Drug Repurposing in Cancer Therapy Book

Drug Repurposing in Cancer Therapy


  • Author : Kenneth K.W. To
  • Publisher : Academic Press
  • Release Date : 2020-07-29
  • Genre: Science
  • Pages : 458
  • ISBN 10 : 9780128199039

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Drug Repurposing in Cancer Therapy Excerpt :

Drug Repurposing in Cancer Therapy: Approaches and Applications provides comprehensive and updated information from experts in basic science research and clinical practice on how existing drugs can be repurposed for cancer treatment. The book summarizes successful stories that may assist researchers in the field to better design their studies for new repurposing projects. Sections discuss specific topics such as in silico prediction and high throughput screening of repurposed drugs, drug repurposing for overcoming chemoresistance and eradicating cancer stem cells, and clinical investigation on combination of repurposed drug and anticancer therapy. Cancer researchers, oncologists, pharmacologists and several members of biomedical field who are interested in learning more about the use of existing drugs for different purposes in cancer therapy will find this to be a valuable resource. Presents a systematic and up-to-date collection of the research underpinning the various drug repurposing approaches for a quick, but in-depth understanding on current trends in drug repurposing research Brings better understanding of the drug repurposing process in a holistic way, combining both basic and clinical sciences Encompasses a collection of successful stories of drug repurposing for cancer therapy in different cancer types

Drug Repurposing in Cancer Therapy Book

Drug Repurposing in Cancer Therapy


  • Author : Kenneth K.W. To
  • Publisher : Academic Press
  • Release Date : 2020-08-17
  • Genre: Science
  • Pages : 458
  • ISBN 10 : 9780128196687

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Drug Repurposing in Cancer Therapy Excerpt :

Drug Repurposing in Cancer Therapy: Approaches and Applications provides comprehensive and updated information from experts in basic science research and clinical practice on how existing drugs can be repurposed for cancer treatment. The book summarizes successful stories that may assist researchers in the field to better design their studies for new repurposing projects. Sections discuss specific topics such as in silico prediction and high throughput screening of repurposed drugs, drug repurposing for overcoming chemoresistance and eradicating cancer stem cells, and clinical investigation on combination of repurposed drug and anticancer therapy. Cancer researchers, oncologists, pharmacologists and several members of biomedical field who are interested in learning more about the use of existing drugs for different purposes in cancer therapy will find this to be a valuable resource. Presents a systematic and up-to-date collection of the research underpinning the various drug repurposing approaches for a quick, but in-depth understanding on current trends in drug repurposing research Brings better understanding of the drug repurposing process in a holistic way, combining both basic and clinical sciences Encompasses a collection of successful stories of drug repurposing for cancer therapy in different cancer types

Drug Repurposing Book

Drug Repurposing


  • Author : Farid A. Badria
  • Publisher : BoD – Books on Demand
  • Release Date : 2020-12-02
  • Genre: Medical
  • Pages : 234
  • ISBN 10 : 9781839685200

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Drug Repurposing Excerpt :

Drug repurposing or drug repositioning is a new approach to presenting new indications for common commercial and clinically approved existing drugs. For example, chloroquine, an old antimalarial drug, showed promising results for treating COVID-19, interfering with MDR in several types of cancer, and chemosensitizing human leukemic cells.This book focuses on the hypothesis, risk/benefits, and economic impacts of drug repurposing on drug discovery in dermatology, infectious diseases, neurological disorders, cancer, and orphan diseases. It brings together up-to-date research to provide readers with an informative, illustrative, and easy-to-read book useful for students, clinicians, and the pharmaceutical industry.

Artificial Intelligence in Oncology Drug Discovery and Development Book

Artificial Intelligence in Oncology Drug Discovery and Development


  • Author : John Cassidy
  • Publisher : BoD – Books on Demand
  • Release Date : 2020-09-09
  • Genre: Medical
  • Pages : 192
  • ISBN 10 : 9781789846898

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Artificial Intelligence in Oncology Drug Discovery and Development Excerpt :

There exists a profound conflict at the heart of oncology drug development. The efficiency of the drug development process is falling, leading to higher costs per approved drug, at the same time personalised medicine is limiting the target market of each new medicine. Even as the global economic burden of cancer increases, the current paradigm in drug development is unsustainable. In this book, we discuss the development of techniques in machine learning for improving the efficiency of oncology drug development and delivering cost-effective precision treatment. We consider how to structure data for drug repurposing and target identification, how to improve clinical trials and how patients may view artificial intelligence.

Drug Repurposing Book

Drug Repurposing


  • Author : Shailendra K. Saxena
  • Publisher : BoD – Books on Demand
  • Release Date : 2022-06-01
  • Genre: Medical
  • Pages : 384
  • ISBN 10 : 9781839699573

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Drug Repurposing Excerpt :

This book focuses on various aspects and applications of drug repurposing, the understanding of which is important for treating diseases. Due to the high costs and time associated with the new drug discovery process, the inclination toward drug repurposing is increasing for common as well as rare diseases. A major focus of this book is understanding the role of drug repurposing to develop drugs for infectious diseases, including antivirals, antibacterial and anticancer drugs, as well as immunotherapeutics.

Conference on Drug Design and Discovery Technologies Book

Conference on Drug Design and Discovery Technologies


  • Author : Manikanta Murahari
  • Publisher : Royal Society of Chemistry
  • Release Date : 2019-11-20
  • Genre: Medical
  • Pages : 350
  • ISBN 10 : 9781788018623

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Conference on Drug Design and Discovery Technologies Excerpt :

This publication is based on peer-reviewed manuscripts from the 2019 Conference on Drug Design & Discovery Technologies (CDDT) held at Ramaiah University of Applied Sciences, India. Providing a wide range of up to date topics on the latest advancements in drug design and discovery technologies, this book ensures the reader receives a good understanding of the scope of the field. Aimed at scientists, students, regulators, academics and consultants throughout the world, this book is an ideal resource for anyone interested in the state of the art in drug design and discovery.

Drug Repositioning  Current Advances and Future Perspectives Book

Drug Repositioning Current Advances and Future Perspectives


  • Author : Yuhei Nishimura
  • Publisher : Frontiers Media SA
  • Release Date : 2019-01-11
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : 9782889456963

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Drug Repositioning Current Advances and Future Perspectives Excerpt :

Drug repositioning is the process of identifying new indications for existing drugs. At present, the conventional de novo drug discovery process requires an average of about 14 years and US$2.5 billion to approve and launch a drug. Drug repositioning can reduce the time and cost of this process because it takes advantage of drugs already in clinical use for other indications or drugs that have cleared phase I safety trials but have failed to show efficacy in the intended diseases. Historically, drug repositioning has been realized through serendipitous clinical observations or improved understanding of disease mechanisms. However, recent technological advances have enabled a more systematic approach to drug repositioning. This eBook collects 16 articles from 112 authors, providing readers with current advances and future perspectives of drug repositioning.

Chloroquine for Cancer  Covid 19  and Disease Book
Score: 5
From 1 Ratings

Chloroquine for Cancer Covid 19 and Disease


  • Author : Justus Hope
  • Publisher : Unknown
  • Release Date : 2020-05
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : 0998055409

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Chloroquine for Cancer Covid 19 and Disease Excerpt :

This is a book for physicians and the lay public to notify all about the benefits of repurposed drugs. These drugs can be used for life-saving purposes when no other effective treatments exist. Drug combinations aimed at Terminal Cancer and the Coronavirus Pandemic are both addressed.

Cancer Policy  Pharmaceutical Safety Book

Cancer Policy Pharmaceutical Safety


  • Author : June M. McKoy
  • Publisher : Springer
  • Release Date : 2018-12-14
  • Genre: Medical
  • Pages : 128
  • ISBN 10 : 9783319438962

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Cancer Policy Pharmaceutical Safety Excerpt :

Cancer Policy: Pharmaceutical Safety provides invaluable information on the interesting and compelling field of cancer drug safety. Identifying and understanding high-priority policy issues and key pharmacovigilance strategies is of paramount importance. In this volume, outstanding and original chapters provide an overview and synthesis of the latest thoughts and findings relating to drug safety in the cancer domain. Topics include natural language processing and pharmacovigilance of alternative cancer pharmaceuticals. The information presented in this volume will improve understanding of emerging strategies to identify adverse drug reactions and drug-drug interactions within the cancer setting and will highlight policies that have been instituted to improve cancer patient safety. In summary, Cancer Policy: Pharmaceutical Safety explores many of the important areas of pharmacovigilance research in oncology.

Drug Repurposing and Repositioning Book

Drug Repurposing and Repositioning


  • Author : Institute of Medicine
  • Publisher : National Academies Press
  • Release Date : 2014-08-08
  • Genre: Medical
  • Pages : 118
  • ISBN 10 : 9780309302074

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Drug Repurposing and Repositioning Excerpt :

Drug development can be time-consuming and expensive. Recent estimates suggest that, on average, it takes 10 years and at least $1 billion to bring a drug to market. Given the time and expense of developing drugs de novo, pharmaceutical companies have become increasingly interested in finding new uses for existing drugs - a process referred to as drug repurposing or repositioning. Historically, drug repurposing has been largely an unintentional, serendipitous process that took place when a drug was found to have an offtarget effect or a previously unrecognized on-target effect that could be used for identifying a new indication. Perhaps the most recognizable example of such a successful repositioning effort is sildenafil. Originally developed as an anti-hypertensive, sildenafil, marketed as Viagra and under other trade names, has been repurposed for the treatment of erectile dysfunction and pulmonary arterial hypertension. Viagra generated more than $2 billion worldwide in 2012 and has recently been studied for the treatment of heart failure. Given the widespread interest in drug repurposing, the Roundtable on Translating Genomic-Based Research for Health of the Institute of Medicine hosted a workshop on June 24, 2013, in Washington, DC, to assess the current landscape of drug repurposing activities in industry, academia, and government. Stakeholders, including government officials, pharmaceutical company representatives, academic researchers, regulators, funders, and patients, were invited to present their perspectives and to participate in workshop discussions. Drug Repurposing and Repositioning is the summary of that workshop. This report examines enabling tools and technology for drug repurposing; evaluates the business models and economic incentives for pursuing a repurposing approach; and discusses how genomic and genetic research could be positioned to better enable a drug repurposing paradigm.

Advanced AI Techniques and Applications in Bioinformatics Book

Advanced AI Techniques and Applications in Bioinformatics


  • Author : Loveleen Gaur
  • Publisher : CRC Press
  • Release Date : 2021-10-18
  • Genre: Computers
  • Pages : 282
  • ISBN 10 : 9781000463019

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Advanced AI Techniques and Applications in Bioinformatics Excerpt :

The advanced AI techniques are essential for resolving various problematic aspects emerging in the field of bioinformatics. This book covers the recent approaches in artificial intelligence and machine learning methods and their applications in Genome and Gene editing, cancer drug discovery classification, and the protein folding algorithms among others. Deep learning, which is widely used in image processing, is also applicable in bioinformatics as one of the most popular artificial intelligence approaches. The wide range of applications discussed in this book are an indispensable resource for computer scientists, engineers, biologists, mathematicians, physicians, and medical informaticists. Features: Focusses on the cross-disciplinary relation between computer science and biology and the role of machine learning methods in resolving complex problems in bioinformatics Provides a comprehensive and balanced blend of topics and applications using various advanced algorithms Presents cutting-edge research methodologies in the area of AI methods when applied to bioinformatics and innovative solutions Discusses the AI/ML techniques, their use, and their potential for use in common and future bioinformatics applications Includes recent achievements in AI and bioinformatics contributed by a global team of researchers

In Silico Drug Design Book

In Silico Drug Design


  • Author : Kunal Roy
  • Publisher : Academic Press
  • Release Date : 2019-02-12
  • Genre: Business & Economics
  • Pages : 886
  • ISBN 10 : 9780128163771

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In Silico Drug Design Excerpt :

In Silico Drug Design: Repurposing Techniques and Methodologies explores the application of computational tools that can be utilized for this approach. The book covers theoretical background and methodologies of chem-bioinformatic techniques and network modeling and discusses the various applied strategies to systematically retrieve, integrate and analyze datasets from diverse sources. Other topics include in silico drug design methods, computational workflows for drug repurposing, and network-based in silico screening for drug efficacy. With contributions from experts in the field and the inclusion of practical case studies, this book gives scientists, researchers and R&D professionals in the pharmaceutical industry valuable insights into drug design. Discusses the theoretical background and methodologies of useful techniques of cheminformatics and bioinformatics that can be applied for drug repurposing Offers case studies relating to the in silico modeling of FDA-approved drugs for the discovery of antifungal, anticancer, antiplatelet agents, and for drug therapies against diseases Covers tools and databases that can be utilized to facilitate in silico methods for drug repurposing