Endocrine Manifestations Of Systemic Autoimmune Diseases

Endocrine Manifestations of Systemic Autoimmune Diseases

• Author : Anonim
• Publisher : Elsevier
• Release Date : 2008-06-05
• Genre: Medical
• Pages : 340
• ISBN 10 : 0080559328

This book is one of the first to evaluate the role of Steroids in autoimmune rheumatic diseases from the basic mechanisms to the clinical involvements and focuses on the importance of steroidal hormones in the pathogenesis and therapeutic management of the autoimmune rheumatic diseases. In particular, the chapters analyze the mechanisms of action and the involvement of adrenal steroids (glucocorticoids) in the neuroendocrine immune system, including effects on the elderly. The perturbations of the HPA axis as a source of altered steroidal synthesis will be discussed and related to some interesting pathological conditions that commonly complicate the autoimmune rheumatic diseases such as psychosis or fibromyalgia. Concerning the role of gonadal steroids (sex hormones), several chapters will discuss clinical and epidemiological evidences of their role, as well as their effects as risk factors in autoimmune rheumatic diseases, including a section on pediatrics. *The premier issue evaluating the role of steroids in autoimmune rheumatic diseases from the basic mechanisms to the clinical involvements *Documents the latest research and indicate recent and coming new therapeutic-biological approaches to the therapy *The book will present therapeutic perspectives concerning the new glucocorticoids, and the effects of biological drugs on their synthesis

Autoimmune Diseases in Endocrinology

• Author : Anthony P. Weetman
• Publisher : Springer Science & Business Media
• Release Date : 2007-12-26
• Genre: Medical
• Pages : 434
• ISBN 10 : 9781597455176

This is a comprehensive and novel text that examines key features that predispose individuals to autoimmune diseases. The first section details the basic mechanism of autoimmunity and examines immunogenetic and environmental factors in autoimmunity. The next section examines autoimmune thyroid disease. The third section takes a look at Type 1 diabetes mellitus. In the final section, authors explain other autoimmune endocrinopathies.

Autoimmune Diseases of the Endocrine System

• Author : Robert Volpe'
• Publisher : CRC Press
• Release Date : 1990-10-05
• Genre: Medical
• Pages : 374
• ISBN 10 : 0849368499

This book is a comprehensive, easy-to-read discussion of the organ-specific autoimmune endocrine diseases emphasizing new contributions and trends for research and management. It begins with a brief chapter introducing the general principles of immunology, followed by discussions covering topics such as immunogenetics and animal models and how they can be applied toward interpreting human autoimmune endocrine diseases, autoimmune thyroid diseases, insulin-dependent diabetes mellitus hypophysitis, and Addison's disease. The book also discusses future trends toward gaining an understanding of these disorders and possible therapeutic principles. It is well-illustrated and will prove to be a useful reference source for internists, endocrinologists, and postgraduate students interested in human autoimmune endocrine diseases.

Endocrine Autoimmunity and Associated Conditions

• Author : A.P. Weetman
• Publisher : Springer Science & Business Media
• Release Date : 2012-12-06
• Genre: Medical
• Pages : 293
• ISBN 10 : 9789401150446

Autoimmunity is the most common cause of endocrine disorders. This volume provides an up-to-date summary of recent advances in this important field. In addition, it describes developments in our understanding of conditions such as vitiligo and pernicious anaemia which are frequently associated with autoimmune endocrinopathies. There is a detailed review of animal models of endocrine disease which have contributed greatly to current knowledge. Furthermore, the aetiology, pathogenesis and treatment of the clinical disorders are discussed in depth. The book will be of interest to anyone working in the areas of endocrinology and immunology.

Auto immunity in the Endocrine System

• Author : R. Volpe
• Publisher : Springer Science & Business Media
• Release Date : 2012-12-06
• Genre: Medical
• Pages : 188
• ISBN 10 : 9783642816246

The present monograph will concern itself with those disorders of the endocrine system, either associated with destruction, interference with function or hyper function, which are considered to be due to auto-immune processes. Endocrinopathies Non-endocrine auto-immune disorders associated with the endocrinopathies Graves' (Basedow's, Parry's) disease Pernicious anaemia Hashimoto's thyroiditis Vitiligo Idiopathic Addison's disease Myaesthenia gravis Insulinopenic diabetes mellitus Sjogren's syndrome Auto-immune oophoritis and orchitis Rheumatoid arthritis Auto-immune hypoparathyroidism Idiopathic thrombocytopenic purpura Auto-immune hypophysitis Chronic active hepatitis Possibly some cases of infertility Primary biliary cirrhosis due to anti-sperm antibodies Reproduced with permission from Volpe (1977) The above table indicates those organ-specific endocrinopathies considered to be due to auto-immune factors, as well as those non-endocrine, organ-specific auto-immune disorders which may be associated with them (Volpe 1977). It is evident that such disorders, occurring without any obvious external cause, raise the very elementary question of how immune processes directed against self constituents could be initiated. Generally, of course, the immune system acts as a regulatory and defence mechanism, and disorders of auto-immunity represent breakdowns in this regulatory system. The following chapters will be concerned with the individual components ofthe endocrine system so affected by auto-immune processes; it will first be necessary to provide an initial chapter for the purpose of summarizing some general principles of immunology, in order to place the immune disorders of the endocrine system in context.

Immunoendocrinology in Health and Disease

• Author : Vincent Geenen
• Publisher : CRC Press
• Release Date : 2004-08-30
• Genre: Medical
• Pages : 808
• ISBN 10 : 9781135539290

One of the first comprehensive references dealing specifically with this new field of interdisciplinary research in medicine, Immunoendocrinology in Health and Disease offers a full scientific picture of where the immune and neuroendocrine systems intersect-placing current understanding of system components, mechanisms, and functions side by side w

Endocrine Immunology

• Author : W. Savino
• Publisher : Karger Medical and Scientific Publishers
• Release Date : 2017-02-28
• Genre: Medical
• Pages : 180
• ISBN 10 : 9783318060140

In the last decades, several in vitro and in vivo studies have revealed the existence of a very complex network between the neuroendocrine and immune system. Important molecular mechanisms underlying these interactions, in both physiological and pathological conditions, have also been described. Indeed, hormones play a pivotal role in the development and functional regulation of the immune system – both innate and acquired responses. Immune system cells present specific hormone receptors and themselves produce some hormones, thus influencing hormone secretion. More recently, the modulation of hormone secretion has been attempted for treating associated autoimmune disorders, further supporting the strong interplay between the endocrine and immune system. Distinguished experts, who have published extensively in their fields, have contributed comprehensive chapters to this volume. The focus is on the various aspects of endocrine-neuro-immune connections, providing an updated panorama - from basics to clinical applications - of current knowledge and still debated issues.

Pulmonary Involvement in Systemic Autoimmune Diseases

• Author : Anonim
• Publisher : Elsevier
• Release Date : 2004-09-11
• Genre: Medical
• Pages : 314
• ISBN 10 : 9780080515441

In this book is found the information essential to diagnosing, managing and treating the lung complications of connective tissue diseases. This is a notoriously difficult area, which continues to puzzle clinicians, despite the fact that these disorders are increasingly frequent (as a result of longer survival in connective tissue disease). In separate chapters, the major connective tissue diseases are reviewed, with detailed discussion of a variety of lung abnormalities, including pleural disease, parenchymal lung disease and pulmonary vascular disease. There are also invaluable overviews of lung histological and CT appearances in these disorders, and a deeply insightful chapter on drug-induced lung disease in connective tissue disease. The emphasis in this book is on accuracy of evaluation and the construction of a logical management plan, based on disease severity and intrinsic progressiveness.

Autoimmune Endocrinopathies

• Author : Robert Volpé
• Publisher : Springer Science & Business Media
• Release Date : 1999-06-04
• Genre: Medical
• Pages : 434
• ISBN 10 : 9781592597048

Dr. Robert Volpé and his distinguished contributors comprehensively review the latest thinking about the theoretical, experimental, and clinical aspects of autoimmune endocrine disorders. These world-renowned experts examine the pathogenesis and immunogenetics of these diseases, discuss the role of sex hormones in autoimmunity, and elucidate the nature of autoantigens. They also provide clinical detail on a wide variety of autoimmune endocrinopathies, including autoimmune thyroid disease, Graves' ophthalmopathy and dermopathy, human insulin-dependent diabetes mellitus, and autoimmune adrenocortical failure. Postpartum autoimmune endocrine syndromes, autoimmune hypophysitis, and the polyglandular autoimmune syndromes are also discussed in detail. Comprehensive and authoritative, Autoimmune Endocrinopathies provides today's most up-to-date understanding of the etiology and pathogenesis of autoimmune endocrine diseases.

Oral Signs of Systemic Disease

• Author : Nasim Fazel
• Publisher : Unknown
• Release Date : 2019
• Genre: Electronic books
• Pages : null
• ISBN 10 : 3030108627

This book provides a comprehensive overview of oral signs of a broad spectrum of systemic diseases including gastrointestinal, hematologic, and endocrine, in addition to infectious, nutritional, autoimmune, genetic and connective tissue diseases. An overview of associated key signs and salient features to look for on oral exam is provided as well as other clinical manifestations, differential diagnoses, and treatment recommendations. The mouth is an important anatomical location with a role in many critical physiologic processes that are frequently involved in conditions that affect the skin or other organ systems. In many instances, oral manifestations of a disease precede the appearance of other stigmata. Therefore, early recognition of oral signs and symptoms associated with underlying systemic diseases can be invaluable to the clinician in establishing a diagnosis and prompt initiation of therapy. This book, written for dermatologists, dentists, otolaryngologists, and oral medicine specialists, offers a structured approach to the therapy and management of diseases affecting the oral mucosa.

Immunoendocrinology Scientific and Clinical Aspects

• Author : George S. Eisenbarth
• Publisher : Springer Science & Business Media
• Release Date : 2010-12-13
• Genre: Medical
• Pages : 579
• ISBN 10 : 9781603274784

Immunoendocrinology is a rapidly developing field of research that seeks to understand the intersection of the immune and endocrine systems. Immunoendocrinology: Scientific and Clinical Aspects explores in detail the current knowledge of immunoendocrinology, namely endocrine disorders produced by disorders of immune function. Chapters cover both basic pathophysiology informed by studies of animal models as well as current understanding of multiple related clinical diseases—their pathophysiology, diagnosis, and therapy. Immunoendocrinology: Scientific and Clinical Aspects captures the central role of immunoendocrinologic processes in the pathogenesis of not only type 1 diabetes but in a range of other autoimmune and endocrine disorders.

Autoimmune Aspects of Endocrine Disorders

• Author : A. Pinchera
• Publisher : Unknown
• Release Date : 1980
• Genre: Autoimmune diseases
• Pages : 456
• ISBN 10 : UCAL:B3884069

Immunology of Endocrine Diseases

• Author : A.M. McGregor
• Publisher : Springer Science & Business Media
• Release Date : 2012-12-06
• Genre: Medical
• Pages : 224
• ISBN 10 : 9789400941717

Nineteen eighty-six is a most appropriate year in which to be writing about developments in the organ-specific, autoimmune endocrine diseases. It celebrates the publication 30 years ago in 1956 of the classic papers of Roitt and Doniach and their co-workers I , and of Rose and Witebsky2 and Adams 3 and Purves . These three sets of fundamental observations provided the initial building blocks upon which much of what has been established in the field in the last 30 years was built. No publication of this nature on endocrine autoimmune disease can cover every aspect of the subject. I have chosen to highlight the organs (thyroid and pancreeas) which have attracted the most attention, and the areas of work within these fields within which most research effort is currently focused. There are still some gaps; the insulin and TSH receptors are not considered, nor in any detail are the role of cytotoxic mechanisms in mediating gland destruction. Molecular biology will undoubtedly in the next few years clarify once and for all the controversy that surrounds the structure of the TSH receptor and T cell cloning, the role of cell-mediated cytotoxicity. The pathogenetic mechanisms underlying autoimmunity are increasingly well understood and the search for the aetiology has begun.

Cutaneous Manifestations of Endocrine Diseases

• Author : Walter K.H. Krause
• Publisher : Springer Science & Business Media
• Release Date : 2008-11-30
• Genre: Medical
• Pages : 197
• ISBN 10 : 9783540883678

Skin lesions are often the first sign for an endocrine disease. Their description is thus of relevance for early diagnosis and treatment of endocrine disease for specialists in endocrinology as well as in dermatology. Lavishly illustrated, this book describes the clinical and histological features of skin lesions observed in endocrine diseases. All features are reader-friendly structured and written in the language of dermatologists in order to enable a simple association between the features observed and the endocrine etiology.

Autoimmune Disease Models

• Author : Irun R. Cohen
• Publisher : Academic Press
• Release Date : 2014-06-28
• Genre: Medical
• Pages : 329
• ISBN 10 : 9780080917368

Because autoimmune disorders can wreak havoc in both humans and animals, these disorders are now the objects of intense and focused research. This book details specific animal models for a variety of autoimmune disorders. The contributors are recognized authorities who deal with the panoply of experimentally induced autoimmune disorders, including encephalomyelitis, allergic neuritis, uveoretinitis, myocarditis, and hepatitis. Also included are discussions of spontaneously appearing diseases such as autoimmune thyroiditis and systemic lupus erythematosus. Many other disorders are also covered in this comprehensive guide. Certain to be an aid in the planning of individual experiments and broader research programs, this book will be a valuable addition to the library of all practicing immunologists interested in immune system function and dysfunction.