Discovery and Development of Therapeutics from Natural Products Against Neglected Tropical Diseases Book

Discovery and Development of Therapeutics from Natural Products Against Neglected Tropical Diseases


  • Author : Goutam Brahmachari
  • Publisher : Elsevier
  • Release Date : 2019-04-15
  • Genre: Medical
  • Pages : 458
  • ISBN 10 : 9780128157244

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Discovery and Development of Therapeutics from Natural Products Against Neglected Tropical Diseases Excerpt :

Discovery and Development of Therapeutics from Natural Products against Neglected Tropical Diseases draws together research on medicinal agents from natural sources as starting points for the design of drugs against Neglected Tropical Diseases (NTDs). From the prediction of promising leads and identification of active agents, to the extraction of complex molecules, the book explores novel, economical and efficacious therapeutics for these diseases. It describes current research and the role of natural products, antimalarial compounds from marine natural products and sesquiterpene lactones, natural antileprotic agents, natural products with potential against Leishmaniasis, Trypanosomiasis and Dengue, and more. In addition, Quinoline and Isoquinoline alkaloids for developing new antiprotozoal agents are discussed, alongside anti-trypanosomatid heterocyclic compounds as structures for development. Combining the expertise of specialists from around the world, this volume aims to support and encourage researchers in the investigation of natural sources as starting points for the development of novel, safe and effective agents for use against neglected tropical diseases. Includes chapters written by active researchers and leading global experts deeply engaged in the research field of natural product chemistry for drug discovery Draws together cutting-edge research advances in natural product chemistry that are targeted at neglected tropical diseases Highlights the future potential of natural products as sources of novel medicinal compounds against neglected tropical diseases

Neglected Tropical Diseases Book

Neglected Tropical Diseases


  • Author : David C. Swinney
  • Publisher : John Wiley & Sons
  • Release Date : 2019-07-25
  • Genre: Medical
  • Pages : 392
  • ISBN 10 : 9783527808649

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Neglected Tropical Diseases Excerpt :

A drug discovery reference to the crippling tropical diseases that affect more than 1 billion people. Neglected Tropical Diseases is the first book of its kind to offer a guide that follows the World Health Organization?s list of neglected tropical diseases. The authors?all are experts on the topic?address the development of effective treatments for 12 crippling infectious diseases that affect almost 20% of the world?s popluation. The book includes information on the common approaches and the most important factors that lead to the development of new drugs for treating tropical diseases. Individual chapters review 12 neglected tropical diseases that are grouped by infectious agent, from viruses to bacteria to eukaryotic parasites. For each of these diseases, the book explains the unmet medical need and explores the current and potential drug discovery strategies. The book also includes information on potential drug compounds derived from natural products. This important book: -Ties together information from different sources for developing novel treatsments forneglected tropical diseases -Is aligned with WHO?s initiative to eradicate tropical diseases -Outlines current and potential drugs for treating tropical diseases -Provides a standard reference for the entire field Written for medicinal chemists, pharmaceutical chemists, pharmaceutical industry, virologists, parasitologists, and specialists on tropics medicine, Neglected Tropical Diseases offers an essential guide and a systematic reference for the development of successful treatments for 12 crippling infectious diseases.

Discovery and Development of Antidiabetic Agents from Natural Products Book

Discovery and Development of Antidiabetic Agents from Natural Products


  • Author : Goutam Brahmachari
  • Publisher : Elsevier
  • Release Date : 2016-10-11
  • Genre: Science
  • Pages : 332
  • ISBN 10 : 9780128096925

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Discovery and Development of Antidiabetic Agents from Natural Products Excerpt :

Discovery and Development of Antidiabetic Agents from Natural Products brings together global research on the medicinal chemistry of active agents from natural sources for the prevention and treatment of diabetes and associated disorders. From the identification of promising leads, to the extraction and synthesis of bioactive molecules, this book explores a range of important topics to support chemists in the discovery and development of safer, more economical therapeutics that are desperately needed in response to this emerging global epidemic. Beginning with an overview of bioactive chemical compounds from plants with anti-diabetic properties, the book goes on to outline the identification and extraction of anti-diabetic agents and antioxidants from natural sources. It then explores anti-diabetic plants from specific regions before looking more closely at the background, isolation, and synthesis of key therapeutic compounds and their derivatives, including Mangiferin, Resveratrol, natural saponins, and alpha-glucosidase enzyme inhibitors. The book concludes with a consideration of current and potential future applications. Combining the expertise of specialists from around the world, this volume aims to support and encourage medicinal chemists investigating natural sources as starting points for the development of standardized, safe, and effective antidiabetic therapeutics. Contains chapters written by active researchers and leading global experts who are deeply engaged in the research field of natural product chemistry for drug discovery Provides comprehensive coverage of cutting-edge research advances in the design of medicinal natural products with potential as preventives and therapeutics for diabetes and related metabolic issues Presents a practical review of the identification, isolation, and extraction techniques that help support medicinal chemists in the lab

Drug Discovery for Leishmaniasis Book

Drug Discovery for Leishmaniasis


  • Author : Carmen Gil
  • Publisher : Royal Society of Chemistry
  • Release Date : 2017-11-02
  • Genre: Uncategoriezed
  • Pages : 402
  • ISBN 10 : 9781782628897

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Drug Discovery for Leishmaniasis Excerpt :

Advances in Medicinal Chemistry Research Book

Advances in Medicinal Chemistry Research


  • Author : Edeildo Ferreira Da Silva, Jr.
  • Publisher : Unknown
  • Release Date : 2019-10-15
  • Genre: Uncategoriezed
  • Pages : 366
  • ISBN 10 : 1536163686

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Advances in Medicinal Chemistry Research Excerpt :

Advances in Medicinal Chemistry Research is a book addressed to undergraduate and postgraduate students, where recent advances in the discovery and development of effective agents against the most remarkable wide-reaching diseases are presented, divided into seven chapters. This first edition of Advances in Medicinal Chemistry Research offers insights into medicinal chemistry that arguably have the most significant impact on our lives than any other. It draws together research on therapeutic agents from natural, synthetic, and virtual screening sources as starting points for the design of drugs against obesity, multidrug-resistant bacteria, neglected tropical diseases, Alzheimer, and cancer. From the prediction of promising hits and identification of active compounds to the extraction of more complex molecules, this book explores a range of essential topics to support the development of novel, economical, and efficacious therapeutics for these diseases, which currently affect a billion people worldwide. Beginning with an overview of obesity, showing the current research landscape, the books shows the importance of natural and synthetic products as promising anti-obesity agents. Subsequently, the medicinal chemistry of modulation of bacterial resistance is presented, focusing on the MFS, RND, ABC, and MATE superfamilies. The book goes on to discuss such topics as antituberculosis, antileishmanial, and anti-hepatitis thiophene-containing compounds, under the medicinal chemistry point of view. Also, potent human glutaminyl cyclase inhibitors are deeply discussed and displayed as hopeful anti-Alzheimer's agents. The last three chapters are focused on the development of researches involving new anticancer agents, initializing with LBDD, SBDD, QSAR, and QM/MM methods applied to the identification of novel promising anticancer compounds. Moreover, IDO1 inhibitors are exhaustively explored and analyzed as a new promise for the immunotherapy of cancer. Finally, a great updat

WIPO Re Search  Advancing science for neglected tropical diseases  malaria and tuberculosis Book

WIPO Re Search Advancing science for neglected tropical diseases malaria and tuberculosis


  • Author : World Intellectual Property Organization
  • Publisher : WIPO
  • Release Date : 2019-06-04
  • Genre: Law
  • Pages : 8
  • ISBN 10 : 978186723xxxx

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WIPO Re Search Advancing science for neglected tropical diseases malaria and tuberculosis Excerpt :

This edition of the Global Challenges In Focus series takes an in-depth look at some of WIPO Re:Search’s most promising scientific collaborations and their potential impacts – as described by the researchers and organizations involved.

Marine Natural Products Book

Marine Natural Products


  • Author : Hiromasa Kiyota
  • Publisher : Springer Nature
  • Release Date : 2021-09-02
  • Genre: Science
  • Pages : 517
  • ISBN 10 : 9789811646379

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Marine Natural Products Excerpt :

This book is a compilation of the latest achievements of leading researchers in marine natural products with extremely diverse structures and biological activities. It presents discussions of isolation, structure elucidation, biosynthesis, total synthesis, and biochemical properties of the compounds with characteristic structures such as macrolides, cyclic depsipeptides, alkaloids, and water-soluble heterocyclic low-molecular-weight compounds, from sponges, bacteria, cyanobacteria, flagellates, and other such organisms. The book especially focuses on heterocyclic natural products as a title in the book series, Topics in Heterocyclic Chemistry.

Rare Diseases and Orphan Products Book

Rare Diseases and Orphan Products


  • Author : Institute of Medicine
  • Publisher : National Academies Press
  • Release Date : 2011-04-03
  • Genre: Medical
  • Pages : 442
  • ISBN 10 : 9780309158060

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Rare Diseases and Orphan Products Excerpt :

Rare diseases collectively affect millions of Americans of all ages, but developing drugs and medical devices to prevent, diagnose, and treat these conditions is challenging. The Institute of Medicine (IOM) recommends implementing an integrated national strategy to promote rare diseases research and product development.

Investing to Overcome the Global Impact of Neglected Tropical Diseases Book

Investing to Overcome the Global Impact of Neglected Tropical Diseases


  • Author : World Health Organization
  • Publisher : World Health Organization
  • Release Date : 2015-08-05
  • Genre: Medical
  • Pages : 191
  • ISBN 10 : 9789241564861

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Investing to Overcome the Global Impact of Neglected Tropical Diseases Excerpt :

This report repositions a group of 17 neglected tropical diseases on the global development agenda at a time of profound transitions in the economies of endemic countries and in thinking about the overarching objectives of development. In doing so it reinvigorates the drive to prevent control eliminate or eradicate diseases that blind maim and disfigure making life miserable for more than a billion people. Undetected and untreated several almost invariably kill. The burden of these diseases is further amplified by the fact that many require chronic and costly care underscoring the economic as well as the health benefits of preventive chemotherapy and early detection and care. The report brings a new dimension to long-term thinking about the future approach to these diseases. For the first time it sets out financing needs options and targets for meeting WHO Roadmap goals by 2020 but also for reaching universal coverage of all people in need by 2030. The report makes one investment case for cost-effectiveness and a second investment case where equity is the focus. It sets targets for ending catastrophic health expenditures and as part of the drive to strengthen health systems for getting services closer to where people live.

Characterization of New Marine Secondary Metabolites for the Treatment of Cancer and Neglected Tropical Diseases Book

Characterization of New Marine Secondary Metabolites for the Treatment of Cancer and Neglected Tropical Diseases


  • Author : Thomas Luke Simmons
  • Publisher : Unknown
  • Release Date : 2008
  • Genre: Uncategoriezed
  • Pages : 161
  • ISBN 10 : OCLC:192095604

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Characterization of New Marine Secondary Metabolites for the Treatment of Cancer and Neglected Tropical Diseases Excerpt :

Small molecules from natural sources are vital to drug discovery by providing molecular diversity and novel chemical scaffolds for further pharmacological development. The emergence of multiple drug resistant pathogens and problems associated with natural product dereplication emphasize the continuing need for the discovery of new and relevant bioactive molecules for the treatment of human disease. This thesis describes the biological activity guided chemical investigation of several marine taxa with emphasis on the isolation and structure elucidation of new secondary metabolites with therapeutic efficacy against cancer and infectious disease. Chapter I introduces the context, rationale and background which form the foundation of the thesis research. Chapter II describes the bioactivity guided discovery of a new cancer compound from a Panamanian marine cyanobacterium Symploca sp. The linear tetrapeptide contains unusual and modified amino residues and exhibits sub-micromolar cancer toxicity with a classic antimitotic mechanism of action. Chapter III describes the discovery of DMMC a new cyclic depsipeptide isolated from a Fijian strain of Lyngbya majuscula. The antitumor effects displayed by this compound were very potent and selective for solid tumor cell lines. A linear analog of DMMC was generated during structure determination, this analog proved to maintain the exquisite and selective activity of the parent molecule. Chapter IV describes the discovery of the viridamides A and B from the cyanobacterium Oscillatoria nigro-viridis. Structure elucidation of these linear lipodepsipeptides revealed the presence of the novel 5-methoxydec-9-ynonic acid residue and subsequent biological evaluation indicated low micromolar efficacy against two species of disease causing protozoan pathogens. Chapter V describes the bioassay guided isolation and structure elucidation of kaviol A, a halogenated phenolic inhibitor of histone deacetylase (HDAC) from a Papua New Guinean strain

Wound Healing Research Book

Wound Healing Research


  • Author : Prasun Kumar
  • Publisher : Springer Nature
  • Release Date : 2021-07-20
  • Genre: Medical
  • Pages : 694
  • ISBN 10 : 9789811626777

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Wound Healing Research Excerpt :

This book presents the latest knowledge on both the physiological and the microbiological aspects of wound healing. Fresh insights into the process of cutaneous wound healing are described, which involves tissue regeneration and repair processes consisting of a sequence of molecular and cellular events. The management of infected wounds is then discussed in detail, covering the roles of traditional medicine practices, novel anti-infective formulations, non-antibiotic approaches, and probiotic bacteria. A section devoted to the interdisciplinary approach to wound care addresses topics including in vitro and in vivo research models, the development of advanced wound dressings, tissue engineering, and the potential applications of bioscaffolds. The authors are all leading researchers in the field. This book is an attempt to showcase current research status and future directions in the area of wound-healing research, which must be of interest to a large group of readers and researchers interested in this field.

Ethnomedicine  A Boon of Nature Book

Ethnomedicine A Boon of Nature


  • Author : Dr. Keshamma E.
  • Publisher : Priya Lokare
  • Release Date : 2022-03-23
  • Genre: Medical
  • Pages : 124
  • ISBN 10 : 978186723xxxx

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Ethnomedicine A Boon of Nature Excerpt :

Ethnic medicine is the evaluation or combination of medicines common in the face of biologically active mixtures of plants and organisms. It is practiced by different ethnic groups, especially those who readily accept Western orders, such as B. Indigenous groups. These customs often collaborate with insects in Africa, America, or worldwide. The term folk medicine is sometimes used interchangeably with traditional medicine. Ethnomedical research is interdisciplinary; in its investigation of conventional prescriptions, it applies ethnobotany and clinical human studies strategies. Frequently, the medication customs it studies are saved simply by oral practice. Regularly these practices establish critical connections with bugs also. Logical ethnomedical studies show either anthropological examination or medication disclosure research. Anthropological investigations look at the social insight and set of conventional medication. Ethnomedicine has been utilized as a beginning stage in drug disclosure, explicitly those using reverse pharmacological methods. Ethnic medicine is a term that refers to a wide range of medical care frameworks, plans, practices, beliefs, and treatment practices that result from the local social transformation of events. Ethnomedicine is also interpreted as examining these frameworks and procedures, rather than understanding them in an anthropological setting, rather than evaluating their adequacy using rational strategies. In any case, such medical care frameworks don't follow the design of present-day or Western medication. All things being equal, these medical care rehearses depend on the one-of-a-kind culture that has emerged from local and native gatherings of individuals. Ethnomedicine isn't restricted to the conspicuous things, such as utilizing native plants and fixings to treat the wiped out.

Neglected Tropical Diseases and Phytochemicals in Drug Discovery Book

Neglected Tropical Diseases and Phytochemicals in Drug Discovery


  • Author : Muhammad Akram
  • Publisher : John Wiley & Sons
  • Release Date : 2021-10-25
  • Genre: Science
  • Pages : 624
  • ISBN 10 : 9781119617150

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Neglected Tropical Diseases and Phytochemicals in Drug Discovery Excerpt :

NEGLECTED TROPICAL DISEASES AND PHYTOCHEMICALS IN DRUG DISCOVERY Explore novel drug discovery updates from medicinal plants to help fight the devastating effects of neglected tropical diseases Neglected Tropical Diseases and Phytochemicals in Drug Discovery delivers a comprehensive exploration of the drug discovery process as it pertains to neglected tropical diseases. The book covers recent advancements in drug discovery, as well as druggable targets and new challenges facing the industry. It offers readers expansive discussions of specific diseases, including protozoan, helminth, bacterial, viral, fungal, and ectoparasitic infections. This book provides readers with insightful perspectives from leading industry voices on fifty years of trends and progress in the search for new, safe, and affordable therapeutic drugs in the fight against neglected tropical diseases. It includes information beneficial to researchers in a variety of fields of biology, chemistry, medicine, and pharmaceuticals. The distinguished authors cover topics including the effects of phytochemicals on the causative agent of leprosy and the potential applicability of phytochemicals in the management of Dengue fever. Readers will also enjoy the inclusion of: Thorough introductions to neglected tropical diseases, phytochemicals, protein targets, and mechanisms in drug discovery, as well as the epidemiology of neglected tropical diseases An exploration of novel bioactive lead compounds for drug discovery against neglected tropical diseases, leishmaniasis, lymphatic filariasis, trypanosomiasis, and schistosomiasis Discussions of protozoan infections, including herbal, nutritional, and traditional remedies for giardiasis and the anti-leishmanial potentials of phytochemicals Examinations of helminth infections, including the prospects of phytochemicals in the treatment of helminthiasis Perfect for medicinal chemists, drug developers, and research and development scientists, Neglected Tropical Diseases

Studies in Natural Products Chemistry Book

Studies in Natural Products Chemistry


  • Author : Atta-ur-Rahman
  • Publisher : Elsevier
  • Release Date : 2022-08-01
  • Genre: Science
  • Pages : 498
  • ISBN 10 : 9780323911009

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Studies in Natural Products Chemistry Excerpt :

Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry. Studies in Natural Products Chemistry covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products. Focuses on the chemistry of bioactive natural products Contains contributions by leading authorities in the field Presents sources of new pharmacophores