DNA Repair in Cancer Therapy Book

DNA Repair in Cancer Therapy


  • Author : Mark R. Kelley
  • Publisher : Academic Press
  • Release Date : 2016-06-07
  • Genre: Medical
  • Pages : 464
  • ISBN 10 : 9780128035993

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DNA Repair in Cancer Therapy Excerpt :

DNA Repair and Cancer Therapy: Molecular Targets and Clinical Applications, Second Edition provides a comprehensive and timely reference that focuses on the translational and clinical use of DNA repair as a target area for the development of diagnostic biomarkers and the enhancement of cancer treatment. Experts on DNA repair proteins from all areas of cancer biology research take readers from bench research to new therapeutic approaches. This book provides a detailed discussion of combination therapies, in other words, how the inhibition of repair pathways can be coupled with chemotherapy, radiation, or DNA damaging drugs. Newer areas in this edition include the role of DNA repair in chemotherapy induced peripheral neuropathy, radiation DNA damage, Fanconi anemia cross-link repair, translesion DNA polymerases, BRCA1-BRCA2 pathway for HR and synthetic lethality, and mechanisms of resistance to clinical PARP inhibitors. Provides a comprehensive overview of the basic and translational research in DNA repair as a cancer therapeutic target Includes timely updates from the earlier edition, including Fanconi Anemia cross-link repair, translesion DNA polymerases, chemotherapy induced peripheral neuropathy, and many other new areas within DNA repair and cancer therapy Saves academic, medical, and pharma researchers time by allowing them to quickly access the very latest details on DNA repair and cancer therapy Assists researchers and research clinicians in understanding the importance of the breakthroughs that are contributing to advances in disease-specific research

DNA Repair and Cancer Book

DNA Repair and Cancer


  • Author : Srinivasan Madhusudan
  • Publisher : CRC Press
  • Release Date : 2013-01-22
  • Genre: Medical
  • Pages : 718
  • ISBN 10 : 9781466577442

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DNA Repair and Cancer Excerpt :

DNA repair is a rapidly advancing field in biology and these systems represent a major defense mechanism against environmental and intracellular damaging agents such as sunlight, ionizing radiation, and reactive oxygen species. With contributions from eminent researchers, this book explores the basics and current trends in this critical field. Topics include carcinogenesis as a predictive and/or prognostic biomarker for cancer therapy, nucleotide excision repair, and tumor genetics and personalized medicine. The contributions provide essential information to scientists, pharmaceutical investigators, and clinicians interested in cancer therapy.

New Research Directions in DNA Repair Book

New Research Directions in DNA Repair


  • Author : Clark Chen
  • Publisher : BoD – Books on Demand
  • Release Date : 2013-05-22
  • Genre: Medical
  • Pages : 674
  • ISBN 10 : 9789535111146

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New Research Directions in DNA Repair Excerpt :

This book is intended for students and scientists working in the field of DNA repair. Select topics are presented here to illustrate novel concepts in DNA repair, the cross-talks between DNA repair and other fundamental cellular processes, and clinical translational efforts based on paradigms established in DNA repair. The book should serve as a supplementary text in courses and seminars as well as a general reference for biologists with an interest in DNA repair.

DNA Damage  DNA Repair and Disease Book

DNA Damage DNA Repair and Disease


  • Author : Miral Dizdaroglu
  • Publisher : Royal Society of Chemistry
  • Release Date : 2020-11-19
  • Genre: Science
  • Pages : 400
  • ISBN 10 : 9781839160868

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DNA Damage DNA Repair and Disease Excerpt :

The DNA of all organisms is constantly being damaged by endogenous and exogenous sources. Oxygen metabolism generates reactive species that can damage DNA, proteins and other organic compounds in living cells. Exogenous sources include ionizing and ultraviolet radiations, carcinogenic compounds and environmental toxins among others. The discovery of multiple DNA lesions and DNA repair mechanisms showed the involvement of DNA damage and DNA repair in the pathogenesis of many human diseases, most notably cancer. These books provide a comprehensive overview of the interdisciplinary area of DNA damage and DNA repair, and their relevance to disease pathology. Edited by recognised leaders in the field, this two-volume set is an appealing resource to a variety of readers including chemists, chemical biologists, geneticists, cancer researchers and drug discovery scientists.

The DNA Damage Response  Implications on Cancer Formation and Treatment Book

The DNA Damage Response Implications on Cancer Formation and Treatment


  • Author : Kum Kum Khanna
  • Publisher : Springer Science & Business Media
  • Release Date : 2009-09-18
  • Genre: Medical
  • Pages : 449
  • ISBN 10 : 9048125618

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The DNA Damage Response Implications on Cancer Formation and Treatment Excerpt :

The ?eld of cellular responses to DNA damage has attained widespread recognition and interest in recent years commensurate with its fundamental role in the ma- tenance of genomic stability. These responses, which are essential to preventing cellular death or malignant transformation, are organized into a sophisticated s- tem designated the “DNA damage response”. This system operates in all living organisms to maintain genomic stability in the face of constant attacks on the DNA from a variety of endogenous by-products of normal metabolism, as well as exogenous agents such as radiation and toxic chemicals in the environment. The response repairs DNA damage via an intricate cellular signal transduction network that coordinates with various processes such as regulation of DNA replication, tr- scriptional responses, and temporary cell cycle arrest to allow the repair to take place. Defects in this system result in severe genetic disorders involving tissue degeneration, sensitivity to speci?c damaging agents, immunode?ciency, genomic instability, cancer predisposition and premature aging. The ?nding that many of the crucial players involved in DNA damage response are structurally and functionally conserved in different species spurred discoveries of new players through similar analyses in yeast and mammals. We now understand the chain of events that leads to instantaneous activation of the massive cellular responses to DNA lesions. This book summarizes several new concepts in this rapidly evolving ?eld, and the advances in our understanding of the complex network of processes that respond to DNA damage.

Carcinogens  Dna Damage And Cancer Risk  Mechanisms Of Chemical Carcinogenesis Book

Carcinogens Dna Damage And Cancer Risk Mechanisms Of Chemical Carcinogenesis


  • Author : Miriam Christine Poirier
  • Publisher : World Scientific
  • Release Date : 2018-09-28
  • Genre: Medical
  • Pages : 392
  • ISBN 10 : 9789813237216

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Carcinogens Dna Damage And Cancer Risk Mechanisms Of Chemical Carcinogenesis Excerpt :

As chemical exposures and cancer rates increase worldwide, there is a need for students, researchers, public health professionals, and physicians to understand the mechanisms connecting exposure with human cancer risk. This new book is an essential reference, as well as introduction to the field of chemical carcinogenesis, with particular focus on DNA damage as a critical link between exposure and disease, and emphasis on biomarkers associated with cancer risk in humans. In addition to DNA damage, related topics covered include metabolism of selected chemical carcinogens, exposure-induced epigenetic changes, cancer-associated mutations and reduction of DNA damage and cancer risk by chemoprevention. The book is designed to be a comprehensive guide to basic principles, a teaching tool for academics, and a map for the development of protective mechanisms to reduce human cancer risk.

DNA Repair and Mutagenesis Book

DNA Repair and Mutagenesis


  • Author : Errol C. Friedberg
  • Publisher : American Society for Microbiology Press
  • Release Date : 2005-11-22
  • Genre: Science
  • Pages : 1118
  • ISBN 10 : 9781555813192

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DNA Repair and Mutagenesis Excerpt :

An essential resource for all scientists researching cellular responses to DNA damage. • Introduces important new material reflective of the major changes and developments that have occurred in the field over the last decade. • Discussed the field within a strong historical framework, and all aspects of biological responses to DNA damage are detailed. • Provides information on covering sources and consequences of DNA damage; correcting altered bases in DNA: DNA repair; DNA damage tolerance and mutagenesis; regulatory responses to DNA damage in eukaryotes; and disease states associated with defective biological responses to DNA damage.

DNA Photodamage Book

DNA Photodamage


  • Author : Roberto Improta
  • Publisher : Royal Society of Chemistry
  • Release Date : 2021-12-22
  • Genre: Science
  • Pages : 346
  • ISBN 10 : 9781839165597

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DNA Photodamage Excerpt :

Induction of DNA damage by sunlight is a major deleterious event in living organisms. Recent developments have dramatically improved our understanding of the photochemical processes involved at the sub-picosecond time scale and along with next generation sequencing and data processing has generated a need for a complete up-to-date coverage of the field. Written in an accessible and comprehensive manner, DNA Photodamage will appeal to all scientists working in the area whether specialists in the discipline or not and provides a complete coverage of the field, from ultrafast spectroscopy to biomedical research. Bridging the gap between photophysical and photochemical research on model systems, and in vivo and in vitro biological studies, this book aims to identify the most important research trends in the field and review their major findings.

Chemically Induced DNA Damage  Mutagenesis  and Cancer Book

Chemically Induced DNA Damage Mutagenesis and Cancer


  • Author : Ashis K. Basu
  • Publisher : MDPI
  • Release Date : 2018-08-27
  • Genre: Science
  • Pages : 274
  • ISBN 10 : 9783038971290

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Chemically Induced DNA Damage Mutagenesis and Cancer Excerpt :

This book is a printed edition of the Special Issue " Chemically-Induced DNA Damage, Mutagenesis, and Cancer" that was published in IJMS

Chromatin and Genomic Instability in Cancer Book

Chromatin and Genomic Instability in Cancer


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2021-09-08
  • Genre: Science
  • Pages : 284
  • ISBN 10 : 9780323855624

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Chromatin and Genomic Instability in Cancer Excerpt :

Chromatin and DNA Repair in Cancer, Volume 364 in the International Review of Cell and Molecular Biology series reviews and details current advances in cell and molecular biology. Chapters in this new release cover Genomic Instability and metabolism in cancer, Histones variants and Histones modifications in cancer and Aging, DNA Double-stranded breaks Repair in Cancer, Reactive oxygen species and DNA damage response in cancer, Transcription-Associated DNA Breaks and Cancer: A Matter of DNA Topology, Mechanisms of Base Excision Repair: Its Significance to Human Health, and more. The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics that are authored by prominent cell and molecular biologists. The articles published in IRCMB have a high impact and an average cited half-life of 9 years. This great resource ranks high amongst scientific journals dealing with cell biology. Publishes only invited review articles on selected topics Authored by established and active cell and molecular biologists, drawn from international sources Offers a wide range of perspectives on specific subjects

Base Excision Repair Pathway  The  Molecular Mechanisms And Role In Disease Development And Therapeutic Design Book

Base Excision Repair Pathway The Molecular Mechanisms And Role In Disease Development And Therapeutic Design


  • Author : Wilson Iii David M
  • Publisher : World Scientific
  • Release Date : 2016-12-08
  • Genre: Science
  • Pages : 824
  • ISBN 10 : 9789814719742

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Base Excision Repair Pathway The Molecular Mechanisms And Role In Disease Development And Therapeutic Design Excerpt :

This book will serve as the preeminent text book on the topic of "base excision repair", a key DNA repair pathway that protects cells from most spontaneous forms of DNA damage, including oxidative lesions that arise both in the nuclear and mitochondrial genomes. The book, which includes contributions from many of the world leaders in the field, provides a detailed description of the molecular mechanisms of base excision repair, as well as its emerging relationship to epigenetic regulation, the aging process and human disease, such as cancer susceptibility, immunological defects and neurological disorders. The book will also cover the state-of-the-art technologies being developed to assess base excision repair capacity among individuals in the population, in addition to the strategies being employed to target base excision repair as part of therapeutic paradigms to eradicate disease, namely cancer. This book represents one of the most extensive efforts to date to cover the topic of "base excision repair". It includes chapters by many of the most established investigators in the field, from all over the world.

Understanding Radiation Biology Book

Understanding Radiation Biology


  • Author : Kenneth Chadwick
  • Publisher : CRC Press
  • Release Date : 2019-11-15
  • Genre: Medical
  • Pages : 16
  • ISBN 10 : 9781000733549

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Understanding Radiation Biology Excerpt :

This book provides a qualitative and quantitative exploration of the action of radiation on living matter which leads to a complete and coherent interpretation of radiation biology. It takes readers from radiation-induced molecular damage in the nucleus of the cell and links this damage to cellular effects such as cell killing, chromosome aberrations and mutations before exploring organ damage, organism lethality and cancer induction. It also deals with radiological protection concepts and the difficulties of predicting the dose–effect relationship for low-dose and dose rate radiation risk. The book ends with separate chapters dealing with the effects of UV light exposure and risk classification of chemical mutagens, both of which are derived by logical extensions of the radiation model. This book will provide the basic foundations of radiation biology for undergraduate and graduate students in medical physics, biomedical engineering, radiological protection, medicine, radiology and radiography. Features Presents a comprehensive insight into radiation action on living matter Contains important implications for radiological protection and regulations Provides analytical methods for applications in radiotherapy

Genomic Uracil Book

Genomic Uracil


  • Author : Krokan Hans Einar
  • Publisher : World Scientific
  • Release Date : 2000-06-15
  • Genre: Science
  • Pages : 304
  • ISBN 10 : 9789813233515

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Genomic Uracil Excerpt :

This book describes genomic uracil in evolution, as a DNA constituent in adaptive and innate immune responses and as a mutagenic lesion causing cancer. Genomic uracil is as old as life and may have been a component in self-replicating molecules in the prebiotic era. The first living cells probably contained uracil in DNA, later to be replaced by thymine. The pioneering work of Nobel Laureate, Tomas Lindahl on spontaneous deamination of DNA cytosine to uracil was followed by his discovery of uracil-DNA glycosylase, which initiates repair of genomic uracil in base excision repair (BER). Uracil-DNA glycosylases are found in all forms of life and in DNA viruses, having roles in DNA repair, replication and epigenetics. The surprising discovery of enzymatic DNA cytosine deamination by the AID/APOBEC deaminases subsequently has implicated genomic uracil in the development of human cancer. The aim of the book is to contribute a reference text for graduate students, molecular biologists, immunologists and cancer biologists. Genomic uracil has become a hot research topic of wide interest after the Nobel Prize in Chemistry 2015 was awarded for DNA repair (Paul Modrich, Aziz Sancar and Tomas Lindahl). Furthermore, genomic uracil has received wide interest among both immunologists and cancer biologists due to its unexpected and fundamental role in adaptive immunity. Genomic uracil, thus, is highly relevant to researchers in different areas of research, but to our knowledge there is no published text that treats genomic uracil in an interdisciplinary way. The authors of this book have in the last three decades worked on genomic uracil and its processing and are among the most highly cited authors in the field.