Drug like Properties  Concepts  Structure Design and Methods Book

Drug like Properties Concepts Structure Design and Methods


  • Author : Li Di
  • Publisher : Elsevier
  • Release Date : 2010-07-26
  • Genre: Science
  • Pages : 552
  • ISBN 10 : 9780080557618

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Drug like Properties Concepts Structure Design and Methods Book Description :

Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties. * Serves as an essential working handbook aimed at scientists and students in medicinal chemistry * Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies * Discusses improvements in pharmacokinetics from a practical chemist's standpoint

Drug like Properties Book

Drug like Properties


  • Author : Edward Harvel Kerns
  • Publisher :
  • Release Date : 2008
  • Genre: Medical
  • Pages : 526
  • ISBN 10 : 0123695201

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Drug like Properties Book Description :

Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties. * Serves as an essential working handbook aimed at scientists and students in medicinal chemistry * Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies * Discusses improvements in pharmacokinetics from a practical chemist's standpoint

Drug Like Properties Book

Drug Like Properties


  • Author : Li Di
  • Publisher : Academic Press
  • Release Date : 2015-12-17
  • Genre: Science
  • Pages : 580
  • ISBN 10 : 9780128013229

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Drug Like Properties Book Description :

Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including solubility and permeability, before exploring how compounds are absorbed, distributed, and metabolized safely and stably. Review chapters provide context and underscore the importance of key concepts such as pharmacokinetics, toxicity, the blood-brain barrier, diagnosing drug limitations, prodrugs, and formulation. Building on those foundations, this thoroughly updated revision covers a wide variety of current methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties for process and product improvement. From conducting key assays for interpretation and structural analysis, the reader learns to implement modification methods and improve each ADME property. Through valuable case studies, structure-property relationship descriptions, and structure modification strategies, Drug-Like Properties, Second Edition, offers tools and methods for ADME/Tox scientists through all aspects of drug research, discovery, design, development, and optimization. Provides a comprehensive and valuable working handbook for scientists and students in medicinal chemistry Includes expanded coverage of pharmacokinetics fundamentals and effects Contains updates throughout, including the authors’ recent work in the importance of solubility in drug development; new and currently us

Discovering and Developing Molecules with Optimal Drug Like Properties Book
Score: 5
From 1 Ratings

Discovering and Developing Molecules with Optimal Drug Like Properties


  • Author : Allen C Templeton
  • Publisher : Springer
  • Release Date : 2014-10-31
  • Genre: Medical
  • Pages : 511
  • ISBN 10 : 9781493913992

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Discovering and Developing Molecules with Optimal Drug Like Properties Book Description :

This authoritative volume provides a contemporary view on the latest research in molecules with optimal drug-like properties. It is a valuable source to access current best practices as well as new research techniques and strategies. Written by leading scientists in their fields, the text consists of fourteen chapters with an underlying theme of early collaborative opportunities between pharmaceutical and discovery sciences. The book explores the practical realities of performing physical pharmaceutical and biopharmaceutical research in the context of drug discovery with short timelines and low compound availability. Chapters cover strategies and tactics to enable discovery as well as predictive approaches to establish, understand and communicate risks in early development. It also examines the detection, characterization, and assessment of risks on the solid state properties of advanced discovery and early development candidates, highlighting the link between solid state properties and critical development parameters such as solubility and stability. Final chapters center on techniques to improve molecular solubilization and prevent precipitation, with particularly emphasis on linking physiochemical properties of molecules to formulation selection in preclinical and clinical settings.

Optimizing the  Drug Like  Properties of Leads in Drug Discovery Book
Score: 4
From 1 Ratings

Optimizing the Drug Like Properties of Leads in Drug Discovery


  • Author : Ronald Borchardt
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-12-31
  • Genre: Medical
  • Pages : 512
  • ISBN 10 : 0387449612

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Optimizing the Drug Like Properties of Leads in Drug Discovery Book Description :

This book arises from a workshop organized by the American Association of Pharmaceutical Scientists entitled "Optimizing the Drug-Like Properties of Leads in Drug Discovery," which took place in Parsippany, NJ in September 2004. The workshop focused on the optimization of the drug-like properties of leads in drug discovery. The volume outlines strategies and methodologies designed to guide pharmaceutical and biotechnology companies through the drug discovery and development process.

ADMET for Medicinal Chemists Book

ADMET for Medicinal Chemists


  • Author : Katya Tsaioun
  • Publisher : John Wiley & Sons
  • Release Date : 2011-02-15
  • Genre: Medical
  • Pages : 512
  • ISBN 10 : 0470922818

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ADMET for Medicinal Chemists Book Description :

This book guides medicinal chemists in how to implement early ADMET testing in their workflow in order to improve both the speed and efficiency of their efforts. Although many pharmaceutical companies have dedicated groups directly interfacing with drug discovery, the scientific principles and strategies are practiced in a variety of different ways. This book answers the need to regularize the drug discovery interface; it defines and reviews the field of ADME for medicinal chemists. In addition, the scientific principles and the tools utilized by ADME scientists in a discovery setting, as applied to medicinal chemistry and structure modification to improve drug-like properties of drug candidates, are examined.

Drug Metabolism and Pharmacokinetics Quick Guide Book

Drug Metabolism and Pharmacokinetics Quick Guide


  • Author : Siamak Cyrus Khojasteh
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-04-07
  • Genre: Medical
  • Pages : 214
  • ISBN 10 : 1441956298

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Drug Metabolism and Pharmacokinetics Quick Guide Book Description :

Drug Metabolism and Pharmacokinetics Quick Guide covers a number of aspects of drug assessment at drug discovery and development stages, topics such as pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations. It covers key concepts, with useful tables on physiological parameters (eg. blood flow to organs in x-species, expression and localization of enzymes and transporters), chemical structure, nomenclature, and moieties leading to bioactivation (with examples). Overall it includes a number of key topics useful at the drug discovery stage, which would serve as a quick reference with several examples from the literature to illustrate the concept.

Blood Brain Barrier in Drug Discovery Book

Blood Brain Barrier in Drug Discovery


  • Author : Li Di
  • Publisher : John Wiley & Sons
  • Release Date : 2015-02-02
  • Genre: Medical
  • Pages : 600
  • ISBN 10 : 9781118788356

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Blood Brain Barrier in Drug Discovery Book Description :

Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant – and most challenging – areas of drug discovery. • Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects • Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies • Covers BBB physiology, medicinal chemistry design principles, free drug hypothesis for the BBB, and transport mechanisms including passive diffusion, uptake/efflux transporters, and receptor-mediated processes • Highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK) • Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths to the market

Pattern Recognition in Bioinformatics Book

Pattern Recognition in Bioinformatics


  • Author : Visakan Kadirkamanathan
  • Publisher : Springer
  • Release Date : 2009-08-31
  • Genre: Science
  • Pages : 452
  • ISBN 10 : 9783642040313

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Pattern Recognition in Bioinformatics Book Description :

This book constitutes the refereed proceedings of the Fourth International Workshop on Pattern Recognition in Bioinformatics, PRIB 2009, held in Sheffield, UK, in September 2009. The 38 revised full papers presented were carefully reviewed and selected from numerous submissions. The topics covered by these papers range from image analysis for biomedical data to systems biology. The conference aims at crating a focus for the development and application of pattern recognition techniques in the biological domain.

Advances in Nucleic Acid Therapeutics Book

Advances in Nucleic Acid Therapeutics


  • Author : Sudhir Agrawal
  • Publisher : Royal Society of Chemistry
  • Release Date : 2019-02-08
  • Genre: Science
  • Pages : 541
  • ISBN 10 : 9781788017329

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Advances in Nucleic Acid Therapeutics Book Description :

The sequencing of the human genome and subsequent elucidation of the molecular pathways that are important in the pathology of disease have provided unprecedented opportunities for the development of new therapeutics. Nucleic acid-based drugs have emerged in recent years to yield extremely promising candidates for drug therapy to a wide range of diseases. Advances in Nucleic Acid Therapeutics is a comprehensive review of the latest advances in the field, covering the background of the development of nucleic acids for therapeutic purposes to the array of drug development approaches currently being pursued using antisense, RNAi, aptamer, immune modulatory and other synthetic oligonucleotides. Nucleic acid therapeutics is a field that has been continually innovating to meet the challenges of drug discovery and development; bringing contributions together from leaders at the forefront of progress, this book depicts the many approaches currently being pursued in both academia and industry. A go-to volume for medicinal chemists, Advances in Nucleic Acid Therapeutics provides a broad overview of techniques of contemporary interest in drug discovery.

Textbook of Drug Design and Discovery  Third Edition Book
Score: 3.5
From 5 Ratings

Textbook of Drug Design and Discovery Third Edition


  • Author : Tommy Liljefors
  • Publisher : CRC Press
  • Release Date : 2002-07-25
  • Genre: Medical
  • Pages : 592
  • ISBN 10 : 0415282888

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Textbook of Drug Design and Discovery Third Edition Book Description :

Building on the success of the previous editions, Textbook of Drug Design and Discovery has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The book follows drug design from the initial lead identification through optimization and structure-activity relationship with reference to the final processes of clinical evaluation and registration. Chapters investigate the design of enzyme inhibitors and drugs for particular cellular targets such as ion channels and receptors, and also explore specific classes of drug such as peptidomimetics, antivirals and anticancer agents. The use of gene technology in pharmaceutical research, computer modeling techniques, and combinatorial approaches are also included.

Drug Design Strategies Book

Drug Design Strategies


  • Author : David J. Livingstone
  • Publisher : Royal Society of Chemistry
  • Release Date : 2011-11
  • Genre: Medical
  • Pages : 498
  • ISBN 10 : 9781849731669

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Drug Design Strategies Book Description :

Shows how different parts of the drug discovery process have developed, with particular emphasis on quantitative aspects and possible future progress.

Modern Approaches in Drug Discovery Book

Modern Approaches in Drug Discovery


  • Author :
  • Publisher : Academic Press
  • Release Date : 2018-10-31
  • Genre: Science
  • Pages : 337
  • ISBN 10 : 9780128153840

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Modern Approaches in Drug Discovery Book Description :

Modern Approaches in Drug Discovery, Volume 611, the latest release in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Target Identification and Validation, Cell Painting/High Content Imaging, Target ID using chemical probes, Mining the microbiome for targets, Data driven approaches for diversity and drug-likeness, Affinity-based screening, Fragment screening (X-ray), Array-based approaches, Hit-to-lead: assessment and improvement of drug-like properties, Hit assessment and prioritization, Lead Optimization: fine tuning and risk mitigation, and more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series Updated release includes the latest information on the Intrinsically Disordered Proteins

Molecular Drug Properties Book

Molecular Drug Properties


  • Author : Raimund Mannhold
  • Publisher : John Wiley & Sons
  • Release Date : 2008-06-25
  • Genre: Science
  • Pages : 502
  • ISBN 10 : 9783527621293

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Molecular Drug Properties Book Description :

This first systematic overview for more than a decade is tailor-made for the medicinal chemist. All the chapters are written by experienced drug developers and include practical examples from real drug candidates. Following an introduction to global drug properties and their impact on drug research, screening and combinatorial chemistry libraries, this handbook demonstrates the best and fastest way to estimate those properties most relevant for the efficiency and pharmacokinetic performance of a drug molecule: lipophilicity,solubility, electronic properties and conformation.

Optimizing the  Drug Like  Properties of Leads in Drug Discovery Book
Score: 4
From 1 Ratings

Optimizing the Drug Like Properties of Leads in Drug Discovery


  • Author : Ronald Borchardt
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-12-31
  • Genre: Medical
  • Pages : 512
  • ISBN 10 : 0387449612

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Optimizing the Drug Like Properties of Leads in Drug Discovery Book Description :

This book arises from a workshop organized by the American Association of Pharmaceutical Scientists entitled "Optimizing the Drug-Like Properties of Leads in Drug Discovery," which took place in Parsippany, NJ in September 2004. The workshop focused on the optimization of the drug-like properties of leads in drug discovery. The volume outlines strategies and methodologies designed to guide pharmaceutical and biotechnology companies through the drug discovery and development process.

Encyclopedia of Cancer Book

Encyclopedia of Cancer


  • Author : Manfred Schwab
  • Publisher : Springer Science & Business Media
  • Release Date : 2008-09-23
  • Genre: Medical
  • Pages : 3235
  • ISBN 10 : 9783540368472

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Encyclopedia of Cancer Book Description :

This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. With an A-Z format of over 7,000 entries, more than 1,000 contributing authors provide a complete reference to cancer. The merging of different basic and clinical scientific disciplines towards the common goal of fighting cancer makes such a comprehensive reference source all the more timely.

Chemical Sciences in Early Drug Discovery Book

Chemical Sciences in Early Drug Discovery


  • Author : Pierfausto Seneci
  • Publisher : Elsevier
  • Release Date : 2018-06-05
  • Genre: Science
  • Pages : 194
  • ISBN 10 : 9780080999289

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Chemical Sciences in Early Drug Discovery Book Description :

Chemical Sciences in Early Drug Discovery: Medicinal Chemistry 2.0 describes how new technologies and approaches can be used to improve the probability of success in fulfilling the perennial goal of finding and developing new drugs. Drawing on the author's extensive experience consulting and teaching in medicinal chemistry, the book outlines ways in which medicinal chemistry is widening its reach to meet modern demands, and how modern technologies and approaches are facilitating this growth into new fields. Supported by examples throughout, the book is a practical resource for organic-medicinal chemists, biological chemists and pharmacologists involved in drug discovery. Reviews the key application of chemistry in drug discovery for both medicinal and non-medicinal chemists, clarifying and explaining the role of medicinal chemistry in supporting the modern drug discovery pipeline Shows how a wider medicinal chemistry view is essential for anyone in an integrated drug discovery project looking to reduce costs and save time Provides the critical success factors needed to successfully identify hits from both biological and chemical perspectives

Engineering of Biomaterials for Drug Delivery Systems Book

Engineering of Biomaterials for Drug Delivery Systems


  • Author : Anilkumar Parambath
  • Publisher : Woodhead Publishing
  • Release Date : 2018-02-01
  • Genre: Technology & Engineering
  • Pages : 404
  • ISBN 10 : 9780081017517

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Engineering of Biomaterials for Drug Delivery Systems Book Description :

Engineering of Biomaterials for Drug Delivery Systems: Beyond Polyethylene Glycol examines the combined issues of PEGylation and viable biomaterials as alternatives. With a strong focus on polymeric biomaterials, the book first reviews the major issues associated with PEGylation and its use in vivo. Chapters then focus on alternative polymer systems for drug delivery systems. Finally, nanoparticles and future perspectives are examined. This book is a valuable resource for scientists and researchers in biomaterials, pharmaceuticals and nanotechnology, and all those who wish to broaden their knowledge in this field. Provides a self-contained work for the field of biomaterials for drug delivery Summarizes the current knowledge on PEGylation and strategies for bypassing it Presents research on an important, though under-represented issue in biomaterials Written by a world-class team of research scientists, engineers and clinicians

Discovering and Developing Molecules with Optimal Drug Like Properties Book
Score: 5
From 1 Ratings

Discovering and Developing Molecules with Optimal Drug Like Properties


  • Author : Allen C Templeton
  • Publisher : Springer
  • Release Date : 2014-10-31
  • Genre: Medical
  • Pages : 511
  • ISBN 10 : 9781493913992

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Discovering and Developing Molecules with Optimal Drug Like Properties Book Description :

This authoritative volume provides a contemporary view on the latest research in molecules with optimal drug-like properties. It is a valuable source to access current best practices as well as new research techniques and strategies. Written by leading scientists in their fields, the text consists of fourteen chapters with an underlying theme of early collaborative opportunities between pharmaceutical and discovery sciences. The book explores the practical realities of performing physical pharmaceutical and biopharmaceutical research in the context of drug discovery with short timelines and low compound availability. Chapters cover strategies and tactics to enable discovery as well as predictive approaches to establish, understand and communicate risks in early development. It also examines the detection, characterization, and assessment of risks on the solid state properties of advanced discovery and early development candidates, highlighting the link between solid state properties and critical development parameters such as solubility and stability. Final chapters center on techniques to improve molecular solubilization and prevent precipitation, with particularly emphasis on linking physiochemical properties of molecules to formulation selection in preclinical and clinical settings.

Screening Book

Screening


  • Author : Angela Dean
  • Publisher : Springer Science & Business Media
  • Release Date : 2006-07-28
  • Genre: Mathematics
  • Pages : 332
  • ISBN 10 : 9780387280141

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Screening Book Description :

The process of discovery in science and technology may require investigation of a large number of features, such as factors, genes or molecules. In Screening, statistically designed experiments and analyses of the resulting data sets are used to identify efficiently the few features that determine key properties of the system under study. This book brings together accounts by leading international experts that are essential reading for those working in fields such as industrial quality improvement, engineering research and development, genetic and medical screening, drug discovery, and computer simulation of manufacturing systems or economic models. Our aim is to promote cross-fertilization of ideas and methods through detailed explanations, a variety of examples and extensive references. Topics cover both physical and computer simulated experiments. They include screening methods for detecting factors that affect the value of a response or its variability, and for choosing between various different response models. Screening for disease in blood samples, for genes linked to a disease and for new compounds in the search for effective drugs are also described. Statistical techniques include Bayesian and frequentist methods of data analysis, algorithmic methods for both the design and analysis of experiments, and the construction of fractional factorial designs and orthogonal arrays. The material is accessible to graduate and research statisticians, and to engineers and chemists with a working knowledge of statistical ideas and techniques. It will be of interest to practitioners and researchers who wish to learn about useful methodologies from within their own area as well as methodologies that can be translated from one area to another.