Endocrine Biomarkers Book

Endocrine Biomarkers

  • Author : Hossein Sadrzadeh
  • Publisher : Elsevier
  • Release Date : 2017-09-25
  • Genre: Medical
  • Pages : 478
  • ISBN 10 : 9780128034187

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Endocrine Biomarkers: Clinical Aspects and Laboratory Determination covers all the pre-analytical variables that can affect test results, both in the clinic and laboratory. Biomarkers of endocrine and bone diseases are discussed from both clinical and laboratory perspectives, and the authors elaborate on the teamwork-based app+roach between the clinician and the laboratory professional in the diagnosis and management of endocrine and bone disorders. Discussions include test utilization, laboratory measurement methods, harmonization and standardization, interpretation of results, and reference intervals. Each chapter ends with a discussion of one or two relevant cases with shared opinions from both a clinician and a clinical chemist. Each chapter also includes a summary box outlining key points and common pitfalls in the use of specific disease biomarkers and tests. Focuses on the traditional, current, and emerging clinical chemistry tests for endocrine and bone diseases, along with their application in individual clinical management Presents a brief discussion of each disorder and its respective interrelationships, along with laboratory methodologies that can be used to aid in evaluation of disorders Reviews common approaches to the measurement of the relevant hormones, with a special focus on measures that require a structured clinical testing scenario Reviews novel chemistry tests as potential means of future diagnostic tests Provides an overview of the current methodology and controversies in the concept of target lipid levels, paying particular attention to the role of clinical chemistry in helping to implement population health targets

Handbook of Diagnostic Endocrinology Book

Handbook of Diagnostic Endocrinology

  • Author : William E. Winter
  • Publisher : Academic Press
  • Release Date : 2020-10-06
  • Genre: Medical
  • Pages : 744
  • ISBN 10 : 9780128182789

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The clinical laboratory plays a critical role in the diagnosis and management of endocrine and related metabolic disorders, which are leading causes of morbidity and mortality in children and adults. The Handbook of Diagnostic Endocrinology, Third Edition, provides a ready reference for the evaluation, diagnosis, and monitoring of such disorders. This revision incorporates translational medicine, connecting what clinicians need to know with those in research providing a clinical context to which they can relate their molecular findings. This book solves the needs of clinicians and researchers by bringing together in one book endocrinology at the molecular and clinical levels. As the intricacies of intracellular signaling have become better understood, states of hormone resistance are now increasingly recognized. The most common endocrinopathy in westernized countries, the metabolic syndrome, results, to a large extent, from insulin resistance. The complexity of the circulating forms of various hormones are acknowledged in this revision. Each chapter focuses on the biochemical tests that are required, either in the basal state or following provocation or suppression, to assist in the diagnosis of the various disorders Describes proper sample collection and relevant interpretations of laboratory tests Contains essential molecular biology and incorporates it with the clinical information Includes the discovery of new diagnostic and treatment methods

Evaluating Endocrine Disruption in Receiving Waters Book

Evaluating Endocrine Disruption in Receiving Waters

  • Author : P. V. Cline
  • Publisher : IWA Publishing
  • Release Date : 2003-01-01
  • Genre: Science
  • Pages : 277
  • ISBN 10 : 9781843396505

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In recent years, concerns have been raised that low concentrations of chemicals may alter the normal functions of the endocrine system, resulting in potentially significant adverse effects on growth, reproduction, and/or development. For domestic wastewater discharges to surface water bodies, estrogenic activity of effluents has been suggested by chemical analysis, biomarkers, and /or in vitro assays. Chemical Measurements. Using sensitive analytical techniques, natural or synthetic hormones and chemicals that mimic estrogen, have been detected in some domestic wastewater effluents and associated watersheds at low concentrations. Biomarkers. Several studies have demonstrated physiological changes in fish that may be attributed to exposure to estrogenic compounds. These include the presence of vitellogenin protein in male fish and/or intersex conditions. In vitro assays. The Yeast Estrogen Screen (YES) has been used to characterize estrogenicity of effluents, influents, biosolids and surface waters. This two-year WERF project explored approaches to evaluate the potential for biomarker formation as a result of effluent exposures, and the subsequent relevance of the emerging assays and physiological measurements on potential adverse impacts to individuals or populations of fish in the receiving streams. The endocrine system is complex, and many factors can influence the physiological measurements, including methods, sex, age, reproductive status, seasonal and circadian rhythms, diet, temperature, etc. and produce transient changes in physiology but no significant effect on the individual.

Ecological Biomarkers Book

Ecological Biomarkers

  • Author : Claude Amiard-Triquet
  • Publisher : CRC Press
  • Release Date : 2016-04-19
  • Genre: Science
  • Pages : 464
  • ISBN 10 : 9781439880531

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Does a change, which affects a few biological macro-molecules, some cells, or a few individuals within a population, have any ecological significance that would allow the prediction of deleterious effects at higher levels of biological organization, namely the population, community, and ultimately the ecosystem? With contributions from experts in the field, Ecological Biomarkers: Indicators of Ecotoxicological Effects explores how biomarkers can be used to predict effects farther down the chain. It presents a synthesis of the state of the art in the methodology of biomarkers and its contribution to ecological risk assessment. This book describes the core biomarkers currently used in environmental research concerned with biological monitoring, biomarkers which correspond to the defences developed by living organisms in response to contaminants in their environment, and biomarkers that reveal biological damage resulting from contaminant stressors. It examines the efficacy of lysosomal biomarkers, immunotoxicity effects, behavioral disturbances, energy metabolism impairments, endocrine disruption measures, and genotoxicity as all indicative of probable toxic effects at higher biological levels. It is time to revisit the biological responses most ecologically relevant in the diagnosis of the health status of an aquatic environment well before it becomes unmanageable. Biomarkers provide a real possibility of delivering an easily measured marker at a simple level of biological organization that is predictably linked to a potentially ecologically significant effect at higher levels of biological organization. The text explores the latest knowledge and thinking on how to use biomarkers as tools for the assessment of environmental health and management.

Percutaneous Venous Blood Sampling in Endocrine Diseases Book

Percutaneous Venous Blood Sampling in Endocrine Diseases

  • Author : Renan Uflacker
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-06
  • Genre: Medical
  • Pages : 183
  • ISBN 10 : 9781461228301

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The emergence of selective venous blood sampling has drama- tically improvedthe diagnosis of many endocrine diseases. Percutaneous Venous Blood Samplingin Endocrine Diseases is the first comprehensive text on current techniques for diag- nosing endocrine diseases employing radiologic techniques of percutaneous venous catheterization. This practical guide discusses anatomical details, procedural techniques, and clinical implications.

Biomarkers Book


  • Author : Robert J Huggett
  • Publisher : CRC Press
  • Release Date : 2018-01-18
  • Genre: Science
  • Pages : 365
  • ISBN 10 : 9781351078726

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This book provides a survey of biochemical, physiological and histological biomarkers of environmental stress, along with evaluations of the strengths and weaknesses of various techniques for different applications. It features in-depth coverage of such topics as DNA adducts, acetylcholinesterase, ATP, endocrine mechanisms, blood chemistry, histopathological biomarkers, stress proteins, foreign and endogenous metabolites, metallothioneins, to name only a few. The book will be especially useful to toxicologists, biochemists, histologists, immunologists, risk analysis specialists, environmental managers, regulators, environmental scientists and engineers.

Novel Targets and Biomarkers in Solid Tumors  2nd Edition Book

Novel Targets and Biomarkers in Solid Tumors 2nd Edition

  • Author : Dong-Hua Yang
  • Publisher : Frontiers Media SA
  • Release Date : 2020-07-16
  • Genre: Uncategoriezed
  • Pages : 285
  • ISBN 10 : 9782889638796

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Use of Biomarkers for Environmental Quality Assessment Book

Use of Biomarkers for Environmental Quality Assessment

  • Author : Jean-Claude Amiard
  • Publisher : CRC Press
  • Release Date : 2000-06-01
  • Genre: Science
  • Pages : 370
  • ISBN 10 : 9054107030

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This work is primarily designed for any person or organization in charge of assessment of the quality of natural resources and of pollution prevention.

Biomarkers in Toxicology Book

Biomarkers in Toxicology

  • Author : Ramesh C. Gupta
  • Publisher : Academic Press
  • Release Date : 2019-02-13
  • Genre: Medical
  • Pages : 1246
  • ISBN 10 : 9780128146569

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Biomarkers in Toxicology, Second Edition, is a timely and comprehensive reference dedicated to all aspects of biomarkers that relate to chemical exposure and their effects on biological systems. This revised and completely updated edition includes both vertebrate and non-vertebrate species models for toxicological testing and the development of biomarkers. Divided into several key sections, this reference volume contains new chapters devoted to topics in microplastics, neuroimmunotoxicity and nutraceuticals, along with a look at the latest cutting-edge technologies used to detect biomarkers. Each chapter contains several references to current literature and important resources for further reading. Given this comprehensive treatment, this book is an essential reference for anyone interested in biomarkers across the scientific and biomedical fields. Evaluates the expansive literature, providing one resource covering all aspects of toxicology biomarkers Includes completely revised chapters, along with additional chapters on the newest developments in the field Identifies and discusses the most sensitive, accurate, unique and validated biomarkers used as indicators of exposure Covers special topics and applications of biomarkers, including chapters on molecular toxicology biomarkers, biomarker analysis for nanotoxicology, development of biomarkers for drug efficacy evaluation, and much more

Atlas of Thyroid and Neuroendocrine Tumor Markers Book

Atlas of Thyroid and Neuroendocrine Tumor Markers

  • Author : Luca Giovanella
  • Publisher : Springer
  • Release Date : 2018-01-22
  • Genre: Medical
  • Pages : 249
  • ISBN 10 : 9783319625065

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This book highlights the increase in thyroid tumors and NET and demonstrates the growing importance of circulating markers in diagnosis as well as treatment and follow-up. Dramatic technical improvements have heightened the clinical impact of well-established, conventional biochemical markers. In addition, more recent genetic and molecular approaches have provided innovative molecular markers. In this context, effective communication between clinicians and laboratory physicians/scientists is essential in allowing all those involved to fully profit from these exciting advances. In this comprehensive, up-to-date book, authors from different laboratory and clinical areas link laboratory and clinical topics. Analytical problems such as interferences, false-negative and false-positive results are discussed in depth, and flow-charts offer insights into identifying and avoiding them. Illustrated clinical cases detail the clinical role and limitations of different tumor markers. Lastly, it explores health technology assessment and economic issues. This is a valuable resource for endocrinologists, oncologists, nuclear medicine physicians, scientists and technologists who want to keep abreast of the latest developments.

Endocrine Tumours Book

Endocrine Tumours

  • Author : Julia M. Polak
  • Publisher : Unknown
  • Release Date : 1985
  • Genre: Cancer
  • Pages : 312
  • ISBN 10 : UOM:39015009548390

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