Endocrine Biomarkers Book

Endocrine Biomarkers

  • Author : Hossein Sadrzadeh
  • Publisher : Elsevier
  • Release Date : 2017-09-25
  • Genre: Medical
  • Pages : 478
  • ISBN 10 : 9780128034187

Endocrine Biomarkers Excerpt :

Endocrine Biomarkers: Clinical Aspects and Laboratory Determination covers all the pre-analytical variables that can affect test results, both in the clinic and laboratory. Biomarkers of endocrine and bone diseases are discussed from both clinical and laboratory perspectives, and the authors elaborate on the teamwork-based app+roach between the clinician and the laboratory professional in the diagnosis and management of endocrine and bone disorders. Discussions include test utilization, laboratory measurement methods, harmonization and standardization, interpretation of results, and reference intervals. Each chapter ends with a discussion of one or two relevant cases with shared opinions from both a clinician and a clinical chemist. Each chapter also includes a summary box outlining key points and common pitfalls in the use of specific disease biomarkers and tests. Focuses on the traditional, current, and emerging clinical chemistry tests for endocrine and bone diseases, along with their application in individual clinical management Presents a brief discussion of each disorder and its respective interrelationships, along with laboratory methodologies that can be used to aid in evaluation of disorders Reviews common approaches to the measurement of the relevant hormones, with a special focus on measures that require a structured clinical testing scenario Reviews novel chemistry tests as potential means of future diagnostic tests Provides an overview of the current methodology and controversies in the concept of target lipid levels, paying particular attention to the role of clinical chemistry in helping to implement population health targets

Toxicity Biomarkers Book

Toxicity Biomarkers

  • Author : S. Srivastava
  • Publisher : IOS Press
  • Release Date : 2005
  • Genre: Medical
  • Pages : 108
  • ISBN 10 : 1586035258

Toxicity Biomarkers Excerpt :

Since the dawn of civilization, humans have feared the unknown risks associated with the use of new natural herbs or other natural medications to cure their pain, aches and illnesses. In the ancient Indian Ayurvedic Medicine which is over 4000 years old, the 'Visha (poison) Tantra (wisdom)' was developed as a discipline of medicine encompassing Toxicology and Preventive Medicines. Visha Tantra included the study of various toxic herbs and animals and their antidotes as well as the biomarkers of toxic effects. In the Visha Tantra and the practice of Ayurvedic medicine, there have been objective descriptions of the changes in colour and amount of urine, changes in the colour of nails, skin, and eyes, breathing patterns, gastrointestinal disturbances, and precautionary measures to prevent adverse effects as biomarkers of toxicity associated with the use of herbal medicines and certain foods. The adverse effects are the inevitable outcome of the environmental and industrial chemicals and pharmaceuticals; however, efforts are ongoing to prevent unexpected life-threatening toxicities and / or irreversible organ damage. The search for non-invasive biomarkers that can be objectively linked to adverse effects associated with man-made synthetic chemicals including pharmaceuticals and environmental pollutants is becoming an important priority for academics, federal agencies, pharmaceutical and industrial companies. This publication is devoted to toxicity biomarkers of target organs of toxicity and molecular epidemiology. It provides a comprehensive review of a wide spectrum of biomarkers, including molecular epidemiology biomarkers of aflatoxin and hepatitis B virus induced hepatocarcinogenesis, cytokines as the biomarkers of hepatocellular injury, drug-induced vascular injury, nephrotoxicity and reproductive toxicity biomarkers.

Use of Biomarkers for Environmental Quality Assessment Book

Use of Biomarkers for Environmental Quality Assessment

  • Author : Jean-Claude Amiard
  • Publisher : CRC Press
  • Release Date : 2021-05-30
  • Genre: Technology & Engineering
  • Pages : 475
  • ISBN 10 : 9781000445640

Use of Biomarkers for Environmental Quality Assessment Excerpt :

This work is primarily designed for any person or organization in charge of assessment of the quality of natural resources and of pollution prevention.

Handbook of Diagnostic Endocrinology Book

Handbook of Diagnostic Endocrinology

  • Author : William E. Winter
  • Publisher : Academic Press
  • Release Date : 2020-10-06
  • Genre: Medical
  • Pages : 744
  • ISBN 10 : 9780128182789

Handbook of Diagnostic Endocrinology Excerpt :

The clinical laboratory plays a critical role in the diagnosis and management of endocrine and related metabolic disorders, which are leading causes of morbidity and mortality in children and adults. The Handbook of Diagnostic Endocrinology, Third Edition, provides a ready reference for the evaluation, diagnosis, and monitoring of such disorders. This revision incorporates translational medicine, connecting what clinicians need to know with those in research providing a clinical context to which they can relate their molecular findings. This book solves the needs of clinicians and researchers by bringing together in one book endocrinology at the molecular and clinical levels. As the intricacies of intracellular signaling have become better understood, states of hormone resistance are now increasingly recognized. The most common endocrinopathy in westernized countries, the metabolic syndrome, results, to a large extent, from insulin resistance. The complexity of the circulating forms of various hormones are acknowledged in this revision. Each chapter focuses on the biochemical tests that are required, either in the basal state or following provocation or suppression, to assist in the diagnosis of the various disorders Describes proper sample collection and relevant interpretations of laboratory tests Contains essential molecular biology and incorporates it with the clinical information Includes the discovery of new diagnostic and treatment methods

Biomarkers in Toxicology Book

Biomarkers in Toxicology

  • Author : Ramesh C. Gupta
  • Publisher : Academic Press
  • Release Date : 2019-02-13
  • Genre: Medical
  • Pages : 1246
  • ISBN 10 : 9780128146569

Biomarkers in Toxicology Excerpt :

Biomarkers in Toxicology, Second Edition, is a timely and comprehensive reference dedicated to all aspects of biomarkers that relate to chemical exposure and their effects on biological systems. This revised and completely updated edition includes both vertebrate and non-vertebrate species models for toxicological testing and the development of biomarkers. Divided into several key sections, this reference volume contains new chapters devoted to topics in microplastics, neuroimmunotoxicity and nutraceuticals, along with a look at the latest cutting-edge technologies used to detect biomarkers. Each chapter contains several references to current literature and important resources for further reading. Given this comprehensive treatment, this book is an essential reference for anyone interested in biomarkers across the scientific and biomedical fields. Evaluates the expansive literature, providing one resource covering all aspects of toxicology biomarkers Includes completely revised chapters, along with additional chapters on the newest developments in the field Identifies and discusses the most sensitive, accurate, unique and validated biomarkers used as indicators of exposure Covers special topics and applications of biomarkers, including chapters on molecular toxicology biomarkers, biomarker analysis for nanotoxicology, development of biomarkers for drug efficacy evaluation, and much more

Ecological Biomarkers Book

Ecological Biomarkers

  • Author : Claude Amiard-Triquet
  • Publisher : CRC Press
  • Release Date : 2016-04-19
  • Genre: Science
  • Pages : 464
  • ISBN 10 : 9781439880531

Ecological Biomarkers Excerpt :

Does a change, which affects a few biological macro-molecules, some cells, or a few individuals within a population, have any ecological significance that would allow the prediction of deleterious effects at higher levels of biological organization, namely the population, community, and ultimately the ecosystem? With contributions from experts in the field, Ecological Biomarkers: Indicators of Ecotoxicological Effects explores how biomarkers can be used to predict effects farther down the chain. It presents a synthesis of the state of the art in the methodology of biomarkers and its contribution to ecological risk assessment. This book describes the core biomarkers currently used in environmental research concerned with biological monitoring, biomarkers which correspond to the defences developed by living organisms in response to contaminants in their environment, and biomarkers that reveal biological damage resulting from contaminant stressors. It examines the efficacy of lysosomal biomarkers, immunotoxicity effects, behavioral disturbances, energy metabolism impairments, endocrine disruption measures, and genotoxicity as all indicative of probable toxic effects at higher biological levels. It is time to revisit the biological responses most ecologically relevant in the diagnosis of the health status of an aquatic environment well before it becomes unmanageable. Biomarkers provide a real possibility of delivering an easily measured marker at a simple level of biological organization that is predictably linked to a potentially ecologically significant effect at higher levels of biological organization. The text explores the latest knowledge and thinking on how to use biomarkers as tools for the assessment of environmental health and management.

Challenges in Endocrine Disruptor Toxicology and Risk Assessment Book

Challenges in Endocrine Disruptor Toxicology and Risk Assessment

  • Author : Alberto Mantovani
  • Publisher : Royal Society of Chemistry
  • Release Date : 2020-12-08
  • Genre: Science
  • Pages : 518
  • ISBN 10 : 9781839160837

Challenges in Endocrine Disruptor Toxicology and Risk Assessment Excerpt :

Insight into the role of hormones, particularly estrogen and testosterone, in health and disease etiology – including interactions with other hormone pathways – has dramatically changed. Estrogen and androgen receptors, with their polymorphisms, are key molecules in all tissues and are involved in a number of homeostatic mechanisms but also pathological processes including carcinogenesis and the development of metabolic and neurological disorders such as diabetes and Alzheimer’s disease. Endocrine disrupting chemicals (EDCs) can interfere with the endocrine (hormone) systems at certain dosages and play a key role in the pathology of disease. Most known EDCs are manmade and are therefore an increasing concern given the number commonly found in household products and the environment. This book will cover the mechanisms of EDC pathology across the spectrum of disease, as well as risk assessment and government and legal regulation to provide a holistic view of the current issues and cutting-edge research in the topic. With contributions from global leaders in the field, this book will be an ideal reference for toxicologists, endocrinologists and researchers interested in developmental biology, regulatory toxicology and the interface between environment and human health.

Novel Biomarkers in the Continuum of Breast Cancer Book

Novel Biomarkers in the Continuum of Breast Cancer

  • Author : Vered Stearns
  • Publisher : Springer
  • Release Date : 2016-03-17
  • Genre: Medical
  • Pages : 279
  • ISBN 10 : 9783319229096

Novel Biomarkers in the Continuum of Breast Cancer Excerpt :

This volume provides a comprehensive review of established and novel biomarkers across the continuum of breast cancer. The volume covers topics related to breast cancer risk and prevention, prediction of response to today’s standard therapies, and markers capable of influencing treatment decisions in the near future. Chapter authors combine their wide-ranging expertise to review the current status of the biomarker and to offer their individual perspectives on how biomarkers may be used in future treatments and research. Breast cancer continues to be the most common malignancy diagnosed in women in the Western world. While there are multiple treatment approaches for breast cancer, today more than ever we recognize that each tumor is unique. The challenge ahead is to consider how to best use validated and novel biomarkers to select the most appropriate treatment(s) for individual patients.

Endocrine Disruptors Book

Endocrine Disruptors

  • Author : Rajesh K. Naz
  • Publisher : CRC Press
  • Release Date : 2004-11-29
  • Genre: Medical
  • Pages : 464
  • ISBN 10 : 9781420038866

Endocrine Disruptors Excerpt :

There is great concern regarding the reproductive and health hazards of endocrine disruptors. Research indicates that men are experiencing declining fertility and an increased incidence of prostate cancer, while women are dealing with increased infertility, early menopause, and breast cancer. As new research reveals the previously unknown risks of these endocrine disruptors, it is imperative to update our knowledge of these controversial chemicals. Endocrine Disruptors: Effects on Male and Female Reproductive Systems, Second Edition examines the reproductive and health hazards of endocrine-disrupting environmental chemicals from epidemiology to etiology, concluding with future directions. Divided into two sections, the first part of the book describes the effects of environmental toxicants on the female reproductive system, with an emphasis on the effects and mechanisms of their action on sex differentiation during development, fertility, and breast cancer. The second part addresses the effects of endocrine disruption on the male reproductive system, focusing on male fertility and the development of benign prostate hyperplasia (BPH) and prostate cancer. Leading authorities contribute expert analyses and up-to-date information on a topic that has become a major concern among the scientific community and the general public. This second edition supplies the most current, critical knowledge on the real risks that endocrine disruptors pose to the population.

Handbook of Therapeutic Biomarkers in Cancer Book

Handbook of Therapeutic Biomarkers in Cancer

  • Author : Sherry X. Yang
  • Publisher : CRC Press
  • Release Date : 2021-02-01
  • Genre: Medical
  • Pages : 678
  • ISBN 10 : 9781000367539

Handbook of Therapeutic Biomarkers in Cancer Excerpt :

This book provides a comprehensive overview of the fast-evolving subject of clinical application of cancer therapeutic biomarkers. The second edition captures significant progress of cancer immunotherapy and emphasizes the genetic basis for selective cancer treatment. It covers an in-depth insight on biomarkers across a broad area of cancer research and oncology with a wealth of integrated genetic and molecular information about specific therapies by a multidisciplinary team of internationally recognized experts. Each chapter focuses on a class of targeted, immunologic, or chemotherapy agents and their companion biomarkers that predict response, benefit or resistance, and severe adverse event. The book will serve as a handbook for health professionals and scientists on the current applicable biomarkers in the management of cancer. The vision into the systemic classification and statistical consideration of therapeutic biomarkers summarized by the book editors and chapter authors will help advance precision medicine—a precisely tailored cancer treatment strategy for cancer patient care.