School of Architecture, the College of Engineering and the College of Natural Resources, with private practice. The course puts forth an effort to break out of the conventional pedagogical structure found in architectural education, primarily the studio and large lecture spaces. The course has been specifically designed to: (1) establish a framework for common content relatin

Design and Digital Interaction Book

Design and Digital Interaction


  • Author : Gjoko Muratovski
  • Publisher : Intellect Books
  • Release Date : 2019-07-10
  • Genre: Design
  • Pages : 192
  • ISBN 10 : 9781789381436

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Design and Digital Interaction Excerpt :

Just as the term design has been going through change, growth and expansion of meaning, and interpretation in practice and education – the same can be said for design research. The traditional boundaries of design are dissolving and connections are being established with other fields at an exponential rate. Based on the proceedings from the IASDR 2017 Conference, Re:Research is an edited collection that showcases a curated selection of 83 papers – just over half of the works presented at the conference. With topics ranging from the introduction of design in the primary education sector to designing information for Artificial Intelligence systems, this book collection demonstrates the diverse perspectives of design and design research. Divided into seven thematic volumes, this collection maps out where the field of design research is now. From Software Engineering to Information Design • Yvette Shen Most academic methodologies are developed from a prescribed methodological process that is limited to a specific area of study. However, the disciplinary landscape in which the knowledge is established is being rapidly reconfigured. Given the vast varieties of practices and knowledge base required from information designers, it is even more crucial for them to look outside of the traditional visual design fields and seek diversities for better research and creation methods. The two disciplines, software engineering and information design, are often perceived as one provides technical solutions to the other. This essay intends to move beyond the common perception, and identify relevant issues in software engineering design that resonate with the information design process. The issues include the multi-component planning approach; the human-oriented agile method; design concepts such as abstraction, decomposition, component modularity, hierarchical relationship and extensibility. The perspectives from software engineering design and information design is examined thro

Teaching and Learning Design Book

Teaching and Learning Design


  • Author : Gjoko Muratovski
  • Publisher : Intellect Books
  • Release Date : 2019-07-10
  • Genre: Design
  • Pages : 182
  • ISBN 10 : 9781789381375

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Teaching and Learning Design Excerpt :

ust as the term design has been going through change, growth and expansion of meaning, and interpretation in practice and education – the same can be said for design research. The traditional boundaries of design are dissolving and connections are being established with other fields at an exponential rate. Based on the proceedings from the 2017 International Association of Societies of Design Research conference, Re:Research is an edited collection that showcases a curated selection of 83 papers – just over half of the works presented at the conference. With topics ranging from the introduction of design in the primary education sector to designing information for Artificial Intelligence systems, this book collection demonstrates the diverse perspectives of design and design research. Divided into seven thematic volumes, this collection maps out where the field of design research is now. Opening a Design Education Pipeline from University to K-12 and Back • Peter Scupelli, Doris Wells-Papanek, Judy Brooks, Arnold Wasserman To prepare students to imagine desirable futures amidst current planetary-level challenges, design educators must think and act in new ways. In this paper, we describe a pilot study that illustrates how educators might teach K-12 students and university design students to situate their making within transitional times in a volatile and exponentially changing world. We describe how to best situate students to align design thinking and learning with future foresight. Here we present a pilot test and evaluate how a university-level Design Futures course content, approach, and scaffolded instructional materials – can be adapted for use in K-12 Design Learning Challenges. We describe the K-12 design-based learning challenges/experiences developed and implemented by the Design Learning Network (DLN). The Design Futures course we describe in this paper is a required course for third-year undergraduate students in the School of Design at Carnegie

Philosophical Frameworks and Design Processes Book

Philosophical Frameworks and Design Processes


  • Author : Gjoko Muratovski
  • Publisher : Intellect Books
  • Release Date : 2019-07-10
  • Genre: Design
  • Pages : null
  • ISBN 10 : 9781789381382

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Philosophical Frameworks and Design Processes Excerpt :

Just as the term design has been going through change, growth and expansion of meaning, and interpretation in practice and education – the same can be said for design research. The traditional boundaries of design are dissolving and connections are being established with other fields at an exponential rate. Based on the proceedings from the IASDR 2017 Conference, Re:Research is an edited collection that showcases a curated selection of 83 papers – just over half of the works presented at the conference. With topics ranging from the introduction of design in the primary education sector to designing information for Artificial Intelligence systems, this book collection demonstrates the diverse perspectives of design and design research. Divided into seven thematic volumes, this collection maps out where the field of design research is now. Two Blind Spots in Design Thinking Estelle Berger From the 1980s, design thinking has emerged in companies as a method for practical and creative problem solving, based on designers’ way of thinking, integrated into a rational and iterative model to accompany the process. In companies, design thinking helped valuing creative teamwork, though not necessarily professional designers’ expertise. By pointing out two blind spots in design thinking models, as currently understood and implemented, this paper aims at shedding light on two rarely described traits of designers’ self. The first relies in problem framing, a breaking point that deeply escapes determinism. The second blind spot questions the post project process. We thus seek to portray designers’ singularity, in order to stimulate critical reflection and encourage the opening-up to design culture. Companies and organizations willing to make the most of designers’ expertise would gain acknowledging their critical heteronomy to foster innovation based on strong and disruptive visions, beyond an out-of-date problem-solving approach to design. Creating Different Modes o

Design Discourse on Business and Industry Book

Design Discourse on Business and Industry


  • Author : Gjoko Muratovski
  • Publisher : Intellect Books
  • Release Date : 2019-07-10
  • Genre: Design
  • Pages : 208
  • ISBN 10 : 9781789381429

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Design Discourse on Business and Industry Excerpt :

Just as the term design has been going through change, growth and expansion of meaning, and interpretation in practice and education – the same can be said for design research. The traditional boundaries of design are dissolving and connections are being established with other fields at an exponential rate. Based on the proceedings from the IASDR 2017 Conference, Re:Research is an edited collection that showcases a curated selection of 83 papers – just over half of the works presented at the conference. With topics ranging from the introduction of design in the primary education sector to designing information for Artificial Intelligence systems, this book collection demonstrates the diverse perspectives of design and design research. Divided into seven thematic volumes, this collection maps out where the field of design research is now. Interaction Between Client and Design Consultant: The Stance of Client to Design Consultant and Its Influence on Design Process Haebin Lee, Muhammad Tufail, Myungjin Kim, KwanMyung Kim Design is essential in product development but several small- and medium-sized enterprises (SMEs) relatively capable of manufacturing are suffered from lack of in-house design ability. For new product design, these SMEs typically employ external designers. In this client–designer interaction, designers propose design solution alternatives to their clients, which clients may accept or reject. In some cases, clients provide designers further design requirements. A study on how interactions are performed and what effects these interactions have on the results of product development is essential to determine what is needed to achieve successful collaborative relationships. Thus, this study analyzed three design development cases that were previously performed to understand how interactions work between clients and designers and its effect on the outcomes. In all cases, the design team developed designs for the clients based on their technological re