Direct Nose to Brain Drug Delivery Book

Direct Nose to Brain Drug Delivery

  • Author : Chandrakantsing Pardeshi
  • Publisher : Academic Press
  • Release Date : 2021-06-16
  • Genre: Business & Economics
  • Pages : 554
  • ISBN 10 : 9780128225233

Direct Nose to Brain Drug Delivery Excerpt :

Direct Nose-to-Brain Drug Delivery provides the reader with precise knowledge about the strategies and approaches for enhanced nose-to-brain drug delivery. It highlights the development of novel nanocarrier-based drug delivery systems for targeted drug delivery to the brain microenvironments with a focus on the technological advances in the development of the novel drug delivery devices for intranasal administration, including special emphasis on brain targeting through nose. This book explores the various quantification parameters to assess the brain targeting efficiency following intranasal administration and includes an overview on the toxicity aspects of the various materials used to develop the direct nose-to-brain drug delivery vehicles and of the regulatory aspects including patents and current clinical status of the potential neurotherapeutics for the effective management of neuro-ailments. Technological advances in new drug delivery systems with diverse applications in pharmaceutical, biomedical, biomaterials, and biotechnological fields are also explained. This book is a crucial source that will assist the veteran scientists, industrial technologists, and clinical research professionals to develop new drug delivery systems and novel drug administration devices for the treatment of neuro-ailments. Explains the targeting approaches for enhanced brain targeting following intranasal drug administration Explores the various nanocarriers developed to date for neurotherapeutic delivery via nose-to-brain Discusses pharmaceutical and biomedical applications after nose-to-brain delivery of therapeutic pharmaceuticals and biologicals

Neuro AIDS Book

Neuro AIDS

  • Author : Alireza Minagar
  • Publisher : Nova Publishers
  • Release Date : 2006
  • Genre: Medical
  • Pages : 280
  • ISBN 10 : 159454610X

Neuro AIDS Excerpt :

During the past two decades, the world scientific community has witnessed major achievements in our understanding of the pathogenesis of HIV infection of the nervous system and HIV-Associated Dementia (HAD). Despite these giant gains, nervous system involvement during AIDS remains a relentlessly progressive disease with a deadly fate in many cases. This book on NeuroAIDS provides a unique resource for both general neurologists as well as basic neuroscientists with profound interests for research on NeuroAIDS. This book has special emphasis on the mechanisms of disease development and progression of HIV-infected patients with NeuroAIDS. The contributors have provided the readers with comprehensive reviews on clinical manifestations of HAD, mechanisms of HIV entry into the central nervous system, the role of cytokines and chemokines in pathogenesis of NeuroAIDS, drug abuse and NeuroAIDS, virus load in HAD, allostasis in HIV and AIDS, stroke in AIDS patients, and neuroimaging of HIV infection of the central nervous system. In addition, there are chapters on Varicella Zoster virus infection of HIV-seropositive and AIDS patients, as well as the molecular basis for opioids and AIDS virus interactions.

Topical Applications and the Mucosa Book

Topical Applications and the Mucosa

  • Author : C. Surber
  • Publisher : Karger Medical and Scientific Publishers
  • Release Date : 2011-02-10
  • Genre: Medical
  • Pages : 174
  • ISBN 10 : 9783805596169

Topical Applications and the Mucosa Excerpt :

Mucosal membranes have unique anatomical and physiological properties -- differing from those of the keratinized epithelium -- which affect drug or chemical absorption. This makes the diagnosis and treatment of diseases of the mucosa a challenge to dermatologists as well as gynecologists, since many conditions are difficult to recognize and well-established principles of skin disease treatment do not apply to the mucosa. This volume is exclusively devoted to the mucosal membrane and delivers a better understanding of this distinctive area. Subsequently to introductory chapters on the morphology and physiology of the mucosa, the topical treatment of impaired mucosal membranes is discussed. A third section covers the wide spectrum of consumer products applied on mucosal surfaces. Finally, the safety of products for mucosal membranes is reviewed.Providing an excellent summary and review of the latest findings and topical applications, this book will be of great value to physicians and clinicians in dermatology or gynecology, pharmacists, scientists and toxicologists who are involved in the development of products for mucosal membranes.

Advances in Medical and Surgical Engineering Book

Advances in Medical and Surgical Engineering

  • Author : Waqar Ahmed
  • Publisher : Academic Press
  • Release Date : 2020-03-21
  • Genre: Technology & Engineering
  • Pages : 418
  • ISBN 10 : 9780128226032

Advances in Medical and Surgical Engineering Excerpt :

Advances in Medical and Surgical Engineering integrates the knowledge and experience of experts from academia and practicing surgeons working with patients. The cutting-edge progress in medical technology applications is making the traditional line between engineering and medical science ever thinner. This is an excellent resource for biomedical engineers working in industry and academia on developing medical technologies. It covers challenges in the application of technology in the clinic with views from an editorial team that is highly experienced in engineering, biomaterials, surgical practice, biomedical science and technology, and that has a proven track record of publishing applied biomedical science and technology. For medical practitioners, this book covers advances in technology in their domain. For students, this book identifies the opportunities of research based on the reviews of utilization of current technologies. The content in this book can also be of interest to policymakers, research funding agencies, and libraries, that are contributing to development of medical technologies. Covers circulatory support, aortic valve implantation and microvascular antestmosis Explores arthroplasty of both the knee and the shoulder Includes tribology of materials, laser treatment and machining of biomaterial

The Blood Brain Barrier  BBB  Book

The Blood Brain Barrier BBB

  • Author : Gert Fricker
  • Publisher : Springer
  • Release Date : 2014-10-24
  • Genre: Science
  • Pages : 163
  • ISBN 10 : 9783662437872

The Blood Brain Barrier BBB Excerpt :

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

Sterile Product Development Book

Sterile Product Development

  • Author : Parag Kolhe
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-10-12
  • Genre: Medical
  • Pages : 585
  • ISBN 10 : 9781461479789

Sterile Product Development Excerpt :

This comprehensive book encompasses various facets of sterile product development. Key concepts relevant to the successful development of sterile products are illustrated through case studies and are covered under three sections in this book: • Formulation approaches that discuss a variety of dosage forms including protein therapeutics, lipid-based controlled delivery systems, PEGylated biotherapeutics, nasal dosage form, and vaccines • Process, container closure and delivery considerations including freeze-thaw process challenges, best practices for technology transfer to enable commercial product development, innovations and advancement in aseptic fill-finish operations, approaches to manufacturing lyophilized parenteral products, pen / auto-injector delivery devices, and associated container closure integrity testing hurdles for sterile product closures • Regulatory and quality aspects in the areas of particulate matter and appearance evaluation, sterile filtration, admixture compatibility considerations, sterilization process considerations, microbial contamination investigations and validation of rapid microbiological methods, and dry and moist heat sterilizers This book is a useful resource to scientists and researchers in both industry and academia, and it gives process and product development engineers insight into current industry practices and evolving regulatory expectations for sterile product development.

Nanoformulations in Human Health Book

Nanoformulations in Human Health

  • Author : Sushama Talegaonkar
  • Publisher : Springer Nature
  • Release Date : 2020-07-31
  • Genre: Medical
  • Pages : 548
  • ISBN 10 : 9783030418588

Nanoformulations in Human Health Excerpt :

This book is an amalgamation of knowledge, experience, and expertise in various aspects of nanotechnology, by experts who are proficient in designing of novel nanoformulations that are used in the treatment of various challenging and prevalent diseases. It is an exhaustive compilation of the multi-faceted arena of nanoformulations and the healthcare system that caters to the needs of academicians, scholars, researchers etc. The most important aspect of the book covers various types of nanoformulations and their applications in treatment of communicable and non-communicable diseases. Each chapter focuses on a particular nanoformulation as well as a disease including the pathophysiology of the disease, the current treatment modalities of diseases, the role of nanoformulation in treatment and other future aspects and directions for further work. Coverage includes neuropathic pain, colon targeting, nose-to-brain drug delivery, skin cancer, arthritis and tuberculosis.

Winterhawk   s Land Book

Winterhawk s Land

  • Author : Michael Dante
  • Publisher : BearManor Media
  • Release Date : 2022-09-27
  • Genre: Fiction
  • Pages : null
  • ISBN 10 : 978186723xxxx

Winterhawk s Land Excerpt :

Michael Dante played the title role in Winterhawk (1975), a Western about a legendary Blackfoot Chief’s character and his principles. In this novella sequel, he pens an ageless saga about ruthless railroad executives trying to assassinate him in order to build their railroad directly through his territory, taking the Blackfoot land without provocation. Winterhawk and his tribe remain strong as long as they can, to protect the land of their people, the land they call home, before the invasion of progress imposes itself on America. This inspiring story of a brave man, who stands up to and fight against those who have their own agenda for his land, evokes the nostalgic atmosphere of Western series that Dante frequently appeared in during American television’s Golden Era, such as Death Valley Days, The Big Valley, Daniel Boone, Custer, The Texan, Bonanza, Maverick, and Cheyenne.

Blood Brain Barrier in Drug Discovery Book

Blood Brain Barrier in Drug Discovery

  • Author : Li Di
  • Publisher : John Wiley & Sons
  • Release Date : 2015-02-02
  • Genre: Medical
  • Pages : 600
  • ISBN 10 : 9781118788356

Blood Brain Barrier in Drug Discovery Excerpt :

Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant – and most challenging – areas of drug discovery. • Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects • Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies • Covers BBB physiology, medicinal chemistry design principles, free drug hypothesis for the BBB, and transport mechanisms including passive diffusion, uptake/efflux transporters, and receptor-mediated processes • Highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK) • Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths to the market

Nanobiotechnology in Neurodegenerative Diseases Book

Nanobiotechnology in Neurodegenerative Diseases

  • Author : Mahendra Rai
  • Publisher : Springer Nature
  • Release Date : 2019-12-02
  • Genre: Medical
  • Pages : 398
  • ISBN 10 : 9783030309305

Nanobiotechnology in Neurodegenerative Diseases Excerpt :

This book focuses on neurodegenerative diseases which have become a major threat to human health. Neurodegenerative diseases are age related disorders and have become increasingly prevalent in the elderly population in recent years. Hence, there is an urgent need to study and develop new strategies and alternative methods for the treatment of neurodegenerative diseases. This book showcases the promises that nanobiotechnology brings in research, diagnosis, and treatment of neurodegenerative diseases. It is very beneficial for varied group of readers including nanotechnologists, biotechnologists, pharmacists, medical professionals, bioengineers, biochemists and researchers working in this field. Nanobiotechnology in Neurodegenerative Diseases include various chapters including neurodegeneration and neurodegenerative diseases, nanotechnology for the rescue of neurodegenerative diseases, promising potential of nanomaterials for diagnosis and therapy of neurodegenerative diseases, nanotechnology mediated nose-to-brain drug delivery, and formulation and characterization of intranasal nanoparticles of antiretroviral drugs.

Nanopharmaceuticals  Principles and Applications Vol  3 Book

Nanopharmaceuticals Principles and Applications Vol 3

  • Author : Vinod Kumar Yata
  • Publisher : Springer Nature
  • Release Date : 2020-08-19
  • Genre: Technology & Engineering
  • Pages : 340
  • ISBN 10 : 9783030471200

Nanopharmaceuticals Principles and Applications Vol 3 Excerpt :

This book is the third volume on this subject and focuses on the recent advances of nanopharmaceuticals in cancer, dental, dermal and drug delivery applications and presents their safety, toxicity and therapeutic efficacy. The book also includes the transport phenomenon of nanomaterials and important pathways for drug delivery applications. It goes on to explain the toxicity of nanoparticles to different physiological systems and methods used to assess this for different organ systems using examples of in vivo systems.

Maxxamillion Book


  • Author : D. D. Romaxx
  • Publisher : Unknown
  • Release Date : 2015-07-12
  • Genre: Uncategoriezed
  • Pages : 40
  • ISBN 10 : 0692367071

Maxxamillion Excerpt :

A heartwarming story of a cute little puppy that due to a family hardship is taken to a local dog shelter. There he learns about his little pink nose that not only makes him different, but creates obstacles in his mind. When he is adopted by very loving parents, it changes his whole world. He shares many wonderful first experiences with his new parents and family until one day when one of his doggie friends tells Maxx a story that turns his world into one of worry and desperation. Maxx learns that what he thought was an obstacle turns into one of the happiest days in his life.

MentHER Book


  • Author : Alicia Syrett
  • Publisher : Createspace Independent Publishing Platform
  • Release Date : 2016-06-11
  • Genre: Uncategoriezed
  • Pages : 62
  • ISBN 10 : 1530774799

MentHER Excerpt :

The Guide for Women Entrepreneurs shares important tips for women in business generally and highlights items that are important for balance during the entrepreneurial journey. The Guide also provides practical tips for entrepreneurs like What Should I Put in a Pitch Deck, Do's and Don'ts in Pitching, Do's and Don'ts in Fundraising, Length of Time for Fundraising, Presenting to an Angel Network, Angel Pet Peeves to Avoid, Diligence on an Investor, and Going Through Diligence as an Entrepreneur. There is a Question and Answer section which addresses positioning yourself as a wife and husband or sister and brother team, offering an adviser equity and the vesting schedule, other forms of financing, conflicting advice from Mentors and Investors, dealing with biased investors, metrics that an investor wants to see, the difference fundraising in NYC and Silicon Valley, the difference between a product and an investment pitch, active or passive investors, the role press plays in fundraising, the ideal level of contact from investors, and my personal advice. The book also includes a section on becoming an angel investor for when entrepreneurs are ready to pay it forward and an Appendix with a sample pitch deck.