DNA Topoisomerases and Cancer Book

DNA Topoisomerases and Cancer


  • Author : Yves Pommier
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-09-21
  • Genre: Medical
  • Pages : 443
  • ISBN 10 : 1461403235

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DNA Topoisomerases and Cancer Excerpt :

DNA topoisomerases represent an essential family of DNA processing enzymes and a large number of topoisomerase inhibitors are used clinically for the treatment of various human cancers. Novels drugs are in clinical development both against type I and type II topoisomerases. The book will include basic biochemical and structural reviews for the cancer-relevant topoisomerases. It will describe how topoisomerase dysfunctions can damage the genome and increase the risk of cancers, and the involvement of topoisomerases in programmed cell death. The book will also present the various topoisomerase inhibitors in clinical use and development and their molecular and cellular mechanisms of action.

DNA Topoisomerases in Cancer Therapy Book

DNA Topoisomerases in Cancer Therapy


  • Author : Toshiwo Andoh
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-06
  • Genre: Science
  • Pages : 202
  • ISBN 10 : 9781461501411

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DNA Topoisomerases in Cancer Therapy Excerpt :

In the mid 80's type I and II enzymes were found to be the intracellular targets of a number of efficacious anticancer drugs such as doxorubicin, mitoxantrone, etoposide and camptothecin as a result of a continued efforts of many investigators, especially Leroy Liu and his collaborators at Johns Hopkins University. Readers will find a series of chapters written by researchers actively engaged in the expanding field of topoisomerase and their inhibitors. The series of chapters cover review articles on pharmacology and the molecular mechanism of topoisomerase I- and II-targeting anticancer drugs in mammals and in the yeast Saccharomyces cerevisiae, which has proved to be a superb model organism for studies of anticancer drugs. This volume compiles up-to-date information on the topoisomerase-targeting compounds in clinical and preclinical development as a useful and important reference book for students and researchers in the field of pharmacology, toxicology, oncology and molecular biology.

Cytotoxic Payloads for AntibodyDrug Conjugates Book

Cytotoxic Payloads for AntibodyDrug Conjugates


  • Author : David E Thurston
  • Publisher : Royal Society of Chemistry
  • Release Date : 2019-07-11
  • Genre: Medical
  • Pages : 480
  • ISBN 10 : 9781788018456

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Cytotoxic Payloads for AntibodyDrug Conjugates Excerpt :

Antibody–drug conjugates (ADCs) represent one of the most promising and exciting areas of anticancer drug discovery. Five ADCs are now approved in the US and EU [i.e., ado-trastuzumab emtansine (KadcylaTM), brentuximab vedotin (AdcetrisTM), inotuzumab ozogamicin (BesponsaTM), gemtuzumab ozogamicin (MylotargTM) and moxetumomab pasudotox-tdfk (Lumoxiti®)] and over 70 others are in various stages of clinical development, with impressive interim results being reported for many. The technology is based on the concept of delivering a cytotoxic payload selectively to cancer cells by attaching it to an antibody targeted to antigens on the cell surfaces. This approach has several advantages including the ability to select patients as likely responders based on the presence of antigen on the surface of their cancer cells and a wider therapeutic index, given that ADC targeting enables a more efficient delivery of cytotoxic agents to cancer cells than can be achieved by conventional chemotherapy, thus minimising systemic toxicity. Although there are many examples of antibodies that have been developed for this purpose, along with numerous linker technologies used to attach the cytotoxic agent to the antibody, there is presently a relatively small number of payload molecules in clinical use. The purpose of this book is to describe the variety of payloads used to date, along with a discussion of their advantages and disadvantages and to provide information on novel payloads at the research stage that may be used clinically in the future.

The DNA Replication Machinery as Therapeutic Targets Book

The DNA Replication Machinery as Therapeutic Targets


  • Author : Andrew F. Gardner
  • Publisher : Frontiers Media SA
  • Release Date : 2019-09-19
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : 9782889459278

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The DNA Replication Machinery as Therapeutic Targets Excerpt :

In all organisms, the DNA replication machinery is responsible for accurate and efficient duplication of the chromosome. Inhibitors of replication proteins are commonly used in anti-cancer and anti-viral therapies. This eBook on “The DNA Replication Machinery as Therapeutic Targets” examines the normal functions of replication proteins as well as strategies to target each step during the replication process including DNA unwinding, DNA synthesis, and DNA damage bypass and repair. Articles discuss current strategies to develop drugs targeting DNA replication proteins as well as future outlooks and needs.

DNA Topology Book

DNA Topology


  • Author : Andrew D. Bates
  • Publisher : Oxford University Press, USA
  • Release Date : 2005
  • Genre: Science
  • Pages : 198
  • ISBN 10 : 019856709X

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DNA Topology Excerpt :

"A key aspect of DNA is its ability to form a variety of structures, this book explains the origins and importance of such structures"--Provided by publisher.

Untangling the Double Helix Book

Untangling the Double Helix


  • Author : James C. Wang
  • Publisher : Unknown
  • Release Date : 2009
  • Genre: Science
  • Pages : 233
  • ISBN 10 : UOM:39015080851556

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Untangling the Double Helix Excerpt :

The problem of unraveling two intertwined strands during the duplication of DNA was recognized shortly after the proposal of the DNA double helix structure in 1953. A group of enzymes called DNA topoisomerases solve this problem by breaking and rejoining DNA molecules in a controlled manner, thereby allowing strands to be passed through each other and thus untangled—not just during DNA replication, but also during many other basic cellular processes. Because of their intimate involvement in the workings of the cell, topoisomerases are also the logical targets of many antibiotics (including Cipro) and anticancer agents. This book, written by James Wang, the discoverer of the first topoisomerase and a leader in the field since, presents ten chapters covering the historical backdrop of the DNA entanglement problem and the discovery of the DNA topoisomerases, how DNA topoisomerases perform their magic in DNA replication, transcription, genetic recombination and chromosome condensation, and how they are targets of therapeutic agents. The book should appeal to readers from undergraduates upwards with interests in the biological and clinical aspects of topoisomerase function, or in the mathematics and physics of topology.

Metallo Drugs  Development and Action of Anticancer Agents Book

Metallo Drugs Development and Action of Anticancer Agents


  • Author : Astrid Sigel
  • Publisher : Walter de Gruyter GmbH & Co KG
  • Release Date : 2018-02-05
  • Genre: Science
  • Pages : 588
  • ISBN 10 : 9783110470734

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Metallo Drugs Development and Action of Anticancer Agents Excerpt :

Volume 18, entitled Metallo-Drugs: Development and Action of Anticancer Agents of the series Metal Ions in Life Sciences centers on biological, medicinal inorganic chemistry. The serendipitous discovery of the antitumor activity of cis-diamminodichloroplatinum(II) (cisplatin) by Barnett Rosenberg in the 1960s is a landmark in metallodrug-based chemotherapy. The success of cisplatin in the clinic, followed by oxaliplatin and carboplatin, along with their drawbacks relating mainly to resistance development and severe toxicity, initiated research on polynuclear platinum complexes and on Pt(IV) complexes as prodrugs. Furthermore, the indicated shortcomings led to the exploration of other transition and main group metal ions, among them Ru(II/III), Au(I/III), Ti(IV), V(IV/V), and Ga(III) including also the essential metal ions Fe(II/III), Cu(I/II), and Zn(II). Ionic as well as covalent and non-covalent interactions between structurally very different complexes and biomolecules like nucleic acids, proteins, and carbohydrates are studied and discussed with regard to their possible anticancer actions. Hence, MILS-18 summarizes the research at the forefront of medicinal inorganic chemistry, including studies on the next-generation, tailor-made anticancer drugs. All this and more is treated in an authoritative and timely manner in the 17 stimulating chapters of this book, written by 39 internationally recognized experts from 10 nations (from the US via Europe to China and Australia). The impact of this vibrant research area is manifested by more than 2700 references, nearly 150 illustrations (more than half in color) and several comprehensive tables. Metallo-Drugs: Development and Action of Anticancer Agents is an essential resource for scientists working in the wide range from enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine including the clinic ... not forgetting that it also provides excellent information for te

DNA Topoisomearases  Biochemistry and Molecular Biology Book

DNA Topoisomearases Biochemistry and Molecular Biology


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 1994-11-07
  • Genre: Science
  • Pages : 320
  • ISBN 10 : 008058120X

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DNA Topoisomearases Biochemistry and Molecular Biology Excerpt :

Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental.

DNA Topoisomerases and Cancer Book

DNA Topoisomerases and Cancer


  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2011-09-21
  • Genre: Uncategoriezed
  • Pages : 456
  • ISBN 10 : 1461403243

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DNA Topoisomerases and Cancer Excerpt :

PARP Inhibitors for Cancer Therapy Book

PARP Inhibitors for Cancer Therapy


  • Author : Nicola J. Curtin
  • Publisher : Humana Press
  • Release Date : 2015-06-13
  • Genre: Medical
  • Pages : 591
  • ISBN 10 : 9783319141510

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PARP Inhibitors for Cancer Therapy Excerpt :

PARP Inhibitors for Cancer Therapy provides a comprehensive overview of the role of PARP in cancer therapy. The volume covers the history of the discovery of PARP (poly ADP ribose polymerase) and its role in DNA repair. In addition, a description of discovery of the PARP family, and other DNA maintenance-associated PARPs will also be discussed. The volume also features a section on accessible chemistry behind the development of inhibitors. PARP inhibitors are a group of pharmacological inhibitors that are a particularly good target for cancer therapy. PARP plays a pivotal role in DNA repair and may contribute to the therapeutic resistance to DNA damaging agents used to treat cancer. Researchers have learned a tremendous amount about the biology of PARP and how tumour-specific defects in DNA repair can be exploited by PARPi. The “synthetic lethality” of PARPi is an exciting concept for cancer therapy and has led to a heightened activity in this area.

Cancer Chemotherapy and Biotherapy Book

Cancer Chemotherapy and Biotherapy


  • Author : Bruce A. Chabner
  • Publisher : Lippincott Williams & Wilkins
  • Release Date : 2011-12-07
  • Genre: Medical
  • Pages : 848
  • ISBN 10 : 9781451148206

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Cancer Chemotherapy and Biotherapy Excerpt :

Updated to include the newest drugs and those currently in development, this Fifth Edition is a comprehensive reference on the preclinical and clinical pharmacology of anticancer agents. Organized by drug class, the book provides the latest information on all drugs and biological agents—their mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance. The authors explain the rationale for use of drugs in specific schedules and combinations and offer guidelines for dose adjustment in particular situations. This edition's introduction includes timely information on general strategies for drug usage, the science of drug discovery and development, economic and regulatory aspects of cancer drug development, and principles of pharmacokinetics. Eight new chapters have been added and more than twenty have been significantly revised. A companion website includes the fully searchable text and an image bank.

Camptothecins in Cancer Therapy Book

Camptothecins in Cancer Therapy


  • Author : Val R. Adams
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-10-27
  • Genre: Medical
  • Pages : 460
  • ISBN 10 : 9781592598663

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Camptothecins in Cancer Therapy Excerpt :

A critical review our current understanding of camptothecins, their shortcomings, and of the possibilities for improving their clinical performance. The authors discuss new camptothecin analog development, drug delivery issues for optimizing their anticancer activity, and their potential use in a variety of different cancers. Additional chapters describe what is known about the biochemistry, the pharmacology, and the chemistry of the camptothecins, including the mechanism of topoisomerase and how camptothecins poison this enzyme, the use of animal models in defining the anticancer potential of camptothecins, and the question of camptothecin resistance.

Medicinal Chemistry of Anticancer Drugs Book

Medicinal Chemistry of Anticancer Drugs


  • Author : Carmen Avendano
  • Publisher : Elsevier
  • Release Date : 2015-06-11
  • Genre: Science
  • Pages : 768
  • ISBN 10 : 9780444626677

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Medicinal Chemistry of Anticancer Drugs Excerpt :

Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design. Presents information in a clear and concise way using a large number of figures Historical background provides insights on how the process of drug discovery in the anticancer field has evolved Extensive references to primary literature

Experimental Therapeutics Book

Experimental Therapeutics


  • Author : Martin Wilkins
  • Publisher : CRC Press
  • Release Date : 2003-03-27
  • Genre: Medical
  • Pages : 248
  • ISBN 10 : 1841842907

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Experimental Therapeutics Excerpt :

As a general rule, for every 10,000 molecules screened in a given program in the laboratory, only one will survive to launch. To minimize costs, companies need to catch potential failures, due either to lack of clinical effect or toxicity, in the early discovery phase, long before they reach patients. Experimental Therapeutics introduces the dynamic and competitive discipline of experimental medicine. Informative, concise, and easy-to-read, the book emphasizes what scientists involved in drug discovery need to know about the rapid advances made in molecular biology, genetics, and technology. Each chapter starts with a summary box, has several high yield boxes, tables, and figures and ends with a reference section that has key URLs and carefully selected references to scientific papers. The book is a useful primer for anyone working to advance the pharmacological management of disease.