Drug Targets in Cellular Processes of Cancer  From Nonclinical to Preclinical Models Book

Drug Targets in Cellular Processes of Cancer From Nonclinical to Preclinical Models


  • Author : Hardeep Singh Tuli
  • Publisher : Unknown
  • Release Date : 2020
  • Genre: Cancer
  • Pages : null
  • ISBN 10 : 9811575878

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Drug Targets in Cellular Processes of Cancer From Nonclinical to Preclinical Models Excerpt :

This book explores potential cellular drug targets for cancer therapy. The first couple of chapters describe conventional treatment (radiotherapy, chemotherapy, and immunotherapy) & detection (biosensors) strategies for cancer. In contrast, the subsequent chapters address the role of cyclin-dependent kinases and cell cycle regulatory proteins in the growth of cancer cells and their potential as target for cancer treatment. The book then discusses the regulation of various pro-apoptotic and anti-apoptotic proteins via chemotherapeutic drugs. In addition, it examines the molecular mechanisms that are critical for mediating autophagic cell death in cancer cells. It subsequently reviews the role of reactive oxygen (ROS) species during carcinogenesis and during chemotherapy, and the potential of anti-inflammatory routes for the development of new therapeutic modulators. Lastly, it describes therapeutic strategies that target the tumor microenvironment and various angiogenic pathways for the treatment of cancer and to develop personalized medicine. Given its scope, the book is valuable resource for oncologists, cancer researchers, clinicians, and pharmaceutical industry personnel.

Drug Targets in Cellular Processes of Cancer  From Nonclinical to Preclinical Models Book

Drug Targets in Cellular Processes of Cancer From Nonclinical to Preclinical Models


  • Author : Hardeep Singh Tuli
  • Publisher : Springer Nature
  • Release Date : 2020-09-30
  • Genre: Medical
  • Pages : 228
  • ISBN 10 : 9789811575860

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Drug Targets in Cellular Processes of Cancer From Nonclinical to Preclinical Models Excerpt :

This book explores potential cellular drug targets for cancer therapy. The first couple of chapters describe conventional treatment (radiotherapy, chemotherapy, and immunotherapy) & detection (biosensors) strategies for cancer. In contrast, the subsequent chapters address the role of cyclin-dependent kinases and cell cycle regulatory proteins in the growth of cancer cells and their potential as target for cancer treatment. The book then discusses the regulation of various pro-apoptotic and anti-apoptotic proteins via chemotherapeutic drugs. In addition, it examines the molecular mechanisms that are critical for mediating autophagic cell death in cancer cells. It subsequently reviews the role of reactive oxygen (ROS) species during carcinogenesis and during chemotherapy, and the potential of anti-inflammatory routes for the development of new therapeutic modulators. Lastly, it describes therapeutic strategies that target the tumor microenvironment and various angiogenic pathways for the treatment of cancer and to develop personalized medicine. Given its scope, the book is valuable resource for oncologists, cancer researchers, clinicians, and pharmaceutical industry personnel.

Drug Targets in Cellular Processes of Cancer  From Nonclinical to Preclinical Models Book

Drug Targets in Cellular Processes of Cancer From Nonclinical to Preclinical Models


  • Author : Hardeep Singh Tuli
  • Publisher : Springer
  • Release Date : 2021-10-02
  • Genre: Medical
  • Pages : 228
  • ISBN 10 : 9811575886

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Drug Targets in Cellular Processes of Cancer From Nonclinical to Preclinical Models Excerpt :

This book explores potential cellular drug targets for cancer therapy. The first couple of chapters describe conventional treatment (radiotherapy, chemotherapy, and immunotherapy) & detection (biosensors) strategies for cancer. In contrast, the subsequent chapters address the role of cyclin-dependent kinases and cell cycle regulatory proteins in the growth of cancer cells and their potential as target for cancer treatment. The book then discusses the regulation of various pro-apoptotic and anti-apoptotic proteins via chemotherapeutic drugs. In addition, it examines the molecular mechanisms that are critical for mediating autophagic cell death in cancer cells. It subsequently reviews the role of reactive oxygen (ROS) species during carcinogenesis and during chemotherapy, and the potential of anti-inflammatory routes for the development of new therapeutic modulators. Lastly, it describes therapeutic strategies that target the tumor microenvironment and various angiogenic pathways for the treatment of cancer and to develop personalized medicine. Given its scope, the book is valuable resource for oncologists, cancer researchers, clinicians, and pharmaceutical industry personnel.

Recent Advances in Cancer Diagnostics and Therapy Book

Recent Advances in Cancer Diagnostics and Therapy


  • Author : Anjana Pandey
  • Publisher : CRC Press
  • Release Date : 2022-01-19
  • Genre: Science
  • Pages : 224
  • ISBN 10 : 9781000528138

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Recent Advances in Cancer Diagnostics and Therapy Excerpt :

The book provides information about different types and stages of cancers and their subtypes with their respective molecular mechanisms, etiology, histopathology and cellular origins of cancer. The book also provides detailed information about cancer incidence, mortality, different type of technologies both bio and nano employed in cancer diagnosis and screening and their applications in cancer therapies. The book will serve the purpose to impart knowledge to its readers about molecular mechanisms of cancer, diagnosis and therapies along with different computational techniques used on a single platform. The chapters include a broad and integrated perspective on cancer related topics. The book covers both conventional and emerging techniques employed in cancer screening and diagnosis including imaging, biomarker and electrochemical nanosensor based approaches with detailed information on sensor development. Similarly, the book also covers the mechanisms of different conventional and emerging herbal & nano therapies used in cancer treatment. The authors then discuss about applications of different computational and mathematical tools such as machine learning methods that can be employed in cancer diagnosis and therapy at the level of personalized medicine. The target readers for the book include university students, course lectures, researchers and industrialists working in the fields of cancer biology, medicine, and pharmacology. Features: An integrated approach to provide information about all aspects of cancer biology, diagnosis and therapy. Covers both conventional and emerging tools/ techniques applicable in cancer screening and diagnosis. Covers the mechanisms of conventional and emerging anticancer drugs and therapies. Provides insights about personalized medicine based approach in cancer diagnosis and therapy.

A Comprehensive Guide to Toxicology in Nonclinical Drug Development Book

A Comprehensive Guide to Toxicology in Nonclinical Drug Development


  • Author : Ali S. Faqi
  • Publisher : Academic Press
  • Release Date : 2016-11-03
  • Genre: Medical
  • Pages : 986
  • ISBN 10 : 9780128036211

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A Comprehensive Guide to Toxicology in Nonclinical Drug Development Excerpt :

A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Second Edition, is a valuable reference designed to provide a complete understanding of all aspects of nonclinical toxicology in the development of small molecules and biologics. This updated edition has been reorganized and expanded to include important topics such as stem cells in nonclinical toxicology, inhalation and dermal toxicology, pitfalls in drug development, biomarkers in toxicology, and more. Thoroughly updated to reflect the latest scientific advances and with increased coverage of international regulatory guidelines, this second edition is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings. Provides unique content that is not always covered together in one comprehensive resource, including chapters on stem cells, abuse liability, biomarkers, inhalation toxicology, biostatistics, and more Updated with the latest international guidelines for nonclinical toxicology in both small and large molecules Incorporates practical examples in order to illustrate day-to-day activities and the expectations associated with working in nonclinical toxicology

Anticancer Drug Development Guide Book

Anticancer Drug Development Guide


  • Author : Beverly A. Teicher
  • Publisher : Springer Science & Business Media
  • Release Date : 2004-02-01
  • Genre: Medical
  • Pages : 451
  • ISBN 10 : 9781592597390

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Anticancer Drug Development Guide Excerpt :

This unique volume traces the critically important pathway by which a "molecule" becomes an "anticancer agent. " The recognition following World War I that the administration of toxic chemicals such as nitrogen mustards in a controlled manner could shrink malignant tumor masses for relatively substantial periods of time gave great impetus to the search for molecules that would be lethal to specific cancer cells. Weare still actively engaged in that search today. The question is how to discover these "anticancer" molecules. Anticancer Drug Development Guide: Preclinical Screening, Clinical Trials, and Approval, Second Edition describes the evolution to the present of preclinical screening methods. The National Cancer Institute's high-throughput, in vitro disease-specific screen with 60 or more human tumor cell lines is used to search for molecules with novel mechanisms of action or activity against specific phenotypes. The Human Tumor Colony-Forming Assay (HTCA) uses fresh tumor biopsies as sources of cells that more nearly resemble the human disease. There is no doubt that the greatest successes of traditional chemotherapy have been in the leukemias and lymphomas. Since the earliest widely used in vivo drug screening models were the murine L 1210 and P388 leukemias, the community came to assume that these murine tumor models were appropriate to the discovery of "antileukemia" agents, but that other tumor models would be needed to discover drugs active against solid tumors.

Current Topics in Nonclinical Drug Development Book

Current Topics in Nonclinical Drug Development


  • Author : Pritam S. Sahota
  • Publisher : CRC Press
  • Release Date : 2020-12-23
  • Genre: Medical
  • Pages : 318
  • ISBN 10 : 9780429648496

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Current Topics in Nonclinical Drug Development Excerpt :

The inaugural volume in the Current Topics in Nonclinical Drug Development Series explores the critical issues and current topics in nonclinical drug development. This first volume covers individual topics and strategies in drug development from compound characterization to drug registration. Written by a variety of experts in the field, recent and rapid advances in technologies and associated changes in regulatory guidance are discussed. Additional features include: Deals with day-to-day issues in study design, evaluation of findings, and presentation of data. Explains new approaches in the development of medical devices. Includes dedicated chapters on the use of bioinformatics in drug development. Addresses strategies for photosafety testing of drugs. Current Topics in Nonclinical Drug Development, Volume I will aid toxicologists, toxicologic pathologists, consultants, regulators, Study Directors, and nonclinical scientists dealing with day-to-day issues in study design, evaluation of findings, and presentation of data. In addition, the book will be a valuable reference for academicians and graduate students pursuing research related to nonclinical drug development.

Drug Discovery Toxicology Book

Drug Discovery Toxicology


  • Author : Yvonne Will
  • Publisher : John Wiley & Sons
  • Release Date : 2016-03-22
  • Genre: Medical
  • Pages : 584
  • ISBN 10 : 9781119053392

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Drug Discovery Toxicology Excerpt :

As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process. • Guides researchers as to what drug safety experiments are both practical and useful • Covers a variety of key topics – safety lead optimization, in vitro-in vivo translation, organ toxicology, ADME, animal models, biomarkers, and –omics tools • Describes what experiments are possible and useful and offers a view into the future, indicating key areas to watch for new predictive methods • Features contributions from firsthand industry experience, giving readers insight into the strategy and execution of predictive toxicology practices

Improving the Quality of Cancer Clinical Trials Book

Improving the Quality of Cancer Clinical Trials


  • Author : Institute of Medicine
  • Publisher : National Academies Press
  • Release Date : 2008-05-12
  • Genre: Medical
  • Pages : 136
  • ISBN 10 : 9780309178259

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Improving the Quality of Cancer Clinical Trials Excerpt :

Scientists and clinicians seek a new paradigm that could improve the efficiency, cost-effectiveness, and overall success rate of cancer clinical trials, while maintaining the highest standards of quality. To explore innovative paradigms for cancer clinical trials and other ways to improve their quality, the National Cancer Policy Forum held a workshop, Improving the Quality of Cancer Clinical Trials, in Washington, DC. The main goals of the workshop were to examine new approaches to clinical trial design and execution that would: (1) better inform decisions and plans of those responsible for developing new cancer therapies (2) more rapidly move new diagnostic tests and treatments toward regulatory approval and use in the clinic (3) be less costly than current trials The resulting workshop summary will serve as input to the deliberations of an Institute of Medicine committee that will develop consensus-based recommendations for moving the field of cancer clinical trials forward.

Abeloff s Clinical Oncology E Book Book

Abeloff s Clinical Oncology E Book


  • Author : Martin D. Abeloff
  • Publisher : Elsevier Health Sciences
  • Release Date : 2008-06-30
  • Genre: Medical
  • Pages : 2592
  • ISBN 10 : 9781437720563

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Abeloff s Clinical Oncology E Book Excerpt :

Carrying on the tradition established by its founding editor, the late Dr. Martin Abeloff, the 4th Edition of this respected reference synthesizes all of the latest oncology knowledge in one practical, clinically focused, easy-to-use volume. It incorporates basic science, pathology, diagnosis, management, outcomes, rehabilitation, and prevention – all in one convenient resource – equipping you to overcome your toughest clinical challenges. What's more, you can access the complete contents of this Expert Consult title online, and tap into its unparalleled guidance wherever and whenever you need it most! Equips you to select the most appropriate tests and imaging studies for diagnosing and staging each type of cancer, and manage your patients most effectively using all of the latest techniques and approaches. Explores all of the latest scientific discoveries' implications for cancer diagnosis and management. Employs a multidisciplinary approach - with contributions from pathologists, radiation oncologists, medical oncologists, and surgical oncologists - for well-rounded perspectives on the problems you face. Offers a user-friendly layout with a consistent chapter format • summary boxes • a full-color design • and more than 1,445 illustrations (1,200 in full color), to make reference easy and efficient. Offers access to the book's complete contents online – fully searchable – from anyplace with an Internet connection. Presents discussions on cutting-edge new topics including nanotechnology, functional imaging, signal transduction inhibitors, hormone modulators, complications of transplantation, and much more. Includes an expanded color art program that highlights key points, illustrates relevant science and clinical problems, and enhances your understanding of complex concepts.

Cancer Vaccines Book

Cancer Vaccines


  • Author : Adrian Bot
  • Publisher : CRC Press
  • Release Date : 2015-05-06
  • Genre: Medical
  • Pages : 280
  • ISBN 10 : 9781841848303

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Cancer Vaccines Excerpt :

Recent advances in immunology and biology have opened new horizons in cancer therapy, included in the expanding array of cancer treatment options, which are immunotherapies, or cancer vaccines, for both solid and blood borne cancers. Cancer Vaccines: From Research to Clinical Practice is the first text in the field to bring immunotherapy treatments from the laboratory trial to the bedside for the practicing oncologist. Cancer Vaccines: From Research to Clinical Practice: Analyzes the most promising classes of investigational immunotherapies, integrating their scientific rationale and clinical potential Discusses "theranostics" as pertaining to immunotherapy, i.e., using molecular diagnostics to identify patients that would most likely benefit from a therapy Presents the new paradigm of biomarker guided R&D and clinical development in immunotherapy of cancer Reviews bottlenecks in translational process of immunotherapies and offers strategies to resolve them

Remington Book

Remington


  • Author : Adeboye Adejare
  • Publisher : Academic Press
  • Release Date : 2020-11-03
  • Genre: Business & Economics
  • Pages : 1030
  • ISBN 10 : 9780128223895

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Remington Excerpt :

Remington: The Science and Practice of Pharmacy, Twenty Third Edition, offers a trusted, completely updated source of information for education, training, and development of pharmacists. Published for the first time with Elsevier, this edition includes coverage of biologics and biosimilars as uses of those therapeutics have increased substantially since the previous edition. Also discussed are formulations, drug delivery (including prodrugs, salts, polymorphism. With clear, detailed color illustrations, fundamental information on a range of pharmaceutical science areas, and information on new developments in industry, pharmaceutical industry scientists, especially those involved in drug discovery and development will find this edition of Remington an essential reference. Intellectual property professionals will also find this reference helpful to cite in patents and resulting litigations. Additional graduate and postgraduate students in Pharmacy and Pharmaceutical Sciences will refer to this book in courses dealing with medicinal chemistry and pharmaceutics. Contains a comprehensive source of principles of drug discovery and development topics, especially for scientists that are new in the pharmaceutical industry such as those with trainings/degrees in chemistry and engineering Provides a detailed source for formulation scientists and compounding pharmacists, from produg to excipient issues Updates this excellent source with the latest information to verify facts and refresh on basics for professionals in the broadly defined pharmaceutical industry

Improving and Accelerating Therapeutic Development for Nervous System Disorders Book

Improving and Accelerating Therapeutic Development for Nervous System Disorders


  • Author : Institute of Medicine
  • Publisher : National Academies Press
  • Release Date : 2014-02-06
  • Genre: Medical
  • Pages : 118
  • ISBN 10 : 9780309292498

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Improving and Accelerating Therapeutic Development for Nervous System Disorders Excerpt :

Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.

Theoretical and Applied Aspects of Systems Biology Book

Theoretical and Applied Aspects of Systems Biology


  • Author : Fabricio Alves Barbosa da Silva
  • Publisher : Springer
  • Release Date : 2018-06-21
  • Genre: Computers
  • Pages : 259
  • ISBN 10 : 9783319749747

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Theoretical and Applied Aspects of Systems Biology Excerpt :

This book presents the theoretical foundations of Systems Biology, as well as its application in studies on human hosts, pathogens and associated diseases. This book presents several chapters written by renowned experts in the field. Some topics discussed in depth in this book include: computational modeling of multiresistant bacteria, systems biology of cancer, systems immunology, networks in systems biology.

A Comprehensive Guide to Toxicology in Preclinical Drug Development Book

A Comprehensive Guide to Toxicology in Preclinical Drug Development


  • Author : Ali S. Faqi
  • Publisher : Academic Press
  • Release Date : 2012-10-18
  • Genre: Medical
  • Pages : 1024
  • ISBN 10 : 9780123878168

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A Comprehensive Guide to Toxicology in Preclinical Drug Development Excerpt :

A Comprehensive Guide to Toxicology in Preclinical Drug Development is a resource for toxicologists in industry and regulatory settings, as well as directors working in contract resource organizations, who need a thorough understanding of the drug development process. Incorporating real-life case studies and examples, the book is a practical guide that outlines day-to-day activities and experiences in preclinical toxicology. This multi-contributed reference provides a detailed picture of the complex and highly interrelated activities of preclinical toxicology in both small molecules and biologics. The book discusses discovery toxicology and the international guidelines for safety evaluation, and presents traditional and nontraditional toxicology models. Chapters cover development of vaccines, oncology drugs, botanic drugs, monoclonal antibodies, and more, as well as study development and personnel, the role of imaging in preclinical evaluation, and supporting materials for IND applications. By incorporating the latest research in this area and featuring practical scenarios, this reference is a complete and actionable guide to all aspects of preclinical drug testing. Chapters written by world-renowned contributors who are experts in their fields Includes the latest research in preclinical drug testing and international guidelines Covers preclinical toxicology in small molecules and biologics in one single source