Disease Pathways Book

Disease Pathways


  • Author : Anastasia P. Nesterova
  • Publisher : Elsevier
  • Release Date : 2019-10-18
  • Genre: Science
  • Pages : 732
  • ISBN 10 : 9780128170878

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Disease Pathways Excerpt :

Disease Pathways: An Atlas of Human Disease Signaling Pathways is designed to fill a void of illustrated reviews about the cellular mechanisms of human diseases. It covers 42 of the most common non-oncologic diseases and illustrates the connections between the molecular causes of the disease and its symptoms. This resource provides readers with detailed information about the disease molecular pathways, while keeping the presentation simple. Pathway models that aggregate the knowledge about protein–protein interactions have become indispensable tools in many areas of molecular biology, pharmacology, and medicine. In addition to disease pathways, the book includes a comprehensive overview of molecular signaling biology and application of pathway models in the analysis of big data for drug discovery and personalized medicine. This is a must-have reference for general biologists, biochemists, students, medical workers, and everyone interested in the cellular and molecular mechanisms of human disease. Over 145 full-color illustrations of the molecular and cellular cascades underlying the disease pathology. Disease pathways are based on computational models from Elsevier’s Disease Pathway Collection, published for the first time outside of Pathway Studio® commercial software. Each relationship on the pathway models is supported by references to scientific articles and can be examined at freely available online resources.

Signaling Pathways in Liver Diseases Book

Signaling Pathways in Liver Diseases


  • Author : Jean-Francois Dufour
  • Publisher : John Wiley & Sons
  • Release Date : 2015-08-24
  • Genre: Medical
  • Pages : 520
  • ISBN 10 : 9781118663363

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Signaling Pathways in Liver Diseases Excerpt :

Signaling Pathways in Liver Diseases, Third Edition again provides hepatologists and hepatology researchers with an expert overview of the complex and novel cellular/extracellular signaling pathways in the liver, and their role in liver diseases. The last few years have seen a great number of developments in this field, which in turn have led to new opportunities for innovative treatments; however, the intricacy of these pathways and their interactions continue to provide a real challenge for clinicians. This outstanding book compiles the emerging knowledge into a single expert resource, cataloguing and organizing it into an accessible and understandable format. With increased focus on the comprehension of cellular mechanisms involved in steatohepatitis, cirrhosis, and liver tumors, which has led to changes in the management of these diseases, this new edition also sees the introduction of exciting new chapters on key emerging areas such as: Autophagy Notch Pathway P13K/PTEN Signaling in Liver Diseases Sirtuins Hepcidin and Iron Epigenetic Regulation of Hepatic Stellate Cells and Liver Fibrosis Oxidative Stress and Signaling in the Liver. Professors Dufour and Clavien have assembled an all-star cast of chapter authors, each of whom has provided clear and appropriate illustrations to reinforce the text, with a key points box offering a concise and handy summary. Self-assessment questions and answers allow the reader to test their own knowledge. Signaling Pathways in Liver Disease, Third Edition is the perfect educational and reference tool to bridge the information exchange between the laboratory, the clinical ward, and the operating room, and an essential tool for the modern-day hepatologist.

Precision Medicine and the Reinvention of Human Disease Book

Precision Medicine and the Reinvention of Human Disease


  • Author : Jules J. Berman
  • Publisher : Academic Press
  • Release Date : 2018-01-26
  • Genre: Business & Economics
  • Pages : 398
  • ISBN 10 : 9780128143940

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Precision Medicine and the Reinvention of Human Disease Excerpt :

Despite what you may have read in the popular press and in social media, Precision Medicine is not devoted to finding unique treatments for individuals, based on analyzing their DNA. To the contrary, the goal of Precision Medicine is to find general treatments that are highly effective for large numbers of individuals who fall into precisely diagnosed groups. We now know that every disease develops over time, through a sequence of defined biological steps, and that these steps may differ among individuals, based on genetic and environmental conditions. We are currently developing rational therapies and preventive measures, based on our precise understanding of the steps leading to the clinical expression of diseases. Precision Medicine and the Reinvention of Human Disease explains the scientific breakthroughs that have changed the way that we understand diseases, and reveals how medical scientists are using this new knowledge to launch a medical revolution. Clarifies the foundational concepts of Precision Medicine, distinguishing this field from its predecessors such as genomics, pharmacogenetics, and personalized medicine. Gathers the chief conceptual advances in the fields of genetics, pathology, and bioinformatics, and synthesizes a coherent narrative for the field of Precision Medicine. Delivers its message in plain language, and in a relaxed, conversational writing style, making it easy to understand the complex subject matter. Guides the reader through a coherent and logical narrative, gradually providing expertise and skills along the way. Covers the importance of data sharing in Precision Medicine, and the many data-related challenges that confront this fragile new field.

Communities in Action Book
Score: 5
From 1 Ratings

Communities in Action


  • Author : National Academies of Sciences, Engineering, and Medicine
  • Publisher : National Academies Press
  • Release Date : 2017-04-27
  • Genre: Medical
  • Pages : 582
  • ISBN 10 : 9780309452960

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Communities in Action Excerpt :

In the United States, some populations suffer from far greater disparities in health than others. Those disparities are caused not only by fundamental differences in health status across segments of the population, but also because of inequities in factors that impact health status, so-called determinants of health. Only part of an individual's health status depends on his or her behavior and choice; community-wide problems like poverty, unemployment, poor education, inadequate housing, poor public transportation, interpersonal violence, and decaying neighborhoods also contribute to health inequities, as well as the historic and ongoing interplay of structures, policies, and norms that shape lives. When these factors are not optimal in a community, it does not mean they are intractable: such inequities can be mitigated by social policies that can shape health in powerful ways. Communities in Action: Pathways to Health Equity seeks to delineate the causes of and the solutions to health inequities in the United States. This report focuses on what communities can do to promote health equity, what actions are needed by the many and varied stakeholders that are part of communities or support them, as well as the root causes and structural barriers that need to be overcome.

Neurobiology of Huntington   s Disease Book

Neurobiology of Huntington s Disease


  • Author : Donald C. Lo
  • Publisher : CRC Press
  • Release Date : 2010-07-02
  • Genre: Science
  • Pages : 338
  • ISBN 10 : 9781420008258

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Neurobiology of Huntington s Disease Excerpt :

In 1993, the genetic mutation responsible for Huntington’s disease (HD) was identified. Considered a milestone in human genomics, this discovery has led to nearly two decades of remarkable progress that has greatly increased our knowledge of HD, and documented an unexpectedly large and diverse range of biochemical and genetic perturbations that seem to result directly from the expression of the mutant huntingtin gene. Neurobiology of Huntington’s Disease: Applications to Drug Discovery presents a thorough review of the issues surrounding drug discovery and development for the treatment of this paradigmatic neurodegenerative disease. Drawing on the expertise of key researchers in the field, the book discusses the basic neurobiology of Huntington’s disease and how its monogenic nature confers enormous practical advantages for translational research, including the creation of robust experimental tools, models, and assays to facilitate discovery and validation of molecular targets and drug candidates for HD. Written to support future basic research as well as drug development efforts, this volume: Covers the latest research approaches in genetics, genomics, and proteomics, including high-throughput and high-content screening Highlights advances in the discovery and development of new drug therapies for neurodegenerative disorders Examines the practical realities of preclinical testing, clinical testing strategies, and, ultimately, clinical usage While the development of effective drug treatments for Huntington's disease continues to be tremendously challenging, a highly interactive and cooperative community of researchers and clinical investigators now brings us to the threshold of potential breakthroughs in the quest for therapeutic agents. The impressive array of drug discovery resources outlined in the text holds much promise for treating this devastating disease, providing hope to long-suffering Huntington’s disease patients and their families.

Improving Healthcare Quality in Europe Characteristics  Effectiveness and Implementation of Different Strategies Book

Improving Healthcare Quality in Europe Characteristics Effectiveness and Implementation of Different Strategies


  • Author : OECD
  • Publisher : OECD Publishing
  • Release Date : 2019-10-17
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : 9789264805903

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Improving Healthcare Quality in Europe Characteristics Effectiveness and Implementation of Different Strategies Excerpt :

This volume, developed by the Observatory together with OECD, provides an overall conceptual framework for understanding and applying strategies aimed at improving quality of care. Crucially, it summarizes available evidence on different quality strategies and provides recommendations for their implementation. This book is intended to help policy-makers to understand concepts of quality and to support them to evaluate single strategies and combinations of strategies.

How Tobacco Smoke Causes Disease Book

How Tobacco Smoke Causes Disease


  • Author : Anonim
  • Publisher : U.S. Government Printing Office
  • Release Date : 2010
  • Genre: Health & Fitness
  • Pages : 728
  • ISBN 10 : UCSD:31822037817723

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How Tobacco Smoke Causes Disease Excerpt :

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

What Your Doctor May Not Tell You about Heart Disease Book

What Your Doctor May Not Tell You about Heart Disease


  • Author : Mark Houston
  • Publisher : Grand Central Life & Style
  • Release Date : 2012-02-06
  • Genre: Health & Fitness
  • Pages : 320
  • ISBN 10 : 9781455506538

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What Your Doctor May Not Tell You about Heart Disease Excerpt :

Coronary heart disease has long been the number one killer in this country, and for decades, we have been told about five basic risk factors: elevated cholesterol, high blood pressure, diabetes, obesity, and smoking. But the truth is that heart disease is much more complex-- with close to 400 risk factors! In this innovative guide, Dr. Mark Houston helps readers discover the causes of heart disease, how to prevent and treat its debilitating effects via nutrition, nutritional supplements, exercise, weight management, and lays to rest to various myths (cholesterol is not the primary cause) based on scientific studies and medical publications. Readers will also learn how to indentify the risk factors most likely to endager them and construct an arsenal of non-pharmacological preventitive strategies that can counteract this most deadly disease.

Clinical Pathways In Vitreoretinal Disease Book

Clinical Pathways In Vitreoretinal Disease


  • Author : Scott M. Steidl
  • Publisher : Thieme
  • Release Date : 2011-01-01
  • Genre: Medical
  • Pages : 524
  • ISBN 10 : 9781604064582

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Clinical Pathways In Vitreoretinal Disease Excerpt :

Vitreoretinal disease is the leading cause of severe vision loss in most developed countries. This all-encompassing new book is designed to enhance diagnosis and treatment of retinal pathology as you proceed from initial finding to differential diagnosis and treatment. Using evidence-based medicine to develop management strategies and featuring pathway diagrams and decision-making trees, the book links specific symptoms to the appropriate diagnosis and most effective treatment. A top team of retinal specialists have come together to create this pace-setting reference, covering everything from retinal detachment and hemorrhage, to pigmented lesions and noninfectious inflammation. Chapters are uniquely arranged by presenting symptom instead of diagnosis, allowing you to find material quickly and easily. Key features of this valuable book:Broad coverage of all important topics, including both pediatric and adult retinal diseasesClinical decision-making trees and pathway diagrams offering a yes-or-no approach to diagnosis and treatmentBeneficial question and answer format provides clarity and explanations for specific problemsHelpful table of contents organized by presenting symptomCLINICAL PATHWAY IN VITREORETINAL DISEASE is essential for all retina specialists, general ophthalmologists, and residents who treat severe vision loss. It offers the valuable information needed to reach an accurate diagnosis and provide optimal patient care. The book also serves as an excellent text for retina and general ophthalmology courses.

Polypharmacology Book

Polypharmacology


  • Author : Zhiguo Wang
  • Publisher : Springer Nature
  • Release Date : 2022-08-01
  • Genre: Medical
  • Pages : 870
  • ISBN 10 : 9783031049989

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Polypharmacology Excerpt :

There is a growing interest in unmet needs for the development of a new discipline in drug discovery and in university education on polypharmacology. However, there has not been a book with the comprehensive compilation of basic knowledge and advanced methodology that is needed. This book aims to meet the needs making Polypharmacology a new sub-discipline of Pharmacology, not only being a hot area of pharmacological research and education but also a new paradigm for drug discovery. It contains the contents covering the entire scope of Polypharmacology including systemic in-depth exposition of basic knowledge, novel concepts, innovative technologies, and translational and clinical applications by showcasing state-of-the-art strategies and step-by-step instructions of cutting-edge methods. The contents of this book targets broad readerships including scientists in pharmacology research and drug development, and university teachers and graduates in medical school or school of pharmacy.

Signal Transduction  Pathways  Mechanisms and Diseases Book

Signal Transduction Pathways Mechanisms and Diseases


  • Author : Ari Sitaramayya
  • Publisher : Springer Science & Business Media
  • Release Date : 2009-12-02
  • Genre: Science
  • Pages : 437
  • ISBN 10 : 9783642021121

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Signal Transduction Pathways Mechanisms and Diseases Excerpt :

Providing an overview of recent developments in the field of signal transduction, this volume emphasizes direct clinical significance. As such, topics like nuclear receptors, apoptosis, growth factors, cell cycles and cancer are examined.

Microbial Metabolism and Disease Book

Microbial Metabolism and Disease


  • Author : Elena L. Paley
  • Publisher : Academic Press
  • Release Date : 2021-03-13
  • Genre: Science
  • Pages : 306
  • ISBN 10 : 9780323884464

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Microbial Metabolism and Disease Excerpt :

Microbiome Metabolic Pathways and Disease provides insight into the interaction of microbial metabolic pathways in the human body and the impact these can have on a variety of diseases. By analyzing these pathways the book seeks to investigate how these metabolic processes can be targeted and manipulated in order to treat various disorders and diseases. Topics covered in the book include microbial shikimate pathways, protein biosynthesis, tryptophan metabolites, microbiome metabolic engineering, fecal microbiota transplantation, and virulence factors. Additionally, a variety of conditions are covered, such as disorders associated with metabolic syndromes, serotonin syndromes, Alzheimer’s disease, and Covid-19, providing a detailed overview of how metabolic pathways of microbiome can impact health and disease in the human body. Explores microbial metabolic pathways in the human body and implications for disease Investigates specific steps involved in metabolic reactions in the human microbiome, including shikimate pathways and tryptophan pathways Considers a variety of diseases and disorders, such as Alzheimer’s disease, metabolic syndromes, Crohn’s disease and Covid-19 Includes analysis of various amino acids and enzymes in microbial and human cells and how these can impact health