Developing Therapeutics for Alzheimer s Disease Book

Developing Therapeutics for Alzheimer s Disease


  • Author : Michael S. Wolfe
  • Publisher : Academic Press
  • Release Date : 2016-05-27
  • Genre: Medical
  • Pages : 676
  • ISBN 10 : 9780128021644

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Developing Therapeutics for Alzheimer s Disease Book Description :

Developing Therapeutics for Alzheimer's Disease: Progress and Challenges provides a thorough overview of the latest advances toward the development of therapeutics for Alzheimer’s disease, along with the major hurdles that still must be overcome and potential solutions to these problems. Despite the lack of progress toward developing therapeutics that can slow or stop the progression of this disease, important discoveries have been made and many promising approaches are advancing in preclinical studies and clinical trials. This book outlines the special challenges related to specific targets and approaches, while presenting a realistic, comprehensive and balanced view of drug discovery and development in this area. Written by international leaders in the field, the book assesses prospects for the emergence of effective agents and allows readers to better understand the challenges, failures, and future potential for research in Alzheimer’s disease. This book is a valuable resource to academic scientists carrying out translational research in Alzheimer’s disease, industrial scientists engaged in Alzheimer's drug discovery, executives in biopharmaceutical companies making strategic decisions regarding the direction of internal research and potential outside partnerships, and graduate-level students pursuing courses on Alzheimer's therapeutics. Provides a realistic but promising assessment of the potential of various therapeutic approaches to Alzheimer’s disease Focuses primarily on neuroprotective agents and cognitive enhancers, as well as approaches to targeting the amyloid B-peptide, tau and Apolipoprotein E Discusses alternative approaches, preclinical and clinical development issues, related biomarkers and diagnostics, and prevention and nonpharmacological approaches

Drug Design and Discovery in Alzheimer   s Disease Book

Drug Design and Discovery in Alzheimer s Disease


  • Author : Atta-ur-Rahman
  • Publisher : Elsevier
  • Release Date : 2015-06-27
  • Genre: Science
  • Pages : 784
  • ISBN 10 : 9780128039601

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Drug Design and Discovery in Alzheimer s Disease Book Description :

Drug Design and Discovery in Alzheimer’s Disease includes expert reviews of recent developments in Alzheimer's disease (AD) and neurodegenerative disease research. Originally published by Bentham as Frontiers in Drug Design and Discovery, Volume 6and now distributed by Elsevier, this compilation of the sixteen articles, written by leading global researchers, focuses on key developments in the understanding of the disease at molecular levels, identification and validation of molecular targets, as well as innovative approaches towards drug discovery, development, and delivery. Beginning with an overview of AD pharmacotherapy and existing blockbuster drugs, the reviews cover the potential of both natural and synthetic small molecules; the role of cholinesterases in the on-set and progression of AD and their inhibition; the role of beta-site APP clearing enzyme-1 (BACE-1) in the production of ß-amyloid proteins, one of the key reasons of the progression of AD; and other targets identified for AD drug discovery. Edited and written by leading experts in Alzheimer’s disease (AD) and other neurodegenerative disease drug development Describes existing drugs for AD and current molecular understanding of the condition Reviews recent advances in the field, including coverage of cholinesterases, BACE-1, and other drug development targets

Neurobiology of Alzheimer s Disease Book

Neurobiology of Alzheimer s Disease


  • Author : David Dawbarn
  • Publisher : Oxford University Press, USA
  • Release Date : 2007
  • Genre: Medical
  • Pages : 468
  • ISBN 10 : 0198566611

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Neurobiology of Alzheimer s Disease Book Description :

Alzheimer's disease is the most common form of dementia in the elderly; 450,000 people in the UK and 4.5 million people in the USA suffer with this disease. This 3rd edition of Neurobiology of Alzheimer's Disease gives a comprehensive and readable introduction to the disease, from molecular pathology to clinical practice. The book is intended for readers new to the field, and it also covers an extensive range of themes for those with in-depth knowledge of Alzheimer's disease. It will therefore act either as an introduction to the whole field of neurodegeneration or it will help experienced researchers to access the latest research in specialist topics. Each chapter is written by eminent scientists leading their fields in neuropathology, clinical practice and molecular neurobiology; appendices detail disease-associate proteins, their sequences, familial mutations and known structures. It will be essential reading for students interested in neurodegeneration and for researchers and clinicians, giving a coherent and cohesive approach to the whole area of research, and allowing access at different levels. For those in the pharmaceutical industry it describes the underlying molecular mechanisms involved in the pathogenesis of Alzheimer's disease and explains how current and potential therapeutics may work.

Alzheimer s Disease Book

Alzheimer s Disease


  • Author : Renee D. Wegrzyn
  • Publisher : CRC Press
  • Release Date : 2012-04-26
  • Genre: Medical
  • Pages : 298
  • ISBN 10 : 9781439827086

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Alzheimer s Disease Book Description :

In recent years, a tremendous amount of effort has been focused on better understanding the fundamentals of Alzheimer’s disease (AD) to facilitate early and accurate diagnosis and appropriately targeted therapeutic treatments. Alzheimer’s Disease: Targets for New Clinical, Diagnostic, and Therapeutic Strategies provides a detailed synopsis of the current state of the art of diagnostics and therapeutics and identifies emerging technologies and molecules that show promise in the management and treatment of AD. With contributions from experts drawn from academia, clinical practice, and the biotechnology and pharmaceutical industries, the book explores: The basis of AD and the role of Aβ oligomers in development of disease Existing and emerging in vitro biomarker-based methodologies for the diagnosis of AD, focusing on genetic, biochemical, and conformational strategies In vivo imaging diagnostic approaches Evolving diagnostic criteria, health regulatory guidelines, biomarkers in clinical trials, and available and emerging therapies Recent progress in small-molecule disease-modifier drug discovery efforts for AD, specifically in the areas of Aβ, tau, and emerging neuroprotective/neurorepair approaches How a case study of AD raises issues regarding clinical and pathologic criteria, risk factors, and the amyloid hypothesis The molecular conformational factors that govern the pathogenicity of aggregating proteins, and how these factors could represent new targets for disease-modifying therapies The latest epidemiological, pathological, biochemical, and behavioral studies that may shed some light on the risk of developing AD and similar dementias after traumatic brain injury Examining current hypotheses and suggesting possible new approaches to therapeutic clinical applications, this volume paves the way for a robust pipeline of therapeutics to combat not only AD, but a whole host of other neurodegenerative diseases.

BACE Book

BACE


  • Author : Varghese John
  • Publisher : John Wiley & Sons
  • Release Date : 2010-03-05
  • Genre: Medical
  • Pages : 272
  • ISBN 10 : 0470594071

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BACE Book Description :

BACE inhibitors and their use in the treatment of Alzheimer's Disease BACE (β-site of APP cleaving enzyme) is a critical component in Alzheimer's Disease (AD), and the development of BACE inhibitors shows great potential as a therapy for the disease. BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease covers virtually all aspects of BACE from initial identification, discovery of inhibitors, and challenges in clinical development, while providing a global understanding essential for productive and successful drug discovery. This book details the story of the discovery of BACE and its role in AD and comprehensively discusses: The development of BACE inhibitors as therapeutics for Alzheimer's disease The research that led to the identification of BACE New BACE inhibitors currently being clinically tested ADME (absorption, distribution, metabolism, excretion) and clinical trial design—topics not addressed in current field literature Cutting-edge technology such as high-throughput screening, structure-based drug design, and QSAR in context of BACE inhibitors and Alzheimer's drug discovery Other approaches to BACE inhibition based on interaction with the precursor protein APP By enhancing the reader's understanding of the various aspects of the BACE drug-discovery process, this much-needed reference will serve as a key resource for all scientists involved in Alzheimer's research—and inspire new approaches to treatment of AD.

Emerging Drugs and Targets for Alzheimer s Disease  Beta amyloid  tau protein and glucose metabolism Book

Emerging Drugs and Targets for Alzheimer s Disease Beta amyloid tau protein and glucose metabolism


  • Author : Ana Martínez
  • Publisher : Royal Society of Chemistry
  • Release Date : 2010
  • Genre: Medical
  • Pages : 317
  • ISBN 10 : 9781849730631

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Emerging Drugs and Targets for Alzheimer s Disease Beta amyloid tau protein and glucose metabolism Book Description :

This volume describes the discovery and development history of the most promising drugs now in development for combating Alzheimer's disease.

Drug Discovery and Development for Alzheimer s Disease  2000 Book

Drug Discovery and Development for Alzheimer s Disease 2000


  • Author : Howard M. Fillit, MD
  • Publisher : Springer Publishing Company
  • Release Date : 2002-01-03
  • Genre: Medical
  • Pages : 296
  • ISBN 10 : 0826115349

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Drug Discovery and Development for Alzheimer s Disease 2000 Book Description :

This prestigious volume presents the findings of an international group of academic and biotechnological researchers. Topics range from early detection programs focusing on genetic factors, novel probes for detecting B-amyloid in the living brain, and the use of telephonic screening and MRI's to the diversity of therapeutic areas such as antioxidants, estrogen agonists and various anti-B-amyloid and anti-tangle approaches. The volume is still an indispensable resource for the psychogeriatrician, psychiatrist, clinical investigator, and neurobiologist, and a must for medical libraries.

Frontiers in Clinical Drug Research   Alzheimer Disorders  Volume 7 Book

Frontiers in Clinical Drug Research Alzheimer Disorders Volume 7


  • Author : Atta-ur-Rahman
  • Publisher : Bentham Science Publishers
  • Release Date : 2018-11-02
  • Genre: Science
  • Pages : 276
  • ISBN 10 : 9781681085609

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Frontiers in Clinical Drug Research Alzheimer Disorders Volume 7 Book Description :

Frontiers in Clinical Drug Research - Alzheimer Disorders is a book series concerned with Alzheimer's disease (AD), a disease that causes dementia, or loss of brain function. This disease affects parts of the brain that affect memory, thought, and language. Chapters in each volume focus on drug research with special emphasis on clinical trials, research on drugs in advanced stages of development and cure for Alzheimer’s disease and related disorders.

Emerging Drugs and Targets for Alzheimer s Disease  Neuronal plasticity  neuronal protection and other miscellaneous strategies Book

Emerging Drugs and Targets for Alzheimer s Disease Neuronal plasticity neuronal protection and other miscellaneous strategies


  • Author : Ana Martinez
  • Publisher : Royal Society of Chemistry
  • Release Date : 2010
  • Genre: Medical
  • Pages : 301
  • ISBN 10 : 9781849730648

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Emerging Drugs and Targets for Alzheimer s Disease Neuronal plasticity neuronal protection and other miscellaneous strategies Book Description :

This volume describes the discovery and development history of the most promising drugs now in development for combating Alzheimer's disease.

Current State of Alzheimer s Disease Research and Therapeutics Book

Current State of Alzheimer s Disease Research and Therapeutics


  • Author : Mary Lou Michaelis
  • Publisher : Academic Press
  • Release Date : 2012
  • Genre: Medical
  • Pages : 383
  • ISBN 10 : 9780123948168

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Current State of Alzheimer s Disease Research and Therapeutics Book Description :

"Providing a cross-section of current research, treatments and potential clinical developments, this volume of Advances in Pharmacology is an essential resource for biologists, pharmacologists and those engaged with Alzheimer's research."--P. [4] of cover.

Alzheimer   s Disease Theranostics Book

Alzheimer s Disease Theranostics


  • Author : Magisetty Obulesu
  • Publisher : Academic Press
  • Release Date : 2019-01-20
  • Genre: Medical
  • Pages : 80
  • ISBN 10 : 9780128167397

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Alzheimer s Disease Theranostics Book Description :

Alzheimer’s Disease Theranostics discusses the latest information on recent theranostic avenues for both the diagnosis and treatment of Alzheimer’s patients. It presents the pros and cons of the probable mechanistic role of nanoparticles in crossing the blood-brain barrier and improving disease symptoms. Finally, it highlights the merits of existing maneuvers and suggests perspectives to aid in future developments. Despite the difficulty of drug delivery to the brain, there are some nanoparticulate platforms demonstrating promise in treating neurodegenerative disorders such as Alzheimer’s disease. Manifold theranostic maneuvers include antioxidants, natural bioactive compounds, gene therapy, and nanotechnological approaches, all of which are discussed in this important work. Examines various theranostic applications for the diagnosis and treatment of Alzheimer’s disease Features a comprehensive overview of nanoparticle therapeutics in the area and use of antioxidants Assesses the common challenges and lessons learned from blood-brain barrier challenges, viral vector approaches and mitochondria-targeted therapeutics

Alzheimer Disease Book

Alzheimer Disease


  • Author : Robert Becker
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-06
  • Genre: Medical
  • Pages : 614
  • ISBN 10 : 9781461241164

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Alzheimer Disease Book Description :

Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders Book

Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders


  • Author : Adeboye Adejare
  • Publisher : Academic Press
  • Release Date : 2016-09-20
  • Genre: Medical
  • Pages : 316
  • ISBN 10 : 9780128028117

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Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders Book Description :

Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders: Alzheimer’s Disease examines the drug discovery process for neurodegenerative diseases by focusing specifically on Alzheimer’s Disease and illustrating the paradigm necessary to ensure future research and treatment success. The book explores diagnosis, epidemiology, drug discovery strategies, current therapeutics, and much more to provide a holistic approach to the discovery, development, and treatment of Alzheimer’s Disease. Through its coverage of the latest research in targeted drug design, preclinical studies, and mouse and rat models, the book is a must-have resource for all pharmaceutical scientists, pharmacologists, neuroscientists, and clinical researchers working in this area. It illustrates why these drugs tend to fail at the clinical stage, and examines Alzheimer’s Disease within the overall context of improving the drug discovery process for the treatment of other neurodegenerative disorders. Provides a compilation of chemical considerations required in drug discovery for the treatment of neurodegenerative disorders Examines different classes of compounds currently being used in discovery and development stages Explores in vitro and in vivo models with respect to their ability to translate these models to human conditions Distills the most significant information across multiple areas of Alzheimer’s disease research to provide a single, comprehensive, and balanced resource

Immunoregulatory Aspects of Immunotherapy Book

Immunoregulatory Aspects of Immunotherapy


  • Author : Seyyed Shamsadin Athari
  • Publisher : BoD – Books on Demand
  • Release Date : 2018-08-01
  • Genre: Medical
  • Pages : 240
  • ISBN 10 : 9781789235081

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Immunoregulatory Aspects of Immunotherapy Book Description :

Immunotherapy is an innovative, leading and valuable approach to the treatment and control of many diseases. It can solve many problems of public health worldwide. Many people in numerous countries are suffering from a wide range of diseases (communicable and non-communicable) that can be cured or controlled by the immune system and immunotherapy. Some immunological diseases (i.e. allergic reactions and asthma, autoimmune disease, immunodeficiency disease, hypersensitivity reactions, etc.) have immune response pathophysiology and by controlling immune system mechanisms, these diseases can be controlled and cured. Immunoregulatory Aspects of Immunotherapy focuses on immune system mechanism, diagnosis, treatment and other related problems. The chapters have applicable and scientific data in immunotherapeutic approaches based on medical sciences, and would be of benefit to all researchers in immunology, allergy and asthma fields. The book discusses the prevention, diagnosis, treatment and follow-up of patients who have dangerous diseases. We hope this book will be a new approach to the immunotherapy of diseases and will improve public health and wellbeing.

Preclinical and clinical issues in Alzheimer   s disease drug research and development Book

Preclinical and clinical issues in Alzheimer s disease drug research and development


  • Author : Cesare Mancuso
  • Publisher : Frontiers Media SA
  • Release Date : 2015-03-03
  • Genre:
  • Pages :
  • ISBN 10 : 9782889194339

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Preclinical and clinical issues in Alzheimer s disease drug research and development Book Description :

Alzheimer’s disease (AD) is a chronic neurodegenerative disorder characterized by progressive cognitive dysfunction and memory loss, inability to perform the activities of daily living and mood disorders. According to the so-called “amyloid cascade hypothesis”, amyloid-ß- peptide (Aß), produced by beta- and gamma- secretase-mediated cleavages of the amyloid precursor protein (APP), plays a pivotal role in the pathogenesis of AD. Aß was also shown to contribute to AD pathology by stimulating the hyperphosphorylation of tau which is responsible for the formation of neurofibrillary tangles. However, the “amyloid cascade hypothesis” was challenged by other theories which lend support to the idea that Aß is not causative but can be considered as an “innocent bystander” in AD. Although preclinical research generated impressive lines of evidence about the several intracellular mechanism(s) whose impairment leads to the onset and progression of AD, clinical research aimed at the development of new drugs capable of preventing or delaying the onset of neuronal damage in AD patients has produced limited results. The drugs currently available for the treatment of AD are acetylcholinesterase inhibitors (AChEI) and the NMDA glutamate receptor antagonist memantine. The AChEI increase acetylcholine levels in the synaptic cleft, which are reduced because of the progressive damage of cholinergic neurons in cognitive brain areas (e.g. amygdala, hippocampus, and frontal cortex), whereas memantine is used to prevent/reduce calcium-dependent excitotoxic neuronal cell death. Both classes of drugs have been shown to improve symptoms related to cognitive decline, but their effects are confined largely to patients with mild to moderate AD, in particular during the first year or so of treatment. An alternative to this symptomatic treatments involves the use of drugs that intervene in the pathogenesis of the disease. Recently, monoclonal antibodies against Aß were proposed a

Central Nervous System Diseases  New Insights for the Healthcare Professional  2011 Edition Book

Central Nervous System Diseases New Insights for the Healthcare Professional 2011 Edition


  • Author :
  • Publisher : ScholarlyEditions
  • Release Date : 2012-01-09
  • Genre: Medical
  • Pages : 205
  • ISBN 10 : 9781464901027

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Central Nervous System Diseases New Insights for the Healthcare Professional 2011 Edition Book Description :

Central Nervous System Diseases: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Central Nervous System Diseases. The editors have built Central Nervous System Diseases: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Central Nervous System Diseases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Central Nervous System Diseases: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Challenges in Elder Care Book

Challenges in Elder Care


  • Author : Edward T. Zawada Jr.
  • Publisher : BoD – Books on Demand
  • Release Date : 2016-10-12
  • Genre: Medical
  • Pages : 118
  • ISBN 10 : 9789535126645

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Challenges in Elder Care Book Description :

This work is intended as a brief but focused compilation to assist with diagnosis and management of the most common serious medical problems in the rapidly growing geriatric population. The geriatric population recently expanded by the fact that the baby boomers have reached the milestone of 65 years of age in the past 5 years. Tips for diagnosis, medication administration, and logistics of cost-effective management in the health-care continuum are presented in this book. The latter often consists of a journey from home to medical office to emergency room to hospital bed to intensive care unit to long-term acute care hospital to skilled nursing facility to long-term residential facility and/or back home, which is also reviewed in the book Geriatrics.

Neuroprotection in Alzheimer s Disease Book

Neuroprotection in Alzheimer s Disease


  • Author : Illana Gozes
  • Publisher : Academic Press
  • Release Date : 2016-12-30
  • Genre: Medical
  • Pages : 342
  • ISBN 10 : 9780128037126

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Neuroprotection in Alzheimer s Disease Book Description :

Neuroprotection in Alzheimer’s Disease offers a translational point-of-view from both basic and clinical standpoints, putting it on the cusp for further clinical development with its emphasis on nerve cell protection, including the accumulation of knowledge from failed clinical trials and new advances in disease management. This book brings together the latest findings, both basic, and clinical, under the same cover, making it easy for the reader to obtain a complete overview of the state-of-the-field and beyond. Alzheimer's disease is the most common form of dementia, accounting for 60 to 80 percent of dementia cases. It is a progressive brain disease that slowly destroys memory, thinking skills, and eventually, even the ability to carry out the simplest tasks. It is characterized by death of synapses coupled to death nerve cells and brain degeneration which is manifested by loss of cognitive abilities. Understanding neuroprotection in Alzheimer’s disease will pave the path to better disease management and novel therapeutics. Comprehensive reference detailing neuroprotection in Alzheimer’s Disease, with details on nerve cell protection and new advances in disease management Combines the knowledge and points-of-view of both medical doctors and basic scientists, putting the subject at the forefront for further clinical development Edited by one of the leading researchers in Alzheimer’s Disease

Alzheimer s Disease Book

Alzheimer s Disease


  • Author : Khalid Iqbal
  • Publisher : John Wiley & Sons
  • Release Date : 2003-01-24
  • Genre: Medical
  • Pages : 888
  • ISBN 10 : 9780470851746

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Alzheimer s Disease Book Description :

Alzheimer's Disease is an ever present problem affecting millions of people around the world and, as people's average lifespan lengthens, its prevalence is set to increase. A global effort is needed to combat the disease, including research to investigate the causes, development of effective treatments and, ultimately, prevention of the disease. Published every two years, these timely books discuss the very latest research. This new volume provides a unique source of reference to the important work being done in this field, it gives academics and clinicians an opportunity to learn about cutting edge developments and covers all aspects of Alzheimer's Disease, including diagnosis, clinical course, epidemiological course and therapeutics and disease mechanisms. Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics will provide essential information for basic and clinical researchers in Alzheimer's Disease and other dementias as well as for those who care for patients.

Dementia  4th Edition Book

Dementia 4th Edition


  • Author : David Ames
  • Publisher : CRC Press
  • Release Date : 2010-11-26
  • Genre: Medical
  • Pages : 824
  • ISBN 10 : 9781444128741

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Dementia 4th Edition Book Description :

Winner of the BMA 2011 book awards: psychiatry category Winner of the Australian Journal of Ageing book of the year award This definitive work on dementia and related disorders has been fully updated and revised to reflect recent advances in this fast-moving field. The incidence of dementia continues to rise as the population of the world ages, and the condition represents one of the most significant challenges facing societies and health professionals in the next half-century. In this, the most comprehensive single volume work available on the subject, the editors have met this challenge by assembling a team of the world's leading experts on all aspects of the condition, from history, epidemiology and social aspects to the latest neurobiological research and advanced therapeutic strategies.