Alzheimer s Disease Drug Development Book

Alzheimer s Disease Drug Development


  • Author : Jeffrey Cummings
  • Publisher : Cambridge University Press
  • Release Date : 2022-03-31
  • Genre: Business & Economics
  • Pages : 575
  • ISBN 10 : 9781108838665

DOWNLOAD BOOK
Alzheimer s Disease Drug Development Excerpt :

Provides a definitive overview of the complex ecosystem facilitating Alzheimer's Disease drug research and development. Demonstrates a drug's journey from in the lab, clinical trial testing, regulatory review, and marketing by pharmaceutical companies. Details the use of artificial intelligence, clinical trial management, and financing models.

Drug Design and Discovery in Alzheimer   s Disease Book

Drug Design and Discovery in Alzheimer s Disease


  • Author : Atta-ur-Rahman
  • Publisher : Elsevier
  • Release Date : 2015-06-27
  • Genre: Science
  • Pages : 784
  • ISBN 10 : 9780128039601

DOWNLOAD BOOK
Drug Design and Discovery in Alzheimer s Disease Excerpt :

Drug Design and Discovery in Alzheimer’s Disease includes expert reviews of recent developments in Alzheimer's disease (AD) and neurodegenerative disease research. Originally published by Bentham as Frontiers in Drug Design and Discovery, Volume 6and now distributed by Elsevier, this compilation of the sixteen articles, written by leading global researchers, focuses on key developments in the understanding of the disease at molecular levels, identification and validation of molecular targets, as well as innovative approaches towards drug discovery, development, and delivery. Beginning with an overview of AD pharmacotherapy and existing blockbuster drugs, the reviews cover the potential of both natural and synthetic small molecules; the role of cholinesterases in the on-set and progression of AD and their inhibition; the role of beta-site APP clearing enzyme-1 (BACE-1) in the production of ß-amyloid proteins, one of the key reasons of the progression of AD; and other targets identified for AD drug discovery. Edited and written by leading experts in Alzheimer’s disease (AD) and other neurodegenerative disease drug development Describes existing drugs for AD and current molecular understanding of the condition Reviews recent advances in the field, including coverage of cholinesterases, BACE-1, and other drug development targets

Alzheimer s Disease Book

Alzheimer s Disease


  • Author : Xudong Huang
  • Publisher : Unknown
  • Release Date : 2020-12-31
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : 0645001708

DOWNLOAD BOOK
Alzheimer s Disease Excerpt :

Drug Design and Discovery in Alzheimer s Disease Book

Drug Design and Discovery in Alzheimer s Disease


  • Author : Atta-Ur-Rahman
  • Publisher : Bentham Science Publishers
  • Release Date : 2015-06-02
  • Genre: Uncategoriezed
  • Pages : 784
  • ISBN 10 : 0128039590

DOWNLOAD BOOK
Drug Design and Discovery in Alzheimer s Disease Excerpt :

Drug Design and Discovery in Alzheimer's Disease includes expert reviews of recent developments in Alzheimer's disease (AD) and neurodegenerative disease research. Originally published by Bentham as Frontiers in Drug Design and Discovery, Volume 6and now distributed by Elsevier, this compilation of the sixteen articles, written by leading global researchers, focuses on key developments in the understanding of the disease at molecular levels, identification and validation of molecular targets, as well as innovative approaches towards drug discovery, development, and delivery. Beginning with an overview of AD pharmacotherapy and existing blockbuster drugs, the reviews cover the potential of both natural and synthetic small molecules; the role of cholinesterases in the on-set and progression of AD and their inhibition; the role of beta-site APP clearing enzyme-1 (BACE-1) in the production of ß-amyloid proteins, one of the key reasons of the progression of AD; and other targets identified for AD drug discovery. Edited and written by leading experts in Alzheimer's disease (AD) and other neurodegenerative disease drug development Describes existing drugs for AD and current molecular understanding of the condition Reviews recent advances in the field, including coverage of cholinesterases, BACE-1, and other drug development targets

Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders Book

Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders


  • Author : Adeboye Adejare
  • Publisher : Academic Press
  • Release Date : 2016-09-20
  • Genre: Medical
  • Pages : 316
  • ISBN 10 : 9780128028117

DOWNLOAD BOOK
Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders Excerpt :

Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders: Alzheimer’s Disease examines the drug discovery process for neurodegenerative diseases by focusing specifically on Alzheimer’s Disease and illustrating the paradigm necessary to ensure future research and treatment success. The book explores diagnosis, epidemiology, drug discovery strategies, current therapeutics, and much more to provide a holistic approach to the discovery, development, and treatment of Alzheimer’s Disease. Through its coverage of the latest research in targeted drug design, preclinical studies, and mouse and rat models, the book is a must-have resource for all pharmaceutical scientists, pharmacologists, neuroscientists, and clinical researchers working in this area. It illustrates why these drugs tend to fail at the clinical stage, and examines Alzheimer’s Disease within the overall context of improving the drug discovery process for the treatment of other neurodegenerative disorders. Provides a compilation of chemical considerations required in drug discovery for the treatment of neurodegenerative disorders Examines different classes of compounds currently being used in discovery and development stages Explores in vitro and in vivo models with respect to their ability to translate these models to human conditions Distills the most significant information across multiple areas of Alzheimer’s disease research to provide a single, comprehensive, and balanced resource

Computational Modeling of Drugs Against Alzheimer   s Disease Book

Computational Modeling of Drugs Against Alzheimer s Disease


  • Author : Kunal Roy
  • Publisher : Humana Press
  • Release Date : 2017-09-29
  • Genre: Medical
  • Pages : 645
  • ISBN 10 : 1493974033

DOWNLOAD BOOK
Computational Modeling of Drugs Against Alzheimer s Disease Excerpt :

This volume describes different computational methods encompassing ligand-based approaches (QSAR, pharmcophore), structure-based approaches (homology modeling, docking, molecular dynamics simulation), and combined approaches (virtual screening) with applications in anti-Alzheimer drug design. Different background topics like molecular etiologies of Alzheimer’s disease, targets for new drug development, and different cheminformatic modeling strategies are covered for completeness. Special topics like multi-target drug development, natural products, protein misfolding, and nanomaterials are also included in connection with computational modeling of anti-Alzheimer drug development. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and authoritative, Computational Modeling of Drugs Against Alzheimer’s Disease is a valuable resource for learning about the latest computational techniques used to study this disease.

Frontiers in CNS Drug Discovery Book

Frontiers in CNS Drug Discovery


  • Author : Atta-ur- Rahman
  • Publisher : Bentham Science Publishers
  • Release Date : 2017-12-19
  • Genre: Medical
  • Pages : 264
  • ISBN 10 : 9781681084435

DOWNLOAD BOOK
Frontiers in CNS Drug Discovery Excerpt :

Frontiers in CNS Drug Discovery is a book series devoted to publishing reviews which highlight the latest advances in drug design and discovery for disorders of the central nervous system (CNS). Eminent scientists write contributions on all areas of CNS drug design and drug discovery, including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The book series is essential reading for all pharmaceutical scientists involved in CNS drug design and discovery who wish to keep abreast of rapid and important developments in the field. The third volume of this series brings reviews on brain tumor treatment, neurodegeneration, hyperalgesia, cholinesterase inhibition and much more.

BACE Book

BACE


  • Author : Varghese John
  • Publisher : John Wiley & Sons
  • Release Date : 2010-03-15
  • Genre: Medical
  • Pages : 282
  • ISBN 10 : 9780470293423

DOWNLOAD BOOK
BACE Excerpt :

BACE inhibitors and their use in the treatment of Alzheimer's Disease BACE (β-site of APP cleaving enzyme) is a critical component in Alzheimer's Disease (AD), and the development of BACE inhibitors shows great potential as a therapy for the disease. BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease covers virtually all aspects of BACE from initial identification, discovery of inhibitors, and challenges in clinical development, while providing a global understanding essential for productive and successful drug discovery. This book details the story of the discovery of BACE and its role in AD and comprehensively discusses: The development of BACE inhibitors as therapeutics for Alzheimer's disease The research that led to the identification of BACE New BACE inhibitors currently being clinically tested ADME (absorption, distribution, metabolism, excretion) and clinical trial design—topics not addressed in current field literature Cutting-edge technology such as high-throughput screening, structure-based drug design, and QSAR in context of BACE inhibitors and Alzheimer's drug discovery Other approaches to BACE inhibition based on interaction with the precursor protein APP By enhancing the reader's understanding of the various aspects of the BACE drug-discovery process, this much-needed reference will serve as a key resource for all scientists involved in Alzheimer's research—and inspire new approaches to treatment of AD.

Emerging Drugs and Targets for Alzheimer s Disease Book

Emerging Drugs and Targets for Alzheimer s Disease


  • Author : Ana Martinez
  • Publisher : Royal Society of Chemistry
  • Release Date : 2010
  • Genre: Medical
  • Pages : 327
  • ISBN 10 : 9781849730648

DOWNLOAD BOOK
Emerging Drugs and Targets for Alzheimer s Disease Excerpt :

This volume describes the discovery and development history of the most promising drugs now in development for combating Alzheimer's disease.

Drug Discovery and Development for Alzheimer s Disease  2000 Book

Drug Discovery and Development for Alzheimer s Disease 2000


  • Author : Institute for the Study of Aging
  • Publisher : Unknown
  • Release Date : 2002-01-03
  • Genre: Medical
  • Pages : 306
  • ISBN 10 : UOM:39015047515849

DOWNLOAD BOOK
Drug Discovery and Development for Alzheimer s Disease 2000 Excerpt :

This prestigious volume presents the findings of an international group of academic and biotechnological researchers. Topics range from early detection programs focusing on genetic factors, novel probes for detecting B-amyloid in the living brain, and the use of telephonic screening and MRI's to the diversity of therapeutic areas such as antioxidants, estrogen agonists and various anti-B-amyloid and anti-tangle approaches. The volume is still an indispensable resource for the psychogeriatrician, psychiatrist, clinical investigator, and neurobiologist, and a must for medical libraries.

Computational Approaches for Identifying Drugs Against Alzheimer s Disease Book

Computational Approaches for Identifying Drugs Against Alzheimer s Disease


  • Author : Radha Mahendran
  • Publisher : Anchor Academic Publishing
  • Release Date : 2017-05
  • Genre: Computers
  • Pages : 73
  • ISBN 10 : 9783960671381

DOWNLOAD BOOK
Computational Approaches for Identifying Drugs Against Alzheimer s Disease Excerpt :

Alzheimer’s disease is the most common form of dementia which is incurable. Although some kinds of memory loss are normal during aging, these are not severe enough to interfere with the level of function. ß-Secretase is an important protease in the pathogenesis of Alzheimer’s disease. Some statine-based peptidomimetics show inhibitory activities to the ß-secretase. To explore the inhibitory mechanism, molecular docking and three-dimensional quantitative structure-activity relationship (3D-QSAR) studies on these analogues were performed. Quantitative structure-activity relationship (QSAR) modeling pertains to the construction of predictive models of biological activities as a function of structural and molecular information of a compound library. The concept of QSAR has typically been used for drug discovery and development and has gained wide applicability for correlating molecular information with not only biological activities but also with other physicochemical properties, which has therefore been termed quantitative structure-property relationship (QSPR). In this study, 3D QSAR and pharmacophore mapping studies were carried out using Accelrys Discovery Studio 2.1. The best nine drugs were selected from the 16 ligands and pharmacophore features were generated.

Frontiers in Clinical Drug Research   Alzheimer Disorders Book

Frontiers in Clinical Drug Research Alzheimer Disorders


  • Author : Atta -Ur Rahman
  • Publisher : Frontiers in Clinical Drug Res
  • Release Date : 2018-11-02
  • Genre: Medical
  • Pages : 276
  • ISBN 10 : 1681085615

DOWNLOAD BOOK
Frontiers in Clinical Drug Research Alzheimer Disorders Excerpt :

Frontiers in Clinical Drug Research - Alzheimer Disorders will be of particular interest to readers interested in drug therapy of this specific neurodegenerative condition and related brain disorders as the series provides relevant reviews written by experts in the field of Alzheimer's disease research.The seventh volume of this series features chapters covering critical discussions on AD biochemistry and new therapies. The reviews in this volume include: - Deep Brain Stimulation in the Treatment of Alzheimer's disease- ASS234: A New and Promising Anti-Alzheimer Agent- Recent Advances in Alzheimer's Drug Discovery Research- Alzheimer's Disease and Proteasome: The Therapeutic Development and Management- Alzheimer ́s Disease: Fundamental Concepts, Novel Findings and Therapeutics Outcomes Coming from the Ca2+/cAMP Signalling Interaction- Alzheimer's Disease: An Approach for Non-Pharmacological Therapies- Past and Present Drug Development for Alzheimer's Disease

Emerging Drugs and Targets for Alzheimer s Disease Book

Emerging Drugs and Targets for Alzheimer s Disease


  • Author : Ana Martinez
  • Publisher : Unknown
  • Release Date : 2010-05-07
  • Genre: Uncategoriezed
  • Pages : 668
  • ISBN 10 : 1849730458

DOWNLOAD BOOK
Emerging Drugs and Targets for Alzheimer s Disease Excerpt :

A comprehensive 2-volume complete set that collects some of the most promising examples of new drugs currently under pharmaceutical development that will reach the Alzheimer's drug market over the next few years as disease-modifying therapeutics.

Design of Hybrid Molecules for Drug Development Book

Design of Hybrid Molecules for Drug Development


  • Author : Michael Decker
  • Publisher : Elsevier
  • Release Date : 2017-04-05
  • Genre: Science
  • Pages : 352
  • ISBN 10 : 9780081011188

DOWNLOAD BOOK
Design of Hybrid Molecules for Drug Development Excerpt :

Design of Hybrid Molecules for Drug Development reviews the principles, advantages, and limitations involved with designing these groundbreaking compounds. Beginning with an introduction to hybrid molecule design and background as to their need, the book goes on to explore a range of important hybrids, with hybrids containing natural products, molecules containing NO- and H2S-donors, dual-acting compounds acting as receptor ligands and enzyme inhibitors, and the design of photoresponsive drugs all discussed. Drawing on practical case studies, the hybridization of molecules for development as treatments for a number of key diseases is then outlined, including the design of hybrids for Alzheimer's, cancer, and malaria. With its cutting-edge reviews of breaking developments in this exciting field, the book offers a novel approach for all those working in the design, development, and administration of drugs for a range of debilitating disorders. Highlights an approach unimpaired by the limitations of the classical search for lead structures - one of the core problems in modern drug development processes, making the content of high relevance for both academic and non-academic drug development processes Pulls together research and design techniques in a novel way to give researchers the best possible platform from which to review the approaches and techniques applied Compares the advantages and disadvantages of these compounds Includes the very latest developments, such as photoactivatable and photo-responsive drugs

Improving and Accelerating Therapeutic Development for Nervous System Disorders Book

Improving and Accelerating Therapeutic Development for Nervous System Disorders


  • Author : Institute of Medicine
  • Publisher : National Academies Press
  • Release Date : 2014-02-06
  • Genre: Medical
  • Pages : 118
  • ISBN 10 : 9780309292498

DOWNLOAD BOOK
Improving and Accelerating Therapeutic Development for Nervous System Disorders Excerpt :

Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.