Endocrine Disruption and Human Health Book

Endocrine Disruption and Human Health


  • Author : Philippa D. Darbre
  • Publisher : Academic Press
  • Release Date : 2015-03-21
  • Genre: Medical
  • Pages : 390
  • ISBN 10 : 9780128011201

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Endocrine Disruption and Human Health Excerpt :

Endocrine Disruption and Human Health starts with an overview of what endocrine disruptors are, the issues surrounding them, and the source of these chemicals in the ecosystem. This is followed by an overview of the mechanisms of action and assay systems. The third section includes chapters written by specialists on different aspects of concern for the effects of endocrine disruption on human health. Finally, the authors consider the risk assessment of endocrine disruptors and the pertinent regulation developed by the EU, the US FDA, as well as REACH and NGOs. The book has been written for researchers and research clinicians interested in learning about the actions of endocrine disruptors and current evidence justifying concerns for human health but is useful for those approaching the subject for the first time, graduate students, and advanced undergraduate students. Provides readers with access to a range of information from the basic mechanisms and assays to cutting-edge research investigating concerns for human health Presents a comprehensive, translational look at all aspects of endocrine disruption and its effects on human health Offers guidance on the risk assessment of endocrine disruptors and current relevant regulatory considerations

Challenges in Endocrine Disruptor Toxicology and Risk Assessment Book

Challenges in Endocrine Disruptor Toxicology and Risk Assessment


  • Author : Alexandra Fucic
  • Publisher : Royal Society of Chemistry
  • Release Date : 2020-12-08
  • Genre: Science
  • Pages : 539
  • ISBN 10 : 9781788017411

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Challenges in Endocrine Disruptor Toxicology and Risk Assessment Excerpt :

Insight into the role of hormones, particularly estrogen and testosterone, in health and disease etiology - including interactions with other hormone pathways - has dramatically changed. Estrogen and androgen receptors, with their polymorphisms, are key molecules in all tissues and are involved in a number of homeostatic mechanisms but also pathological processes including carcinogenesis and the development of metabolic and neurological disorders such as diabetes and Alzheimer's disease. Endocrine disrupting chemicals (EDCs) can interfere with the endocrine (hormone) systems at certain dosages and play a key role in the pathology of disease. Most known EDCs are manmade and are therefore an increasing concern given the number commonly found in household products and the environment. This book will cover the mechanisms of EDC pathology across the spectrum of disease, as well as risk assessment and government and legal regulation to provide a holistic view of the current issues and cutting-edge research in the topic. With contributions from global leaders in the field, this book will be an ideal reference for toxicologists, endocrinologists and researchers interested in developmental biology, regulatory toxicology and the interface between environment and human health.

Endocrine Disruption and Human Health Book

Endocrine Disruption and Human Health


  • Author : Philippa D. Darbre
  • Publisher : Academic Press
  • Release Date : 2021-09-19
  • Genre: Medical
  • Pages : 538
  • ISBN 10 : 9780128219881

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Endocrine Disruption and Human Health Excerpt :

Updated with new and expanded chapters, Endocrine Disruption and Human Health, Second Edition provides an introduction to what endocrine disruptors are, the issues surrounding them, the source of these chemicals in the ecosystem and the mechanisms of action and assay systems. Contributions by specialists are included to discuss the varying effects of endocrine disruption on human health, and procedures for risk assessment of endocrine disruptors, and current approaches to their regulation are also covered. With new material on topics such as low-term, low dose mixtures, windows of susceptibility, epigenetics, EDCs effect on the gut microbiome, EDCs in from polluted air and oral exposures, green chemistry, and nanotechnology, the new edition of Endocrine Disruption and Human Health is a valuable and informative text for academic and clinical researchers and other health professionals approaching endocrine disruption and its effects on human health for the first time, graduate students, and advanced undergraduate students. Provides readers with access to a range of information from the basic mechanisms and assays through to cutting-edge research investigating concerns for human health Presents a comprehensive, translational look at all aspects of endocrine disruption and its effects on human health Offers guidance on the risk assessment of endocrine disruptors and current relevant regulatory considerations Newly added content on topics like low-term, low dose mixtures, windows of susceptibility to EDCs, EDCs effect on the gut microbiome, green chemistry, and nanotechnology

Endocrine Disrupting Chemicals Book

Endocrine Disrupting Chemicals


  • Author : Andrea C. Gore
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-06-08
  • Genre: Medical
  • Pages : 361
  • ISBN 10 : 9781597451079

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Endocrine Disrupting Chemicals Excerpt :

This book provides comprehensive coverage of the three most important themes in the field of Endocrine Disrupting Chemicals (EDC) research: the basic biology of EDCs, particularly their effects on reproductive systems; EDC effects on humans and wildlife, including biomedical considerations; and potential interventions and practical advice for dealing with the problem of EDCs.

Environmental Issues and Sustainable Development Book

Environmental Issues and Sustainable Development


  • Author : Suriyanarayanan Sarvajayakesavalu
  • Publisher : BoD – Books on Demand
  • Release Date : 2021-05-27
  • Genre: Science
  • Pages : 400
  • ISBN 10 : 9781838809164

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Environmental Issues and Sustainable Development Excerpt :

In recent years, attention to climate change and its associated impacts on economic and social development has increased significantly. Extreme weather conditions worldwide are threatening the survival of sensitive species and habitats. The situation is so dire that governments, academia, and non-governmental organizations across the globe are actively working to meet the United Nations Sustainable Development Goals. This book enhances understanding of environmental changes and the relative response to the socio-economic challenges of development. It provides a comprehensive overview of the impact of environmental change on natural resources and the climate, as well as discusses waste management and sustainable solutions.

Endocrine Disruptors and Puberty Book

Endocrine Disruptors and Puberty


  • Author : Evanthia Diamanti-Kandarakis
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-12-01
  • Genre: Medical
  • Pages : 378
  • ISBN 10 : 1607615614

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Endocrine Disruptors and Puberty Excerpt :

Endocrine disruption represents one of the most controversial environmental issues of our time. Mounting evidence stemming from more than 10 years of experimental, epidemiological and clinical studies has transformed the once generally discounted subject of endocrine disruptors into an issue of tremendous concern not only within the scientific community but among society as a whole. Following initial evidence from basic research, endocrine disruption in humans has now emerged as a major medical challenge. In this respect, puberty, a crucial developmental stage, has been definitively identified as a key window of vulnerability with regard to endocrine disruptors. Written by leading authorities in the field, Endocrine Disruptors and Puberty offers an engaging and comprehensive overview of this fascinating and rapidly growing problem. An indispensable resource for all clinicians and scientists interested in this challenging endocrinologic topic, Endocrine Disruptors and Puberty is a timely contribution that will help navigate a path toward understanding the problem and developing solutions.

Endocrine Disruptors in the Environment Book

Endocrine Disruptors in the Environment


  • Author : Sushil K. Khetan
  • Publisher : John Wiley & Sons
  • Release Date : 2014-05-23
  • Genre: Technology & Engineering
  • Pages : 408
  • ISBN 10 : 9781118891155

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Endocrine Disruptors in the Environment Excerpt :

Endocrine Disruptors in the Environment A concise and engaging overview of endocrine disruption phenomena that brings complex concepts within the reach of non-specialists For most of the last decade, the science of endocrine disruption has evolved with more definitive evidence of its damaging potential to health and environment. This book lists the major environmental chemicals of concern and their mechanism of endocrine disruption including remedial measures for them. Divided into three parts, Endocrine Disruptors in the Environment begins with an overview of the endocrine system and endocrine disruptors, discussing their salient features and presenting a historical perspective of endocrine disruption phenomena. It then goes on to cover hormone- signaling mechanisms, followed by various broad classes of putative endocrine disruptors, before introducing readers to environmental epigenetic modifications. Part two of the book focuses on removal processes of various EDCs by biotic and abiotic transformation/degradation. The last section consists of four chapters embracing themes on finding solutions to environmental EDCs—including their detection, regulation, replacement, and remediation. Endocrine Disruptors in the Environment is the first book to detail the endocrine effects of several known environmental contaminants and their mechanism of endocrine disruption. Additionally, it: Covers both the chemistry and biology of endocrine disruption and compiles almost all the known endocrine disrupting environmental chemicals and their mechanisms of toxicity Addresses policy and regulatory issues relevant to EDCs including scientific uncertainty and precautionary policy Brings forth the use of Green Chemistry principles in avoiding endocrine disruption in the designing and screening for safer chemicals and remediation of the EDCs in aquatic environment Includes a useful glossary of technical terms, a list of acronyms, topical references, and a subject index Endocrine Disru

Endocrine Disruptors Book

Endocrine Disruptors


  • Author : Ahmed R. G.
  • Publisher : BoD – Books on Demand
  • Release Date : 2018-10-10
  • Genre: Medical
  • Pages : 154
  • ISBN 10 : 9781789841510

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Endocrine Disruptors Excerpt :

The World Health Organization estimated that each year there are more than 13 million deaths caused by environmental causes. Exposure to endocrine disrupting chemicals (EDCs) during development may cause long-term health outcomes. This book, Endocrine Disruptors, includes eight chapters that illustrate potential endocrine-disrupting activities in water, sediments, crops, animals, and humans. This book assesses the relationship between the EDCs and development, reproduction, or obesity. Finally, detection of the levels of EDCs by autobioluminescent cellular bioreporters is discussed. Scientists, physicians, neuroendocrinologists, neurotoxicologists, and lay readers who have engaged in EDC studies or practice will discover that this book offers insight into all areas of EDC research.

Endocrine Disruption in Fish Book

Endocrine Disruption in Fish


  • Author : David E. Kime
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-06
  • Genre: Science
  • Pages : 396
  • ISBN 10 : 9781461549437

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Endocrine Disruption in Fish Excerpt :

The last half-century has shown a dramatic increase in the standard of living of millions of people in Europe, North America and many parts of the Third World. This has, in many ways been brought about by scientific and technical developments which were initiated in the 1940s and 1950s. Promises were then made that nuclear energy would provide electricity so cheap that it would not need metering, pesticides would end malnutrition throughout the world and plastics and other synthetic chemicals would revolutionise our manufacturing industry and our way of life. Whilst some of these promises have been fulfilled, the problems of long-term health risks to humans and wildlife arising from the use, production and disposal of these products were either unknown or deliberately understated. Nuclear power is rendered economically unviable when the real cost of decommissioning and storage of waste for several millenia is included, and the effects on health of both humans and wildlife of early pest eradication programmes with organochlorine pesticides were well documented in Rachel Carson's "Silent Spring". Evidence of the effects of aerosols and refrigerants on depletion of the ozone layer has led to restriction on the use of CFCs, and there is now increasing evidence of climate change resulting from our profligate use of fossil fuels.

Count Down Book
Score: 4
From 4 Ratings

Count Down


  • Author : Shanna H. Swan
  • Publisher : Scribner
  • Release Date : 2021-02-23
  • Genre: Health & Fitness
  • Pages : 304
  • ISBN 10 : 9781982113667

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Count Down Excerpt :

In the tradition of Silent Spring and The Sixth Extinction, an urgent, meticulously researched, and groundbreaking book about the ways in which chemicals in the modern environment are changing—and endangering—human sexuality and fertility on the grandest scale, from renowned epidemiologist Shanna Swan. In 2017, author Shanna Swan and her team of researchers completed a major study. They found that over the past four decades, sperm levels among men in Western countries have dropped by more than 50 percent. They came to this conclusion after examining 185 studies involving close to 45,000 healthy men. The result sent shockwaves around the globe—but the story didn’t end there. It turns out our sexual development is changing in broader ways, for both men and women and even other species, and that the modern world is on pace to become an infertile one. How and why could this happen? What is hijacking our fertility and our health? Count Down unpacks these questions, revealing what Swan and other researchers have learned about how both lifestyle and chemical exposures are affecting our fertility, sexual development—potentially including the increase in gender fluidity—and general health as a species. Engagingly explaining the science and repercussions of these worldwide threats and providing simple and practical guidelines for effectively avoiding chemical goods (from water bottles to shaving cream) both as individuals and societies, Count Down is at once an urgent wake-up call, an illuminating read, and a vital tool for the protection of our future.

Veterans and Agent Orange Book

Veterans and Agent Orange


  • Author : Institute of Medicine
  • Publisher : National Academies Press
  • Release Date : 2014-03-06
  • Genre: Medical
  • Pages : 1006
  • ISBN 10 : 9780309288897

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Veterans and Agent Orange Excerpt :

From 1962 to 1971, the US military sprayed herbicides over Vietnam to strip the thick jungle canopy that could conceal opposition forces, to destroy crops that those forces might depend on, and to clear tall grasses and bushes from the perimeters of US base camps and outlying fire-support bases. Mixtures of 2,4-dichlorophenoxyacetic acid (2,4-D), 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), picloram, and cacodylic acid made up the bulk of the herbicides sprayed. The main chemical mixture sprayed was Agent Orange, a 50:50 mixture of 2,4-D and 2,4,5-T. At the time of the spraying, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the most toxic form of dioxin, was an unintended contaminant generated during the production of 2,4,5-T and so was present in Agent Orange and some other formulations sprayed in Vietnam. Because of complaints from returning Vietnam veterans about their own health and that of their children combined with emerging toxicologic evidence of adverse effects of phenoxy herbicides and TCDD, the National Academy of Sciences (NAS) was asked to perform a comprehensive evaluation of scientific and medical information regarding the health effects of exposure to Agent Orange, other herbicides used in Vietnam, and the various components of those herbicides, including TCDD. Updated evaluations are conducted every two years to review newly available literature and draw conclusions from the overall evidence.Veterans and Agent Orange: Update 2012 reviews peer-reviewed scientific reports concerning associations between health outcomes and exposure to TCDD and other chemicals in the herbicides used in Vietnam that were published in October 2010-September 2012 and integrates this information with the previously established evidence database. This report considers whether a statistical association with herbicide exposure exists, taking into account the strength of the scientific evidence and the appropriateness of the statistical and epidemiological methods used to detec

Hormonally Active Agents in the Environment Book

Hormonally Active Agents in the Environment


  • Author : National Research Council
  • Publisher : National Academies Press
  • Release Date : 2000-02-03
  • Genre: Science
  • Pages : 453
  • ISBN 10 : 9780309064194

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Hormonally Active Agents in the Environment Excerpt :

Some investigators have hypothesized that estrogens and other hormonally active agents found in the environment might be involved in breast cancer increases and sperm count declines in humans as well as deformities and reproductive problems seen in wildlife. This book looks in detail at the science behind the ominous prospect of "estrogen mimics" threatening health and well-being, from the level of ecosystems and populations to individual people and animals. The committee identifies research needs and offers specific recommendations to decision-makers. This authoritative volume: Critically evaluates the literature on hormonally active agents in the environment and identifies known and suspected toxicologic mechanisms and effects of fish, wildlife, and humans. Examines whether and how exposure to hormonally active agents occursâ€"in diet, in pharmaceuticals, from industrial releases into the environmentâ€"and why the debate centers on estrogens. Identifies significant uncertainties, limitations of knowledge, and weaknesses in the scientific literature. The book presents a wealth of information and investigates a wide range of examples across the spectrum of life that might be related to these agents.

Sicker  Fatter  Poorer Book

Sicker Fatter Poorer


  • Author : Leonardo Trasande
  • Publisher : Houghton Mifflin
  • Release Date : 2019
  • Genre: Health & Fitness
  • Pages : 245
  • ISBN 10 : 9781328553492

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Sicker Fatter Poorer Excerpt :

A leading voice in public health policy and top environmental medicine scientist reveals the alarming truth about how hormone-disrupting chemicals are affecting our daily lives--and what we can do to protect ourselves and fight back. Lurking in our homes, hiding in our offices, and polluting the air we breathe is something sinister. Something we've turned a blind eye to for far too long. Dr. Leonardo Trasande, a pediatrician, professor, and world-renowned researcher, tells the story of how our everyday surroundings are making us sicker, fatter, and poorer. Dr. Trasande exposes the chemicals that disrupt our hormonal systems and damage our health in irreparable ways. He shows us where these chemicals hide--in our homes, our schools, at work, in our food, and countless other places we can't control--as well as the workings of policy that protects the continued use of these chemicals in our lives. Drawing on extensive research and expertise, he outlines dramatic studies and emerging evidence about the rapid increases in neurodevelopmental, metabolic, reproductive, and immunological diseases directly related to the hundreds of thousands of chemicals that we are exposed to every day. Unfortunately, nowhere is safe. But, thanks to Dr. Trasande's work on the topic, and his commitment to effecting change, this book can help. Through a blend of narrative, scientific detective work, and concrete information about the connections between chemicals and disease, he shows us what we can do to protect ourselves and our families in the short-term, and how we can help bring the change we deserve.

Toxic Cocktail Book

Toxic Cocktail


  • Author : Barbara Demeneix
  • Publisher : Oxford University Press
  • Release Date : 2017-01-02
  • Genre: Psychology
  • Pages : 240
  • ISBN 10 : 9780190260958

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Toxic Cocktail Excerpt :

In today's world, everyone carries a toxic load of dozens of industrially produced chemicals in their bloodstream. Not only do these adversely affect the health of adults and children, but also, and more worryingly, they damage the development of unborn infants. The amniotic fluid of pregnant women has been found to contain a variety of chemicals, such as pesticides, plasticizers, disinfectant products, flame-retardants, surfactants and UV filters, many of which interfere with fetal physiology, especially thyroid hormone action. Thyroid hormone is vital for brain development, particularly for the fetus during pregnancy and for toddlers. In fact, children born to women who lack this thyroid hormone (or who are unwittingly exposed to thyroid-disrupting chemicals) have lower IQs and more neurodevelopmental problems. Evolution of the human brain has involved multiple changes and processes dependent on thyroid hormone. The urgent question thus arises: Is chemical pollution poisoning brain development and reversing evolution's most outstanding achievement: the human brain? And if so, as this book convincingly illuminates, what can be done about it both collectively and individually? Toxic Cocktail provides a clear view of how many environmental chemicals interfere with brain development. As a result, this book looks at how we define and test IQ, the evidence for IQ loss, and how chemical pollution and thyroid hormone disruption can be actors in this process, as well as increasing neurodevelopmental disease risk.

Environmental Impacts on Reproductive Health and Fertility Book

Environmental Impacts on Reproductive Health and Fertility


  • Author : Tracey J. Woodruff
  • Publisher : Cambridge University Press
  • Release Date : 2010-01-28
  • Genre: Medical
  • Pages : null
  • ISBN 10 : 9781139484848

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Environmental Impacts on Reproductive Health and Fertility Excerpt :

Many reproductive and developmental health problems are caused by exposure to chemicals that are widely dispersed in our environment. These problems include infertility, miscarriage, poor pregnancy outcomes, abnormal fetal development, early puberty, endometriosis, and diseases and cancers of reproductive organs. The compelling nature of the collective science has resulted in recognition of a new field of environmental reproductive health. Focusing on exposures to environmental contaminants, particularly during critical periods in development and their potential effects on all aspects of future reproductive life-course, this book provides the first comprehensive source of information bringing together the arguments that are spread out among various scientific disciplines in environmental health, clinical and public health fields. It provides a review of the science in key areas of the relationship between environmental contaminants and reproductive health outcomes, and recommendations on efforts toward prevention in clinical care and public policy.