Discovery and Development of Antidiabetic Agents from Natural Products Book

Discovery and Development of Antidiabetic Agents from Natural Products


  • Author : Goutam Brahmachari
  • Publisher : Elsevier
  • Release Date : 2016-10-11
  • Genre: Science
  • Pages : 332
  • ISBN 10 : 9780128096925

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Discovery and Development of Antidiabetic Agents from Natural Products Excerpt :

Discovery and Development of Antidiabetic Agents from Natural Products brings together global research on the medicinal chemistry of active agents from natural sources for the prevention and treatment of diabetes and associated disorders. From the identification of promising leads, to the extraction and synthesis of bioactive molecules, this book explores a range of important topics to support chemists in the discovery and development of safer, more economical therapeutics that are desperately needed in response to this emerging global epidemic. Beginning with an overview of bioactive chemical compounds from plants with anti-diabetic properties, the book goes on to outline the identification and extraction of anti-diabetic agents and antioxidants from natural sources. It then explores anti-diabetic plants from specific regions before looking more closely at the background, isolation, and synthesis of key therapeutic compounds and their derivatives, including Mangiferin, Resveratrol, natural saponins, and alpha-glucosidase enzyme inhibitors. The book concludes with a consideration of current and potential future applications. Combining the expertise of specialists from around the world, this volume aims to support and encourage medicinal chemists investigating natural sources as starting points for the development of standardized, safe, and effective antidiabetic therapeutics. Contains chapters written by active researchers and leading global experts who are deeply engaged in the research field of natural product chemistry for drug discovery Provides comprehensive coverage of cutting-edge research advances in the design of medicinal natural products with potential as preventives and therapeutics for diabetes and related metabolic issues Presents a practical review of the identification, isolation, and extraction techniques that help support medicinal chemists in the lab

Discovery and Development of Neuroprotective Agents from Natural Products Book

Discovery and Development of Neuroprotective Agents from Natural Products


  • Author : Goutam Brahmachari
  • Publisher : Elsevier
  • Release Date : 2017-05-18
  • Genre: Science
  • Pages : 490
  • ISBN 10 : 9780128097694

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Discovery and Development of Neuroprotective Agents from Natural Products Excerpt :

Discovery and Development of Neuroprotective Agents from Natural Products draws together global research on medicinal agents from natural sources as starting points for the design of neuroprotective drugs. From the prediction of promising leads and identification of active agents to the extraction of complex molecules, the book explores a range of important topics to support the development of safer, more economical therapeutics for these increasingly prevalent diseases. Beginning with an overview of current developments in the field, the book goes on to explore the identification, extraction and phytochemistry of such neuroprotective agents as antioxidants, biophenols and naturally occurring anti-inflammatory steroid analogues. Specific natural sources of bioactive agents are reviewed, and the development of these agents into therapeutics for a number of specific neurological disorders, including Alzheimer’s disease, Parkinson’s disease and ischemic brain stroke, are discussed. Combining the expertise of specialists from around the world, this in the Natural Products Drug Discovery series aims to support and encourage researchers in the investigation of natural sources as starting points for the development of standardized, safe and effective neuroprotective drugs. Features chapters written by active researchers and leading global experts deeply engaged in the research field of natural product chemistry for drug discovery Includes comprehensive coverage of cutting-edge research advances in the design of drugs from natural products targeted at different kinds of neurodegenerative diseases Offers a practical review of identification, isolation and extraction techniques to support medicinal chemists in the lab

Discovery and Development of Therapeutics from Natural Products Against Neglected Tropical Diseases Book

Discovery and Development of Therapeutics from Natural Products Against Neglected Tropical Diseases


  • Author : Goutam Brahmachari
  • Publisher : Elsevier
  • Release Date : 2019-04-15
  • Genre: Medical
  • Pages : 458
  • ISBN 10 : 9780128157244

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Discovery and Development of Therapeutics from Natural Products Against Neglected Tropical Diseases Excerpt :

Discovery and Development of Therapeutics from Natural Products against Neglected Tropical Diseases draws together research on medicinal agents from natural sources as starting points for the design of drugs against Neglected Tropical Diseases (NTDs). From the prediction of promising leads and identification of active agents, to the extraction of complex molecules, the book explores novel, economical and efficacious therapeutics for these diseases. It describes current research and the role of natural products, antimalarial compounds from marine natural products and sesquiterpene lactones, natural antileprotic agents, natural products with potential against Leishmaniasis, Trypanosomiasis and Dengue, and more. In addition, Quinoline and Isoquinoline alkaloids for developing new antiprotozoal agents are discussed, alongside anti-trypanosomatid heterocyclic compounds as structures for development. Combining the expertise of specialists from around the world, this volume aims to support and encourage researchers in the investigation of natural sources as starting points for the development of novel, safe and effective agents for use against neglected tropical diseases. Includes chapters written by active researchers and leading global experts deeply engaged in the research field of natural product chemistry for drug discovery Draws together cutting-edge research advances in natural product chemistry that are targeted at neglected tropical diseases Highlights the future potential of natural products as sources of novel medicinal compounds against neglected tropical diseases

Drug Discovery and Development Book
Score: 5
From 1 Ratings

Drug Discovery and Development


  • Author : Ramarao Poduri
  • Publisher : Springer Nature
  • Release Date : 2021-02-15
  • Genre: Medical
  • Pages : 522
  • ISBN 10 : 9789811555343

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Drug Discovery and Development Excerpt :

This book describes the processes that are involved in the development of new drugs. The authors discuss the history, role of natural products and concept of receptor interactions with regard to the initial stages of drug discovery. In a single, highly readable volume, it outlines the basics of pharmacological screening, drug target identification, and genetics involved in early drug discovery. The final chapters introduce readers to stem therapeutics, pharmacokinetics, pharmacovigilance, and toxicological testing. Given its scope, the book will enable research scholars, professionals and young scientists to understand the key fundamentals of drug discovery, including stereochemistry, pharmacokinetics, clinical trials, statistics and toxicology.

Antidiabetic Plants for Drug Discovery Book

Antidiabetic Plants for Drug Discovery


  • Author : Deepu Pandita
  • Publisher : CRC Press
  • Release Date : 2023-01-26
  • Genre: Health & Fitness
  • Pages : 355
  • ISBN 10 : 9781000575118

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Antidiabetic Plants for Drug Discovery Excerpt :

This volume takes an in-depth look at the potential pharmacological applications of 11 important antidiabetic plants, examining their antihyperglycemic, hypoglycemic, and anti-lipidemic properties along with current genome editing research perspectives. Plant natural products, or phytoconstituents, are promising candidates for antidiabetic pharmacological actions. The phytoconstituents, such as fl avonoids, terpenoids, saponins, carotenoids, alkaloids and glycosides, play vital roles in the current and future potent antidiabetic drug development programs Each chapter reviews a particular plant with antidiabetic properties, explaining the therapeutic aspects, its active antidiabetic compounds, and relevant genome editing technology. The specific plants discussed include Azadirachta indica (commonly known as neem, nimtree or Indian lilac), Gymnema sylvestre (commonly called gymnema, Australian cowplant, and Periploca of the woods), Syzygium cumini (commonly known as Malabar plum, Java plum, black plum, jamun or jambolana), Ceylon cinnamon (or true cinnamon, as opposed to cassia cinnamon), insulin plant (or Costus pictus), Trigonella foenum-graecum (better known as fenugreek), Mulberry, Nigella sativa L. (black caraway, also known as black cumin, nigella, kalojeera, kalonji or kalanji), Aegle marmelos (L.) (commonly known as bael (or bili or bhel), also Bengal quince, golden apple, Japanese bitter orange, stone apple or wood apple), Ficus benghalensis (the banyan, banyan fig and Indian banyan), and of course, garlic (Allium sativum). Antidiabetic Plants for Drug Discovery: Pharmacology, Secondary Metabolite Profiling, and Ingredients with Insulin Mimetic Activity will serve as a valuable source of information for students, drug researchers, medical practitioners, diabetic patients, and many others in the effort to gain understand of how these plant drug molecules can help fight diabetes.

Natural Products in Medicinal Chemistry Book

Natural Products in Medicinal Chemistry


  • Author : Stephen Hanessian
  • Publisher : John Wiley & Sons
  • Release Date : 2013-12-18
  • Genre: Medical
  • Pages : 652
  • ISBN 10 : 9783527676552

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Natural Products in Medicinal Chemistry Excerpt :

The inspiration provided by biologically active natural products to conceive of hybrids, congeners, analogs and unnatural variants is discussed by experts in the field in 16 highly informative chapters. Using well-documented studies over the past decade, this timely monograph demonstrates the current importance and future potential of natural products as starting points for the development of new drugs with improved properties over their progenitors. The examples are chosen so as to represent a wide range of natural products with therapeutic relevance among others, as anticancer agents, antimicrobials, antifungals, antisense nucleosides, antidiabetics, and analgesics. From the content: * Part I: Natural Products as Sources of Potential Drugs and Systematic Compound Collections * Part II: From Marketed Drugs to Designed Analogs and Clinical Candidates * Part III: Natural Products as an Incentive for Enabling Technologies * Part IV: Natural Products as Pharmacological Tools * Part V: Nature: The Provider, the Enticer, and the Healer

Natural Products in Clinical Trials Book

Natural Products in Clinical Trials


  • Author : Atta-ur- Rahman
  • Publisher : Bentham Science Publishers
  • Release Date : 2018-03-03
  • Genre: Medical
  • Pages : 253
  • ISBN 10 : 9781681082134

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Natural Products in Clinical Trials Excerpt :

Natural products continue to play a key role in drug development. A recent analysis of the drug market in the developed world revealed that 40% of total clinically approved drugs were either unmodified natural products or their semi-synthetic derivatives. This book series focuses on reviews of exciting new bioactive natural products that have huge potential as drugs. It highlights the everlasting importance of natural products in our lives. Each volume brings reviews contributed by eminent scientists in the field. The first volume covers the following topics: - bioactive compounds from marine invertebrates - natural product derived drugs for immunological and inflammatory diseases - clinical trials of curcumin, camptothecin, astaxanthin, and biochanin - antibacterial and antifungal drugs from natural sources - natural products as anti-HIV medicines.

Recent Advances in Natural Products Science Book

Recent Advances in Natural Products Science


  • Author : Ahmed Al-Harrasi
  • Publisher : CRC Press
  • Release Date : 2022-07-21
  • Genre: Medical
  • Pages : 254
  • ISBN 10 : 9781000622133

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Recent Advances in Natural Products Science Excerpt :

This book provides a summarized information related to the global herbal drug market and its regulations, ethnopharmacology of traditional crude drugs, isolation of phytopharmaceuticals, phytochemistry, standardization, and quality assessment of crude drugs. Natural products science has constantly been developing with comprehensive data contemplating different parts of natural drugs, such as global trade, quality control and regulatory concerns, traditional medicine systems, production and utilization of drugs, and utilization of medicinal and aromatic plants. This broad information about crude drugs gives rise to a subject that is now recognized as advance natural products science. By contemplating all of this thorough knowledge of the areas, this book is intended to provide considerably to the natural products science. The area of natural products science involves a broad range of topics, such as the pharmacognostical, phytochemical, and ethno-pharmacological aspects of crude drugs. Each chapter gives a sufficient understanding to academicians and researchers in the respective topic. This book includes 40 illustrations and descriptions of roughly 80 medicinal plants used for herbal medicine. The book is an imperative source for all researchers, academicians, students, and those interested in natural products science. FEATURES Includes advance knowledge and detailed developments in natural products science Discusses the most important phytopharmaceuticals used in the pharmaceutical industry Explores the analysis and classification of novel plant-based medicinal compounds Includes standardization, quality control, and global trade of natural products Gives a deep understanding related to recent advances in herbal medicines to treat various ailments Discusses national and WHO regulations and policies related to herbal medicines Covers the complete profile of some important traditional medicinal plants, especially their historical background, biology, and chemistry

Phenotypic Drug Discovery Book

Phenotypic Drug Discovery


  • Author : Angelique Augustin
  • Publisher : Royal Society of Chemistry
  • Release Date : 2020-12-10
  • Genre: Medical
  • Pages : 273
  • ISBN 10 : 9781788018760

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Phenotypic Drug Discovery Excerpt :

Phenotypic drug discovery has been highlighted in the past decade as an important strategy in the discovery of novel medical entities. This book aims to equip researchers with a thought-provoking guide to the application and development of contemporary phenotypic drug discovery for clinical success.

Cardioprotective Natural Products  Promises And Hopes Book

Cardioprotective Natural Products Promises And Hopes


  • Author : Brahmachari Goutam
  • Publisher : World Scientific
  • Release Date : 2017-10-27
  • Genre: Medical
  • Pages : 356
  • ISBN 10 : 9789813231177

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Cardioprotective Natural Products Promises And Hopes Excerpt :

Cardioprotective Natural Products: Promises and Hopes focuses on the recent advances in the research of bioactive natural products with cardioprotective potential against various cardiovascular diseases/disorders. The aim of this book is to underline the promise and future hope in bioactive natural molecules, herbal formulations, natural dietary supplements and related materials in the prevention and cure of cardiovascular diseases in a scientific way. This book, which comprises a variety of about 9 chapters written by active researchers and leading experts, brings together an overview of current discoveries and trends in this field. This volume is also an outstanding source of information with regard to the industrial application of natural products for medicinal purposes. The broad interdisciplinary approach adopted in this book ensures that it is much more interesting to scientists deeply engaged in the research and/or use of bioactive natural products. It will serve not only as a valuable resource for researchers in their own fields to predict promising leads for developing pharmaceuticals to prevent and treat disease manifestations, but will hopefully also motivate young scientists to engage in the dynamic field of natural products research. Contents: Cardioprotective Natural Products: Promises and Hopes — An Overview (Goutam Brahmachari) Naturally Occurring Matrix Metalloproteinase Inhibitors: A Group of Promising Cardioprotective Agents (Tayebeh Anajafi, Abbas Sedigh and Sanku Mallik ) Promising Natural Cardioprotective Agents in Drug- and Toxin-Induced Pathophysiology (Semantee Bhattacharya and Parames C Sil) Natural Products Against Drug-Induced Cardiotoxicity (Meghana Koneru, Nasiruddin Nalban, Bidya Dhar Sahu and Ramakrishna Sistla ) Cardioprotective Potential of Medicinal Plants in Attenuating Doxorubicin-Induced Cardiotoxicity (Sameer N Goyal, C R Patil, Nimisha Mishra, Rajesh Mohanraj and Shreesh Ojha) The Role of Dietary Supplements in Cardiovascula

Medicinal Foods as Potential Therapies for Type 2 Diabetes and Associated Diseases Book

Medicinal Foods as Potential Therapies for Type 2 Diabetes and Associated Diseases


  • Author : Solomon Habtemariam
  • Publisher : Academic Press
  • Release Date : 2019-06-08
  • Genre: Medical
  • Pages : 1180
  • ISBN 10 : 9780081029237

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Medicinal Foods as Potential Therapies for Type 2 Diabetes and Associated Diseases Excerpt :

Medicinal Foods as Potential Therapies for Type-2 Diabetes and Associated Diseases: The Chemical and Pharmacological Basis of their Action focuses on active pharmacological principles that modulate diabetes, associated risk factors, complications and the mechanism of action of widely used anti-diabetic herbal plants—rather than just the nutritional composition of certain foods. The book provides up-to-date information on acclaimed antidiabetic super fruits, spices and other food ingredients. Sections cover diabetes and obesity at the global level, the physiological control of carbohydrate and lipid metabolism, the pathophysiology of type-2 diabetes, the chemistry and pharmacology of a variety of spices, and much more. This book will be invaluable for research scientists and students in the medical and pharmaceutical sciences, medicinal chemistry, herbal medicine, drug discovery/development, nutrition science, and for herbal practitioners and those from the nutraceutical and pharm industries. Provides background knowledge on type-2 diabetes and its pathophysiology and therapeutic targets down to the molecular level Explores, in detail, the chemistry or secondary metabolites of the indicated foods that potentially modify diabetes and/or associated diseases Examines the pharmacological findings on medicinal foods, including available clinical trials

Natural Products as Source of Molecules with Therapeutic Potential Book

Natural Products as Source of Molecules with Therapeutic Potential


  • Author : Valdir Cechinel Filho
  • Publisher : Springer
  • Release Date : 2018-12-07
  • Genre: Science
  • Pages : 531
  • ISBN 10 : 9783030005450

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Natural Products as Source of Molecules with Therapeutic Potential Excerpt :

This book addresses the highly relevant and complex subject of research on drugs from natural products, discussing the current hot topics in the field. It also provides a detailed overview of the strategies used to research and develop these drugs. Respected experts explore issues involved in the production chain and when looking for new medicinal agents, including aspects such as therapeutic potential, functional foods, ethnopharmacology, metabolomics, virtual screening and regulatory scenarios. Further, the book describes strategic methods of isolation and characterization of active principles, biological assays, biotechnology of plants, synthesis, clinical trials and the use of tools to identity active principles.

Neuroprotective Natural Products Book
Score: 5
From 1 Ratings

Neuroprotective Natural Products


  • Author : Goutam Brahmachari
  • Publisher : John Wiley & Sons
  • Release Date : 2017-06-19
  • Genre: Medical
  • Pages : 372
  • ISBN 10 : 9783527341863

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Neuroprotective Natural Products Excerpt :

Focusing on the molecular mechanisms of powerful naturally occurring agents and their implication for drug discovery, this timely book presents an overview of the most recent research advances in the field of bioactive natural products and natural drug formulations to combat today's destructive diseases. To this extent, the authors discuss the most severe neurological disorders in our modern civilization, such as Alzheimer's, Parkinson's and Huntington's disease, as well as ischemic brain stroke and depression. The emerging diversity of active compounds is covered in detail, including flavonoids, cannabinoids and oleanolic acid, while experts in the field explain the chemistry, mode of action and clinical aspects of novel neuroprotective natural products. In each case, the benefits of treatments using natural products are addressed from the perspective of modern as well as traditional medicine. With its multidisciplinary viewpoint, this is the ideal companion for medicinal and natural products chemists as well as neuroscientists, biochemists, pharmacologists, neurobiologists, and phytotherapists.

Biological Macromolecules Book

Biological Macromolecules


  • Author : Amit Kumar Nayak
  • Publisher : Academic Press
  • Release Date : 2021-12-01
  • Genre: Science
  • Pages : 672
  • ISBN 10 : 9780323856386

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Biological Macromolecules Excerpt :

Biological Macromolecules: Bioactivity and Biomedical Applications presents a comprehensive study of biomacromolecules and their potential use in various biomedical applications. Consisting of four sections, the book begins with an overview of the key sources, properties and functions of biomacromolecules, covering the foundational knowledge required for study on the topic. It then progresses to a discussion of the various bioactive components of biomacromolecules. Individual chapters explore a range of potential bioactivities, considering the use of biomacromolecules as nutraceuticals, antioxidants, antimicrobials, anticancer agents, and antidiabetics, among others. The third section of the book focuses on specific applications of biomacromolecules, ranging from drug delivery and wound management to tissue engineering and enzyme immobilization. This focus on the various practical uses of biological macromolecules provide an interdisciplinary assessment of their function in practice. The final section explores the key challenges and future perspectives on biological macromolecules in biomedicine. Covers a variety of different biomacromolecules, including carbohydrates, lipids, proteins, and nucleic acids in plants, fungi, animals, and microbiological resources Discusses a range of applicable areas where biomacromolecules play a significant role, such as drug delivery, wound management, and regenerative medicine Includes a detailed overview of biomacromolecule bioactivity and properties Features chapters on research challenges, evolving applications, and future perspectives

The Evolution of Drug Discovery Book

The Evolution of Drug Discovery


  • Author : Enrique Ravina
  • Publisher : John Wiley & Sons
  • Release Date : 2011-04-18
  • Genre: Medical
  • Pages : 531
  • ISBN 10 : 9783527326693

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The Evolution of Drug Discovery Excerpt :

The discovery and use of medicines is just as fascinating a human scientific endeavor as space flight or the tracing of human evolution. It is also the everyday task of hundreds of thousands of pharmacists, pharmaceutical chemists and researchers worldwide. Based on his profound knowledge of past and present paradigms in the development of medicines, Enrique Ravina takes the reader from the very beginnings of pharmacology to the multibillion-dollar business it represents today. Recounting the often spectacular successes and failures of innovative drugs as well as the people who discovered them, he brings abstract science to life in anecdotal form. For anyone with a more than superficial interest in the science of drugs and all those interested in knowing how drugs have been developed, how they have reached us, and became part of our daily life. This book is beautifully illustrated, containing many rare and historical photographs of drugs and their discoverers, and abounds with references to the primary literature, listing seminal publications alongside more modern reviews for readers seeking further details. With a Foreword by Hugo Kubinyi