Fragment Based Drug Discovery Book

Fragment Based Drug Discovery


  • Author : Steven Howard
  • Publisher : Royal Society of Chemistry
  • Release Date : 2015-07-03
  • Genre: Medical
  • Pages : 314
  • ISBN 10 : 9781849739085

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Fragment Based Drug Discovery Excerpt :

Fragment-based drug discovery is a rapidly evolving area of research, which has recently seen new applications in areas such as epigenetics, GPCRs and the identification of novel allosteric binding pockets. The first fragment-derived drug was recently approved for the treatment of melanoma. It is hoped that this approval is just the beginning of the many drugs yet to be discovered using this fascinating technique. This book is written from a Chemist's perspective and comprehensively assesses the impact of fragment-based drug discovery on a wide variety of areas of medicinal chemistry. It will prove to be an invaluable resource for medicinal chemists working in academia and industry, as well as anyone interested in novel drug discovery techniques.

In Silico Lead Discovery Book

In Silico Lead Discovery


  • Author : Maria A. Miteva
  • Publisher : Bentham Science Publishers
  • Release Date : 2011
  • Genre: Science
  • Pages : 201
  • ISBN 10 : 9781608051427

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In Silico Lead Discovery Excerpt :

Computer-aided drug design and in silico screening have contributed to the discovery of several compounds that have either reached the market or entered clinical trials. In silico Lead Discovery is a compilation of the efforts of several experts on bioinf

Fragment based Drug Discovery Book

Fragment based Drug Discovery


  • Author : Daniel A. Erlanson
  • Publisher : John Wiley & Sons
  • Release Date : 2016-02-23
  • Genre: Medical
  • Pages : 524
  • ISBN 10 : 9783527337750

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Fragment based Drug Discovery Excerpt :

From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current methods and applications of fragment-based discovery, as well as an outlook on where the field is headed. The first part discusses basic considerations of when to use fragment-based methods, how to select targets, and how to build libraries in the chemical fragment space. The second part describes established, novel and emerging methods for fragment screening, including empirical as well as computational approaches. Special cases of fragment-based screening, e. g. for complex target systems and for covalent inhibitors are also discussed. The third part presents several case studies from recent and on-going drug discovery projects for a variety of target classes, from kinases and phosphatases to targeting protein-protein interaction and epigenetic targets.

Inhibitors of Molecular Chaperones as Therapeutic Agents Book

Inhibitors of Molecular Chaperones as Therapeutic Agents


  • Author : Timothy D. Machajewski
  • Publisher : Royal Society of Chemistry
  • Release Date : 2014
  • Genre: Medical
  • Pages : 443
  • ISBN 10 : 9781849736664

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Inhibitors of Molecular Chaperones as Therapeutic Agents Excerpt :

This book aims to provide a comprehensive examination of the field of molecular chaperone inhibition and its application to pharmaceutical research. With several small molecule inhibitors in oncology clinical development, there is clearly intense interest in the chaperones as a molecular target. Filling a significant gap in the market by providing a detailed comparison of discovery programs across the industry, this text will find broad interest among researchers in the field of molecular chaperone pharmaceutical research, oncology research, and medicinal chemistry. Arranged into three main sections the book covers structure and function, small molecule inhibitors and concludes with a section discussing clinical perspectives. With specific chapters covering the discovery of key molecules such as, BIIB028, STA-9090, Serenex Hsp90 inhibitor, NVP-AUY922 and NVP-HSP990, this comprehensive text will be an essential treatise for researchers working in academia and industry.

In Silico Methods for Drug Design and Discovery Book

In Silico Methods for Drug Design and Discovery


  • Author : Simone Brogi
  • Publisher : Frontiers Media SA
  • Release Date : 2020-10-09
  • Genre: Science
  • Pages : 504
  • ISBN 10 : 9782889660575

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In Silico Methods for Drug Design and Discovery Excerpt :

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Frontiers in Drug Design and Discovery Book

Frontiers in Drug Design and Discovery


  • Author : Atta-ur- Rahman
  • Publisher : Bentham Science Publishers
  • Release Date : 2010-12-13
  • Genre: Medical
  • Pages : 644
  • ISBN 10 : 9781608052011

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Frontiers in Drug Design and Discovery Excerpt :

"Frontiers in Drug Design and Discovery" is an Ebook series devoted to publishing the latest and the most important advances in drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery inclu

In Silico Drug Discovery and Design Book

In Silico Drug Discovery and Design


  • Author : Claudio N. Cavasotto
  • Publisher : CRC Press
  • Release Date : 2015-08-06
  • Genre: Medical
  • Pages : 558
  • ISBN 10 : 9781482217858

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In Silico Drug Discovery and Design Excerpt :

In Silico Drug Discovery and Design: Theory, Methods, Challenges, and Applications provides a comprehensive, unified, and in-depth overview of the current methodological strategies in computer-aided drug discovery and design. Its main aims are to introduce the theoretical framework and algorithms, discuss the range of validity, strengths and limita

Fragment based Approaches in Drug Discovery Book

Fragment based Approaches in Drug Discovery


  • Author : Wolfgang Jahnke
  • Publisher : John Wiley & Sons
  • Release Date : 2006-12-13
  • Genre: Science
  • Pages : 391
  • ISBN 10 : 9783527608607

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Fragment based Approaches in Drug Discovery Excerpt :

This first systematic summary of the impact of fragment-based approaches on the drug development process provides essential information that was previously unavailable. Adopting a practice-oriented approach, this represents a book by professionals for professionals, tailor-made for drug developers in the pharma and biotech sector who need to keep up-to-date on the latest technologies and strategies in pharmaceutical ligand design. The book is clearly divided into three sections on ligand design, spectroscopic techniques, and screening and drug discovery, backed by numerous case studies.

Concepts and Experimental Protocols of Modelling and Informatics in Drug Design Book

Concepts and Experimental Protocols of Modelling and Informatics in Drug Design


  • Author : Om Silakari
  • Publisher : Academic Press
  • Release Date : 2020-11-05
  • Genre: Business & Economics
  • Pages : 396
  • ISBN 10 : 9780128205471

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Concepts and Experimental Protocols of Modelling and Informatics in Drug Design Excerpt :

Concepts and Experimental Protocols of Modelling and Informatics in Drug Design discusses each experimental protocol utilized in the field of bioinformatics, focusing especially on computer modeling for drug development. It helps the user in understanding the field of computer-aided molecular modeling (CAMM) by presenting solved exercises and examples. The book discusses topics such as fundamentals of molecular modeling, QSAR model generation, protein databases and how to use them to select and analyze protein structure, and pharmacophore modeling for drug targets. Additionally, it discusses data retrieval system, molecular surfaces, and freeware and online servers. The book is a valuable source for graduate students and researchers on bioinformatics, molecular modeling, biotechnology and several members of biomedical field who need to understand more about computer-aided molecular modeling. Presents exercises with solutions to aid readers in validating their own protocol Brings a thorough interpretation of results of each exercise to help readers compare them to their own study Explains each parameter utilized in the algorithms to help readers understand and manipulate various features of molecules and target protein to design their study

Glycogen Synthase Kinases   Advances in Research and Application  2013 Edition Book

Glycogen Synthase Kinases Advances in Research and Application 2013 Edition


  • Author : Anonim
  • Publisher : ScholarlyEditions
  • Release Date : 2013-06-21
  • Genre: Medical
  • Pages : 89
  • ISBN 10 : 9781481688208

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Glycogen Synthase Kinases Advances in Research and Application 2013 Edition Excerpt :

Glycogen Synthase Kinases—Advances in Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about ZZZAdditional Research in a concise format. The editors have built Glycogen Synthase Kinases—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Glycogen Synthase Kinases—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Antimicrobials Book

Antimicrobials


  • Author : Flavia Marinelli
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-10-04
  • Genre: Medical
  • Pages : 364
  • ISBN 10 : 9783642399688

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Antimicrobials Excerpt :

Reports on the emergence and prevalence of resistant bacterial infections in hospitals and communities raise concerns that we may soon no longer be able to rely on antibiotics as a way to control infectious diseases. Effective medical care would require the constant introduction of novel antibiotics to keep up in the “arms race” with resistant pathogens. This book closely examines the latest developments in the field of antibacterial research and development. It starts with an overview of the growing prevalence of resistant Gram-positive and Gram-negative pathogens, including their various resistance mechanisms, prevalence, risk factors and therapeutic options. The focus then shifts to a comprehensive description of all major chemical classes with antibacterial properties, their chemistry, mode of action, and the generation of analogs; information that provides the basis for the design of improved molecules to defeat microbial infections and combat the emerging resistances. In closing, recently developed compounds already in clinical use, those in preclinical or first clinical studies, and a number of promising targets to be exploited in the discovery stage are discussed.

The Practice of Medicinal Chemistry Book

The Practice of Medicinal Chemistry


  • Author : Camille Georges Wermuth
  • Publisher : Elsevier
  • Release Date : 2015-07-01
  • Genre: Science
  • Pages : 902
  • ISBN 10 : 9780124172135

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The Practice of Medicinal Chemistry Excerpt :

The Practice of Medicinal Chemistry, Fourth Edition provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough treatment of basic medicinal chemistry principles, this updated edition has been revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery. With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to reference for all academic and pharmaceutical researchers who need a complete understanding of medicinal chemistry and its application to drug discovery and development. Includes updated and expanded material on systems biology, chemogenomics, computer-aided drug design, and other important recent advances in the field Incorporates extensive color figures, case studies, and practical examples to help users gain a further understanding of key concepts Provides high-quality content in a comprehensive manner, including contributions from international chapter authors to illustrate the global nature of medicinal chemistry and drug development research An image bank is available for instructors at www.textbooks.elsevier.com

Towards Efficient Designing of Safe Nanomaterials Book

Towards Efficient Designing of Safe Nanomaterials


  • Author : Jerzy Leszczynski
  • Publisher : Royal Society of Chemistry
  • Release Date : 2012-09-30
  • Genre: Science
  • Pages : 378
  • ISBN 10 : 9781849735476

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Towards Efficient Designing of Safe Nanomaterials Excerpt :

The expanding field of nanotechnology is now one of the most promising areas of science. However, because some nanoparticles can have a negative impact on human health and the environment, the design of novel materials must always be accompanied by a comprehensive risk assessment. Until now, the information on the methods available has been fragmented and incomplete. This book is the first to provide a comprehensive review of recent progress and challenges in the risk assessment of nanomaterials by empirical and computational techniques. Topics covered include: benefits versus risks, carbon based nanomaterials, environmental detection and quantitative analysis, chemometric modelling, human exposure assessment, toxicity testing, nano-QSAR, risk assessment strategies, policy and regulatory frameworks.

BioNMR in Drug Research Book

BioNMR in Drug Research


  • Author : Oliver Zerbe
  • Publisher : John Wiley & Sons
  • Release Date : 2006-03-06
  • Genre: Science
  • Pages : 502
  • ISBN 10 : 9783527605422

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BioNMR in Drug Research Excerpt :

The vast progress made in the investigation of biomolecules using NMR has only recently been rewarded with the Nobel Prize for Kurt Wüthrich. Edited by a former coworker of Wüthrich, this book presents the theoretical background on NMR of biomolecules, plus the use of NMR techniques in determining the structures of proteins and nucleic acids. BioNMR spectroscopy offers a universal tool for examining the binding of an active substance to its target protein. Its use thereby benefits the rational development of drugs. This interaction can now be investigated in a hitherto unparalleled precision and displayed in 3D - an important prerequisite for the targeted development of new active substances. The latest methods for characterizing substance-receptor complexes are demonstrated backed by many case studies from pharmaceutical research. Thus it comes as no surprise that a large number of the authors are working for leading pharmaceutical companies. With its successful mixture of basic information and application strategies, coupled with many real-life examples, this is an invaluable guide for both NMR spectroscopists and pharmaceutical researchers.

PlantOmics  The Omics of Plant Science Book

PlantOmics The Omics of Plant Science


  • Author : Debmalya Barh
  • Publisher : Springer
  • Release Date : 2015-03-18
  • Genre: Science
  • Pages : 825
  • ISBN 10 : 9788132221722

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PlantOmics The Omics of Plant Science Excerpt :

PlantOmics: The Omics of Plant Science provides a comprehensive account of the latest trends and developments of omics technologies or approaches and their applications in plant science. Thirty chapters written by 90 experts from 15 countries are included in this state-of-the-art book. Each chapter describes one topic/omics such as: omics in model plants, spectroscopy for plants, next generation sequencing, functional genomics, cyto-metagenomics, epigenomics, miRNAomics, proteomics, metabolomics, glycomics, lipidomics, secretomics, phenomics, cytomics, physiomics, signalomics, thiolomics, organelle omics, micro morphomics, microbiomics, cryobionomics, nanotechnology, pharmacogenomics, and computational systems biology for plants. It provides up to date information, technologies, and their applications that can be adopted and applied easily for deeper understanding plant biology and therefore will be helpful in developing the strategy for generating cost-effective superior plants for various purposes. In the last chapter, the editors have proposed several new areas in plant omics that may be explored in order to develop an integrated meta-omics strategy to ensure the world and earth’s health and related issues. This book will be a valuable resource to students and researchers in the field of cutting-edge plant omics.