Drug Resistance in Colorectal Cancer  Molecular Mechanisms and Therapeutic Strategies Book

Drug Resistance in Colorectal Cancer Molecular Mechanisms and Therapeutic Strategies


  • Author : Chi Hin Cho
  • Publisher : Academic Press
  • Release Date : 2020-05-24
  • Genre: Science
  • Pages : 240
  • ISBN 10 : 9780128199381

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Drug Resistance in Colorectal Cancer Molecular Mechanisms and Therapeutic Strategies Excerpt :

Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies, Volume Eight, summarizes the molecular mechanisms of drug resistance in colorectal cancer, along with the most up-to-date therapeutic strategies available. The book discusses reasons why colorectal tumors become refractory during the progression of the disease, but also explains how drug resistance occurs during chemotherapy. In addition, users will find the current therapeutic strategies used by clinicians in their practice in treating colorectal cancer. The combination of conventional anticancer drugs with chemotherapy-sensitizing agents plays a pivotal role in improving the outcome of colorectal cancer patients, in particular those with drug-resistant cancer cells. From a clinical point-of-view, the content of this book provides clinicians with updated therapeutic strategies for a better choice of drugs for drug-resistant colorectal cancer patients. It will be a valuable source for cancer researchers, oncologists and several members of biomedical field who are dedicated to better treat patients with colorectal cancer. Presents a systemic summary of molecular mechanisms for a quick and in-depth understanding Updates current trends in the field with pioneering information on drug resistance Encompasses both basic and clinical approaches for a better understanding of unsolved problems from a holistic point-of-view

Colorectal Cancer Book

Colorectal Cancer


  • Author : Jindong Chen
  • Publisher : BoD – Books on Demand
  • Release Date : 2018-05-16
  • Genre: Medical
  • Pages : 128
  • ISBN 10 : 9781789231007

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Colorectal Cancer Excerpt :

With international experts sharing their experience and knowledge on these different aspects in the management of colorectal cancer, this book has this opportunity to offer all physicians treating colorectal cancer, as well as researchers, updated information concerning the biology, diagnosis, screening, and treatment of colorectal carcinoma. This book provides a detailed evaluation of diagnostic modalities, in-depth analysis of screening for colorectal cancer, recent advances in treatment, and principles and trends in the management of colorectal cancer. This updated knowledge will be an interesting and informative read for any clinician involved in the management of patients with colorectal cancer. In addition, readers such as related physicians, researchers, and colorectal cancer patients are potential beneficiaries of this book.

Drug Resistance in Colorectal Cancer  Molecular Mechanisms and Therapeutic Strategies Book

Drug Resistance in Colorectal Cancer Molecular Mechanisms and Therapeutic Strategies


  • Author : Chi Hin Cho
  • Publisher : Academic Press
  • Release Date : 2020-06-22
  • Genre: Science
  • Pages : 240
  • ISBN 10 : 9780128199374

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Drug Resistance in Colorectal Cancer Molecular Mechanisms and Therapeutic Strategies Excerpt :

Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies, Volume Eight, summarizes the molecular mechanisms of drug resistance in colorectal cancer, along with the most up-to-date therapeutic strategies available. The book discusses reasons why colorectal tumors become refractory during the progression of the disease, but also explains how drug resistance occurs during chemotherapy. In addition, users will find the current therapeutic strategies used by clinicians in their practice in treating colorectal cancer. The combination of conventional anticancer drugs with chemotherapy-sensitizing agents plays a pivotal role in improving the outcome of colorectal cancer patients, in particular those with drug-resistant cancer cells. From a clinical point-of-view, the content of this book provides clinicians with updated therapeutic strategies for a better choice of drugs for drug-resistant colorectal cancer patients. It will be a valuable source for cancer researchers, oncologists and several members of biomedical field who are dedicated to better treat patients with colorectal cancer. Presents a systemic summary of molecular mechanisms for a quick and in-depth understanding Updates current trends in the field with pioneering information on drug resistance Encompasses both basic and clinical approaches for a better understanding of unsolved problems from a holistic point-of-view

Mechanisms of Drug Resistance in Neoplastic Cells Book

Mechanisms of Drug Resistance in Neoplastic Cells


  • Author : Paul V. Woolley
  • Publisher : Elsevier
  • Release Date : 2017-01-31
  • Genre: Health & Fitness
  • Pages : 416
  • ISBN 10 : 9781483220758

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Mechanisms of Drug Resistance in Neoplastic Cells Excerpt :

Bristol-Myers Cancer Symposia, Volume 9: Mechanisms of Drug Resistance in Neoplastic Cells provides information on both basic scientific and clinical studies on the causes and implications of tumor cell resistance to common antineoplastic agents. The book describes the colon cancer as a model for resistance to antineoplastic drugs; mathematical modeling of drug resistance; and the mechanism of induced gene amplification in mammalian cells. The text also discusses the cellular concomitants of multidrug resistance; resistance to alkylating agents; and the phosphoprotein and protein kinase C changes in human multidrug-resistant cancer cells. Novel drugs that affect glutathione metabolism; the regulation of genes encoding drug-metabolizing enzymes in normal and preneoplastic tissues; and the relevance of glutathione S-transferases to anticancer drug resistance are also considered. The book further tackles the cellular resistance to cyclophosphamide; the preclinical and clinical experiences with drug combinations designed to inhibit DNA repair in resistant human tumor cells; and the modification of the cytotoxicity of DNA-directed chemotherapeutic agents by polyamine depletion. The text also demonstrates multidrug resistance and the circumvention of resistance. Oncologists, molecular biologists, biochemists, geneticists, and pharmacologists will find the book invaluable.

Notch Signaling Mediates Drug Resistance in Colorectal Cancer Cells Via Effects on DNA Repair Proteins Book

Notch Signaling Mediates Drug Resistance in Colorectal Cancer Cells Via Effects on DNA Repair Proteins


  • Author : Dennis George
  • Publisher : Unknown
  • Release Date : 2016
  • Genre: Uncategoriezed
  • Pages : 79
  • ISBN 10 : OCLC:957491596

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Notch Signaling Mediates Drug Resistance in Colorectal Cancer Cells Via Effects on DNA Repair Proteins Excerpt :

Colorectal cancer (CRC) is the second leading cause of cancer deaths in the United States and the third most commonly diagnosed cancer in men and women. Despite tremendous progress in diagnosis, prevention, and treatment efforts, tumor recurrence and chemoresistance remain as considerable challenges. Treatment options are limited if surgery and chemotherapy are unsuccessful. Several studies have implicated the Notch signaling pathway in conferring drug resistance to tumor cells, in addition to increased CRC aggressiveness and potential for metastatic spread. Our group previously showed that Notch-1 signaling is highly associated with promoting cancer stem cell properties in CRC cells. Furthermore, we have also confirmed that human colon tissue samples isolated from CRC patients indicate higher expression of DNA repair proteins associated with Base Excision Repair (BER). Herein, we hypothesized that Notch signaling confers drug resistance to tumor cells via signaling effects on critical proteins associated with DNA repair. Methods: The experiments conducted in this study utilized the colon cancer cell line HCT-116. These cells were transduced with an IRES-GFP retrovirus expressing human intracytoplasmic domain of Notch-1 (ICN1). Another group of HCT-116 cells was transduced with a small hairpin mRNA construct (sh59) that effectively knocked out Notch-1 action. Cell lines were exposed to varying concentrations of cytarabine and cisplatin, potent DNA damaging agents, and observed for chemosensitivity. Western blot analysis was performed using standard methodology. Results: Small hairpin mRNA (sh59) transduction into the colon tumor cell line HCT-116 resulted in a significantly decreased expression of critical BER DNA repair enzymes, Poly (ADP-Ribose) Polymerase 1 (PARP1) and 8-Oxoguanine glycosylase (OGG1). These changes were accompanied by significantly higher chemosensitivity of these cells to cytarabine and cisplatin treatment as opposed to cells expressing constitu

Drug Transporters in Drug Disposition  Effects and Toxicity Book

Drug Transporters in Drug Disposition Effects and Toxicity


  • Author : Xiaodong Liu
  • Publisher : Springer Nature
  • Release Date : 2019-09-30
  • Genre: Medical
  • Pages : 580
  • ISBN 10 : 9789811376474

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Drug Transporters in Drug Disposition Effects and Toxicity Excerpt :

This book provides with a comprehensive overview of the role of drug transporters in drug disposition and efficacy/toxicity, as well as drug-drug interactions and recent advances in the field. Transporters are known determinants of drug disposition and efficacy/toxicity. In general, they are divided into solute carrier (SLC) and ATP binding cassette (ABC) families, and are located along cell membranes, where they mediate drug uptake into cells and export out of cells. Drug transporters are essential in maintaining cell homeostasis, and their gene mutations may cause or contribute to severe human genetic disorders, such as cystic fibrosis, neurological disease, retinal degeneration, anemia, and cholesterol and bile transport defects. Conversely, some diseases may also alter transporter functions and expressions, in turn aggravating disease process. Further, since over-expression of some ABC transporters is a potential contributor to multidrug-resistance (MDR), the book presents a number of strategies to overcome MDR, including ABC transporter inhibitors and applying epigenetic methods to modulate transporter expressions and functions. This book is useful for graduate students and professionals who are looking to refresh or expand their knowledge of this exciting field.

Identification of Novel MiRNAs Contributing to Drug Resistance in Colorectal Cancer Book

Identification of Novel MiRNAs Contributing to Drug Resistance in Colorectal Cancer


  • Author : Yang Zang
  • Publisher : Unknown
  • Release Date : 2015
  • Genre: Uncategoriezed
  • Pages : 346
  • ISBN 10 : OCLC:968205469

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Identification of Novel MiRNAs Contributing to Drug Resistance in Colorectal Cancer Excerpt :

Colorectal cancer is the third most common diagnosed and the second leading lethal cancer in the United States. Development of drug resistance is one of the primary causes of colorectal cancer relapse yet underlying mechanisms is still largely unknown and therapeutic treatments remain limited. Here we show that expression of miR-520g/miR-587 is correlated with drug resistance of colon cancer cells. Ectopic expression of miR-520g/miR-587 confers resistance to 5-FU or oxaliplatin-induced apoptosis in vitro and attenuates the potency of 5-FU in the inhibition of tumor growth in a mouse xenograft model in vivo. Further studies indicate that miR-520g mediates drug resistance through down-regulation of p21 expression. Moreover, p53 suppresses miR-520g expression. Inhibition of miR-520g in p53 -/- cells increases their sensitivity to 5-FU treatment. On the other hand, MiR-587 modulates drug resistance through down-regulation of expression of PPP2R1B, which is a direct target of miR-587. Knockdown of PPP2R1B up-regulates pAKT (T308) and XIAP expression, enhancing resistance to 5-FU in colorectal cancer cells, whereas rescue of PPP2R1B in MiR-587 expressing cells decreases pAKT(308) and XIAP expression and re-sensitizes the cells to 5-FU treatment. An AKT inhibitor MK2206 significantly reduces pAKT(T308) and XIAP expression in MiR-587 expressing cells, neutralizing the resistance of the cells to 5-FU cytotoxicity. In addition, inhibition of miR-587 in colon cancer cells increases their sensitivity to 5-FU treatment through the PPP2R1B/pAKT/XIAP signaling axis. Importantly, studies of patient samples indicate that expression of miR-520g/miR-587 correlates with chemoresistance in colorectal cancer, while expression of PPP2R1B is reversely correlated with chemoresistance in these patient samples. these findings indicate that the p53/miR-520g/p21 and miR-587/PPP2R1B/pAKT/XIAP signaling axis play important roles in mediating response to chemotherapy in colorectal cancer. A major

Multi Drug Resistance in Cancer Book

Multi Drug Resistance in Cancer


  • Author : Jun Zhou
  • Publisher : Humana Press
  • Release Date : 2012-08-09
  • Genre: Medical
  • Pages : 492
  • ISBN 10 : 1617796646

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Multi Drug Resistance in Cancer Excerpt :

Chemotherapy is one of the major treatment options for cancer patients; however, the efficacy of chemotherapeutic management of cancer is severely limited by multidrug resistance, in that cancer cells become simultaneously resistant to many structurally and mechanistically unrelated drugs. In the past three decades, a number of mechanisms by which cancer cells acquire multidrug resistance have been discovered. In addition, the development of agents or strategies to overcome resistance has been the subject of intense study. This book contains comprehensive and up-to-date reviews of multidrug resistance mechanisms, from over-expression of ATP-binding cassette drug transporters such as P-glycoprotein, multidrug resistance-associated proteins, and breast cancer resistance p- tein to the drug ratio-dependent antagonism and the paradigm of cancer stem cells. The book also includes strategies to overcome multidrug resistance, from the development of compounds that inhibit drug transporter function to the modulation of transporter expression. In addition, this book contains techniques for the detection and imaging of drug transporters, methods for the investigation of drug resistance in animal models, and strategies to evaluate the efficacy of resistance reversal agents. The book intends to provide a state-of-the-art collection of reviews and methods for both basic and clinician investigators who are interested in cancer multidrug resistance mechanisms and reversal strategies. Tianjin, China Jun Zhou v Contents Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v Contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix 1 Multidrug Resistance in Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Bruce C. Baguley 2 Multidrug Resistance in Oncology and Beyond: From Imaging of Drug Efflux Pumps to

Characterising Changes in Adhesion and Enzyme Activity Related to Drug Resistance in Colon Cancer Cells Book

Characterising Changes in Adhesion and Enzyme Activity Related to Drug Resistance in Colon Cancer Cells


  • Author : Heather Dekker
  • Publisher : Unknown
  • Release Date : 2018
  • Genre: Colon (Anatomy)
  • Pages : 78
  • ISBN 10 : OCLC:1122755467

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Characterising Changes in Adhesion and Enzyme Activity Related to Drug Resistance in Colon Cancer Cells Excerpt :

Metastatic colorectal cancer is often fatal, and drug resistance to chemotherapeutic agents is one of the primary contributing factors to this lethality. Drug resistance arises from exposure to chemotherapies, and it can be mediated through a variety of mechanisms. One of these mechanisms is alteration of enzymes within the cancer cells to affect the processing or removal of the drug. Carboxylesterase is an example of an enzyme that converts irinotecan, a drug used in metastatic colorectal cancer treatments, into the active metabolite SN-38. Carboxylesterase enzymes are found in high quantities in both the liver and intestinal cells. The presence of carboxylesterase in intestinal and liver cells is an important consideration in the processing of colorectal cancer treatments. Glutathione S-transferase is another enzyme that has been implicated in drug resistance because of its ability to conjugate reduced glutathione to xenobiotic substances, facilitating their removal. Additionally, drug resistance can affect the behaviours of cells. Drug-resistant cells can exhibit changes in their motility and aggressiveness compared to drug-sensitive cells. In this study I investigated cellular behavioural changes in SN-38-resistant colon cancer cells compared to their SN-38-sensitive counterparts. In addition to behavioural changes, I also sought to determine if elevations in carboxylesterase and glutathione S-transferase enzymes were contributing to the drug resistance in these colon cancer cells.

Cancer Drug Resistance Book

Cancer Drug Resistance


  • Author : Beverly A. Teicher
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-11-09
  • Genre: Medical
  • Pages : 617
  • ISBN 10 : 9781597450355

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Cancer Drug Resistance Excerpt :

Leading experts summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to anticancer drugs, and suggest new approaches to preventing and overcoming it. The authors review physiological resistance based upon tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, and genetic changes that alter drug target molecules by decreasing or eliminating drug binding and efficacy. Highlights include new insights into resistance to antiangiogenic therapies, oncogenes and tumor suppressor genes in therapeutic resistance, cancer stem cells, and the development of more effective therapies. There are also new findings on tumor immune escape mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.

Colorectal Cancer Book

Colorectal Cancer


  • Author : Luis Rodrigo
  • Publisher : BoD – Books on Demand
  • Release Date : 2016-09-07
  • Genre: Medical
  • Pages : 440
  • ISBN 10 : 9789535125440

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Colorectal Cancer Excerpt :

Colorectal cancer (CRC) is a major health problem because it represents around 10% of all cancers and achieves a worldwide estimate of 1.4 million newly diagnosed cases annually, resulting in approximately 700,000 deaths. Approximately 19-31% of patients present liver metastases. At diagnosis, a further 23-38% will develop extra-hepatic disease. Over the past decade, the widespread use of modern chemotherapeutic and biological agents, combined with laparoscopic surgical techniques, has improved the prognosis of metastatic CRC. A better understanding of the biology of the tumor, along with high efficiency of diagnostic and therapeutic methods, as well as the spread of screening programs, will improve the survival of the CRC patients in the near future.

Breast Cancer Chemosensitivity Book

Breast Cancer Chemosensitivity


  • Author : Dihua Yu
  • Publisher : Springer Science & Business Media
  • Release Date : 2009-12-30
  • Genre: Medical
  • Pages : 175
  • ISBN 10 : 9780387740393

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Breast Cancer Chemosensitivity Excerpt :

In Breast Cancer Chemosensitivity, a group of world leading experts review critical aspects of resistance to systemic therapy in breast cancer patients. Beginning with a clinical overview of the problem, the book then focuses on the latest findings of molecular mechanisms of drug resistance. Coverage provides an example of using novel approaches for chemosensitization of breast cancer cells that gives readers an idea about the future direction in breast cancer treatment. It allows those who are interested in breast cancer therapy to get a jump-start on critical issues in breast cancer therapeutic resistance.